1,773 results match your criteria: "Aichi Medical University School of Medicine.[Affiliation]"
Prognostic scores for patients with salivary adenoid cystic carcinoma without lymph node metastasis.
Oral Oncol
October 2023
Department of Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address:
Article Synopsis
- Adenoid cystic carcinoma (AdCC) of the salivary gland is a slow-growing cancer that can sometimes spread to distant sites, although not commonly through lymph nodes.
- A study of 175 patients without lymph node metastasis identified key prognostic factors that influence disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS), particularly focusing on positive surgical margins and tumor stage.
- The findings showed that patients with no positive prognostic factors (PS0) had significantly better 10-year survival rates compared to those with one or more positive factors (PS1, PS2), indicating the importance of these factors in predicting patient outcomes.
CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma.
Cell Death Discov
July 2023
Department of Biochemistry, , Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
Article Synopsis
- Malignant mesothelioma (MMe) is a rare and aggressive cancer with a poor prognosis, despite known genetic factors like BAP1 gene alterations.
- Researchers created BAP1 knockout human mesothelial cell clones to identify new targeted therapies and discovered that the CAMK2D gene is highly expressed in these cells and in many MMe tissues.
- They identified the CaMKII inhibitor KN-93 as a promising treatment that effectively reduces tumor growth in models of BAP1-deficient MMe, presenting a potential new approach for therapy.
Poor outcome of allogeneic transplantation for therapy-related acute myeloid leukemia induced by prior chemoradiotherapy.
Ann Hematol
October 2023
Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan.
Therapy-related acute myeloid leukemia (t-AML) is a therapeutic challenge as a late complication of chemotherapy (CHT) and/or radiotherapy (RT) for primary malignancy. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) presents itself as a curative approach. To establish the optimal allo-HSCT strategy for t-AML, we evaluated the relationship between characteristics of primary malignancy and allo-HSCT outcomes.
View Article and Find Full Text PDFHigh-risk Combinations of Additional Chromosomal Abnormalities in Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia: JALSG Ph+ALL TKI-SCT Study.
Hemasphere
June 2023
Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
Changing trends in the risk factors for second primary malignancies after autologous stem cell transplantation for multiple myeloma before and after the introduction of proteasome inhibitors and immunomodulatory drugs.
Haematologica
December 2023
Department of Hematology, National Hospital Organization Okayama Medical Center, Okayama.
Article Synopsis
- * Out of 2,340 patients, 43 developed SPMs, with a cumulative incidence rate of 2.5% at 60 months, indicating that while SPMs occurred, the risk was lower than mortality from multiple myeloma itself (36.5% at 60 months).
- * Key risk factors for developing SPMs included the use of immunomodulatory drugs (IMiDs) and radiation, showing higher incidence rates in patients treated after the introduction of novel agents compared to
Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant.
Haematologica
January 2024
Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima.
Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model.
Blood Cancer J
July 2023
Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki, 889-1692, Japan.
Endoscopic Lesions of Postoperative Anastomotic Area in Patients With Crohn's Disease in the Biologic Era: A Japanese Multi-Centre Nationwide Cohort Study.
J Crohns Colitis
December 2023
Department of Gastroenterology and Hepatology, Kyorin University School of Medicine, Tokyo, Japan.
Article Synopsis
- A study evaluated postoperative anastomotic lesions in Crohn's disease (CD) patients who underwent intestinal resection, finding that these lesions commonly recur within a year.
- Researchers analyzed data from 267 patients and noted that the severity and prevalence of these lesions increased over time, leading to more interventions for those with more severe lesions.
- The findings suggest that intermediate and severe lesions might indicate recurrent disease, while mild lesions may not, highlighting the need for further prospective studies to improve treatment approaches.
Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect.
Blood
September 2023
Division of Hematology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.
Chronic graft-versus-host disease (cGVHD) is a multiorgan syndrome with clinical features resembling those of autoimmune diseases. Thus, understanding commonalities in the pathophysiology of cGVHD and autoimmune diseases, such as the presence of disease-risk HLA alleles, is imperative for developing novel therapies against cGVHD. Alloantibodies against H-Y antigens encoded on the Y-chromosome are well-described risk factors for cGVHD in female-to-male transplantation.
View Article and Find Full Text PDFAdverse impact of delay of platelet recovery after autologous hematopoietic cell transplantation for aggressive non-Hodgkin lymphoma and multiple myeloma.
