89 results match your criteria: "Albacete University Hospital Complex[Affiliation]"
Circulating miRNAs Associated With 3-Month Outcome in Patients With Acute Ischemic Stroke.
Neurology
January 2025
From the Neurovascular Research Group (I.F.-P., M.V.-P., L.R.-Á., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-B., J.J.-C.), Hospital del Mar Research Institute; Neurology Department (I.F.-P., E.G.S., A.O., E.C.-G., A.R.-C., A.S.-P., A.M.-G., J.J.-C.), Hospital Del Mar; Faculty of Medicine and Life Sciences (E.G.S., A.O., E.C.-G., A.R.-C., J.J.-C.), Universitat Pompeu Fabra, Barcelona, Spain; Department of Psychiatry (C.S.-T.), Washington University School of Medicine, St. Louis, MO; Department of Neurology (F.F.P.), Arnau de Vilanova Hospital, Lleida; Clinical Neurosciences Group (F.F.P., G.A.), Biomedical Research Institute of Lleida, University of Lleida; Neurobiology Laboratory (S.T., G.C., C.V.-B.), Neurology Department, Son Espases University Hospital, Health Research Institute of Balearic Islands; Department of Biology (G.C., C.V.-B.), Universitat de les Illes Balears, Palma de Mallorca; Department of Neurology (T.S.), and Research Unit (G.S.-H.), Albacete University Hospital Complex; and Center for Cooperative Research in Biosciences (U.L.), Basque Research and Technology Alliance, Bizkaia Technology Park, Derio, Spain.
Background And Objectives: Post-ischemic stroke (IS) outcomes vary widely among individuals, independently of clinical factors. This variability could be related to epigenetic mechanisms that regulate biological processes involved in recovery after ischemia. While several microRNAs (miRNAs) and their target genes are implicated in the pathophysiology of IS, their role in functional outcomes remains unclear.
View Article and Find Full Text PDFQuantifying HLA Mismatches at Epitope Level in Haplo-HSCT: Impact in the Outcome in Strategies Using PTCy.
HLA
November 2024
Department of Hematology, University Hospital of Salamanca, Salamanca, Spain.
Haploidentical haematopoietic stem cell transplantation (haplo-HSCT) is one of the most effective therapies for treating malignant haematological disorders. However, HLA disparities are significant barriers to the success of this process since they increase the risk of graft versus host disease (GvHD). HLA disparities quantification could help to anticipate the probability and degree of GvHD, but the best tool for such quantification remains a challenge.
View Article and Find Full Text PDFSix New Variants of HLA-DPA1*01:03 Identified by Next-Generation Sequencing.
HLA
November 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Genomic sequence of HLA-DPA1*01:03:01:81, -DPA1*01:03:01:89, -DPA1*01:03:01:90, -DPA1*01:03:01:91, -DPA1*01:03:01:93 and -DPA1*01:03:01:94 alleles in Spanish individuals.
View Article and Find Full Text PDFHLA-DQA1*05:115, the first DQA1 allele described with an alanine at position 59 of alpha-1 domain.
HLA
September 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
HLA-DQA1*05:115 shows an alanine at position 59 not described previously.
View Article and Find Full Text PDFHyperangulated versus Macintosh blades for intubation with videolaryngoscopy in ICU: the randomised multicentre INVIBLADE-ICU trial study protocol.
BMJ Open
September 2024
Pharmacology, Pharmacy and Pharmaceutical Technology Department, University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
Article Synopsis
- Tracheal intubations in the ICU face challenges like poor glottic view and higher complication rates; this study compares the efficacy of two videolaryngoscope (VL) types: the standard Macintosh blade versus a hyperangulated blade.
- The INtubation VIdeolaryngoscopy BLADE-ICU trial is a randomized, controlled study conducted across 29 ICUs in Spain, focusing on first-attempt intubation success as the primary outcome, along with other measures like time to intubation and complication rates.
- The study has ethical approval and aims to improve airway management outcomes, with patient enrollment starting in May 2024 and anticipated results to be published in 2025.
Clinical characteristics and impact on patient-reported outcomes and quality of life of people with ambulatory secondary progressive multiple sclerosis: DISCOVER study.
Mult Scler Relat Disord
October 2024
Neurology Department, CEMCAT, Vall d'Hebrón University Hospital, Barcelona, Spain.
Background: People with secondary progressive multiple sclerosis (pwSPMS) experience increasing disability, which impacts negatively on their health-related quality of life (HRQoL). Our aims were to assess the impact of secondary progressive multiple sclerosis (SPMS) on functional status and HRQoL and describe the clinical profile in this population.
