3 results match your criteria: "Aix Marseille Universitx00E9;[Affiliation]"
Tissue-Specific Regulation of Drosophila NF-x03BA;B Pathway Activation by Peptidoglycan Recognition Protein SC.
J Innate Immun
October 2016
Institut de Biologie du Dx00E9;veloppement de Marseille, UMR 7288, CNRS, Aix Marseille Universitx00E9;, Marseille, France.
In Drosophila, peptidoglycan (PGN) is detected by PGN recognition proteins (PGRPs) that act as pattern recognition receptors. Some PGRPs such as PGRP-LB or PGRP-SCs are able to cleave PGN, therefore reducing the amount of immune elicitors and dampening immune deficiency (IMD) pathway activation. The precise role of PGRP-SC is less well defined because the PGRP-SC genes (PGRP-SC1a, PGRP-SC1b and PGRP-SC2) lie very close on the chromosome and have been studied using a deletion encompassing the three genes.
View Article and Find Full Text PDFPatterns of Methylphenidate Use and Assessment of Its Abuse among the General Population and Individuals with Drug Dependence.
Eur Addict Res
September 2016
Aix Marseille Universitx00E9;, Institut de Neurosciences Timone, CNRS 7289, Service de Pharmacologie Clinique et Pharmacovigilance, APHM, CEIP-Addictovigilance Paca Corse, Marseille, France.
Article Synopsis
- The study investigates the extent and patterns of methylphenidate (MPH) abuse, particularly in cases where it is intravenously administered after being crushed.
- Data collected revealed a 166% increase in MPH prescriptions from 2005 to 2011, primarily among male adults with drug dependence, particularly those on opiate treatments.
- The findings highlight significant health risks associated with MPH abuse, such as cardiovascular issues and psychiatric problems, prompting a call for increased awareness and intervention efforts among healthcare professionals.
The Gateway Hypothesis, Common Liability to Addictions or the Route of Administration Model A Modelling Process Linking the Three Theories.
Eur Addict Res
July 2016
Centre d'x00C9;pidx00E9;miologie et de Santx00E9; Publique des Armx00E9;es, INSERM - IRD - Universitx00E9; Aix-Marseille, Marseille, France.
Background: The aim of this study was to describe the transitions between tobacco (T), cannabis (C) and other illicit drugs (OIDs) initiations, to simultaneously explore several substance use theories: gateway theory (GT), common liability model (CLM) and route of administration model (RAM).
Methods: Data from 2 French nationwide surveys conducted in 2005 and 2010 were used (16,421 subjects aged 18-34). Using reported ages at initiations, we reconstituted a retrospective cohort describing all initiation sequences between T, C and OID.