The global impact of adverse childhood experiences on criminal behavior: A cross-continental study.

Background: Adverse Childhood Experiences (ACEs) have been associated with a greater risk of later criminal offending. However, existing research in this area has been primarily conducted in Western developed countries and cross-cultural studies are rare.

Objectives: This study examined the relationship between ACEs and criminal behaviors in young adults living in 10 countries located across five continents, after accounting for sex, age, and cross-national differences.

Clinical and biological risk factors associated with inflammation in patients with type 2 diabetes mellitus.

Background: Chronic inflammation has been associated with insulin resistance and related metabolic dysregulation, including type 2 diabetes mellitus (T2DM). Several non modifiable (i.e.

Knowledge of ovarian cancer symptoms among women in Palestine: a national cross-sectional study.

Introduction: Ovarian cancer (OC) is often diagnosed at advanced stages. This study aimed to assess the Palestinian women's knowledge about OC symptoms and determine the factors associated with having good knowledge.

Methods: A cross-sectional study was conducted from July 2019 to March 2020 in the two main areas of Palestine: the West Bank and Jerusalem as well as the Gaza Strip.

Tacrolimus and herbs interactions: a review.

The calcineurin inhibitor tacrolimus (TAC) shows inter-and intra-individual variability in blood levels and has a narrow therapeutic index. To reduce the chance of fluctuations in immunosuppressive activity and potential drug interactions, it is critical to keep track of drug concentrations. Cytochrome-P450 (CYP) isoenzymes CYP3A4 and CYP3A5, as well P-glycoprotein (P-gp) are involved in TAC bioavailability.

COVID-19: Factors associated with psychological distress, fear, and coping strategies among community members across 17 countries.

Background: The current pandemic of COVID-19 impacted the psychological wellbeing of populations globally.

Objectives: We aimed to examine the extent and identify factors associated with psychological distress, fear of COVID-19 and coping.

Methods: We conducted a cross-sectional study across 17 countries during Jun-2020 to Jan-2021.

Efficacy and Safety of Pectoral Nerve Block (Pecs) Compared With Control, Paravertebral Block, Erector Spinae Plane Block, and Local Anesthesia in Patients Undergoing Breast Cancer Surgeries: A Systematic Review and Meta-analysis.

Objective: We aimed to compare the safety and efficacy of pectoral nerve block (Pecs) I and II with control or other techniques used during breast cancer surgeries such as local anesthesia, paravertebral block, and erector spinae plane block (ESPB).

Methods: We searched 4 search engines (PubMed, Cochrane Library, Scopus, and Web of Science) for relevant trials, then extracted the data and combined them under random-effect model using Review Manager Software.

Results: We found 47 studies, 37 of them were included in our meta-analysis.

Breast Cancer Risk From Modifiable and Non-Modifiable Risk Factors among Palestinian Women: A Systematic Review and Meta-Analysis.

Objective: Breast cancer (BC) is known as one of the deadliest forms of cancer, and it is increasing globally. Identifying risk factors for BC is a key point in developing preventive strategies to reduce its occurrence. Herein, we aimed to conduct a systematic review and meta-analysis focus on the risk factors for BC in Palestine.

Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents.

Three novel pyrazolo-[4,3-][1,2,4]triazolopyrimidine derivatives (, , and ) were designed, synthesized, and evaluated for their in vitro biological activity. All three compounds exhibited different levels of cytotoxicity against cervical and breast cancer cell lines. However, compound showed the best antiproliferative activity against all tested tumor cell lines, including HCC1937 and HeLa cells, which express high levels of wild-type epidermal growth factor receptor (EGFR).

Long-term health effects after conflict-related traumatic amputation among patients in Gaza.

Background: In the past 10-15 years, thousands of civilians in Gaza have experienced conflict-related traumatic injuries. How injuries affect survivors' risks of negative long-term health effects and serious illness is unclear. We report follow-up findings in a group of patients with traumatic amputations.

Cellulose-Based Hectocycle Nanopolymers: Synthesis, Molecular Docking and Adsorption of Difenoconazole from Aqueous Medium.

The goal of this work was to develop polymer-based heterocycle for water purification from toxic pesticides such as difenoconazole. The polymer chosen for this purpose was cellulose nanocrystalline (CNC); two cellulose based heterocycles were prepared by crosslinking with 2,6-pyridine dicarbonyl dichloride (Cell-X), and derivatizing with 2-furan carbonyl chloride (Cell-D). The synthesized cellulose-based heterocycles were characterized by SEM, proton NMR, TGA and FT-IR spectroscopy.

Determination of risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus in a Palestinian Diabetes Study.

Objective: To determine the risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus.

Methods: A total of 164 hypertensive patients with type 2 diabetes patients aged 38-60 years were selected from 7 primary healthcare centers in Gaza city, Palestine. Interview questionnaire were employed to collect data related to age, gender, smoking habits, and physical activity pattern.

Vitamin C deficiency and risk of metabolic complications among adults with chronic respiratory diseases: A case-control study.

Background: Chronic respiratory disease (CRD) is an airflow limitation that represents a wide array of serious diseases. The aim of this study is to examine the influence of vitamin C deficiency on metabolic health-related quality in individuals with and without chronic respiratory disease in the Gaza Strip.

Methods: A matched case-control study including 52 cases of CRD and 52 controls of healthy participants were matched by age, sex, body mass index (BMI) and waist circumferences (WC).