Methods: DISCOVER is an observational, cross-sectional, multicenter study with retrospective data collection in real-world clinical practice in Spain.
Eight new variants of HLA-DQB1*03 identified by next-generation sequencing.
HLA
August 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Genomic sequence of HLA-DQB1*03:01:01:60, -DQB1*03:01:01:61, -DQB1*03:01:01:62, -DQB1*03:01:01:63, -DQB1*03:02:01:23, -DQB1*03:02:01:24, -DQB1*03:02:01:25 and -DQB1*03:03:02:14 alleles in Spanish individuals.
View Article and Find Full Text PDFAutologous Pericranium Graft for Necrotizing Scleritis.
Cornea
December 2024
Ophthalmology Department, Albacete University Hospital Complex, Albacete, Spain; and.
Purpose: The purpose of this study was to describe the clinical outcome of scleral staphyloma secondary to necrotizing scleritis treated with autologous pericranial grafting.
Case Report: A 63-year-old woman with necrotizing scleritis and choroidal protrusion underwent homologous scleral grafting, which failed. The patient's medical management was optimized for control of her systemic inflammation, and she underwent a second surgery consisting of autologous pericranium grafted to the parietal region.
Frailty as a Risk Factor for Depression after COVID-19 Hospital Admission.
Geriatrics (Basel)
July 2024
Nursing School, Castilla-La Mancha University, 02071 Albacete, Spain.
Background: This work aims to establish the relationship between depression and epidemiological or imaging variables, frailty, and cognitive status in patients who suffered hospital admission for COVID-19.
Methods: A longitudinal observational study investigated 72 patients admitted for COVID-19 to a hospital in Spain. Patients were evaluated at discharge and six months later.
Use of oral moist tobacco (snus) in puberty and its association with asthma in the population-based RHINESSA study.
BMJ Open Respir Res
July 2024
Department of Global Public Health and Primary Care, Centre for International Health, University of Bergen Faculty of Medicine and Dentistry, Bergen, Norway.
Objectives: To investigate the association of early snus use initiation (≤15 years of age) with asthma and asthma symptoms.
Design: Cross-sectional analysis of a population-based cohort.
Setting: Study centres in Norway, Sweden, Iceland, Denmark and Estonia, from 2016 to 2019.
Characterisation of five new variants of HLA-DPA1.
HLA
June 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Genomic sequence of HLA-DPA1*01:03:01:73, -DPA1*01:03:01:80, DPA1*01:03:01:82, -DPA1*01:155:01:02, -DPA1*02:02:02:16 alleles in Spanish individuals.
View Article and Find Full Text PDFExploring the Pathogenicity of SETX I1942T Variant in Ataxia with Oculomotor Apraxia Type 2 Through Segregation Analysis.
Mov Disord Clin Pract
August 2024
Department of Neurology, Dr. Balmis General University Hospital, Alicante, Spain.
Genomic sequence of five new variants of HLA-DQA1 in non-coding regions.
HLA
May 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Characterisation of HLA-DQA1*01:02:01:30, HLA-DQA1*01:03:01:14, HLA-DQA1*03:03:01:20, HLA-DQA1*04:01:01:13, HLA-DQA1*05:05:01:40 alleles in Spanish individuals.
View Article and Find Full Text PDFESASO classification relevance in the diagnosis and evolution in diabetic macular edema patients after dexamethasone implant treatment.
Graefes Arch Clin Exp Ophthalmol
September 2024
Department of Ophthalmology, Albacete University Hospital Complex, C/ Seminario, 4, E-02006, Albacete, Spain.
Purpose: To assess the clinical relevance of The European School for Advanced Studies in Ophthalmology (ESASO) classification in patients with diabetic macular edema (DME) after their first dexamethasone implant (DEXI) treatment.
Methods: Retrospective real-world study conducted on consecutive DME patients who underwent DEXI treatment and were controlled at month-2. Subjects were initially classified according to the ESASO classification stages.
Four new intronic variants of HLA-DQB1 detected by next-generation sequencing.
HLA
March 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Characterization of HLA-DQB1*02:02:01:18, -DQB1*02:02:01:19, -DQB1*03:02:01:20 and -DQB1*05:03:01:10 alleles in Spanish individuals.
View Article and Find Full Text PDFInfluence of prior treatment protocol on intravitreal dexamethasone implant behavior in patients with diabetic macular edema in real-world practice.
Expert Opin Drug Saf
February 2024
Department of Ophthalmology, Albacete University Hospital Complex, Albacete, Spain.
