11,591 results match your criteria: "Albany Medical College; lamarj@amc.edu.[Affiliation]"

Associations of exposure to PM and its compounds with carotid intima-media thickness among middle-aged adults.

Sci Total Environ

December 2024

Department of Environmental Health Sciences, School of Public Health, University at Albany, State University of New York, Rensselaer, NY, USA. Electronic address:

Article Synopsis
  • Exposure to fine particulate matter (PM), particularly black carbon (BC), is linked to an increased thickness of carotid arteries, which is a risk factor for cardiovascular diseases.
  • The study analyzed data from 3,257 participants, examining how one-year exposure to various PM compounds affects carotid intima media thickness (cIMT) through linear regression and Bayesian kernel machine regression models.
  • Results indicated a significant correlation between higher BC exposure and increased cIMT, suggesting that specific PM compounds like BC may be better indicators of adverse cardiovascular health than just overall PM mass.
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Does the geographic region of plastic surgery away rotations influence residency match success by region?

J Plast Reconstr Aesthet Surg

December 2024

Department of surgery, Division of Plastic Surgery, Albany Medical Center, Albany, NY, USA. Electronic address:

Introduction: Integrated plastic surgery is consistently one of the most competitive residency specialties to successfully match. Students, advisors, and mentors are constantly looking for strategies to increase the odds of successfully matching. Away rotations (AR) give students and residency programs a chance to experience each other and get a gage of program fit and gives the student ability to show interest in a geographic region.

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  • Synovial sarcoma (SS) is a rare type of cancer, primarily found in genitourinary tissues, commonly linked to the SS18::SSX gene fusion, and its paratesticular occurrence is extremely uncommon, with only 4 documented cases prior to this study.
  • This research details the characteristics and genetic profile of the largest cohort of paratesticular SS patients, analyzing data from 14 individuals aged 15 to 47, all of whom underwent surgical removal of the tumors and some received chemotherapy.
  • The findings indicate a generally poor prognosis for paratesticular SS even after aggressive treatment, emphasizing the need for thorough diagnostic methods to differentiate it from similar conditions, and supporting the use of SS18-SS
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Trauma-informed care (TIC) is a patient-centered, strength-based approach to caring for and empowering patients. The adolescent well visit is an opportune moment to assess and address the impact of trauma. Given the well-documented impact of trauma exposure on adolescent health, and the relationship present between social determinants of health and trauma, physicians and advanced practice practitioners are well positioned to utilize TIC in the medical visit.

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  • The ongoing GUARDIAN study aims to evaluate the feasibility and acceptability of genome sequencing as an addition to traditional newborn screening across diverse racial and ethnic groups in New York City.
  • As of the interim analysis covering 4,000 newborns, 72% of approached families consented to participate, reflecting a representative sample of various racial and ethnic demographics.
  • The study primarily assessed the screen-positive rate, enrollment rate, and successful sequencing completion, with a large majority of families opting to screen for both early-onset genetic conditions and additional neurodevelopmental disorders.
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Coherence in Chemistry: Foundations and Frontiers.

Chem Rev

November 2024

Department of Chemistry, Duke University, Durham, North Carolina 27708, United States.

Article Synopsis
  • Coherence involves the correlations between waves and is crucial in understanding molecular behaviors in chemistry research.
  • The review highlights varying definitions and concepts of "coherence" and "quantum coherence," linking them to interference patterns and their complex nature.
  • By clarifying these definitions, the aim is to improve communication and understanding in the diverse field of molecular sciences.
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Background This study analyzed the incidence, characteristics, and mortality risk associated with cryptogenic organizing pneumonia (COP) among hospitalizations for systemic lupus erythematosus (SLE) with lung involvement. Methods Adult hospitalizations from the 2016-2020 nationwide inpatient sample were analyzed using relevant International Classification of Diseases (ICD)-10 codes for SLE with lung involvement (M32.13) and COP (J84.

