Role of the AMP-Activated Protein Kinase in the Pathogenesis of Polycystic Ovary Syndrome.

Polycystic ovary syndrome (PCOS) is a complex disorder characterized by elevated androgen levels, menstrual irregularities, and polycystic morphology of the ovaries. Affecting 6-10% of women in childbearing age, PCOS is a leading cause of infertility worldwide. In recent years, there has been a growing acknowledgment of the involvement of adenosine monophosphate-activated protein kinase (AMPK) in the development of polycystic ovary syndrome (PCOS).

Shifting cold to hot tumors by nanoparticle-loaded drugs and products.

Cold tumors lack antitumor immunity and are resistant to therapy, representing a major challenge in cancer medicine. Because of the immunosuppressive spirit of the tumor microenvironment (TME), this form of tumor has a low response to immunotherapy, radiotherapy, and also chemotherapy. Cold tumors have low infiltration of immune cells and a high expression of co-inhibitory molecules, such as immune checkpoints and immunosuppressive molecules.

Thermodynamic and structural investigation of oily wastewater treatment using peach kernel and walnut shell based activated carbon.

Despite the many articles about activated carbon with different precursors in adsorption process, no in-depth research has been carried out to understand the causes of the difference in surface adsorption characteristics of activated carbon with different precursors and different activation processes. In this work, the ability of two active carbon adsorbents made of walnut shell and peach kernel by two chemical and physical methods (totally 4 different types of activated carbon) in treatment of oily wastewater including diesel, gasoline, used oil or engine lubricant has been compared. The results show that the chemical activated peach carbon active with 97% hardness has provided the highest hardness and physical activated walnut carbon active has obtained the lowest hardness value (87%).

Dendritic cell-derived exosomes (Dex): Underlying the role of exosomes derived from diverse DC subtypes in cancer pathogenesis.

Exosomes are nanometric membrane vesicles of late endosomal origin that are released by most, if not all, cell types as a sophisticated means of intercellular communication. They play an essential role in the movement of materials and information between cells, transport a variety of proteins, lipids, RNA, and other vital data, and over time, they become an essential part of the drug delivery system and a marker for the early detection of many diseases. Dendritic cells have generated interest in cancer immunotherapy due to their ability to initiate and modify effective immune responses.

An FeO supported -phenylenediamine based tetraaza Schiff base-Cu(ii) complex as a novel nanomagnetic catalytic system for synthesis of pyrano[2,3-]pyrazoles.

In this research, we present a post-synthetic method for synthesizing a novel nanomagnetic Cu Schiff base complex and investigate its efficiency in catalytic organic conversion reactions. Various spectroscopic analyses were employed to characterize the physiochemical characteristics of the resulting nanocomposite. The experimental results successfully demonstrate the catalytic application of the prepared Cu-complex in the preparation of pyrano[2,3-]pyrazole heterocycles.

Bacterial contamination of cockroaches in different wards of hospital, restaurant and home.

Cockroaches are very capable of mechanically transmitting harmful microorganisms, which is seen to be a severe hazard to the general public's health. The purpose of this study was the evaluation of cockroach bacterial contamination in various locations throughout Babylon. 300 cockroaches were caught from different wards of the hospital, restaurants, and houses.

Translational research of new developments in targeted therapy of colorectal cancer.

A severe global health concern is the rising incidence and mortality rate of colorectal cancer (CRC). Chemotherapy, which is typically used to treat CRC, is known to have limited specificity and can have noticeable side effects. A paradigm shift in cancer treatment has been brought about by the development of targeted therapies, which has led to the appearance of pharmacological agents with improved efficacy and decreased toxicity.

Immunohistochemical expression of T-cell subsets (CD4 and CD8) in oral lichen planus.

Introduction: oral lichen planus (OLP) is a common oral mucosal disease with various clinical manifestations. The most predominant types are reticular and erosive. Despite extensive research on the causes of OLP, the exact etiology remains unclear.

A density functional theory study on the potential application of Ni and Co doped ZnO nanosheets as a carrier for ciclopirox anticancer drug.

The Ni and Co doping effect on the ciclopirox (CPX) drug delivery performance of a ZnO ‎nanosheet (ZnO-NS) was investigated theoretically. Doping Ni and Co metals into the ZnO-NS ‎increased the adsorption energy of CPX from -7.9 to -27.

Optimization of oil industry wastewater treatment system and proposing empirical correlations for chemical oxygen demand removal using electrocoagulation and predicting the system's performance by artificial neural network.

The alarming pace of environmental degradation necessitates the treatment of wastewater from the oil industry in order to ensure the long-term sustainability of human civilization. Electrocoagulation has emerged as a promising method for optimizing the removal of chemical oxygen demand (COD) from wastewater obtained from oil refineries. Therefore, in this study, electrocoagulation was experimentally investigated, and a single-factorial approach was employed to identify the optimal conditions, taking into account various parameters such as current density, pH, COD concentration, electrode surface area, and NaCl concentration.

Evaluating the effectiveness of Moringa oleifera leaf capsules in controlling glycemic and hypertension levels in type 2 diabetes patients.

