Assessment of decreased ovarian reserve and systemic inflammatory markers.

Given the significance of investigating ovarian reserve in infertile women, the limitations of existing diagnostic tests, and the absence of similar studies in this area, the present study aimed to examine the relationship between systemic inflammatory markers in patients with diminished ovarian reserve referred to the fertility clinic of Alzahra Hospital in Rasht in the year 2023. This cross-sectional analytical study was conducted on 174 patients referred to the Alzahra Hospital fertility clinic in Rasht. Patients were divided into two categories based on their serum levels of anti-Müllerian hormone (AMH):AMH >1.

Animal origins free products in cell culture media: a new frontier.

Despite the importance of finding replacements for fetal bovine serum (FBS), very few studies have focused on this subject. Historically, the use of animals and their derivatives in growth, reproduction, and physiological studies has raised several concerns. The supplementation of culture media with FBS, also known as fetal calf serum, continues to be widespread, despite its limitations in quality, reproducibility, and implications for animal welfare.

Inflammatory aortic aneurysm a rare presentation of abdominal aortic aneurysm (AAA): A case report study.

Introduction: An Inflammatory abdominal aortic aneurysm (IAAA) is an inflammatory condition involving the abdominal aorta, accounting for 4-7 % of all abdominal aortic aneurysms (AAAs). In general, AAA is asymptomatic, but IAAA can have some features, including pain, constitutional symptoms, elevated inflammatory markers, and distinguishes findings on imaging.

Presentation Of Case: This article is about a 65-year-old man with flank pain who was diagnosed incidentally with IAAA and underwent surgery.

Morphological and Prognostic Values of Skin Lesions in Patients with COVID-19.

The dermatological manifestations of the coronavirus cause severe acute respiratory syndrome. The current study investigates the morphological and histopathological relationship between the emergence of skin lesions and the severity of COVID-19 across the course of the disease via a cross-sectional study. There were skin lesions (maculopapular rash, vesiculobullous lesions, urticarial lesions, cutaneous thromboembolic "CT," and erythema multiforme-like lesions "EM-like") in confirmed COVID-19 instances.

SPECT-MPI iterative denoising during the reconstruction process using a two-phase learned convolutional neural network.

Purpose: The problem of image denoising in single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is a fundamental challenge. Although various image processing techniques have been presented, they may degrade the contrast of denoised images. The proposed idea in this study is to use a deep neural network as the denoising procedure during the iterative reconstruction process rather than the post-reconstruction phase.

Opioid Use Disorder and intracerebral hemorrhage in Isfahan, Iran: a case-control study.

Background: Opium use disorder is a significant health problem in our country, leading to a considerable number of health issues. Opium has several detrimental effects on its consumers. However, the effect of Opium use disorder on intracerebral hemorrhage (ICH) has not been evaluated.

Evaluation of Guilan University of Medical Sciences medical interns' attitudes regarding breaking bad news to patients based on the SPIKES model, 2020 to 2022.

Background: Bad news may be defined as "any information which adversely and seriously affects an individual's view of his or her future." It seems necessary for physicians to use a specific method to break the bad news to patients properly. Due to the importance of this skill and its effects on patient's hope and motivation to continue his treatment process, in this study, we evaluate the interns of Guilan University of Medical Sciences' attitude to breaking bad news (BBN) to the patients based on strategy for BBN, perception of condition or seriousness, invitation from the patient to give information, knowledge: giving medical facts, explore emotions, and sympathize (SPIKES) model in 2020-2022.

Efficacy of Licorice as Adjunctive Therapy in Critically Ill Patients with COVID-19: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.

Objective: There is no definitive pharmacological strategy for COVID-19; thus, medicinal herbs can be an appropriate option for COVID-19 management. We investigated the efficacy of a D-reglis tablet (root extract of licorice) as adjuvant therapy in critically ill patients with COVID-19 at intensive care units (ICUs) of Alzahra Teaching Hospital affiliated with Isfahan University of Medical Sciences, Isfahan, Iran.

Methods: In the present double-blind, randomized, placebo-controlled clinical trial, critically ill cases with COVID-19 ( = 52) received a D-reglis tablet (760 mg) or a placebo tablet for 5 days.

TLR signaling pathway and the effects of main immune cells and epigenetics factors on the diagnosis and treatment of infertility and sterility.

Recurrent pregnancy loss (RPL), often known as spontaneous miscarriages occurring two or more times in a row, is a reproductive disease that affects certain couples. The cause of RPL is unknown in many cases, leading to difficulties in therapy and increased psychological suffering in couples. Toll-like receptors (TLR) have been identified as crucial regulators of inflammation in various human tissues.

