Elevated cerebrospinal fluid biomarkers of neuroinflammation and neuronal damage in essential hypertension with secondary insomnia: Implications for Alzheimer's disease risk.

Essential hypertension (EH) with secondary insomnia is associated with increased risks of neuroinflammation, neuronal damage, and Alzheimer's disease (AD). However, its relationship with specific cerebrospinal fluid (CSF) biomarkers of neuronal damage and neuroinflammation remains unclear. This case-control study compared CSF biomarker levels across three groups: healthy controls (HC, n = 64), hypertension-controlled (HTN-C, n = 54), and hypertension-uncontrolled (HTN-U, n = 107) groups, all EH participants experiencing secondary insomnia.

Beyond the blade: Unveiling the nexus of spirituality and human dissection among medical and allied health students in Nigeria.

This study investigated how human dissection affects students' spiritual beliefs, and how their existing spiritual beliefs influence their perceptions of human dissection. This cross-sectional study assessed 760 medical students with human dissection experience using an online questionnaire developed from interviews and the Spirituality Orientation Inventory, including questions on dissection experience, spirituality, spiritual perceptions about dissection, and the impact of dissection on spirituality. Descriptive analysis and Chi-squared tests were used to determine proportions and relationships between variables, with statistical significance at p < 0.

Effect of hay type and breed on the fattening, centesimal and fatty acid composition of Nigerian sheep.

This study aimed to evaluate the intake, performance, quality, and fatty acids (FA) composition of the meat of three Nigerian sheep breeds (Balami, Uda, and Yankasa) fed two different hays, Brachiaria decumbens or Digitaria smutsii. A total of sixty sheep, twenty from each breed, Balami, Uda, and Yankasa, were used, with average body weights of 24.7 ± 3.

The consequences of climate change and male reproductive health: A review of the possible impact and mechanisms.

A global decline in male fertility has been reported, and climate change is considered a major cause of this. Climate change refers to long-term shifts in temperatures and weather patterns, and results from greenhouse gas emissions like carbon dioxide and methane that act as a blanket wrapped around the earth, trapping heat and elevating temperatures. Sad to say, the consequences of climatic variation are beyond the dramatic elevated temperature, they include cold stress, increased malnutrition, air pollution, cardiovascular diseases respiratory tract infections, cancer, sexually transmitted infections, mental stress, and heat waves.

Parametric analysis on the global design of flexible riser under different environmental conditions using OrcaFlex.

The application of flexible risers has led to increased production of fluid contents in the marine industry. This paper presents the design challenges of a flexible riser subjected to internal pressure under deep-water conditions, at a water depth of 2000 m. Parametric variations with extensive dynamic analysis were carried out.

The contraceptive active ingredient levonorgestrel disrupts the physiology of Macrocyclops albidus.

Active pharmaceutical ingredients, such as levonorgestrel (LNG), continue to increase in aquatic ecosystems and are detected in environmental matrices; however, their ability to bioaccumulate and cause reproductive, developmental, and biochemical defects in benthic organisms, such as Macrocyclops albidus, is unknown. This study investigated the effects of LNG on the oxidative stress response, reproduction, and development of M. albidus.

Antiplasmodial Activity of Probiotic YZ01 in ANKA Infected BALB/c Mice.

Malaria remains a significant global health challenge, with the deadliest infections caused by . In light of the escalating drug resistance and the limited effectiveness of available vaccines, innovative treatment approaches are urgently needed. This study explores the potential of the probiotic YZ01, isolated from traditionally fermented kindirmo milk, to modify host responses to ANKA infection.

CSQUiD: an index and non-probability framework for constrained skyline query processing over uncertain data.

Uncertainty of data, the degree to which data are inaccurate, imprecise, untrusted, and undetermined, is inherent in many contemporary database applications, and numerous research endeavours have been devoted to efficiently answer skyline queries over uncertain data. The literature discussed two different methods that could be used to handle the data uncertainty in which objects having continuous range values. The first method employs a probability-based approach, while the second assumes that the uncertain values are represented by their median values.

Evaluation of the double-zone hemolysis (DZH) test for the detection of livestock-associated methicillin-resistant .

Unlabelled: Livestock-associated methicillin-resistant (LA-MRSA), such as clonal-complex (CC)398, are of clinical relevance due to their multi-drug resistance profiles, adding to the overall burden of MRSA in humans. The objective was to evaluate the double-zone hemolysis (DZH) test as a simple and reliable method for detecting LA-MRSA in the clinical microbiology laboratory. isolates assigned to CC398 ( = 183; 152 MRSA/31 methicillin-susceptible [MSSA]), CC1 ( = 44; MRSA), and other CCs ( = 144; 94 MRSA/50 MSSA) were investigated.