A computational study of structural differences of binding of NADP and G6P substrates to G6PD Mediterranean, G6PD A-, G6PD Cairo and G6PD Gaza mutations.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common X-linked inherited enzymopathic disorder that may lead to transfusion-requiring acute hemolytic anemia (AHA) triggered by fava beans ingestion, infection or some drugs. The gene encoding for G6PD carries a large number of genetic variants that have varying pathogenicity. We reported on three G6PD variants in the Gaza Strip Palestinian population with differing clinical impacts and frequencies: G6PD Mediterranean, African G6PD A-, and G6PD Cairo.

Benchmark calculations of proton affinity and gas-phase basicity using multilevel (G4 and G3B3), B3LYP and MP2 computational methods of para-substituted benzaldehyde compounds.

This study presents the benchmark calculations of proton affinities (PAs) and gas-phase basicities (GBs) of 8-para substituted benzaldehyde compounds using the multilevel model chemistries (G3B3 and G4), density-functional quantum model (B3LYP) and ab initio model (MP2). The results show that the computed properties are strongly correlated with the available experimental data. The PAs and the GBs of other eight para-substituted benzaldehyde compounds, for which the experimental data does not currently exist, have been calculated using G3B3 and B3LYP methods.

Effect of on Carbamazepine Pharmacokinetics in Rabbits.

Objectives: Carbamazepine (CBZ) is a well-known drug prescribed to treat epilepsy and the preferred drug for trigeminal neuralgia. This study was conducted to investigate the effect of extract (PGE) on the disposition of CBZ, a CYP3A4 substrate, in rabbits.

Materials And Methods: An randomized parallel design was used to examine herb-drug interactions in 12 male rabbits distributed into 2 groups.

Spectrophotometric Determination of Dopamine in Bulk and Dosage Forms Using 2,4-Dinitrophenylhydrazine.

Objectives: Dopamine (DA) hydrochloride is a sympathomimetic agent used therapeutically for the correction of hemodynamic disorders associated with shock episodes. Although several analytical methods have been described, a spectroscopic assay of DA after chemical derivatization with 2,4-dinitrophenylhydrazine (DNP) is still unexamined. Therefore, the optimization of the reaction parameters and validation of developed method were required.

Absorption Study of Acebutolol by Modulating P-glycoprotein with Verapamil in Rats.

Objectives: Acebutolol HCl (ABL) is a selective β-adrenergic receptor blocking agent that is preferably administered by the oral route despite its low bioavailability (30-50%). The purpose of this study was to evaluate the effect of verapamil HCl (VER) [as P-glycoprotein inhibitor (P-gp)] on the intestinal absorption of ABL by comparing the changes in the absorption rate constant (k) of ABL.

Materials And Methods: intestinal perfusion was conducted in healthy male Wistar albino rats to study the absorption phase of ABL.

Staff Perception of Respect for Human Rights of Users and Organizational Well-being: A Study in Four Different Countries of the Mediterranean Area.

Background: The perception by mental health service staff of respect for users' rights is a fundamental component of organizational well-being. The objective of this work is to examine how cultural differences and the working context can influence the perception of respect for users' rights in mental health professionals in the Mediterranean area.

Methods: An observational survey carried out in four different mental health networks in four countries of the Mediterranean area (Tunisia, North-Macedonia, Italy, Palestine).

Efficiency of High and Standard Value Diffusion-Weighted Magnetic Resonance Imaging in Grading of Gliomas.

Background: Glioma is the most common fatal malignant tumor of the CNS. Early detection of glioma grades based on diffusion-weighted imaging (DWI) properties is considered one of the most recent noninvasive promising tools in the assessment of glioma grade and could be helpful in monitoring patient prognosis and response to therapy.

Aim: This study aimed to investigate the accuracy of DWI at both standard and high values ( = 1000 s/mm and  = 3000 s/mm) to distinguish high-grade glioma (HGG) from low-grade glioma (LGG) in clinical practice based on histopathological results.

Country-level correlates of the Dark Triad traits in 49 countries.

Objectives: The Dark Triad traits (i.e., narcissism, psychopathy, Machiavellianism) capture individual differences in aversive personality to complement work on other taxonomies, such as the Big Five traits.

Structure of Dark Triad Dirty Dozen Across Eight World Regions.

The Dark Triad (i.e., narcissism, psychopathy, Machiavellianism) has garnered intense attention over the past 15 years.

Identifying density-based local outliers in medical multivariate circular data.

This article is considered to be the first to deal with the problem of outlier-detection in multivariate circular data. The proposed algorithm is an extension of the Local Outlier Factor (LOF) method. Two different circular distances are used; taking into account the close bounded range of circular variables, and testing all possible permutations.

Molecular Understanding of Severe Cases of β-Thalassemia in the Nablus Region, West Bank, Palestine.

Hemoglobinopathies are common inherited monogenic diseases that are likely to remain a serious regional health problem where thalassemias and sickle cell disease are prevalent. In regions where recessive alleles for hemoglobinopathy disorders are present with high consanguinity rates, such as in Palestine, coinheritance of two different genetic defects becomes anticipated and prevalent. In this report, we characterize the molecular variants of the gene for 16 patients with transfusion-dependent anemia registered at the Thalassemia Patient Friends Society in Nablus governorate, West Bank, Palestine.

Genetic predisposition in type 2 diabetes: A promising approach toward a personalized management of diabetes.

Diabetes mellitus, also known simply as diabetes, has been described as a chronic and complex endocrine metabolic disorder that is a leading cause of death across the globe. It is considered a key public health problem worldwide and one of four important non-communicable diseases prioritized for intervention through world health campaigns by various international foundations. Among its four categories, Type 2 diabetes (T2D) is the commonest form of diabetes accounting for over 90% of worldwide cases.