Prevalence of Polypharmacy and Factors Associated with it Among Saudi Older Adults - Results from the Saudi National Survey for Elderly Health (SNSEH).

Background And Objectives: The percentage of Saudi older adults (SOA) is increasing over time. With advanced age, the prevalence of chronic diseases and multiple disabilities are increasing. This leads to increase utilization of multiple medications.

The Characteristics of Clinical Studies Submitted to the Saudi Food and Drug Authority from 2009 until 2020.

Background: Clinical trials are crucial in contemporary evidence-based medicine for discovering new treatments for diseases. Their registration in a registry increases the transparency in the dissemination of knowledge about clinical research. It is essential to understand the activity of clinical trials in a country, thus identifying research gaps.

Determining the prevalence of symptoms and risk of obstructive sleep apnoea among old Saudis.

Objectives: This study aimed to determine the prevalence of symptoms and risk of obstructive sleep apnoea (OSA) and to identify the risk factors associated with OSA among old Saudis.

Methods: In this population-based survey, we administered the Saudi National Survey for Elderly Health to old Saudis between 2006 and 2007. Symptoms of OSA and its associated risk factors were determined using the Berlin questionnaire.

Smartphone addiction and associated factors among postgraduate students in an Arabic sample: a cross-sectional study.

Background: Smartphone addiction, as with other behavioral addictions, is associated with social, physical, and mental health issues. In this article, we investigated the prevalence of smartphone addiction among postgraduate students and evaluated its correlation with social demographics, depression, attention-deficit/hyperactivity disorder (ADHD), and nicotine dependence.

Objectives: The objective of this study was to investigate the prevalence of smartphone addiction among Middle Eastern postgraduate students, determine the factors associated with smartphone addiction, and estimate the incidence rate of major depressive disorder (MDD), ADHD, insomnia, and nicotine addiction among postgraduate students with smartphone addiction.

The Utilization of Complementary and Alternative Medicine among Saudi Older Adults: A Population-Based Study.

Background: Complementary and alternative medicine (CAM) is an integral part of patients' therapeutic experience worldwide. Among Saudi older adults, less is known about CAM utilization.

Objectives: To determine the prevalence, patterns, and factors associated with CAM utilization among SOA.

Fabrication of MnFeO nanoparticles embedded chitosan-diphenylureaformaldehyde resin for the removal of tetracycline from aqueous solution.

In this study, a magnetic composite was synthesized using chitosan, diphenylurea and formaldehyde with magnetic nanoparticles, (MnFeO) via condensation polymerization. The newly synthesized magnetic nanocomposite (CDF@MF) was characterized using several analytical techniques including Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) and etc. To investigate the applicability of CDF@MF, it was employed as an adsorbent for rapidly removal of an antibiotic, namely, tetracycline (TC), from aqueous solution using several factors such as pH, the adsorbent dose, the initial concentration and the contact time.

The prevalence of benzodiazepines utilization and its association with falls among Saudi older adults; results from the Saudi national survey for elderly Health (SNSEH).

Purpose: First, to determine benzodiazepines prevalence (BDZs) among Saudi older adults (SOA); Second, to quantify the association between BDZs use and falls among SOA. Third, to determine falls effect on all-cause mortality among SOA.

Methods: This is a cross-sectional study that used the Saudi National Survey for Elderly Health; a nationally-representative, population-based survey.

Survival difference between mucinous vs. non-mucinous colorectal cancer following cytoreductive surgery and intraperitoneal chemotherapy.

Background: It is believed that the oncologic behavior of mucinous colorectal adenocarcinoma (MC) is different from non-mucinous adenocarcinoma (NMC). The aim of the study is to compare long-term survivals between patients with MC and those with NMC following cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC).

Methods: This was a retrospective study of prospectively collected data of patients with peritoneal metastases of colorectal origin following CRS and IPC.

Simultaneous Determination of Paracetamol and Chlorzoxazone in Their Combined Pharmaceutical Formulations by Reversed-phase Capillary Liquid Chromatography Using a Polymethacrylate Monolithic Column.

Recently, analytical separation techniques have the potential toward green approaches to reduce the environmental impact. This study focuses on the development of an analytical method for the determination of paracetamol and chlorzoxazone in their pharmaceutical combination. The separation was achieved using a home-made capillary column (0.

Prevention of peritoneal recurrence in high-risk colorectal cancer and evidence of T4 status as a potential risk factor.

Peritoneal metastasis (PM) following primary resection of colorectal cancer is common. The combined use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy has significantly improved the survival outcome of patients with colorectal PM (CRPM). Diagnosing and treating early PM is essential as its extent is correlated with poorer outcomes.

Cellulose gum and copper nanoparticles based hydrogel as antimicrobial agents against urinary tract infection (UTI) pathogens.

In the present study, stable copper nanoparticles (CuNPs) were successfully prepared in the hydrogel matrix. The prepared nanocomposite (HCuNPs) was characterized via x-ray diffraction (XRD), electron microscopy (TEM), and energy-dispersive (EDX) and x-ray photoelectron spectroscopic (XPS) studies. The wide scan XPS spectra support the presence of C, N and O in neat hydrogel; while, the XPS spectra of HCuNPs demonstrate the presence of Cu along with C, N, and O elements.