Cytotherapy
November 2023
Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address:
Article Synopsis
- The study looked at how quickly platelets recover after a type of cancer treatment called autologous hematopoietic cell transplantation (AHCT) and how it affects patients' health.
- They found that patients who had quicker platelet recovery after 28 days had better chances of living longer and experiencing fewer health problems.
- The researchers also figured out how many special cells (CD34 cells) each group of patients needed to recover their platelets quickly, showing that different patient conditions affected this recovery.
Artesunate and cisplatin synergistically inhibit HNSCC cell growth and promote apoptosis with artesunate‑induced decreases in Rb and phosphorylated Rb levels.
Oncol Rep
August 2023
Department of Otorhinolaryngology‑Head and Neck Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi 480‑1195, Japan.
In the treatment of head and neck cancer, cisplatin is often used as a therapeutic agent; however, its efficacy is limited and it can cause renal dysfunction as an adverse effect. For this reason, the use of cisplatin is limited in elderly patients with reduced renal function. Recently, artemisinin, which was developed as an antimalarial drug, was found to have antitumor effects and is effective in combination with other anticancer drugs.
View Article and Find Full Text PDFAuthor Correction: A convolutional neural network-based model that predicts acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Commun Med (Lond)
June 2023
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Characteristics of uroflowmetry patterns in men with detrusor underactivity revealed by artificial intelligence.
Int J Urol
October 2023
Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Objectives: To elucidate the characteristics of uroflowmetry (UFM) observed in men with detrusor underactivity (DU) using our developed artificial intelligence (AI) diagnostic algorithm to distinguish between DU and bladder outlet obstruction (BOO).
Methods: Subjective and objective parameters, including four UFM parameters (first peak flow rate, time to first peak, gradient to first peak, and the ratio of first peak flow rate to maximum flow rate [Q ]) selected by analyzing the judgment basis of the AI diagnostic system, were compared in 266 treatment-naive men with lower urinary tract symptoms (LUTS). Patients were divided into the DU (70; 26.
Unrelated female-to-male bone marrow transplantation would be preferred over cord blood transplantation in male patients.
Cytotherapy
November 2023
Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan. Electronic address:
Article Synopsis
- Female-to-male allogeneic hematopoietic stem cell transplantation (allo-HCT) increases the risk of non-relapse mortality and chronic graft-versus-host disease (GVHD), while unrelated cord blood transplantation (UCBT) shows better outcomes in terms of chronic GVHD.
- A study in Japan compared survival outcomes of male recipients undergoing UCBT versus unrelated female-to-male bone marrow transplantation (UFMBMT) from 2012 to 2020, analyzing a total of 3,430 cases.
- Results indicated that HLA-mismatched UFMBMT significantly reduced the risk of relapse and improved overall survival, suggesting that males may benefit more from bone marrow transplants from female donors compared to cord
Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.
Cancer Med
August 2023
Department of Oral and Maxillofacial Surgery, Aichi Medical University Hospital, Nagakute, Japan.
Background: Epidermal growth factor receptor (EGFR) is frequently overexpressed in oral squamous cell carcinoma (OSCC), and EGFR-targeting therapeutics have been widely employed to treat patients with a variety of carcinomas including OSCC. Here, we aimed to investigate alternative signaling for OSCC survival under the disruption of EGFR signaling.
Methods: OSCC cell lines, namely HSC-3 and SAS, were utilized to investigate how EGFR disruption affects cell proliferation.
Risk factors and outcome of Stenotrophomonas maltophilia infection after allogeneic hematopoietic stem cell transplantation: JSTCT, Transplant Complications Working Group.
Ann Hematol
September 2023
Department of Hematology, Oita University Hospital, Oita, Japan.
Stenotrophomonas maltophilia (S. maltophilia) is an aerobic nonfermenting Gram-negative bacillus widely distributed in the environment that has inherent multidrug resistance to beta-lactam and carbapenem antibiotics. S.
View Article and Find Full Text PDFClinical characteristics of late-onset interstitial pneumonia after allogeneic hematopoietic stem cell transplantation.
Int J Hematol
August 2023
Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
Non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation (HSCT) remain fatal. In particular, information regarding late-onset interstitial lung disease predominantly including organizing pneumonia and interstitial pneumonia (IP) is limited. A retrospective nationwide survey was conducted using data collected from the Japanese transplant outcome registry database from 2005 to 2010.
View Article and Find Full Text PDFComparison of Gastric Cancer Risk Classifications Using Conventional and New Pepsinogen Criteria.
Gastroenterol Res Pract
May 2023
Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan.
