54 results match your criteria: "Ajou Medical Center[Affiliation]"

Introduction: Grip strength serves as a significant marker for diagnosing and assessing sarcopenia, particularly in elderly populations. The study aims to explore the relationship between individual thigh muscle volumes and grip strength, leveraging advanced AI-based UNETR segmentation techniques for accurate muscle volume assessment.

Methods: The study included 49 participants from a cohort of 478 patients diagnosed with hip fractures at Gyeongsang National University Hospital.

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Background: Hip fractures are a common and debilitating condition, particularly among older adults. Loss of muscle mass and strength is a common consequence of hip fractures, which further contribute to functional decline and increased disability. Assessing changes in individual thigh muscles volume in follow-up patients can provide valuable insights into the quantitative recovery process and guide rehabilitation interventions.

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  • Cementless fixation for hip arthroplasty is gaining popularity due to benefits like shorter surgery time and avoiding complications from bone cement, but it has a risk of intraoperative periprosthetic femoral fractures (IOPFx).
  • A study reviewed 4,806 hip arthroplasties from 2003 to 2020 to identify factors increasing IOPFx risk, considering patient demographics, surgical details, and implant characteristics.
  • The study found that factors like female gender, childhood hip disease, stove-pipe femur, combined surgical approach, and the use of standard-length stems significantly increased the likelihood of IOPFx, emphasizing caution when selecting standard-length cementless stems.
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  • Hemiarthroplasty is a common treatment for displaced femoral neck fractures in elderly patients, but it carries a risk of dislocation; a new method called the posterior approach with inferior capsulotomy (PAICO) was introduced to improve stability.
  • A study compared 25 patients treated with PAICO to a historical control group of 3,477 patients who had a conventional approach and found no dislocations in the PAICO group versus a 1.3% rate in the control group.
  • The PAICO technique showed similar operation times and complication rates, and it is recommended for surgeons seeking to minimize dislocation risks in knee surgeries.
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  • The study investigates synovial fluid cell counts, specifically the monocyte-to-lymphocyte ratio (MLR), as potential biomarkers for predicting treatment response in knee osteoarthritis patients.
  • After analyzing 96 patients who received intra-articular corticosteroid injections, it was found that those who did not respond to treatment had significantly higher MLR values.
  • The research suggests that MLR could be a useful predictive marker for determining which patients are likely to benefit from conservative treatment approaches for knee osteoarthritis.
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Digital Templating of Hip Arthroplasty Using Microsoft PowerPoint: A Pilot Study with Technical Details.

Bioengineering (Basel)

March 2024

Department of Orthopaedic Surgery, Ajou University School of Medicine, Ajou Medical Center, Suwon 16499, Republic of Korea.

Templating is essential in hip arthroplasty preparation, facilitating implant size prediction and surgical rehearsal. It ensures the selection of suitable implants according to patient anatomy and disease, aiming to minimize post-operative complications. Various templating methods exist, including traditional acetate templating on both analog and digital images, alongside digital templating on digital images, which is categorized into 2D and 3D approaches.

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Background: We calculated psoas muscle area (PMA) z-scores in high-risk neuroblastoma patients undergoing treatment to examine the clinical significance of sarcopenia in this cohort.

Methods: We analyzed retrospective data from patients aged 0-18 who were diagnosed with abdominal neuroblastoma between 2005 and 2019 at Samsung Medical Center. Patients categorized as high-risk undergone induction chemotherapy, neuroblastoma excision, and tandem high-dose chemotherapy with autologous stem cell transplantation (HDCT/auto-SCT) were selected.

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: Hip fractures are commonly found in elderly patients, and often result in chronic pain and decreased physical function, as well as worsening of overall health. It is known that early surgical intervention during the acute phase and rehabilitation are important for improving clinical outcomes for these patients. However, the importance of management for improving the quality of life of these patients is becoming more emphasized.

