Deepfake video detection: YOLO-Face convolution recurrent approach.

Recently, the deepfake techniques for swapping faces have been spreading, allowing easy creation of hyper-realistic fake videos. Detecting the authenticity of a video has become increasingly critical because of the potential negative impact on the world. Here, a new project is introduced; You Only Look Once Convolution Recurrent Neural Networks (YOLO-CRNNs), to detect deepfake videos.

A New Deep Learning-Based Methodology for Video Deepfake Detection Using XGBoost.

Currently, face-swapping deepfake techniques are widely spread, generating a significant number of highly realistic fake videos that threaten the privacy of people and countries. Due to their devastating impacts on the world, distinguishing between real and deepfake videos has become a fundamental issue. This paper presents a new deepfake detection method: you only look once-convolutional neural network-extreme gradient boosting (YOLO-CNN-XGBoost).

CoQ10 augments candesartan protective effect against tourniquet-induced hind limb ischemia-reperfusion: Involvement of non-classical RAS and ROS pathways.

Tourniquet is a well-established model of hind limb ischemia-reperfusion (HLI/R) in rats. Nevertheless, measures should be taken to alleviate the expected injury from ischemia/ reperfusion (I/R). In the present study, 30 adult male Sprague-Dawley rats were randomly divided into 5 groups (n = 6): control, HLI/R, HLI/R given candesartan (1 mg/kg, P.

Impact of combined therapy of mesenchymal stem cells and sitagliptin on a metabolic syndrome rat model.

Background: Emerging evidence suggests that mesenchymal stem cells (MSCs) have many anti-inflammatory and regenerative properties, which makes it a suitable candidate for the treatment of many diseases including metabolic syndrome (MetS). However, a major difficulty with stem cell therapy is to maintain cell viability, properties and function after implantation in vivo. This study aims to test the hypothesis that the combined therapy of MSCs and sitagliptin can effectively ameliorate MetS complications induced by high-fat and high-fructose diet (HFFD) in rats.

Exploring the FTIR, Optical and Nuclear Radiation Shielding Properties of Samarium-Borate Glass: A Characterization through Experimental and Simulation Methods.

(TlO)-(LiO)-(BO)-(SmO) glass system with various SmO additives ( = 0, 0.2, 0.4, 0.

Enhancing semantic belief function to handle decision conflicts in SoS using k-means clustering.

Background: The endeavouring to offer complex special functions from individual systems gave rise to what is known as the System of Systems (SoS). SoS co-integrating systems together while allowing for absorbing more systems in the future. SoS as an integrated system simplifies operations, reduces costs, and ensures efficiency.

Pyridine-derived VEGFR-2 inhibitors: Rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking.

Novel pyridine-derived compounds (5-19) were designed and synthesized, and their anticancer activities were evaluated against HepG2 and MCF-7 cells, targeting the VEGFR-2 enzyme. Compounds 10, 9, 8, and 15 were found to be the most potent derivatives against the two cancer cell lines, HepG2 and MCF-7, respectively, with IC  = 4.25 and 6.

Design, synthesis, molecular docking, in silico ADMET profile and anticancer evaluations of sulfonamide endowed with hydrazone-coupled derivatives as VEGFR-2 inhibitors.

A new series of sulfonamide endowed with hydrazone coupled to dimethyl and/or diethyl malonates were prepared. Various sulfa drugs were diazotized and followed by coupling with active methylene of dimethyl and/or diethyl malonate to afford the new intermediates hydrazones 3 and 4. The reactivity of hydrazone derivatives towards hydrazines was investigated.

Effect of Subantimicrobial Dose Doxycycline Treatment on Gingival Crevicular Fluid Levels of MMP-9 and MMP-13 in Periodontitis Stage 2, Grade B in Subjects with Type 2 Diabetes Mellitus.

