Comprehensive analysis of electrochemical biosensors for early ovarian cancer detection.

Ovarian cancer is one of the leading causes of mortality among women worldwide. However, early detection can significantly reduce mortality rates and mitigate subsequent complications related to both economic burden and mental well-being. Despite the development in the field of medical diagnosis, the death rates due to ovarian cancer have sharply increased.

Bioactive secondary metabolites from fungal endophytes, and , associated with and : an study.

Two pure fungal strains were isolated and identified from and , namely, (OR673586) and (OR673589), respectively. The extract and fractions of secondary metabolites of each fungus were evaluated for antioxidant, anti-inflammatory, antimicrobial, antibiofilm, antidiabetic, and cytotoxic activities. The chloroform fraction of showed potent cytotoxic activity (IC = 7.

Discovery of pyrazole-based analogs as CDK2 inhibitors with apoptotic-inducing activity: design, synthesis and molecular dynamics study.

The discovery of novel CDK2 inhibitors is crucial for developing targeted anticancer therapies. Thus, in this study, we aimed to design, synthesize, and evaluate a series of novel pyrazole derivatives (2a-g, 7a-d, 8a and b, 9, and 10) for their potential as CDK2/cyclin A2 enzyme inhibitors. The newly synthesized compounds were screened at 50 μM for CDK2 inhibition, followed by IC profiling of the most promising candidates.

Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management modulation of the cGAS-STING pathway.

NAFLD/NASH has emerged as a global health concern with no FDA-approved treatment, necessitating the exploration of novel therapeutic elements for NASH. Probiotics are known as an important adjunct therapy in NASH. Zbiotics (ZB183) is the first commercially available genetically engineered probiotic.

Antiviral activity of pyrazole derivatives bearing a hydroxyquinoline scaffold against SARS-CoV-2, HCoV-229E, MERS-CoV, and IBV propagation.

The ongoing global threat posed by coronaviruses necessitates the urgent development of effective antiviral agents. In this study, we investigated the potential of hydroxyquinoline-pyrazole candidates as antiviral agents against a range of coronaviruses, including SARS-CoV-2, MERS-CoV, and HCoV-229E. Molecular docking studies were conducted to assess the binding affinity of the synthesized compounds to key viral proteins.

Correction: Rosavin improves insulin resistance and alleviates hepatic and kidney damage modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals.

[This corrects the article DOI: 10.1039/D4MD00023D.].

Unveiling the photocatalytic potential of graphitic carbon nitride (g-CN): a state-of-the-art review.

Graphitic carbon nitride (g-CN)-based materials have emerged as promising photocatalysts due to their unique band structure, excellent stability, and environmental friendliness. This review provides a comprehensive and in-depth analysis of the current state of research on g-CN-based photocatalysts. The review summarizes several strategies to improve the photocatalytic performance of pristine g-CN, , by creating heterojunctions, doping with non-metallic and metallic materials, co-catalyst loading, tuning catalyst morphology, metal deposition, and nitrogen-defect engineering.

Molecularly imprinted polymer-based electrochemical sensors for monitoring the persistent organic pollutants chlorophenols.

Because of the serious risks they pose to the environment and public health, chlorophenols (CPs), a typical class of the most persistent organic pollutants, have drawn increasing attention. Monitoring CPs effectively has become a pressing and difficult problem. The rapidly increasing need for onsite and real-time CP detection has led to the consideration of electrochemical sensing as a workable solution.

Rosavin improves insulin resistance and alleviates hepatic and kidney damage modulating the cGAS-STING pathway and autophagy signaling in HFD/STZ-induced T2DM animals.

: Inflammation-mediated insulin resistance in type 2 diabetes mellitus (T2DM) increases complications, necessitating investigation of its mechanism to find new safe therapies. This study investigated the effect of rosavin on the autophagy and the cGAS-STING pathway-related signatures (ZBP1, STING1, DDX58, LC3B, TNF-α) and on their epigenetic modifiers (miR-1976 and lncRNA AC074117.2) that were identified from analysis in T2DM animals.

Unveiling the multifaceted antiproliferative efficacy of root extract by dual modulation of apoptotic and inflammatory genes, inducing cell cycle arrest, and targeting COX-2.

Chicory ( L. ) is a renowned medicinal plant traditionally used for various ailments, yet the pharmacological potential of its roots, particularly in terms of antitumor activity, remains elusive. In the present study, we explore, for the first time, the metabolomic profile of ethanolic extract from roots (CIR) and further unveil its antiproliferative potential.

Nanomaterials-modified reverse osmosis membranes: a comprehensive review.

Because of its great efficiency and widespread application, reverse osmosis (RO) is a popular tool for water desalination and purification. However, traditional RO membranes have a short lifespan due to membrane fouling, deterioration, decreased salt rejection rate, and the low water flux with aging. As a result, membrane modification has received a lot of attention recently, with nanomaterials being extensively researched to improve membrane efficacy and lifespan.

β-Enaminonitrile in the synthesis of tetrahydrobenzo[]thiophene candidates with DFT simulation, antiproliferative assessment, molecular docking, and modeling pharmacokinetics.

Among sulfur-including heterocycles, the benzothiophene skeleton is one of the worthy structure fragments that exhibit structural similarities with active substrates to develop various potent lead molecules in drug design. Thus, some tetrahydrobenzo[]thiophene candidates were prepared from the β-enaminonitrile scaffold reactions with diverse carbon-centered electrophilic reagents and supported with DFT studies. The antiproliferative effect was screened against MCF7 and HePG2 cancer cell lines, and the results displayed the highest potency of imide 5, Schiff base 11, and phthalimido 12 candidates.