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Importance: The HEALing Communities Study (HCS) evaluated the effectiveness of the Communities That HEAL (CTH) intervention in preventing fatal overdoses amidst the US opioid epidemic.

Objective: To evaluate the impact of the CTH intervention on total drug overdose deaths and overdose deaths involving combinations of opioids with psychostimulants or benzodiazepines.

Design, Setting, And Participants: This randomized clinical trial was a parallel-arm, multisite, community-randomized, open, and waitlisted controlled comparison trial of communities in 4 US states between 2020 and 2023.

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Objectives: Ureteral strictures after kidney transplant are an uncommon but significant cause of morbidity. This systematic literature review investigated risk factors for ureteral stricture formation after renal transplant and overall rate of strictures after renal transplant.

Materials And Methods: We used PubMed, Medline, and Cochrane Library to search for relevant articles concerning renal transplant and posttransplant complications (ureteral stricture).

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There have been significant advances in the medical and surgical options available for contraception and management of menses for individuals, including those with intellectual developmental disorder. This new statement frames the ethical, legal, and medical issues of permanent contraception in children, adolescents, and young adults with intellectual developmental disorder, emphasizing the importance of utilizing long-acting reversible and minimally invasive treatments, whenever possible. The historical use and abuse of permanent contraception is briefly reviewed, providing the foundation for ongoing ethical and legal considerations, including issues of informed consent.

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Objective: The study objective was to characterize shared online experiences surrounding craniosynostosis.

Methods: Isolated and syndromic craniosynostosis-related consecutive posts (N = 700) made by patients and caregivers were extracted from TikTok and Instagram between 2017-2024. A cross-sectional qualitative analysis following guidelines for practical thematic analysis was performed.

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Background: Urogynecologic literature confirms that pelvic floor disorders are detrimental to sexual function in heterosexual women and that sexual function improves following treatment. Few data exist regarding these issues in women who have sex with women, potentially affecting patient-provider interactions, treatment choices and outcomes.

Objective: To describe sexual function concerns of women with pelvic floor disorders among women who have sex with women.

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Article Synopsis
  • The study investigated the relationship between metabolic syndrome, its components, and certain proteins (adipokines) with the effectiveness of advanced therapies in patients with rheumatoid arthritis (RA).
  • It included 2,368 patients, revealing that 29% had metabolic syndrome, which significantly decreased their chances of achieving meaningful improvement in disease activity after 6 months of treatment.
  • The findings suggest that while metabolic syndrome hampers treatment response for both TNFi and non-TNFi therapies, the adipokines measured did not influence clinical outcomes.
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  • A survey was conducted among neurosurgeons to understand their preferences for lumbar pedicle screw placement techniques and the use of intraoperative neuromonitoring (IONM), factoring in their level of experience.
  • Results showed that less experienced neurosurgeons favored stereotactic navigation, while more experienced ones preferred fluoroscopic guidance, with both groups using robotic navigation minimally.
  • IONM was mainly utilized by surgeons who employed multiple techniques, and there was no consensus on the need for multimodality IONM during robotic or stereotactic navigation.
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Article Synopsis
  • Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
  • The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
  • The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
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  • Racial and ethnic discrimination in medical education must be investigated to reduce disparities and promote inclusivity among students.
  • The study analyzed data from over 37,000 medical students to explore how experiences of racial discrimination impact their personal and professional identity development.
  • Results indicated that while most students felt supported in their development, African American or Black students reported significantly lower support compared to other racial and ethnic groups.
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Background: Drug-resistant tuberculosis is a growing public health threat, and early characterization of the resistance phenotype is essential for guiding treatment and mitigating the high mortality associated with the disease. However, the slow growth rate of Mycobacterium tuberculosis, the causative agent of tuberculosis, necessitates several weeks for conventional culture-dependent drug susceptibility testing (DST). In addition, there are no widely available molecular diagnostic assays for evaluating resistance to newer tuberculosis drugs or drugs with complex resistance mechanisms.