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  • The study investigated bone turnover markers (BTMs) - CTX, P1NP, and osteocalcin - in Korean patients with osteoporosis through a multicenter clinical analysis.
  • It focused on pre- and post-menopausal women and men, collecting demographic data and measuring BTM levels, while excluding patients without sufficient test results.
  • Results showed significant BTM levels in both genders, with teriparatide increasing P1NP and denosumab decreasing CTX, providing valuable data for future bone health assessments in Koreans.
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  • The study focused on improving tendon and ligament reconstruction surgeries by using engineered mesenchymal stem cells (Sy-MSCs) to create scaffold-free fibrocartilage for better healing at the bone-to-tendon interface (BTI).
  • Methods included isolating Sy-MSCs from rat knee joints, cultivating them in various differentiation media, and optimizing collagenase treatment to enhance how well the grafts integrated.
  • The results showed that using TGF-β and CTGF together led to better fibrocartilage formation, and collagenase treatment significantly improved cell attachment without sacrificing tensile strength, ultimately leading to enhanced healing in ACL reconstruction models.
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Deviation of Latitude Cut: A Simple Sign to Differentiate Total Hip Arthroplasty from Hemiarthroplasty in Radiography.

J Clin Med

September 2023

Department of Orthopaedic Surgery, Ajou University School of Medicine, Ajou Medical Center, Suwon 16499, Republic of Korea.

This study aims to propose latitude cut deviation for differentiating hip arthroplasty types and evaluate its diagnostic utility in distinguishing total hip arthroplasty (THA) from hemiarthroplasty using radiography. After assessing various cup designs from top manufacturers for THA and hemiarthroplasty, we conducted a retrospective study on 40 patients (20 THA and 20 hemiarthroplasty). Three readers independently evaluated the radiographs, assessing acetabular sparing, cup-bone interface texture, and latitude cut deviation.

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Background: The purpose of this study was to verify the accuracy and validity of using machine learning (ML) to select risk factors, to discriminate differences in feature selection by ML between men and women, and to develop predictive models for patients with osteoporosis in a big database.

Methods: The data on 968 observed features from a total of 3,484 the Korea National Health and Nutrition Examination Survey participants were collected. To find preliminary features that were well-related to osteoporosis, logistic regression, random forest, gradient boosting, adaptive boosting, and support vector machine were used.

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Background: Dual energy X-ray absorptiometry (DXA) is a preferred modality for screening or diagnosis of osteoporosis and can predict the risk of hip fracture. However, the DXA test is difficult to implement easily in some developing countries, and fractures have been observed before patients underwent DXA. The purpose of this systematic review is to search for studies that predict the risk of hip fracture using artificial intelligence (AI) or machine learning, organize the results of each study, and analyze the usefulness of this technology.

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  • The study aimed to explore the demographic and radiological factors associated with lesser trochanter splitting (LTS) irreducible intertrochanteric fractures and assess clinical outcomes for patients treated with dynamic hip screws (DHS).
  • A total of 13 cases (3.1% of intertrochanteric fractures) were analyzed, revealing a mean patient age of 50.4 years, predominantly male involvement, and fractures largely resulting from high-energy trauma.
  • All patients achieved bone union post-surgery, with no complications reported, highlighting that reduction quality varied but was generally acceptable in the majority of cases.
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  • Degenerative meniscus tears (DMTs) commonly occur in osteoarthritic knees, with current treatment focused on surgical removal rather than regeneration, which may worsen arthritis.
  • Research into regenerating meniscus tissue is complicated by its complex structure and the need for growth factors, but a new approach proposes using decellularized meniscus extracellular matrix (DMECM) combined with patient-derived stem cells without these additional components.
  • This method successfully creates meniscus tissue that mimics natural characteristics and structure, showing promising results in a pig model, indicating the potential for improved treatment options for patients with DMTs.
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Background: Femoral neck fractures are a common injury in older adults and their management presents a significant challenge for orthopedic surgeons. The Femoral Neck System (FNS) was recently introduced for the fixation of femur neck fractures. Although neck shortening was reduced with the FNS, the complication rates were not reduced.

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Fibrocartilage extracellular matrix augmented demineralized bone matrix graft repairs tendon-to-bone interface in a rabbit tendon reconstruction model.