Some pyrimidohexahydroquinoline candidates: synthesis, DFT, cytotoxic activity evaluation, molecular docking, and studies.

Some hexahydroquinoline candidates were prepared by reacting 2-amino-3-cyano-1-cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The computational chemical approach agreed with the product-testing results. The produced substances were examined for their antiproliferative activity against liver carcinoma (HepG2), breast adenocarcinoma (MCF7), prostate cancer (PC3), and colon cancer (HCT116) cell lines.

Rapid catalytic reduction of environmentally toxic azo dye pollutant by Prussian blue analogue nanocatalyst.

The release of toxic azo dyes pollutants in the environment from different industries represents a public health concern and a serious environmental problem. Therefore, the conversion of hazardous methyl orange (MO) azo dye to environmentally benign products is a critical demand. In this work, an eco-friendly Prussian blue analogue (PBA) was synthesized and its catalytic activity toward the reduction of MO was investigated.

In the pursuit of novel therapeutic agents: synthesis, anticancer evaluation, and physicochemical insights of novel pyrimidine-based 2-aminobenzothiazole derivatives.

Cancer remains a worldwide healthcare undertaking, demanding continual innovation in anticancer drug development due to frequent drug resistance and adverse effects associated with existing therapies. The benzothiazole compounds, particularly 2-aminobenzothiazole derivatives, have attracted interest for their versatility in generating novel anticancer agents. This study explores the synthesis, and anticancer evaluation of new pyrimidine-based 2-aminobenzothiazole derivatives.

Design and synthesis of novel chloropyridazine hybrids as promising anticancer agents acting by apoptosis induction and PARP-1 inhibition through a molecular hybridization strategy.

Guided by the molecular hybridization principle, a novel series of 4-chloropyridazinoxyphenyl conjugates (3a-h, 4a-e, and 5) was designed and synthesized as proposed apoptotic inducers and PARP-1 inhibitors. The growth inhibition % of the designed hybrids was investigated in eleven cancer cell lines, where the anticancer activities were found to be in the following order: 4-chloropyridazinoxyphenyl-aromatic ketones hybrids (3a-h) > 4-chloropyridazinoxyphenyl-benzyloxyphenylethan-1-one hybrids (4a-e) > 4-chloropyridazinoxyphenyl-thiazolidine-2,4-dione hybrid (5). Further, the most sensitive three cancer cell lines (HNO97, FaDu, and MDA-MB-468) were selected to measure the IC values of the new hybrids.

Facile sonochemically-assisted bioengineering of titanium dioxide nanoparticles and deciphering their potential in treating breast and lung cancers: biological, molecular, and computational-based investigations.

Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to the sustainability of chemical processes and minimizes hazardous effects. Herein, titanium dioxide (TiO) NPs were bioengineered using a novel and facile ultrasound-assisted approach utilizing the greenly extracted essential oil of . FTIR and UV-Vis spectrophotometry were used to confirm the formation of TiO NPs.

Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone derivatives.

Thiophene-2-carbohydrazide was used in this study to produce some thiophene-containing oxadiazole, triazole, and thiazolidinone derivatives through reactions with various carbon-centered electrophiles. Besides, the hydrazone obtained was allowed to react with mercaptoacetic acid and acetic anhydride to construct thiazolidinone and oxadiazole derivatives. The results of computational chemical study and outcomes of the experiments were in good agreement.

Current perspectives, challenges, and future directions in the electrochemical detection of microplastics.

Microplastics (5 μm) are a developing threat that contaminate every environmental compartment. The detection of these contaminants is undoubtedly an important topic of study because of their high potential to cause harm to ecosystems. For many years, scientists have been assiduously striving to surmount the obstacle of detection restrictions and minimize the likelihood of receiving results that are either false positives or false negatives.

and studies of -loaded electrospun PLGA/PMMA/collagen nanofibers for accelerating topical wound healing.

This work aims to develop plant extract-loaded electrospun nanofiber as an effective wound dressing scaffolds for topical wound healing. Electrospun nanofibers were fabricated from leaf extract (SCLE), poly(lactic--glycolic acid) (PLGA), poly(methyl methacrylate) (PMMA), collagen and glycine. Electrospinning conditions were optimized to allow the formation of nanosized and uniform fibers that display smooth surface.

Exploitation of multi-walled carbon nanotubes/Cu(ii)-metal organic framework based glassy carbon electrode for the determination of orphenadrine citrate.

Metal organic frameworks (MOFs), with structural tunability, high metal content and large surface area have recently attracted the attention of researchers in the field of electrochemistry. In this work, an unprecedented use of multi-walled carbon nanotubes (MWCNTs)/copper-based metal-organic framework (Cu-BTC MOF) composite as an ion-to-electron transducer in a potentiometric sensor is proposed for the determination of orphenadrine citrate. A comparative study was conducted between three proposed glassy carbon electrodes, Cu-MOF, (MWCNTs) and MWCNTs/Cu-MOF composite based sensors, where Cu-MOF, MWCNTs and their composite were utilized as the ion-to-electron transducers.

Bioorthogonal activation of prodrugs, for the potential treatment of breast cancer, using the Staudinger reaction.

Selective prodrug activation at a tumor site is crucial to maximise the efficiency of chemotherapy approaches and minimise side effects due to off-site activation. In this paper, a new prodrug activation strategy is reported based on the bioorthogonal Staudinger reaction. The feasibility of this prodrug activation strategy was initially demonstrated using 9-azido sialic acid 4 as a trigger and two novel triphenylphosphine-modified N-mustard-PRO 10 and doxorubicin-PRO 12 prodrugs in an HPLC-monitored release study.