Genotype and Haplotype Analysis With In Silico Prediction of TMPRSS2 Gene in Jordanian Population.

Background: The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global health concern. The entry of the virus into host cells is facilitated by the transmembrane protease serine 2 (TMPRSS2) receptor, and genetic variations in the TMPRSS2 gene may influence disease susceptibility. However, there is a lack of knowledge regarding TMPRSS2 genetic variants and haplotypes in the Jordanian population.

Phytochemical Profiling, Acute Toxicity, and Hepatoprotective Effects of in Thioacetamide-Induced Liver Cirrhosis in Rats.

Evaluation of of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory-related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of (MEAL) against thioacetamide (TAA)-induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin-Ciocalteu and 10% AlCl3 procedure using a spectrophotometer.

Subtalar Arthroereisis for Symptomatic Flexible Flatfoot in Adolescents: A Prospective Study of 26 Feet.

Background: Flexible flatfoot is a normal finding in infants and the arch is shaped spontaneously in most children before the age of 10 years. Flexible flatfoot is a common deformity in both adolescent and adult populations.

Objective: This prospective study aims to assess the functional and radiological outcomes of subtalar arthroereisis in adolescent patients with symptomatic flexible flatfoot.

A novel HEMA copolymer hydrogel with antifouling and anti-inflammatory activity as a promising medical device coating layer to prevent microbial adhesion.

Compared to antimicrobial agents, anti-adhesive surfaces can reduce bacteria adhesion and biofilm formation in catheters, providing better selectivity, efficiency, and device life span. In this research, novel anionic surface biomaterials were created and tested to reduce microbial adhesion and colonization in medical device coating. Maleic anhydride (MA) was polymerized with 2-HEMA in varying amounts to produce a p(HEMA--MA) hydrogel copolymer.

Metabolic syndrome prediction based on body composition indices.

Background: Metabolic syndrome (MetS) is an important public health issue that has been lately linked as a growing concern worldwide.

The Objective: To find out which anthropometric and body composition indices can prognosticate MetS in Jordanian adult females.

Methods: A sample of 656 Jordanian adult females was recruited (January-March 2024) in the middle of Jordan.

Antimicrobial activities of seasonally collected bee products: honey, propolis, royal jelly, venom, and mellitin.

Ethanolic extracts of seasonally collected natural bee products (honey, propolis, royal jelly (RJ), and bee venom (BV)) were tested for their potential as antimicrobial agents against antibiotic-resistant bacteria and fungi. These extracts exhibited various inhibitory effects on antibiotic-resistant bacteria (Streptococcus pneumoniae, Staphylococcus aureus, MRSA, Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Proteus vulgaris, and Haemophilus influenzae) and fungi (Aspergillus brasiliensis and Candida albicans), with the exception of S. pneumonia, which was not inhibited by honey and RJ extracts, and P.

Corneal stromal mapping characteristics in normal corneas using anterior segment SD-OCT.

This study investigated how normal corneal stromal profiles change with age, sex, and corrected intraocular pressure (IOP). A retrospective observational analytical study was conducted in Jordan, employing anterior segment spectral-domain optical coherence tomography AS-OCT, a measured corneal stromal thickness (CST) in 134 eyes across the central 6-mm corneal diameter. People between the ages of 18 and 79 were included, and the mean CST values were linked to age groups, IOP, and cis-gender populations, with the exclusion of certain eye conditions.

Gender-Specific Malnutrition and Muscle Depletion in Gastric and Colorectal Cancer: Role of Dietary Intake in a Jordanian Cohort.

Objectives: This study aimed to assess malnutrition and muscle mass depletion risk in gastrointestinal cancer patients, exploring the differences between gastric and colorectal cancer, with a focus on gender0specific variations and dietary intake. It also examined whether muscle depletion mediates the relationship between dietary intake and malnutrition risk.

Methods: A sample of 100 Jordanian pre-operative gastrointestinal cancer patients (60 male, 40 female) with gastric or colorectal cancer were assessed for malnutrition risk using the malnutrition universal screening tool (MUST) and for muscle depletion using fat-free mass index (FFMI) and mid-upper arm muscle area (MUAMA).

Multiple imputation methods: a case study of daily gold price.

Data imputation strategies are necessary to address the prevalent difficulty of missing values in data observation and recording operations. This work utilizes diverse imputation methods to forecast and complete absent values inside a financial time-series dataset, specifically the daily prices of gold. The predictive accuracy of imputed data is assessed in comparison to the original entire dataset to ensure its robustness.

Improving food safety compliance of potential employees through a novel model of knowledge, attitude, commitment, and practice.

The global burden of foodborne illnesses remains high due to consumption of contaminated food. Vigilant attention from all, particularly food handlers, is needed to address food safety concerns and minimize the risks that affect consumer health, international business, and tourism worldwide. The main objectives of this study were to: (i) evaluate the food safety knowledge, attitudes, commitment (involving affective, continuance, and normative types), and practices of students studying subjects related to food sciences in Jordanian universities and (ii) examine the impact of knowledge and attitude on commitment, and subsequently, on relevant practices using structural equation modeling.

Efficacy and safety of sofpironium in treatment of primary hyperhidrosis: a systematic review.

Background: Primary axillary hyperhidrosis has limited noninvasive and effective treatment, and we present the use of sofpironium bromide as a promising treatment option. We aimed to assess the efficacy and safety of sofpironium in patients with primary hyperhidrosis.