Co-occurrence of anti-phospholipid syndrome and posterior reversible encephalopathy syndrome in a patient with Autoimmune hepatitis: A case report.

Posterior reversible encephalopathy syndrome (PRES) is a neurological disease characterized by a variety of neurological findings, in accordance with radiological characteristics. PRES is commonly secondary to elevated BP and/or conditions such as autoimmune patients receiving immunosuppressive drugs. Our case involves a 36-year-old female with a history of autoimmune hepatitis (AIH), who presented with sudden onset headaches from 3 weeks prior, and a single episode of seizure attack the morning before admission.

Comparing sucrose solution with distilled water for pain management in premature infant venipuncture: randomized clinical trial.

Introduction And Importance: Managing pain is critical, especially for premature infants undergoing frequent painful procedures. Uncontrolled pain can lead to lasting harm in growth, cognitive development, and future pain responses.

Methods: A double-blinded clinical investigation involving 150 premature infants was performed in a neonatal intensive care unit.

Stillbirth risk by fetal size among 126.5 million births in 15 countries from 2000 to 2020: A fetuses-at-risk approach.

Objective: To compare stillbirth rates and risks for small for gestational age (SGA), large for gestational age (LGA) and appropriate for gestational age (AGA) pregnancies at 24-44 completed weeks of gestation using a birth-based and fetuses-at-risk approachs.

Design: Population-based, multi-country study.

Setting: National data systems in 15 high- and middle-income countries.

Designing a core data set for benign hysterectomy registration system and its implementation in a referral teaching hospital in Northwest Iran.

Background And Aims: Although minimally invasive hysterectomy offers advantages, abdominal hysterectomy remains the predominant surgical method. Creating a standardized dataset and establishing a hysterectomy registry system present opportunities for early interventions in reducing volume and selecting benign hysterectomy methods. This research aims to develop a dataset for designing benign hysterectomy registration system.

Linc00513 sponges miR-7 to modulate TGF-β signaling in azoospermia.

Azoospermia, or the complete absence of sperm in the ejaculate, affects about 1% of men worldwide and is a significant fertility challenge. This study investigates Linc00513, a long non-coding RNA, and its potential role in regulating the TGF-β signaling pathway, a key player in spermatogenesis, in the context of azoospermia. We show that Linc00513 expression is significantly lower in testicular tissues from azoospermic patients than in HS1 controls.

Vitamins, minerals and their maternal levels' role in brain development: An updated literature-review.

One's neurobehavioural and mental health are built during the exact and complex process of brain development. It is thought that fetal development is where neuropsychiatric disorders first emerged. Behavioural patterns can change as a result of neuropsychiatric illnesses.

Aquaporin expression in cryopreserved human sperm: exploring the capabilities of natural deep eutectic solvents (NADEs).

Background: Aquaporins (AQPs) are essential proteins that facilitate the rapid movement of water and cryoprotective agents (CPAs) during the cryopreservation process, and ensure the cryo-tolerance of sperm cells.

Objective: This study evaluated the preservation of aquaporin levels in human sperm after undergoing freezing using natural deep eutectic solvents (NADES) as CPAs for cryoprotection.

Materials And Methods: From June 2021 to October 2022, 35 semen samples with normal sperm parameters were acquired from the Mehr Infertility Treatment Institute in Rasht, Iran.

Placenta accreta outcomes and risk factors in a referral hospital in north of Iran: A case control study.

Background: Placenta accreta syndrome (PAS) may led to heavy blood loss and maternal death. Here we analyzed the main risk factors of PAS pregnancies and its complications in a referral hospital in the north of Iran.

Methods: In a case control study, all pregnant women with PAS referred to our department during 2016 till 2021 were enrolled and divided in two groups case (PAS+) and control (PAS-) based on preoperative imaging, intraoperative findings, and pathological reports.

New long noncoding RNA biomarkers and ceRNA networks on miR-616-3p in colorectal cancer: Bioinformatics-based study.

Background: Cancer development is aided by the role of long noncoding RNAs (lncRNAs) that act as competing endogenous RNAs (ceRNAs) absorbing microRNAs (miRNAs). We aimed to discover a novel regulatory axis in colorectal cancer (CRC) and potential biomarkers based on miR-616-3p.

Materials And Methods: The gene expression omnibus database was mined for differentially expressed lncRNAs (DELs) and mRNAs.