3 results match your criteria: "Al-Azhar University Nasr City 11884 Cairo Egypt hamadaorganic@azhar.edu.eg.[Affiliation]"

An essential target for COVID-19 is the main protease of SARS-CoV-2 (M). With the objective of targeting this receptor, a novel set of pyrido[1,2-]pyrrolo[2,3-]pyrimidines with terminal carboxamide fragments was designed, synthesized, and considered as an initial motif for the creation of effective pan-coronavirus inhibitors. Accordingly, nine derivatives (21-29) have been introduced for assay to evaluate their antiviral activity and cytotoxicity effect against COVID-19 virus using Vero cells.

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The global COVID-19 pandemic became more threatening especially after the introduction of the second and third waves with the current large expectations for a fourth one as well. This urged scientists to rapidly develop a new effective therapy to combat SARS-CoV-2. Based on the structures of β-adrenergic blockers having the same hydroxyethylamine and hydroxyethylene moieties present in the protease inhibitors which were found previously to inhibit the replication of SARS-CoV, we suggested that they may decrease the SARS-CoV-2 entry into the host cell through their ability to decrease the activity of RAAS and ACE2 as well.

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Bioassay-guided investigation of extract resulted in the identification of seven steroidal saponins (Turgidosterones 1-7). They were evaluated for their antifungal, antileishmanial, and antitrypanosomal activities. Turgidosterone 6 was the most active antifungal against and (IC values of 2.

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