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Acute kidney injury (AKI) is a significant cause of morbidity and mortality, especially in low and lower-middle income countries. Data from the third iteration of the International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) were used to evaluate the organization of structures and services for the provision of AKI care in world countries and ISN regions. An international survey of key stakeholders (clinicians, policymakers, and patient advocates) from countries affiliated with the ISN was conducted from July to September 2022 to assess structures and services for AKI care across countries.

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Celebrating the Trainee Takeover of .

Australas Psychiatry

December 2024

Discipline of Psychiatry, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.

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Stress fracture of bone under physiological multiaxial cyclic loading: Activity-based predictive models.

Bone

January 2025

Center for Biotechnology and Interdisciplinary Studies, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; Rensselaer-Icahn School of Medicine Center for Engineering and Precision Medicine, New York, NY 10029, USA. Electronic address:

Article Synopsis
  • The study focuses on creating a reliable model for bone failure under repetitive loading, addressing limitations of previous uniaxial models that overestimate bone durability during physical activity.
  • Using cadaveric tibiae from donors aged 21 to 85, the research tested four engineering failure criteria (Von Mises, Tsai-Wu, Findley critical plane, and maximum shear strain) to better predict fatigue fractures.
  • Results showed that older individuals experience significantly lower fatigue life, with the model accurately predicting fracture occurrences after 5,000 to 200,000 cycles of activity, highlighting age-related risks in bone health.
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To date, studies of the role for epidermal integrin α3β1 in cutaneous wound re-epithelialization have produced conflicting results: wound studies in skin from global α3-null neonatal mice have implicated the integrin in promoting timely wound re-epithelialization, whereas studies in adult mice with constitutive, epidermal-specific α3β1 deletion have not. The objective of this study was to utilize a model of inducible α3β1 deletion in the epidermis to clarify the role of α3β1 in the healing of adult wounds. We utilized the recently developed transgenic K14::α3 mice (ie, inducible α3 epidermal knockout), permitting us to delete floxed alleles (α3) from epidermis just prior to wounding with topical treatment of 4-hydroxytamoxifen.

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Article Synopsis
  • Formyl peptide receptors (FPR), especially Fpr1 and Fpr2, are important in directing immune cell movement towards bacterial signals but their role in tuberculosis (TB) immunity has not been well studied.
  • Research showed that levels of Fpr1 and Fpr2 increased in the lungs and blood of mice, rabbits, and humans with TB, indicating they might play a significant role in the immune response against Mycobacterium tuberculosis (Mtb).
  • The study found that while Fpr2 deletion had no effect on TB outcomes, Fpr1-deficient mice had better control of bacterial growth, highlighting the unique functions of Fpr1 in immune response and the need for more research to fully understand its impact on TB
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  • Testicular cancer is increasingly common among young adults, prompting research into new treatment options like isoalantolactone (IATL), a natural compound from specific plants.
  • The study shows that IATL reduces cancer cell viability and induces apoptosis (cell death) by affecting various cellular pathways and proteins involved in growth and death regulation.
  • Additionally, IATL promotes a process called ferroptosis and downregulates proteins that inhibit apoptosis, indicating its promise as an anticancer treatment for testicular cancer.
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  • The study focuses on the impact of persistent bacterial gastroenteritis in children, revealing that 45.5% of participants experienced at least one persistent episode during the research period.
  • Persistent infections were defined as three or more consecutive months of positive test results, with affected children showing an average of 150 days of positive symptoms.
  • While persistent infections did not significantly affect short-term weight gain, they were linked to a decrease in linear growth over nine months, indicating a serious health risk for young children.
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  • Oral submucous fibrosis (OSF) is linked to areca nut chewing and is associated with fibrosis progression mediated by long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT).
  • The study found MIAT is overexpressed in OSF cases and contributes to myofibroblast activation by suppressing inhibitory effects on certain mRNAs.
  • Targeting the MIAT axis could be a potential therapeutic strategy for treating OSF due to its role in enhancing fibrotic tissue activation.
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