147 results match your criteria: "Al-Ameen College of Pharmacy[Affiliation]"
Background: The aim of the present study was to evaluate the neuroprotective effect of allantoin in cisplatin-induced toxicity in rats.
Methods: Adult male Wistar rats weighing 160-200 g were used. Neuropathy was induced by injecting cisplatin (2 mg/kg, ip, twice a week for 6 weeks) and the rats were concurrently treated with allantoin (200 and 400 mg/kg, po) for 8 weeks.
Biomed Pharmacother
July 2019
Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India; Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, USA. Electronic address:
Diabetes-induced male sexual dysfunction is associated with endothelial dysfunction. Inhibition of soluble epoxide hydrolase (sEH) is known to improve endothelial function in diabetes. Therefore, we hypothesized that sEH inhibitor (sEHI), [trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid] / t-TUCB can restore the male sexual function in diabetic rat.
View Article and Find Full Text PDFJ Integr Med
July 2019
PG and Research Centre in Biotechnology, MGR College, Hosur, Tamil Nadu 635109, India. Electronic address:
Objective: Diabetes is a common metabolic disease with several complications in its patients. Often, people living with diabetes develop erectile dysfunction (ED). The primary aim of this work was to investigate the effect of phloroglucinol in diabetes-induced ED in rats.
View Article and Find Full Text PDFDrug Dev Ind Pharm
December 2018
a Department of Pharmaceutics, Al-Ameen College of Pharmacy, Bangalore , Karnataka , India.
Different nanoparticles, namely solid lipid nanoparticles, nanocrystals and nanosponges loaded with atorvastatin were successfully fabricated with desirable technological properties which reckoned promising methods of their preparation. Further, suitable characterization and evaluation parameters for in-vitro and in-vivo studies were conducted which led to increase in drug's bioavailability, provided better in-vivo efficacy and reduced toxicity in treating hyperlipidemia systemically. Particle sizes were found to be less than 300 nm with minimal polydispersity indices and maximized entrapment efficiency which are pre-requisites for their absorption in intestines.
View Article and Find Full Text PDFProstaglandins Other Lipid Mediat
May 2018
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address:
Background: Pharmacological inhibition of soluble epoxide hydrolase (sEH) enhances the synaptic function in the CNS and has a protective role in cognitive decline. We hypothesized that the sEH inhibitor TPPU might prevent the diabetes-induced decline in learning and memory which is associated with an alteration in the level of neurotransmitters and oxidative stress.
Methods: Type 1 diabetes was induced in rats and the animals were treated with TPPU for 8 weeks.
Pharmacol Rep
April 2018
Department of Pharmaceutical Chemistry, Al-Ameen College of Pharmacy, Bangalore, Karnataka, India. Electronic address:
Background: Well known risk factors for diabetic erectile dysfunction include impaired nitric oxide synthesis and endothelial dysfunction. We proposed to evaluate the efficacy of nitric oxide donor, molsidomine in rat model of diabetic erectile dysfunction.
Methods: Streptozotocin (52mg/kg, ip) induced diabetic male rats were treated with molsidomine (5 and 10mg/kg, po) for 8 weeks.
Naunyn Schmiedebergs Arch Pharmacol
February 2018
Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru, India.
Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β-receptor antagonist with vasodilator and antioxidant property, to evaluate its neuroprotective effect in streptozotocin-induced diabetic neuropathy in rats. Diabetic neuropathy develops within 4-6 weeks after administration of streptozotocin (55 mg/kg, i.
View Article and Find Full Text PDFPharmacognosy Res
January 2017
Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine, Bengaluru, Karnataka, India.
Background And Objectives: Mudabbar/ is referred to the processes performed on the drugs to detoxify, purify, and enhance therapeutic action and to reduce its doses before making the formulations in Unani medicine. It improves quality of drugs either by optimizing its desirable characteristics or minimizing the undesirable ones; it makes drug effective, safe, and specific. There is a need of comparative evaluation to understand its significance.
View Article and Find Full Text PDFJ Biomater Sci Polym Ed
January 2018
a Department of Pharmacology , Al-Ameen College of Pharmacy, Bangalore , India.
The aim of this study was to develop a chitosan-based risedronate/zinc-hydroxyapatite intrapocket dental film (CRZHDF) for applications in the treatment of alveolar bone loss in an animal model of periodontitis. The physical characteristics (folding endurance, pH, mucoadhesive strength, risedronate content and release) of CRZHDF, exhibited results within the limit. X-ray diffraction analysis indicates reduced or disappeared crystallinity of risedronate and zinc-hydroxyapatite in presence of chitosan.