Biomater Adv

September 2023

Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon, Republic of Korea; Cell Therapy Center, Ajou Medical Center, Suwon, Republic of Korea. Electronic address:

Current tendon/ligament reconstructions integrate via scar tissue rather than proper bone-tendon interface regeneration, which affects graft longevity, changes in bone tunnel size, and functional outcomes. The purpose of this study was to develop a functional demineralized bone matrix (DBM) + fibrocartilage extracellular matrix (FCECM) composite scaffold, characterize its physicochemical properties, and evaluate its efficacy in repairing tendon-bone interface in a rabbit tendon reconstruction model. Solubilized FCECM was loaded and crosslinked on to DBM scaffolds via gamma-irradiation to create DBM + FCECM scaffolds.

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Background: This study aimed to analyze the differences in the stability of fractures, stress distribution around the distal-most screw according to the length of the plate and the trajectory of the bolt in Pauwels type III femoral neck fracture using the femoral neck system (FNS).

Methods: Finite element models of Pauwels type III femoral neck fractures were established with surgical variations in the trajectory of the bolt (central, inferior, valgus, and varus) and length of the lateral plate (1- and 2-hole plate). The models were subsequently subjected to normal walking and stair-climbing loads.

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Potential of secretome of human fetal cartilage progenitor cells as disease modifying agent for osteoarthritis.

Life Sci

July 2023

Department of Orthopedic Surgery, School of Medicine, Ajou University, Suwon, Republic of Korea; Institute of Regenerative Medicine, Wake Forest University, NC, USA; Advanced Translational Engineering & Medical Science, Seoul, Republic of Korea. Electronic address:

Article Synopsis
  • Osteoarthritis (OA) results from an imbalance in cartilage tissue synthesis and degradation, and a new therapeutic agent that can help with both is needed, as existing treatments show limited long-term success in cartilage repair.
  • This study focuses on the human fetal cartilage progenitor cells-secretome (ShFCPC), analyzing its effects in comparison to human bone marrow-derived mesenchymal stem cells-secretome (ShBMSC) and hyaluronan (HA) through secretome analysis and evaluations in both lab and animal models of OA.
  • Key findings reveal that ShFCPC is rich in extracellular matrix molecules that aid in maintaining cellular activities during OA, and it effectively protects against cell death and promotes cartilage repair by reducing inflammation and improving the healing
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Background: In the emergency room, clinicians spend a lot of time and are exposed to mental stress. In addition, fracture classification is important for determining the surgical method and restoring the patient's mobility. Recently, with the help of computers using artificial intelligence (AI) or machine learning (ML), diagnosis and classification of hip fractures can be performed easily and quickly.

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  • - The study focused on the rare occurrence of intramedullary nail breakage in patients treated for intertrochanteric fractures using the proximal femoral nail antirotation (PFNA) method, reviewing 35 cases of mechanical failure from 2005 to 2018.
  • - Of those patients, 28% experienced nail breakage, typically occurring around 8 months post-surgery, with larger horizontal offsets identified as a significant risk factor.
  • - The researchers also found that a CCD angle of 130° resulted in a shorter lever arm for stress, increasing nail breakage risk, although there was no direct link between the CCD angle and actual breakage incidents.
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Atypical periprosthetic femoral fracture with stem breakage: a case report.

Osteoporos Int

September 2022

Department of Orthopedic Surgery, Daejeon Eulji Medical Center, Eulji University School of Medicine, 95 Dunsan-Seoro, Seo-gu, Daejeon, 302-799, South Korea.

Although the American Society for Bone and Mineral Research definition of atypical femoral fracture excludes periprosthetic fractures, fractures around the prosthesis with clinical features of atypical femoral fractures have been reported in the literature. All fractures reported thus far have been distal to the prosthetic segment; however, we encountered a case of a stress fracture in the middle of the femoral component segment. An 86-year-old woman with a history of bisphosphonate osteoporosis treatment and revisional total hip arthroplasty visited our outpatient clinic complaining of pain in the left thigh and groin.

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  • More orthopedic patients are being diagnosed with mental disorders, which is becoming a common issue for orthopedic surgeons.
  • Understanding the psychiatric history and mental health of these patients is crucial for improving surgical outcomes.
  • Surgeons should conduct psychiatric evaluations and consultations to manage these conditions effectively before and after orthopedic procedures.
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