The aim of this study was to investigate the effect of using subantimicrobial dose doxycycline as an adjunct in periodontitis stage 2, grade B in subjects with type 2 diabetes mellitus. A total of thirty patients were divided into the following two groups with reference to periodontitis, type 2 diabetes mellitus, and administration of the doxycycline drug: Group I: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP only. Group II: patients with periodontitis stage 2, grade B and type 2 diabetes mellitus who received SRP and doxycycline 20 mg.

Role of alkali metal oxide type on the degradation and in vivo biocompatibility of soda-lime-borate bioactive glass.

In this work, it is the first time to study the effect of replacing of Na O by a fixed amount of Li O or K O in soda-lime-borate glass on its in vivo biocompatibility. The glass composition was based on xM O-20x Na O20 CaO60 B O , (wt %), where, M OLi O and K O, and consequently, samples encoded BN100, BK50, and BL50. The degradation test was carried out in 0.

The antibacterial and antihemolytic activities assessment of zinc oxide nanoparticles synthesized using plant extracts and gamma irradiation against the uro-pathogenic multidrug resistant Proteus vulgaris.

In the case of Proteus vulgaris infection, the increased occurrence of multidrug-resistance strains has become a critical challenge in the treatment of urinary tract diseases. Therefore, using plant extracts as eco-friendly antibacterial provides an attractive solution to battle bacterial infection. The current study investigates the antibacterial and antihemolytic activity of nine medicinal plant extracts against P.

assessment of dual (antiviral and antitumor) activity of a novel lectin produced by the newly cyanobacterium isolate, MHM-632 MK014210.1.

A novel lectin was purified from newly cyanobacterium isolate, MHM-632 MK014210.1 using affinity chromatography with a molecular weight of 120 kDa under native-PAGE and 30 kDa on reducing-PAGE, represented tetramer nature of this lectin. Oscillatorial lectin showed stability at 60 °C for 30 min, pH-dependent, with the highest activities over the pH range of 6-8, and required zinc ions to express its full activity.

The use of cyanobacterial metabolites as natural medical and biotechnological tools: review article.

Cyanobacteria are photosynthetic, Gram-negative bacteria that are considered one of the most morphologically diverse groups of prokaryotes with a chief role in the global nutrient cycle as they fixed gaseous carbon dioxide and nitrogen to organic materials. Cyanobacteria have significant adaptability to survive in harsh conditions due to they have different metabolic pathways with unique compounds, effective defensive mechanisms, and wide distribution in different habitats. Besides, they are successfully used to face different challenges in several fields, including industry, aquaculture, agriculture, food, dairy products, pollution control, bioenergy, and pharmaceutics.

DNA binding studies of novel diazatruxenones analogs as potential anticancer agents: Synthesis, antitumor investigation, DNA binding, SAR and molecular modeling calculation.

A series of polycyclic skeleton of truxene and triazatruxene analogs has been synthesized and evaluated for antitumor and DNA binding activities. The synthesized structures were confirmed by different spectroscopic techniques such as IR, HNMR, CNMR, and mass spectroscopy. The antitumor screening was performed adopting the NCI protocol against 60 different cell lines.

Design, green synthesis, molecular docking and anticancer evaluations of diazepam bearing sulfonamide moieties as VEGFR-2 inhibitors.

Novel series of diazepam bearing sulfonamide moieties 5 and 7 were designed, synthesized and evaluated for anticancer activity against HepG2, HCT-116 and MCF-7 cell lines. MCF-7 was the most sensitive cell line to the influence of the new derivatives. In particular, compound 5 was found to be the most potent derivative overall the tested compounds against the three HepG2, HCT116 and MCF-7 cancer cell lines with IC = 8.

Biochemical characterization and application of a novel lectin from the cyanobacterium Lyngabya confervoides MK012409 as an antiviral and anticancer agent.

In the present study, a novel lectin was purified from the newly isolated cyanobacterium, Lyngabya confervoides MK012409 and tested for its antiviral and anticancer activity. Out of 30 isolates, Mabroka-s isolate which identified as Lyngabya confervoides MK012409 showed the highest agglutination titer. Lyngabyal lectin showed the greatest haemagglutination activity with pigeon/rabbit erythrocytes with a minimum concentration of 2.