Methods: We systematically searched the databases for Studies that assessed sofpironium bromide in patients with primary axillary hyperhidrosis.

Potential reuse of greywater for irrigation of tomato () plants and its effect on plants growth and soil.

The goal of this study is to examine the reactions of tomato () plants to both untreated greywater and treated greywater filtered through a zeolite. In a randomized block arrangement, tomato plants were irrigated with greywater, treated greywater, or tap water. Number and total fecal coliforms were found in soil, tomato leaves, and fruits.

Regioselective Dimerization of Methylcyclopentadiene inside Cucurbit[7]uril.

The molecular confinement within rigid macrocyclic receptors can trigger catalytic activity and steer the selectivity of organic reactions. In this work, the dimerization of methylcyclopentadiene (MCPD) isomers in the presence of cucurbit[7]uril (CB7) was found to display, besides a large rate acceleration, a striking regioselectivity in aqueous solution at pH 3, different from the thermodynamic products predominating in the absence of the supramolecular catalyst. Among the different possible regioisomers and diastereomers, the endo-3,7-dimethyl-3a,4,7,7a-tetrahydro-1H-4,7-methanoindene adduct was selectively formed, which is otherwise found only as a minor product in the dimerization of neat MCPD or in commercial dimeric mixtures.

Cucurbit[7]uril and β-cyclodextrin as hosts for dopamine: complexation, affinity, and computational insights.

Dopamine (DP), an essential neurotransmitter implicated in diverse brain functions, was investigated as a guest molecule within the host cavities of cucurbit[7]uril (CB7) and β-cyclodextrin (βCD) using isothermal titration calorimetry (ITC), UV-titration, H NMR, molecular dynamics (MD) and density functional theory (DFT) calculations. The experimentally estimated binding constants of the 1:1 complexes of DP with CB7 and βCD were found to be 5.3 × 10 and 2.

Self-efficacy, Knowledge and Outcomes Expectations Foot Self-care among Diabetic Patients with High-Risk Feet in Jordan.

Background: Patients with high-risk feet and diabetes are prone to develop diabetes-related foot ulcers (DFUs). To prevent DFUs and their costs and impacts on diabetes mellitus (DM) patients' productivity and quality of life, patients' foot self-care (FSC) practices are essential to screen for DFUs. Our study aimed to assess the self-efficacy and outcome expectations about FSC and evaluate the knowledge about DFUs among patients with DM in Jordan.

Factors Associated with Tobacco Smoking Initiation in Jordan: A Cross-Sectional Study.

Objectives: In this study, our goal is to determine the average age of initiation of smoking and to discuss factors associated with smoking initiation and how they differ among different age groups. Such data may provide inspiration for the government to implement strong and comprehensive tobacco control policies.

Methods: A descriptive cross-sectional study was applied to a random sample of at least 370 participants who were categorized into four age groups ((15 years - 24 years), (25 years - 44 years), (45 years - 64 years), and (65+ years)) from all districts of al-Balqa Jordan using a modified questionnaire made on google forms.

Stress-Inducible Expression of Transcription Factor Improves Water Deficit Tolerance in Transgenic Barley Plants.

Barley ( L.), a major cereal crop grown in arid and semi-arid regions, faces significant yield variability due to drought and heat stresses. In this study, the gene, encoding an ABA-dependent transcription factor, was cloned using specific primers from water deficit-stressed barley seedlings.

Nephro- and Cardiotoxic Effects of Etoricoxib: Insights into Arachidonic Acid Metabolism and Beta-Adrenergic Receptor Expression in Experimental Mice.

Etoricoxib is a widely used anti-inflammatory drug, but its safety profile concerning cardiovascular and renal health remains inadequately explored. This study aimed to assess the nephro- and cardiotoxic effects of etoricoxib in a murine model, with a focus on its impact on arachidonic acid-metabolizing enzymes and beta-adrenergic receptors associated with drug-induced toxicity. Thirty-five mice were randomly assigned to five groups: control, low-dose etoricoxib, high-dose etoricoxib, low-dose celecoxib, and high-dose celecoxib (a well-known nephro- and cardiotoxic NSAID).

Recurrent Early Pregnancy Loss and Congenital Thrombophilia: A Prospective Study.

: This study aims to investigate the role of congenital single nucleotide thrombophilia in young females with early recurrent pregnancy loss (RPL). : We studied 120 pregnant females with RPL and 80 matched females as a control with no RPL. Females were aged ≤ 35 years, had at least two consecutive first-trimester RPLs, and the acquired cause of RPL was excluded.

Impact of Juice and Empagliflozin on Glycemic Control in Rats.

Diabetes mellitus (DM) is a major global health concern characterized by high blood glucose levels. This study investigates the effects of (cactus) juice and empagliflozin, both alone and in combination, on glycated hemoglobin (HbA1c) levels in healthy and streptozotocin-induced diabetic rats. Eighty Wistar albino male rats were divided into eight groups, with four groups being diabetic.

Base Deficit, International Normalized Ratio, and Glasgow Coma Scale (BIG) is a Predictor Tool for Survival and Mortality of Pediatric Trauma Patients.

Background: An accurate estimate of the survival and mortality at the initial trauma evaluation is essential to ensure appropriate triage and stratification of the patients for progressive care. One of the recognized tools for predicting mortality is the BIG Score, composed of admission base deficit, international normalized ratio (INR), and Glasgow Coma Scale (GCS). This study evaluates the BIG scale in predicting survival and mortality rates among pediatric trauma patients.