Regulatory, diagnostic, and therapeutic roles of microRNAs in chronic liver diseases.

Fibrogenesis is initially performed during tissue damage to protect the remaining tissues from the progressive death of epithelial cells, infiltration of immune and inflammatory cells, and local degrading enzymes. Inflammation can lead to excessive extracellular matrix deposition by fibroblasts and the induction of fibrosis in many organs, such as the liver. MiRNAs are small noncoding RNAs that mediate mRNA repression or destabilization, leading to translational repression.

Evaluating the Radioactive Waste Produced per Patient by Radiopharmaceutical Sources and Measuring the Radioactive Contamination of Surfaces and Staff at the Bushehr Nuclear Medicine Department.

Background: Nuclear medicine is an integral and developing field in diagnosing and treating diseases. Monitoring individuals' protection and radiation contamination in the workplace is vital for preserving working environments.

Objective: This study aimed to monitor the nuclear medicine department's personnel, environment, and wastes to determine the level of occupational radiation and environmental pollution in Bushehr's nuclear medicine department.

Correlation between plasma biochemical parameters and cardio-hepatic iron deposition in thalassemia major patients.

Introduction: Major Thalassemia patients suffer from iron overload and organ damage, especially heart and liver damage. Early diagnosis and treatment with a chelator can reduce the complications and mortality of iron overload. Therefore, we aimed to investigate the biochemical and hematological predictors as an alternative and indirect indicator of iron deposition in heart and liver cells in comparison with the MRI T2* method as the gold standard.

Ginger intervention on body weight and body composition in adults: a GRADE-assessed systematic review and dose-response meta-analysis of 27 randomized controlled trials.

Context: Ginger consumption may have an inverse relationship with obesity and metabolic syndrome parameters; however, clinical trials have reported contradictory results.

Objective: To systematically review and analyze randomized controlled trials (RCTs) assessing the effects of ginger on body weight and body composition parameters.

Methods: Databases were searched for appropriate articles up to August 20, 2022.

Clinical heterogeneity in families with multiple cases of inborn errors of immunity.

Background: Inborn errors of immunity (IEI) are a diverse range of genetic immune system illnesses affecting the innate and/or adaptive immune systems. Variable expressivity and incomplete penetrance have been reported in IEI patients with similar clinical diagnoses or even the same genetic mutation.

Methods: Among all recorded patients in the national IEI registry, 193 families with multiple cases have been recognized.

Translation, cross-cultural adaptation, and validation of the Persian version of Everyday Memory Questionnaire-Revised (EMQ-R) in patients with multiple sclerosis.

Purpose: The present research translated and validated the Persian version of the Everyday Memory Questionnaire-Revised (EMQ-R) in patients with multiple sclerosis (MS).

Methods: A two-step study was performed in the current work. First, the scale was translated and culturally adopted to Persian.

Designing and Validation of Self-Assessment Tool of Professional Competency and Its Psychometrics in the Administrators of Preschool Educational Centers.

Background: The role of preschool administrators in raising children is increasing day by day, so the purpose of this study was to detect the validity and reliability of the professional competency questionnaire and its psychometric assessment in preschool administrators.

Methods: This descriptive study was conducted on 380 preschool administrators with a minimum age of 25 and a maximum of 65 year participated in 2018. The sampling method was stratified from four regions of north, south, west and east of Tehran, Iran.

Socioeconomic difference in physical activity in children and their parents: The childhood and adolescence surveillance and prevention of adult noncommunicable disease study.

Background: As a health-related behavior, physical activity (PA) differs according to individual's socioeconomic status (SES). This study aimed to assess the socioeconomic difference in leisure-time PA among Iranian students and their parents at national and regional levels.

Study Design: Nationwide cross-sectional study.

Measuring the Structures of the Health Belief Model Integrated with Health Literacy in Predicting University Students' Adoption of Smoking Preventive Behaviors.

Objectives: One of the priorities of public health in reducing smoking is to prevent young people from becoming smokers. Health literacy (HL), smoking, and preventive behaviors are related. Moreover, HL has a potential impact on strengthening the Health Belief Model (HBM).

Exploring the Influence of Users' Characteristics in Continuance Intention to Use Electronic Medical Records (EMR): Extending the Expectation Confirmation Model (ECM).

Even though the "user characteristics" (UC) can influence "acceptance" and "the continuance intention to use" of information systems such as electronic medical records (EMR), the effect of UC has not been adequately evaluated in post-adoption models. This study seeks to examine the effect of UC on post-usage of EMR using the expectation confirmation model (ECM). A total of 450 questionnaires was collected by a survey to extend ECM by integrating UC using structural equation modeling (SEM).

The Impact of Inflation and Its Uncertainty on Pharmaceutical Prices: Evidence from Iran.