Moringa oleifera (MO) phytochemicals and therapeutic properties improve hyperglycemia and treat type 2 diabetes. Thus, this study examined the effects of MO leaf capsules on blood glucose management in type 2 diabetic mellitus (T2DM) and hypertension and their safety. A prospective placebo-controlled experiment randomly assigned 24 patients to receive 3g and 6g of MO leaf capsules twice a day or a placebo for three months.

The developing role of extracellular vesicles in autoimmune diseases: special attention to mesenchymal stem cell-derived extracellular vesicles.

Autoimmune diseases are complex, chronic inflammatory conditions initiated by the loss of immunological tolerance to self-antigens. Nowadays, there is no effective and useful therapy for autoimmune diseases, and the existing medications have some limitations due to their nonspecific targets and side effects. During the last few decades, it has been established that mesenchymal stem cells (MSCs) have immunomodulatory functions.

Modeling and Optimal Operating Conditions of Hollow Fiber Membrane for CO/CH Separation.

In this work, the capture of carbon dioxide using a dense hollow fiber membrane was studied experimentally and theoretically. The factors affecting the flux and recovery of carbon dioxide were studied using a lab-scale system. Experiments were conducted using a mixture of methane and carbon dioxide to simulate natural gas.

UV and solar-based photocatalytic degradation of organic pollutants from ceramics industrial wastewater by Fe-doped ZnS nanoparticles.

UV and solar-based photocatalytic degradation of 2,4-dichlorophenol (2,4-DCP) as an organic contaminant in ceramics industry wastewater by ZnS and Fe-doped ZnS NPs was the focus of this research. Nanoparticles were prepared using a chemical precipitation process. The cubic, closed-packed structure of undoped ZnS and Fe-doped ZnS NPs was formed in spherical clusters, according to XRD and SEM investigations.

NK cells direct the perspective approaches to cancer immunotherapy.

Natural killer (NK) cells are innate immune cells with cytotoxic potentials to kill cancerous cells in several mechanisms, which could be implied for cancer therapy. While potent, their antitumor activities specially for solid tumors impaired by inadequate tumor infiltration, suppressive tumor microenvironment, cancer-associated stroma cells, and tumor-supportive immune cells. Therefore, manipulating or reprogramming these barriers by prospective strategies might improve current immunotherapies in the clinic or introduce novel NK-based immunotherapies.

Image Smart Segmentation Analysis Against Diabetic Foot Ulcer Using Internet of Things with Virtual Sensing.

Diabetic foot ulcer (DFU) is a problem worldwide, and prevention is crucial. The image segmentation analysis of DFU identification plays a significant role. This will produce different segmentation of the same idea, incomplete, imprecise, and other problems.

Solar light driven enhanced photocatalytic treatment of azo dye contaminated water based on Co-doped ZnO/ g-CN nanocomposite.

The current research concentrated on the Co-precipitation synthesis of g-CN (CN), ZnO, ZnO/CN, and Co-doped ZnO/CN nanocomposite, as well as the solar light enhanced photocatalytic treatment of Reactive Red 120 (RR120) from genuine wool textile effluent. The 3D flower-like structure of Co-doped ZnO distributed on the surface of CN thin sheets, according to structural studies employing XRD and SEM examinations Electrochemical experiments exhibited that the Co-doped ZnO/CN nanocomposite has a large electroactive surface area. The optical band-gap values of CN, ZnO, ZnO/CN, and Co-doped ZnO/CN nanocomposites were 2.

The role of protein kinases in diabetic neuropathic pain: an update review.

Objectives: Diabetic neuropathic pain (DNP) is a debilitating symptom of diabetic neuropathy which seriously impairs patient's quality of life. Currently, there is no specific therapy for DNP except for duloxetine and gabapentin that show limited utility in alleviating DNP. The present review aims to discuss the central role of protein kinases in the pathogenesis of DNP and their therapeutic modulation.

Cancer Stem Cells in Colorectal Cancer: Implications for Targeted Immunotherapies.

Purpose: Colorectal cancers are composed of heterogeneous cell populations in the concepts of genetic and functional degrees that among them cancer stem cells are identified with their self-renewal and stemness capability mediating primary tumorigenesis, metastasize, therapeutic resistance, and tumor recurrence. Therefore, understanding the key mechanisms of stemness in colorectal cancer stem cells (CRCSCs) provides opportunities to discover new treatments or improve existing therapeutic regimens.

Methods: We review the biological significance of stemness and the results of potential CRCSC-based targeted immunotherapies.

Synthesis and electrochemical study of enzymatic graphene oxide-based nanocomposite as stable biosensor for determination of bevacizumab as a medicine in colorectal cancer in human serum and wastewater fluids.

This work's goal was the fabrication of a graphene oxide-based nanocomposite biosensor for the determination of bevacizumab (BVZ) as a medicine for colorectal cancer in human serum and wastewater fluids. For the fabrication electrode, graphene oxide was electrodeposited on GCE (GO/GCE), and then DNA and monoclonal anti-bevacizumab antibodies were immobilized on the GO/GCE surface, respectively (Ab/DNA/GO/GCE). Structural characterization using XRD, SEM, and Raman spectroscopy confirmed the binding of DNA to GO nanosheets and the interaction of Ab with the DNA/GO array.