3 results match your criteria: "Al Ain University Abu Dhabi[Affiliation]"
Advancements and Challenges in Antiamyloid Therapy for Alzheimer's Disease: A Comprehensive Review.
Int J Alzheimers Dis
July 2024
AAU Health and Biomedical Research Centre Al Ain University, Abu Dhabi, UAE.
Article Synopsis
- Alzheimer's disease (AD) is characterized by the buildup of amyloid-beta proteins and tangles in the brain, and recent advancements in antiamyloid therapy aim to address this condition.
- Lecanemab, a newly approved monoclonal antibody, has shown promise in slowing cognitive decline for early AD and mild cognitive impairment, yet it presents challenges including side effects and the need for additional tests.
- Future research is needed to develop preventive strategies for AD and create more accessible and cost-effective treatments that target various aspects of the disease.
Poly(lactic--glycolic acid) (PLGA) nanoparticles (NPs) are commonly used for drug delivery because of their favored biocompatibility and suitability for sustained and controlled drug release. To prolong NP circulation time, enable target-specific drug delivery and overcome physiological barriers, NPs camouflaged in cell membranes have been developed and evaluated to improve drug delivery. Here, we discuss recent advances in cell membrane-coated PLGA NPs, their preparation methods, and their application to cancer therapy, management of inflammation, treatment of cardiovascular disease and control of infection.
View Article and Find Full Text PDFComputer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease.
Acta Pharm
September 2021
College of Pharmacy, Al Ain University Abu Dhabi, UAE, P.O. Box 112612.
COVID-19 was declared a pandemic by the World Health Organization (WHO) in March 2020. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). The aim of this study is to target the SARS-CoV-2 virus main protease (M) structure-based virtual screening.
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