View Article and Find Full Text PDFArch Oral Biol
January 2018
Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.
Objective: The aim of this study was to develop a chitosan-metformin based intrapocket dental film (CMIDF) for applications in the treatment of periodontitis and alveolar bone loss in an rat model of periodontitis.
Design: CMIDF inserts were fabricated by the solvent casting technique. The fabricated inserts were evaluated for physical characteristics such as folding endurance, surface pH, mucoadhesive strength, metformin content uniformity, and release.
Mol Neurobiol
July 2018
Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru, Karnataka, India.
While astrocytes throughout the CNS share many common traits, they exhibit significant differences in function and number among brain regions. The aim of the present study is to assess the effect of region-specificity and number of astrocytes on the survival of dopaminergic neurons under stress, and to understand the possible mechanism by which these astrocytes extend neuroprotection to dopaminergic neurons. Purified astrocytes obtained from forebrain, midbrain, and hindbrain region were characterized through FACS and immunofluorescence.
View Article and Find Full Text PDFCytotherapy
October 2017
School of Regenerative Medicine, Manipal University, Bengaluru, Karnataka, India.
Diabetic neuropathy (DN) is among the most debilitating complications of diabetes. Here, we investigated the effects of human dental pulp stem cell (DPSC) transplantation in Streptozotocin (STZ)-induced neuropathic rats. Six weeks after STZ injection, DPSCs were transplanted through two routes, intravenous (IV) or intramuscular (IM), in single or two repeat doses.
View Article and Find Full Text PDFJ Drug Target
September 2017
a Department of Pharmaceutics , Al-Ameen College of Pharmacy, Bangalore , India.
High prevalence of topical fungal infections is perceived in majority of nations worldwide accounting for numerous serious systemic complications. Of several fungal infections, candidiasis is one of the widespread infections which is manifested due to localisation and proliferation of fungi. Present pharmacotherapy offers an effective treatment but possesses serious limitations like inadequate solubility, ineffectiveness in lowering diseased condition and patient incompliance.
View Article and Find Full Text PDFJ Drug Deliv
March 2017
Pharmaceutics Division, Faculty of Pharmacy, Al-Ameen College of Pharmacy, Bangalore, Karnataka 560027, India.
Kanamycin sulphate (KS) is a protein synthesis inhibitor. Due to its intense hydrophilicity, KS is cleared from the body within 8 h. KS has a very short plasma half-life (2.
View Article and Find Full Text PDFCardiovasc Ther
June 2017
Department of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, USA.
Aim: We designed a study to evaluate the cardioprotective effect of two soluble epoxide hydrolase (sEH) inhibitors, 1-(1-propanoylpiperidin-4-yl)-3-(4-trifluoromethoxy)phenyl)urea (TPPU) and trans-4-{4-[3-(4-trifluoromethoxyphenyl)-ureido]cyclohexyloxy}benzoic acid (t-TUCB), in ischemia-reperfusion (IR) model.
Methods: Cardioprotective effects of the sEH inhibitors were evaluated against IR-induced myocardial damage in hearts from normal, hypertensive, and diabetic rats using Langendorff's apparatus. In addition, the effect of sEH inhibitors on endothelial function was evaluated in vitro and ex vivo using isolated rat thoracic aorta.
AAPS PharmSciTech
August 2017
Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Hosur Road, Bangalore, 27, Karnataka, India.
Drug delivery to deep-seated tissues such as bone has been a major complication till date. This preferential drug delivery is further important in targeting anti-tumour agents to bone metastasis owing to its complexity. The present study involves the formulation of PLGA nanoparticles and conjugation with zolendronic acid-a bisphosphonate which will anchor the nanosystem to bone due to its selective bone affinity.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
February 2017
Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.
Osteoporosis therapeutics has been monopolized mainly by bisphosphonates, which are potent anti-osteoporotic drugs, while they do not promote bone formation or replenish the already resorbed bone. Although strontium substituted hydroxyapatite (SrHA) has been proclaimed to improve bone properties in an osteoporotic animal model, there is no published data on direct delivery of SrHA nanoparticles by bisphosphonate-like zoledronic acid (ZOL) to the bone. Therefore, this study was designed to investigate the potential of using SrHA/ZOL nanoparticle-based drug formulation in an ovariectomized rat model of postmenopausal osteoporosis.
View Article and Find Full Text PDFJ Microencapsul
November 2016
a Pharmaceutics Division, Faculty of Pharmacy , Al-Ameen College of Pharmacy, Bangalore , Karnataka , India.