Pharmaceutical productions are recognized as an essential commodity in the economical literature; therefore, an increase in their prices leads to an increase in the household budget. Currently, about 15-20% of the entire health expenditure in Iran is allocated to the pharmaceutical sector. This study aimed to investigate the effect of inflation and its uncertainty on inflation in pharmaceutical prices in Iran.

HIV/AIDS policy-making in Iran: A stakeholder analysis.

Introduction: The present study aims to identify and analyze HIV/AIDS stakeholders in Iran.

Methods: This qualitative stakeholder analysis was conducted in 2018 nationwide, both retrospectively and prospectively. Purposive sampling was applied and followed by snowball sampling until data saturation.

The Cost-Effectiveness and Cost-Utility of Statin Drug for the Treatment of Patients with Cardiovascular Disease, A Systematic Review.

Cardiovascular diseases impose a burden of disease and economic burden on society. With regard to different drugs are used to treat cardiovascular disease; these interventions should be economically evaluated and them that the most cost-effective were selected. The aim of this study was to investigate the studies carried on the cost-effectiveness and cost-utility of statin drugs for the treatment of patients with cardiovascular disease between 2004 and 2020.

Fabrication of a customized impression metal jig for an implant-supported overdenture with a milled bar.

The use of computer-aided design/computer-aided manufacturing technology simplifies the laboratory and clinical steps for the fabrication of implant prostheses. It also reduces additional costs for the prosthetic components and technical procedures. This article describes a modified impression technique using an impression metal jig to enhance the accuracy of final impression and also to eliminate the need for the try-in of resin pattern of the milled bar.

Decomposition of socioeconomic inequality in growth disorders to its determinants in pediatric population: the CASPIAN IV study.

Purpose: The current study aims to evaluate socioeconomic inequality in growth disorders and its determinants in Iranian children and adolescents.

Methods: In this nationwide cross-sectional survey, 14,880 students aged 6-18 years were selected through multistage cluster sampling method from urban and rural areas of 30 provinces of Iran in 2011. Socioeconomic status (SES) was calculated using principle component analysis.

A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran.

Population exposure to environmental contaminants can be precisely observed through human biomonitoring studies. The present study aimed to systematically review all the biomonitoring studies conducted in Iran on some selected carcinogen environmental pollutants. In this systematic review study, 11 carcinogen agents were selected including arsenic, cadmium, chromium, nickel, lindane, benzene, trichloroethylene (TCE), pentachlorophenol (PCP), radon-222, radium-224, - 226, - 228, and tobacco smoke.

Is the quality of life different in single and remarried elderly?

Background: Due to increasing number of the world population, elderly individual's quality of life (QOL) is a matter of concern and marital status as one of the objective measures of QOL is of paramount importance. This study was done to compare the QOL between single and remarried elderly.

Materials And Methods: This case-control study was conducted on 200 elderly people in Qaen (Southern Khorasan province), Iran.

Effect of Intracanal Glass-Ionomer Barrier Thickness on Microleakage in Coronal Part of Root in Endodontically Treated Teeth: an In Vitro Study.

Statement Of The Problem: The most common cause of endodontic treatment failures is improper coronal sealing. Therefore, besides to proper root sealing, coronal sealing which is supported by a proper restoration has a major role in endodontic treatment success, and coronal microleakage should be considered as an etiologic factor in endodontic treatment failure. Glass-ionomer (GI) has been proposed as a coronal barrier for microleakage after endodontic treatment.

Predictive accuracy of performance oriented mobility assessment for falls in older adults: A systematic review.

Performance Oriented Mobility Assessment (POMA) is a commonly used screening tool for identifying patients at risk of falling. The purpose of this systematic review was to determine the overall predictive accuracy of POMA for falls in community-dwelling older adults. This review could provide useful information to use POMA in both research and clinical settings.

Spermatogenesis Recovery Potentials after Transplantation of Adipose Tissue-Derived Mesenchymal Stem Cells Cultured with Growth Factors in Experimental Azoospermic Mouse Models.

Objective: Approximately 1% of the male population suffers from obstructive or non-obstructive azoospermia. Previous in vitro studies have successfully differentiated mesenchymal stem cells (MSCs) into germ cells. Because of immunemodulating features, safety, and simple isolation, adipose tissue-derived MSCs (AT-MSCs) are good candidates for such studies.

Gender Determines the Pattern of Correlation between Body Mass Index and Major Depressive Disorder among Children and Adolescents: Results from Iranian Children and Adolescents' Psychiatric Disorders Study.

We aimed to determine the correlation of BMI with depression and to determine the role of gender in this association, in a large study sample. We used the data of participants in the Iranian Children and Adolescents' Psychiatric Disorders (IRCAP) Study, conducted in 2017. This study was a national community-based, cross-sectional study in which the urban and rural areas of all provinces of Iran were covered.