The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response.

Background: An enhanced aerobic glycolysis ("Warburg effect") associated with an increase in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and resistance to radiation and chemotherapy. We investigated the radiation- and chemo-sensitizing effects of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac in different cancer cell types.

Methods: The effects of a non-lethal concentration of diclofenac was investigated on c-MYC and Lactate Dehydrogenase (LDH) protein expression/activity and the Heat shock Protein (HSP)/stress response in human colorectal (LS174T, LoVo), lung (A549), breast (MDA-MB-231) and pancreatic (COLO357) carcinoma cells.

Dexamethasone effects on Bax expression in the mouse testicular germ cells.

Exposure to glucocorticoids (GCs) leads to numerous changes in various biological systems including the reproductive system. The aim of the present study was to find out whether dexamethasone (Dex), a widely used GC, would influence the apoptosis and expression of Bax, an important proapoptotic protein, in the mouse testicular germ cells. Experimental groups of 8 male NMRI mice received one of the following treatments daily for 7 days: 4, 7 and 10 mg/kg Dex.

Comparison of flame atomic absorption spectrometry (FAAS) and Cerimetric methods for the determination of ferrous sulfate content of some pharmaceutical products.

The iron content of ferrous sulphate syrup and tablet, ferroglobin, and Fefol were determined by both titration with cerium (Cerimetric method) proposed by united state pharmacopeias and flame atomic absorption spectrometry (FAAS). In FAAS both external calibration and standard addition method were used to evaluate the matrix effects. In the determination of iron content of ferrous sulphate tablet and syrup FAAS using external standard give approximately the same results as cerimetric methods of analysis.

Bacterial infections in burn patients at a burn hospital in Iran.

Background & Objective: The major challenge for a burn team is nosocomial infection in burn patients, which is known to cause over 50% of burn deaths. Most studies on infection in burn patients focus on burn wound infection, whereas other nosocomial infections in these patients are not well described. We undertook this study to determine three types of nosocomial infections viz.

Nutrition education alone improves dietary practices but not hematologic indices of adolescent girls in Iran.

Background: Iron-deficiency anemia is the most prevalent nutritional deficiency worldwide. Iron-deficiency anemia has particular negative consequences on women in their childbearing years, and its prevention is a high priority in most health systems.

Objective: This interventional study assessed the effect of nutrition education on hematologic indices, iron status, nutritional knowledge, and nutritional practices of high-school girls in Iran.

Comparison between bioelectrical impedance analysis and body mass index methods in determination of obesity prevalence in Ahvazi women.

Background: Obesity has an increasing trend worldwide. Recently, application of body mass index (BMI) cutoff points of obesity classification for all population studies has been questioned. On the other hand, bioelectrical impedance analysis (BIA) is a safe, accurate, reliable and inexpensive method for screening the overweight and obesity in such studies.