Modification and characterization of Nano cellulose crystalline from Eichhornia crassipes using citric acid: An adsorption study.

In this study, Eichhornia crassipes (EC) was exposed to Chemical modification using citric acid to enhancement adsorption capacity and form Modified Nano Cellulose Crystalline (MNCC) powders and comparison study was performed to remove two different dyes as Reactive blue 21 (RB21) and Crystal violet (CV). Characterization of MNCC was investigated by X-Ray Diffraction analysis (XRD), Fourier Transform infrared spectroscopy (FTIR), Thermal Gravimetric Analysis (TGA), Dynamic Light Scatting (DLS) and Transmission electron microscopy (TEM) as well as Scanning Electron Microscopy (SEM) and results, prove that MNCC is in Nano scale and has crystalline structure as well as ester form. Examine parameters such as adsorbent dose (0.

Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.

Background: Hepatic ischemia/reperfusion (I/R) injury occurs in different clinical settings as hepatic transplantation, and different types of shock. I/R injury is the main cause of hepatic damage and failure due to the production of reactive oxygen species (ROS) and inflammatory cytokines. Dimethyl fumarate (DMF), an immunomodulatory drug, activates cellularantioxidantsignaling pathways exerting cytoprotective properties.

Gingival crevicular fluid levels of prolactin hormone in periodontitis patients before and after treatment and in healthy controls.

Objective: Prolactin (PRL) acts as a hormone and as a cytokine and is linked to the pathogenesis of a variety of chronic inflammatory diseases. This study aimed to investigate a potential role for prolactin in the pathogenesis of periodontitis by assessing its local gingival crevicular levels before and after periodontal treatment, compared to controls.

Materials And Methods: 40 participants were included and divided into 2 groups.

Molecular effects of Moringa leaf extract on insulin resistance and reproductive function in hyperinsulinemic male rats.

Background: Many studies have reported that insulin resistance impairs the antioxidant defense system and causes male infertility. is a medicinal plant that has been employed for the medicament of many disorders. It controls the levels of glucose and manages male sexual disorders.

Towards breast cancer targeting: Synthesis of tetrahydroindolocarbazoles, antibreast cancer evaluation, uPA inhibition, molecular genetic and molecular modelling studies.

A series of some new tetrahydroindolocarbazole derivatives has been synthesized. The structure of the synthesized compounds has been confirmed by different spectroscopic techniques such as IR, NMR, elemental analysis and mass spectrometry. The target compounds were evaluated for their antitumor activity against breast cancer cell line MCF-7, their GI% and their LC have been determined.

Evaluation of Adjunctive Use of Low-Level Diode Laser Biostimulation with Combined Orthodontic Regenerative Therapy.

Background: The combined orthodontic regenerative therapy approach can greatly enhance periodontal conditions and dentofacial aesthetics in many situations. The purpose of this study was to evaluate the effectiveness of 940nm low-level diode laser biostimulation in enhancement of intrabony wound healing with combined orthodontic/regenerative therapy in chronic periodontitis subjects suffering from malocclusion.

Methods: Fifteen chronic periodontitis adult patients with at least two intrabony defects and requiring orthodontic treatment for abnormalities in occlusion were included.

A Randomized Placebo-Controlled Intervention with β-Glucan in the Treatment of Localized Aggressive Periodontitis.

Background And Objectives: The success of any surgical procedure is predominately influenced by the pattern of its wound healing. The objective of the present study was to assess gingival crevicular fluid (GCF) and serum matrix metalloproteinase-8 (MMP-8) levels during the early healing phase of root coverage procedures. MMP-8 levels on days four and seven were correlated with the wound healing index (WHI) to evaluate the presence of MMP-8 during early post-surgical wound healing after root coverage procedures.