The role of GATA4 in mesenchymal stem cell senescence: A new frontier in regenerative medicine.

The Mesenchymal Stem Cell (MSC) is a multipotent progenitor cell with known differentiation potential towards various cell lineage, making it an appealing candidate for regenerative medicine. One major contributing factor to age-related MSC dysfunction is cellular senescence, which is the hallmark of relatively irreversible growth arrest and changes in functional properties. GATA4, a zinc-finger transcription factor, emerges as a critical regulator in MSC biology.

Assessing the impact of mindfulness programs on attention-deficit/ hyperactivity disorder in children and adolescents: a systematic review.

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder which poses challenges for the individuals with the disorder and their families. While stimulant medications are effective, a comprehensive approach, including psychosocial and behavioral interventions, is recommended. There is a growing body of research exploring the potential benefits of mindfulness-based interventions for children with ADHD.

Variational graph autoencoder for reconstructed transcriptomic data associated with NLRP3 mediated pyroptosis in periodontitis.

The NLRP3 inflammasome, regulated by TLR4, plays a pivotal role in periodontitis by mediating inflammatory cytokine release and bone loss induced by Porphyromonas gingivalis. Periodontal disease creates a hypoxic environment, favoring anaerobic bacteria survival and exacerbating inflammation. The NLRP3 inflammasome triggers pyroptosis, a programmed cell death that amplifies inflammation and tissue damage.

Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis.

Osteoarthritis, the most common arthritic condition, is an age-related progressive disease characterized by the loss of cartilage and synovial inflammation in the knees and hips. Development of pain, stiffness, and considerably restricted mobility of the joints are responsible for the production of matrix metalloproteinases and cytokines. Although several treatments are available for the management of this disease condition, they possess limitations at different levels.

Professional self-actualisation of pharmacist in the United Arab Emirates: a pilot study.

Objective: This pilot study evaluated the professional self-actualisation (PSA) of pharmacists in the United Arab Emirates (UAE) across various practice settings.

Methods: Our study was conducted in the UAE from February to May 2024 and targeted pharmacists in hospitals, community pharmacies, industry, and academia. A PSA questionnaire was developed using validated instruments and expert input, and included items on professional fulfilment (PF), societal acceptance (SA), work environment (WE), autonomy and professional opportunities (APO), involvement in professional advocacy (IPA), and the impact of work on personal relationships (IWPR).

Smoking trends and awareness among Indian university students: A qualitative study.

Introduction: Adolescence and early adulthood are recognized as the most vulnerable periods for smoking initiation in India. This is likely due to the increased freedom that young adults have to experiment with different identities and behaviors.

Objective: To explore the background of smoking initiation, understand the motivators and barriers to quitting smoking, and assess university students' perceptions and knowledge of Tobacco Cessation Centers (TCCs).

Advancing surgical education: An evaluation of laparoscopic simulation training for medical students.

Objective: To examine the medical students' awareness of laparoscopic surgery as well as assess the perceived importance of laparoscopic simulation training, and its impact on students' confidence, career aspirations, proficiency, spatial skills, and physical tolerance.

Design: Descriptive and comparative study using pre- and post-training assessments.

Setting: Simulation training sessions centred on laparoscopic surgery techniques.

Comparison of the stability of immediate dental implant placement in fresh molar extraction sockets in the maxilla and mandible: a controlled, prospective, non-randomized clinical trial.

The aim of this study was to assess the stability of immediate dental implants in fresh molar extraction sockets and to compare those placed in the maxilla and mandible. This was a controlled, prospective, non-randomized clinical trial; the maxilla was the test group and the mandible was the control group. Thirty patients with an unrestorable molar tooth who needed immediate implant placement were included.

A Rare Case of Pneumomediastinum, Pneumoretroperitoneum and Subcutaneous Emphysema Due to Crystal Methamphetamine Abuse.

Background: Crystal methamphetamine abuse is a growing concern due to its significant adverse effects on various organ systems.

Case Description: This report presents a rare case of pneumomediastinum, pneumoretroperitoneum and subcutaneous emphysema resulting from crystal methamphetamine abuse. The exact mechanism linking methamphetamine abuse to pneumomediastinum remains ambiguous.

Artificial Intelligence in Health Professions Education assessment: AMEE Guide No. 178.

Health Professions Education (HPE) assessment is being increasingly impacted by Artificial Intelligence (AI), and institutions, educators, and learners are grappling with AI's ever-evolving complexities, dangers, and potential. This AMEE Guide aims to assist all HPE stakeholders by helping them navigate the assessment uncertainty before them. Although the impetus is AI, the Guide grounds its path in pedagogical theory, considers the range of human responses, and then deals with assessment types, challenges, AI roles as tutor and learner, and required competencies.

Effect of statins and antihyperglycemics on chronic kidney disease in patients with type 2 diabetes mellitus: a retrospective cohort study with a 12-year follow-up.

Background: Chronic Kidney Disease (CKD) represents a significant worldwide health challenge, with far-reaching implications for both patients and healthcare systems. This study aimed to identify the incidence of CKD at stages 3-5, analyzed the impact of statin and other antihyperglycemic interventions, on the CKD progression in individuals with T2DM.