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015.

Background: The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world.

Objectives: The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden.

Methods: CVD mortality was estimated from vital registration and verbal autopsy data.

Body dysmorphic disorder: history and curiosities.

Body dysmorphic disorder is a chronic psychiatric disorder characterized by excessive preoccupation with an absent or minimal physical deformity. It causes severe distress and impairs normal functioning. In the last centuries, this disorder has been mentioned in the medical literature by important mental health practitioners by different names, such as "dysmorphophobia" or "dermatologic hypochondriasis".

How Much Information is Lost When You Only Collect One 24-Hour Urine Sample during the Initial Metabolic Evaluation?

Purpose: During the initial metabolic evaluation the need for 1 vs 2, 24-hour urine collections is debated. While data suggest that mean urine chemistry measures are similar on consecutive samples, it remains unclear how much, if any, information is lost when only 1 sample is collected.

Materials And Methods: Using analytical files from Litholink Corporation® (1995 to 2013) we identified adults with kidney stones who underwent initial metabolic testing.

Macroporous natural capsules extracted from Phoenix dactylifera L. spore and their application in oral drugs delivery.

Macroporous natural sporopollenin exine capsules (SEC) were extracted from date palm (Phoenix dactylifera L.) and coated by natural polymer composite (carboxymethyl cellulose with epichlorohydrin). The polymer coated exine capsules (PCEC) were used in in-vitro investigations for controlled delivery of paracetamol.

Delivery of ibuprofen by natural macroporous sporopollenin exine capsules extracted from Phoenix dactylifera L.

Sporopollenin macroporous capsules (SMCs) were extracted from date palm (Phoenix dactylifera L.) spores and coated by a natural polymer composite (chitosan with glutaraldehyde). The polymer coated macroporous capsules SMC@poly were used in the in vitro-controlled delivery of ibuprofen.

Development of carboxymethyl cellulose-based hydrogel and nanosilver composite as antimicrobial agents for UTI pathogens.

Silver nanoparticles (AgNPs) containing hydrogel composite were first synthesized by preparing a new hydrogel from carboxymethyl cellulose (CMC), polyvinyl alcohol (PVA), and the cross-linker ethylene glycol diglycidyl ether (EGDE), followed by the incorporation of AgNPs by microwave radiation. The resulting neat hydrogels and AgNPs-hydrogel composites were characterized using spectral, thermal, microscopic analysis and X-ray diffraction (XRD) analyses. The SEM and TEM results demonstrated that the synthesized AgNPs were spherical with diameters ranging from 8 to 14nm.

Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients.

Our aim was to evaluate the association between the expression and the polymorphism of TLR4/NF-κB pathways and colon cancer. TLR4 (rs4986790, rs10759932, rs10759931 and rs2770150) were genotyped in blood samples from Colorectal patients and healthy controls. TLR4 and cytokines inflammatory expression were evaluated by real time PCR on 40 matching normal and colon tissues and the protein level by Immunohistochemistry.

Geographic Variation in the Quality of Secondary Prevention for Nephrolithiasis.

Objective: To examine the variation in the quality of secondary prevention for nephrolithiasis across health care markets.

Methods: Using analytical files from Litholink Corporation (2003-2012), we identified adults with nephrolithiasis and abnormal urine biochemistries on 24-hour urine collection. After assigning all patients to a hospital referral region (HRR), we determined the proportion of patients in each HRR who underwent on-treatment follow-up testing (our measure of quality).

Expression and new exon mutations of the human Beta defensins and their association on colon cancer development.

The development of cancer involves genetic predisposition and a variety of environmental exposures. Genome-wide linkage analyses provide evidence for the significant linkage of many diseases to susceptibility loci on chromosome 8p23, the location of the human defensin gene cluster. Human β-defensins (hBDs) are important molecules of innate immunity.

Statin Use and Risk of Sepsis After Percutaneous Nephrolithotomy.

Purpose: To examine the association between statin medication use and sepsis risk after percutaneous nephrolithotomy (PCNL).

Materials And Methods: Using medical claims data, we identified working-age adults with urinary stone disease who were treated with PCNL. Among this cohort, we determined which patients had a prescription fill for a statin agent that encompassed their surgery date.

A learning skills course for the 1st year medical students: an experience at a Saudi medical school.

Background: Every year nearly 1,500 students enter into medical program after passing high school and national aptitude exams. However, many students experience frustration, failure, and psychological morbidities like stress, depression, and anxiety because they are not aware of their learning styles or do not have effective learning skills and strategies. The College of Medicine of Al-Imam Muhammad ibn Saud Islamic University has adopted the outcome based, community oriented, Spiral Curriculum.

Ramadan fasting ameliorates oxidative stress and improves glycemic control and lipid profile in diabetic patients.

Purpose: The effects of Ramadan fasting on public health are important. The present study characterized the metabolic effects of Ramadan fasting and evaluated its influence on oxidative stress in diabetic patients.

Methods: The current study was carried out in the city of Benha, Egypt, during the period from July 12, 2012 to October 4, 2012.