Background And Objective: Intravitreal dexamethasone implant (DEXI) has been placed as an effective option to treat diabetic macular edema (DME). However, there is no consensus on the best time to introduce it. We conducted a study to evaluate anatomical and functional behavior after the first DEXI according to previous treatment.
View Article and Find Full Text PDFGenomic sequence of the HLA-B*40:01:02:61, -B*48:01:01:14, and -C*01:02:01:69 alleles.
HLA
January 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Characterization of HLA-B*40:01:02:61, -B*48:01:01:14, and -C*01:02:01:69 alleles in Spanish individuals.
View Article and Find Full Text PDFReal-world effectiveness and safety of oral semaglutide in people living with type 2 diabetes: A nationwide multicentre retrospective observational study (ENDO S-RWD).
Diabetes Obes Metab
April 2024
Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Biomedical Research Institute of Malaga (IBIMA), Faculty of Medicine, University of Malaga, Malaga, Spain.
Symptom-related screening programme for early detection of chronic thromboembolic pulmonary hypertension after acute pulmonary embolism: the SYSPPE study.
Thorax
January 2024
Respiratory Unit, Medical-Surgical Unit of Respiratory Diseases, Virgen del Rocio University Hospital, Sevilla, Spain
Article Synopsis
- Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious complication that can occur after acute pulmonary embolism (PE), and this study evaluated a screening program for its detection among PE survivors.
- The study involved contacting patients diagnosed with acute PE two years prior to assess for symptoms like dyspnoea, leading to further testing for CTEPH diagnosis.
- The results showed that the symptom screening led to a significant increase in CTEPH diagnoses, highlighting the importance of follow-up protocols for better patient outcomes.
Three novel variants of HLA-DQB1*06 identified by next-generation sequencing.
HLA
January 2024
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Characterization of HLA-DQB1*06:472, -DQB1*06:02:01:34 and -DQB1*06:04:01:06 alleles in Spanish individuals.
View Article and Find Full Text PDFThree novel alleles HLA-A*02:1092, -A*29:01:01:11 and -B*44:03:01:58 identified by next-generation sequencing.
HLA
December 2023
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Three novel HLA Class I alleles, -A*02:1092, -A*29:01:01:11 and -B*44:03:01:58, characterized in Spanish individuals.
View Article and Find Full Text PDFFathers' preconception smoking and offspring DNA methylation.
Clin Epigenetics
August 2023
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
Background: Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking.
View Article and Find Full Text PDFFour novel HLA alleles: HLA-DPA1*01:03:01:68, -DPA1*01:03:01:71, -DQA1*02:01:01:06, and -DQB1*06:03:01:19.
HLA
October 2023
Immunology Unit, Clinical Analysis Department, Albacete University Hospital Complex, Albacete, Spain.
Four novel HLA Class II alleles, HLA-DPA1*01:03:01:68, -DPA1*01:03:01:71, -DQA1*02:01:01:06, and -DQB1*06:03:01:19, characterized in Spanish individuals.
View Article and Find Full Text PDFThe impact of frailty on intra-hospital survival in older patients with COVID-19 infection: the importance of early identification. SEMI-COVID National Registry.
Rev Clin Esp (Barc)
October 2023
Internal Medicine Department, Regional University Hospital of Málaga, Instituto de Investigación Biomedica de Málaga (IBIMA- Plataforma BIONAND), University of Málaga (UMA), Málaga, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
Background: Emerging evidence suggests that frailty may be a significant predictor of poor outcomes in older individuals hospitalized due to COVID-19. This study aims to determine the prognostic value of frailty on intrahospital patient survival.
Methods: This observational, multicenter, nationwide study included patients aged 70 years and older who were hospitalized due to COVID-19 in Spain between March 1 and December 31, 2020.
Multicentre study on the accuracy of lung ultrasound in the diagnosis and monitoring of respiratory sequelae in the medium and long term in patients with COVID-19.
Front Med (Lausanne)
May 2023
Álvaro Cunqueiro Hospital in Vigo, Pneumology Service, NeumoVigo I + i, Southern Galicia Biomedical Research Institute (IISGS), Vigo, Spain.
Article Synopsis
- Lung ultrasound (LUS) is more effective than X-ray in identifying lung issues in COVID-19 pneumonia, but its long-term diagnostic value post-recovery is not well-established.
- *This multicenter study followed COVID-19 patients over 3 and 12 months post-discharge, using LUS and comparing the results with high-resolution CT scans.
- *Findings indicated that LUS had higher sensitivity and specificity in medium-term evaluations compared to X-ray, suggesting its potential for monitoring long-term lung health in COVID-19 survivors.