Expression of apoptosis regulatory proteins p53 and Bcl-2 in skin of patients with chronic renal failure on maintenance haemodialysis.

Background: Chronic renal failure results in multi-organ system derangement including cardiovascular, gastrointestinal, neurological, endocrinal, blood and dermatological abnormalities. Maintenance of skin homeostasis requires a delicate balance between proliferation, differentiation and apoptosis. p53 and Bcl-2 proteins play a central role in the regulation of apoptosis.

Effect of laser resurfacing on p53 expression in photoaged facial skin.

Background: p53 overexpression has been reported in photoaged skin. Meanwhile, p53 gene mutations have been implicated as an important factor in the pathogenesis of ultraviolet (UV) light-induced skin cancer.

Objective: The objective was to evaluate the effect of laser resurfacing on the epidermal thickness and expression of p53 in photoaged skin.

Apoptosis, P53 and Bcl-2 expression in response to topical calcipotriol therapy for psoriasis.

Background: The histopathologic changes characteristic of psoriasis might be related to suppressed apoptosis. The P53 and Bcl-2 proteins play a central role in the regulation of apoptosis. This study aimed to evaluate P53 and Bcl-2 expression and apoptotic cells in the psoriatic skin before and after topical calcipotriol therapy.

Treatment of periungual vitiligo with erbium-YAG-laser plus 5-flurouracil: a left to right comparative study.

Despite the multiple treatment modalities available for vitiligo, none of them gives satisfactory results in the periungual type. In this study we tried to explore and evaluate the effects of the combination treatment of erbium:YAG laser resurfacing and topical 5-flurouracil in periungual vitiligo. Nine adult patients presenting with periungual vitiligo lesions were included in this prospective left-right comparative study.

Effect of topical tretinoin on photoaged facial skin: a histometric, immunohistochemical and ultrastructural study.

Background: Topical tretinoin is a recognized treatment for photoageing.

Aim: To evaluate the microscopic changes induced by topical tretinoin used to treat mild to moderate photodamage in dark-skinned patients aged 30 to 50 years.

Patients And Methods: Biopsy specimens were obtained from the facial skin of 11 patients before and after treatment with topical tretinoin.

Evaluation of the effects of NB-UVB in both segmental and non-segmental vitiligo affecting different body sites.

Background: Narrow band (NB)-UVB has been used in the treatment of vitiligo for years but statistical evaluation of the clinical response in both segmental and non-segmental vitiligo patients has yet to be assessed.

Objectives: Statistical evaluation of the clinical response of vitiligo patients to NB-UVB in both segmental and non-segmental types affecting different body sites.

Methods: This study included 150 patients with vitiligo either segmental (10%) or non-segmental (90%).

A clinical and epidemiological study of lichen planus among Egyptians of al-Minya province.

Lichen planus (LP) is a papulosquamous disease that affects skin and mucous membranes. It may also affect hair and nails. From the middle east, studies concerning its prevalence and clinical characteristics are few.

Continuous-wave Nd:Yag laser hyperthermia: a successful modality in treatment of basal cell carcinoma.

It was observed that malignant tumor cells are more sensitive than normal cells to heat. Hyperthermia is known to be cytotoxic at temperatures above 41 degrees C and selectively lethal to cancer cells. The aim of the present study was to evaluate the therapeutic efficacy of continuous wave Nd:Yag laser-induced hyperthermia in treatment of basal cell carcinoma (BCC).

Trichloroacetic acid peeling versus dermabrasion: a histometric, immunohistochemical, and ultrastructural comparison.

Background: Trichloroacetic acid (TCA) chemical peel and dermabrasion are beneficial methods for treatment of photoaged skin.

Objective: In this study, we evaluated the changes induced by these therapies on various structures of facial skin of nine dark-skinned patients (Fitzpatrick types IV-V; TCA, five patients; dermabrasion, four patients) demonstrating different degrees of photodamage.

Methods: Routine histopathology coupled with histometric computer-assisted image analysis was used to assess epidermal changes.

Effect of topical tretinoin, chemical peeling and dermabrasion on p53 expression in facial skin.

The tumour suppressor protein p53 is a phosphoprotein that is activated by DNA damage. It is involved in the decision whether the cells should stop replication and proceed to repair their DNA, or to die by apoptosis. In the present study, we evaluate the effect of some treatment modalities on the expression of p53 in facial skin.

Expression of p53 in normal sun-exposed and protected skin (type IV-V) in different decades of age.

The checkpoint protein p53, which is activated by DNA damage, is involved in the decision whether the cells should stop replication and proceed to repair their DNA or die by apoptosis. We evaluate the expression of p53 and the number of apoptotic cells in normal sun-exposed (face) and protected (abdomen) skin in Egyptians between 6 and 77 years of age. The degree of p53 expression in facial skin significantly increases from a score of 1.

Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin.

Cutaneous aging is a complex biological phenomenon affecting the different constituents of the skin. To compare the effects of intrinsic and extrinsic aging processes, a total of 83 biopsies were collected from sun-exposed and protected skin of healthy volunteers representing decades from the 1st to the 9th (6-84 years of age). Routine histopathology coupled with computer-assisted image analysis was used to assess epidermal changes.

Density of viral particles in pre and post Nd: YAG laser hyperthermia therapy and cryotherapy in plantar warts.

Background: Warts often present a difficult treatment problem for clinicians because of the lack of specific antipapillomavirus agents. Plantar warts, in particular, represent a therapeutic challenge.

Methods: Twenty-five patients with plantar warts were treated with Nd:YAG hyperthermia and another 25 were treated with cryotherapy.