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Bleomycin induced sensitivity to TRAIL/Apo-2L-mediated apoptosis in human seminomatous testicular cancer cells is correlated with upregulation of death receptors.

Anticancer Agents Med Chem

August 2015

Akdeniz University Medical Faculty Department of Biochemistry 07070 Antalya Turkey.

Mujgan Timur Aysegul Cort Evrim Ozdemir Sureyya Bilmen Sarikcioglu Salih Sanlioglu

The most common solid tumor is testicular cancer among young men. Bleomycin is an antitumor antibiotic used for the therapy of testicular cancer. TRAIL is a proapoptotic cytokine that qualified as an apoptosis inducer in cancer cells.

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Bleomycin induced sensitivity to TRAIL/Apo-2L-mediated apoptosis in human seminomatous testicular cancer cells is correlated with upregulation of death receptors.