Targeting mutation sites in the omicron variant of SARS-CoV-2 as potential therapeutic strategy against COVID-19 by antiretroviral drugs.

The multiple mutation of the spike (S) protein of the Omicron SARS-CoV-2 variant is a major concern, as it has been implicated in the severity of COVID-19 and its complications. These mutations have been attributed to COVID-19-infected immune-compromised individuals, with HIV patients being suspected to top the list. The present study investigated the mutation of the S protein of the omicron variant in comparison to the Delta and Wuhan variants.

Assessment of field performance and bruchid resistance during seed storage of a genetically modified cowpea expressing the alpha-amylase inhibitor 1 protein from common bean.

Introduction: The cowpea weevil, Fab., is the most economically important storage pest of cowpeas, causing up to 100 percent grain losses within six months of storage. To sustainably resist weevil damage, the cowpea cultivar IT86D-1010 was genetically modified via -mediated transformation to produce event CSI-32, which expresses the kidney bean alpha-amylase inhibitor 1 (αAI-1) protein exclusively in the seed, providing suppression of weevil development.

Prevalence and Possible Predictors of Helicobacter Pylori Infection Among Adult Patients with Sickle Cell Disease in Ahmadu Bello University Teaching Hospital North-West, Nigeria.

Background: Helicobacter Pylori infection occurs worldwide. Patients with Sickle Cell Disease (SCD) may present with abdominal symptoms due to different pathophysiological mechanisms. SCD patients are predisposed to infections due to immune deficiency, abdominal symptoms like dyspepsia and recurrent abdominal pain have been associated with infection.

Histopathologic and Immunohistochemical Analysis of Neurofibromas in a North-Western Nigerian Tertiary Hospital: A Ten-Year Retrospective Study.

Background: Neurofibromas are the most common benign nerve sheath tumours occurring as solitary sporadic tumours or multiple Syndromic tumours associated with neurofibromatosis type 1(NF1). In Nigeria and West Africa, there is a paucity of literature and studies on neurofibromas. This study aims to analyse the histopathologic and immunohistochemical patterns of neurofibromas and determine the frequency, demographic and anatomic distributions.

Validation and optimization of smart eye camera as teleophthalmology device for the reduction of preventable and treatable blindness in Nigeria.

Background/objectives: Limited resources and staffing hinders efforts to reduce preventable blindness, especially in low- to middle-income countries. The slit-lamp examination (SLE), which is essential for ophthalmology practices, is often unavailable in primary and secondary eye care facilities due to the high costs and lengthy training required for operation. We conducted a cross-sectional, multicentre study exploring the potential for a smart eye camera (SEC; a tele-ophthalmology handheld device developed by OUI Inc.

Isolation and Molecular Characterization of Pathogenic Leptospira spp. from Brown Rats (Rattus norvegicus) in Zaria and Environs, Kaduna, Nigeria, 2022.

Leptospirosis caused by the pathogenic serovars of Leptospira spp. is a zoonotic disease of global importance. Brown rats (Rattus norvegicus), due to their worldwide distribution and reservoir host status, are considered the most important reservoir for environmental leptospiral persistence and infections in animals.

Antiplasmodial potential of compounds isolated from Ziziphus mucronata and their binding to Plasmodium falciparum HGXPRT using biophysical and molecular docking studies.

The increasing resistance of Plasmodium parasites to currently available antiplasmodial therapies poses a significant challenge in treating malaria. Since ancient times, plants have served as a primary source of novel pharmacologically active compounds for drug development. Therefore, this study aimed to explore the antiplasmodial properties of pentacyclic triterpenes isolated from Ziziphus mucronata bark, with an emphasis on their mechanism of action.

Perceived work-related stress and associated factors among the surgical workforce in a Nigerian tertiary health facility: A cross-sectional study.

Healthcare workers continue to experience high levels of work-related stress which continue to negatively affect their psychological, physical, and emotional well-being. This is even more prevalent among healthcare workers who work in surgical specialities, with the surgical operation room becoming a known stressor at hospitals. This study aims to assess work-related stress among surgical team members at Ahmadu Bello University Teaching Hospital in Zaria between January 2021-2022.

Clovibactin and Staphylococcus aureus: a new weapon against resistant strains.

Clovibactin is a new depsipeptide and highly efficacious against () , including methicillin-resistant and vancomycin-resistant , with no apparent resistance. Clovibactin outclasses current antibiotics such as vancomycin. Here, we discuss its efficacy, emphasize the need for new antibiotics owing to growing global antibiotic resistance, highlight its mode of action and possible benefits over current treatments.