Kanamycin sulphate (KS) is a Mycobacterium tuberculosis protein synthesis inhibitor. KS is polycationic, a property responsible for KS poor oral absorption half-life (2.5 h) and rapid renal clearance, which results in serious nephrotoxicity/ototoxicity.
View Article and Find Full Text PDFIndian J Pharmacol
June 2017
Department of Pharmacology, Al-Ameen College of Pharmacy, Bengaluru - 560 027, Karnataka, India.
Background: Diabetes-induced oxidative stress and hypertension play a major role in the development of nephropathy. Hence, the present study was undertaken to evaluate the protective effects of molsidomine, a nitric oxide donor in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats.
Materials And Methods: Type 1 diabetes was induced through a single dose of STZ (52 mg/kg, i.
Drug Deliv Transl Res
February 2017
Pharmaceutics Division, Faculty of Pharmacy, Al-Ameen College of Pharmacy, Near Lal Bagh Main gate, Hosur Road, Bangalore, Karnataka, 560027, India.
Moxifloxacin (MOX) is a Mycobacterium tuberculosis DNA gyrase inhibitor. Due to its intense hydrophilicity, MOX is cleared from the body within 24 h and required for repetitive doses which may then result in hepatotoxicity and acquisition of MOX resistant-TB, related with its use. To overcome the aforementioned limitations, the current study aimed to develop PLGA nanoparticles (PLGA NPs), to act as an efficient carrier for controlled delivery of MOX.
View Article and Find Full Text PDFInt J Nanomedicine
March 2017
Department of Pharmaceutics, Al-Ameen College of Pharmacy.
Most of the dental surgeries require preoperative anesthetic and postoperative analgesic for painless procedures. A multidrug transmucosal drug delivery system loaded with lignocaine (Lig) base for immediate release and solid lipid nanoparticles (SLNs) of diclofenac (Dic) diethylamine for prolonged release was developed. SLNs were prepared by solvent emulsion-evaporation method with Precirol ATO 5 and Geleol as lipids and Pluronic F 68 as surfactant and optimized with Box-Behnken design for particle size and entrapment efficiency.
View Article and Find Full Text PDFJ Pharmacopuncture
March 2016
R&D Center, The Himalaya Drug Company, Bangalore, India.
Objectives: The present study was undertaken to evaluate the immunomodulatory (IM) activity of IM-133N, a herbal combination in various immunotherapeutic experimental models.
Methods: The IM activity of IM-133N was evaluated against three experimental models namely, effect of IM- 133N against Escherichia coli (E. coli)-induced abdominal sepsis in mice, and carbon clearance test was performed in Wistar albino rats to evaluated the phagocytic potential of IM-133N, in addition IM-133N was evaluated for its immunoglobulin enhancing potential in rats, where the immunoglobulin levels were measured by zinc sulphate turbity (ZST) test.
Interdiscip Sci
September 2017
University Abou-Bakr Belkaid, Faculty of Science, Department of Chemistry, Laboratory of Natural Substances and Bioactive (LASNABIO), Tlemcen, Algeria.
In silico molecular modeling studies were carried out on some newly synthesized flavanoid analogues. Search for potential targets for these compounds was performed using pharmacophore-mapping algorithm employing inverse screening of some representative compounds to a large set of pharmacophore models constructed from human target proteins. Further, molecular docking studies were carried out to assess binding affinity of these compounds to proteins mediating tumor growth.
View Article and Find Full Text PDFMater Sci Eng C Mater Biol Appl
June 2016
Laboratory for Integrative Multiscale Engineering Materials and Systems, Department of Aerospace Engineering, Indian Institute of Science, Bangalore 560012, India.
Targeting of superior osteogenic drugs to bone is an ideal approach for treatment of osteoporosis. Here, we investigated the potential of using risedronate/zinc-hydroxyapatite (ZnHA) nanoparticles based formulation in a rat model of experimental osteoporosis. Risedronate, a targeting moiety that has a strong affinity for bone, was loaded to ZnHA nanoparticles by adsorption method.
View Article and Find Full Text PDFPharmacognosy Res
April 2016
Department of Pharmacognosy, Al-Ameen College of Pharmacy, Bengaluru, Karnataka, India.
Background: Quality control of Unani polyherbal formulations is the need of the day for better acceptance of Unani medicine. Qurse Tabasheer (QT) is a Unani polyherbal formulation containing six ingredients, Tabasheer (Siliceous concretions) (Bambosa arundinaceae Retz.), Gule Surkh (Rosa damascena Mill.
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