Background: New serum pepsinogen (PG) criteria have been shown to indicate more accurately infection with (). We sought to improve risk classification for gastric cancer by adopting the new PG criteria with the addition of an antibody test.
Methods: The study participants were 275 patients with gastric cancer and 275 apparently healthy controls from case-control study data.
Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling.
Sci Rep
May 2023
Department of Neural iPSC Research, Institute for Medical Science of Aging, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Pathophysiological analysis and drug discovery targeting human diseases require disease models that suitably recapitulate patient pathology. Disease-specific human induced pluripotent stem cells (hiPSCs) differentiated into affected cell types can potentially recapitulate disease pathology more accurately than existing disease models. Such successful modeling of muscular diseases requires efficient differentiation of hiPSCs into skeletal muscles.
View Article and Find Full Text PDFA variety of cellular therapies including hematopoietic cell transplantation (HCT) hold the promise to treat medical conditions and diseases that currently have limited or no effective therapeutic options. A number of cellular therapies other than HCT, such as CAR T-cell therapy, are currently in preclinical and clinical development and the field is rapidly growing. The current activity of cellular therapies, including HCT, in the clinical setting are summarized in this article.
View Article and Find Full Text PDFPrognostic impact of complex and/or monosomal karyotypes in post-transplant poor cytogenetic acute myeloid leukaemia: A quantitative approach.
Br J Haematol
July 2023
Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan.
To evaluate the prognostic impact of complex karyotype (CK) and/or monosomal karyotype (MK) in combination with various clinical factors on allogeneic stem cell transplantation (HSCT) outcomes of patients with acute myeloid leukaemia (AML), we analysed the registry database of adult AML patients who underwent allogeneic HSCT between 2000 and 2019 in Japan. Among 16 094 patients, those with poor cytogenetic risk (N = 3345) showed poor overall survival (OS) after HSCT (25.3% at 5 years).
View Article and Find Full Text PDFRadial nerve palsy caused by a rapidly growing intramuscular hematoma in an infant with biliary atresia: a case report.
BMC Pediatr
May 2023
Department of Pediatrics, Aichi Medical University School of Medicine, 1-1, Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Article Synopsis
- - Biliary atresia (BA) is a rare condition in infants that leads to jaundice and can cause vitamin K deficiency bleeding (VKDB), leading to complications such as hematomas from vaccinations.
- - A case of an 82-day-old girl with BA developed a significant hematoma in her arm after receiving a pneumococcal vaccine, resulting in a radial nerve palsy due to the bleeding.
- - Timely detection and management of BA and VKDB are crucial, as delays can lead to severe consequences, including lasting nerve damage even after treatment interventions like liver transplant.
A convolutional neural network-based model that predicts acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Commun Med (Lond)
May 2023
Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Background: Forecasting acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is highly challenging with conventional statistical techniques due to complex parameters and their interactions. The primary object of this study was to establish a convolutional neural network (CNN)-based prediction model for aGVHD.
Method: We analyzed adult patients who underwent allogeneic HSCT between 2008 and 2018, using the Japanese nationwide registry database.
Impact of HLA-mismatched unrelated transplantation in patients with adult T-cell leukemia/lymphoma.
Bone Marrow Transplant
September 2023
Department of Hematology and Rheumatology, Kagoshima University Hospital, Kagoshima, Japan.
Article Synopsis
- A Japanese study examined the effects of transplanting HLA-mismatched unrelated donors in adult T-cell leukemia-lymphoma patients from 2000 to 2018, comparing three donor types: matched related donors (MRD), fully matched unrelated donors (8/8MUD), and one allele-mismatched unrelated donors (7/8MMUD).
- Out of 1191 patients, those receiving transplants from 7/8MMUD donors showed a higher risk of non-relapse mortality (31.5%) but a lower risk of cancer relapse (34.4%) compared to the MRD group.
- The findings suggest that 7/8MMUD donors can serve as a viable option when fully
Allogeneic stem cell transplantation for children and adolescents/young adults with de novo blastic phase chronic myeloid leukemia in the tyrosine kinase inhibitor era.
Am J Hematol
August 2023
Department of Cell Processing and Transfusion, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Article Synopsis
- - The study examined 165 children and young adults with a specific type of leukemia known as de novo blastic phase chronic myeloid leukemia.
- - Researchers found that the status of the disease at the time of hematopoietic stem cell transplantation was crucial in predicting patient outcomes.
- - This indicates that the condition of patients before they undergo the transplant can significantly influence their chances of recovery and overall prognosis.