Methods: This was a single-center retrospective cohort study based on data derived from electronic medical records (EMR) of UAE populations with diabetes mellitus, registered at outpatient clinics at Tawam Hospital in Al Ain, UAE, between January 2011 and December 2021.

Monitoring of Antibiotic Resistance Patterns Within Al-Karak Governmental Hospital, Jordan, in 2022.

: Antimicrobial resistance is considered one of the foremost global public health challenges, and its prevalence is increasing. In Jordan, particularly in Al-Karak Governorate, there is a lack of sufficient data on antimicrobial resistance to make accurate assessments. The main aim of the current study was to evaluate antibiotic resistance trends in clinical specimens from 2022 and assess antibiotic resistance patterns.

Hippocampal Viral-Mediated Urokinase Plasminogen Activator (uPA) Overexpression Mitigates Stress-Induced Anxiety and Depression in Rats by Increasing Brain-Derived Neurotrophic Factor (BDNF) Levels.

Emerging evidence suggests the serine protease, urokinase plasminogen activator (uPA), may play an important role in the modulation of mood and cognitive functions. Also, preliminary evidence indicates that uPA modulates BDNF activity that is known to be involved in the pathogenesis of mood disorders. However, the physiological functions of uPA in specific brain regions for mediating stress-related emotional behaviors remain to be elucidated.

Potential mutagenicity of aflatoxin B1 in Egyptian spices.

The current study aimed to detect the mutagenic impacts of aflatoxin B1 (AFB1), which is produced by Aspergillus group fungi, via a high-plant genotoxicity test. Different durations of treatment (3 h, 6 h, and 12 h) were used to treat the Vicia faba root tips with varying concentrations of Aflatoxin B1 (AFB1) following the approved protocol for plant assays published by the International Program on Chemical Safety (IPCS) and the World Health Organization (WHO). The data obtained indicated that AFB1 not only has the ability to induce various alterations in the process of mitosis, ranging from increasing to decreasing mitotic and phase indices but also leads to many mitotic aberrations.

Role of physical and dentofacial features in bullying among United Arab Emirates schoolchildren and its impact on school performance - A cross-sectional study.

Background: Bullying has a lasting effect on young, vulnerable minds, especially among school-aged youngsters. With the help of this study, we intended to examine how physical and dentofacial characteristics contribute to bullying among kids and how it affects their academic performance.

Methods: This retrospective cross-sectional study consisted of a self-reported anonymous, pretested questionnaire divided into three major domains, with due institutional ethical clearance being obtained before the study's commencement.

Unveiling nature's antidiabetic potential in Berberis orthobotrys seeds for alloxan-induced diabetic rats.

To illustrate the anti-diabetic properties of Berberis orthobotrys seeds was the aim of the current study. After a series of experiments, two doses of aqueous methanolic extract of the seeds were selected i.e.

Influence of different print orientations on properties and behavior of additively manufactured resin dental devices: A systematic review and meta-analysis.

Statement Of Problem: Different factors affect 3-dimensionally (3D) printed resin products. However, evidence on the effect of the print orientation on resin dental devices is lacking.

Purpose: The purpose of this systematic review and meta-analysis was to assess the impact of print orientation on the properties and accuracy of 3D printed implant surgical guides, occlusal devices, clear orthodontic retainers, and aligners.

Method development and validation on RP-HPLC method for estimation of xanthohumol in nanostructured lipid carriers drug delivery systems.

Xanthohumol(Xn) is isolated from female inflorescences of Humulus lupulus. It has been discovered that Xn and its formulation are useful in the treatment of cancer. As this bioactive compound has medicinal importance, hence, a novel, precise, and sensitive HPLC method should be developed.

A Systematic Review and Meta-Analysis of the Prevalence of Dental Caries in the Permanent Teeth of Arab Children.

Despite the global prevalence of dental caries, there is a paucity of comprehensive data on the extent of this issue among children in the Arab region. This systematic review and meta-analysis aimed to evaluate the prevalence of dental caries and the associated Decayed, Missing, and Filled Teeth (DMFT) indices in permanent teeth among children from 4 to under 18 years of age in the Arab region. A comprehensive review of various studies was conducted.

Psychometric properties of an Arabic translation of the 13-item short mood and feelings questionnaire- parent version (SMFQ-P) to screen for depression in children.

Background: Understanding the connection between parental wellbeing and its impact on childhood depression is crucial in order to develop targeted interventions and support systems that can mitigate potential long-term effects on mental health. This study focuses on examining the properties of an Arabic translation of a questionnaire called Short Mood and Feelings Questionnaire Parent Version (SMFQ-P) as a preliminary step toward validating a culturally relevant screening tool for childhood depression in Lebanon.

Methods: A total of 502 parents, recruited through a snowball method, took part in the survey with an age of 36.

Profile of maladaptive and normative eating behaviors in correlation with rumination: a cross-sectional study among Lebanese adults.

Background: Dieting is a common practice around the world. People who wish to lose weight, improve their eating habits, or reach a desired level of health often diet. Rumination, a pattern of repetitive negative thoughts and emotions, is typically found when individuals diet.