49 results match your criteria: "Agriculture and Life Science Research Institute[Affiliation]"

Effect of the Ratio of Protein to Water on the Weak Gel Nonlinear Viscoelastic Behavior of Fish Myofibrillar Protein Paste from Alaska Pollock.

Gels

November 2024

Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.

The linear and nonlinear rheological behaviors of fish myofibrillar protein (FMP) paste with 75%, 82%, and 90% moisture content were evaluated using small-amplitude oscillatory shear (SAOS) and large-amplitude oscillatory shear (LAOS) tests. SAOS revealed pastes with 75% and 82% moisture exhibited solid-like behavior, characterized by higher storage modulus (G') than loss modulus (G″), indicative of weak gel properties with a strong protein interaction. In contrast, the 90% moisture content showed more viscous behavior due to weakened protein-protein entanglements.

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A novel method for real-time inhalation toxicity assessment in mice using respirometric system: A promising tool for respiratory toxicology.

Ecotoxicol Environ Saf

November 2024

Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Article Synopsis
  • * This study introduced a new method using a respirometer to measure oxygen consumption in ICR mice exposed to various concentrations of benzene, toluene, and xylene, revealing significant decreases in respiration rates at high concentrations of benzene and toluene.
  • * The method was validated in a model of pulmonary fibrosis, showing a strong link between weight loss and decreased oxygen consumption, suggesting oxygen consumption might serve as a reliable endpoint in inhalation toxicity assessments without needing to sacrifice animals.
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3,4,5-trimethoxycinnamic acid methyl ester isolated from Polygala tenuifolia enhances hippocampal LTP through PKA and calcium-permeable AMPA receptor.

Biochem Pharmacol

December 2024

Department of Advanced Translational Medicine, Graduate School, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea; Department of Pharmacology, College of Medicine, Konkuk University, Chungju 27478, Republic of Korea; Institute of Biomedical Sciences & Technology, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Alzheimer's disease (AD) is a degenerative brain disorder characterized by progressive cognitive decline and neuronal death due to extracellular deposition of amyloid β (Aβ) and intracellular deposition of tau proteins. Recently approved antibody drugs targeting Aβ have been shown to slow the progression of the disease, but they have minimal effects on cognitive improvement. Therefore, there is a need to develop drugs with cognitive-enhancing effects that can be used in conjunction with these antibody treatments.

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Article Synopsis
  • Diamide insecticides have been used for over ten years to control beet armyworm pests, but resistance has developed, complicating their ongoing effectiveness.
  • Researchers identified a specific mutation (I4790 M) in the ryanodine receptor gene of S. exigua associated with resistance, although its prevalence varied among different populations in Korea.
  • The study highlighted CYP9A40 as a key gene in metabolic resistance, showing a strong correlation between its expression and increased resistance to diamides, suggesting combined strategies for better pest control and management of insecticide resistance.
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Carbamate insecticides have been used for over four decades to control brown planthopper, , but resistance has been reported in many countries, including the Republic of Korea. The bioassay results on resistance to fenobucarb showed that the LC values were 3.08 for the susceptible strain, 10.

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Novel approach on the evaluation of enzyme-aided alkaline extraction of polysaccharide from Hordeum vulgare husk and molecular insight on the multifunctional scaffold.

Int J Biol Macromol

October 2024

Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, South Korea; Future F Biotech Co., Ltd., Chuncheon 24341, South Korea. Electronic address:

Article Synopsis
  • The study focuses on the benefits of barley husk, specifically its water-soluble xylan (BH-WSX), highlighting its high dietary fiber and prebiotic content that support gut health.
  • Researchers extracted BH-WSX and found it to have a significant yield, specific molecular characteristics, and antioxidant properties, suggesting it could be useful for food applications.
  • Advanced analyses, including spectroscopy and thermal testing, confirmed the chemical composition and structure of BH-WSX, making it a promising candidate for enhancing gut microbiota and potentially preventing adhesion of harmful bacteria.
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Geraniin from the methanol extract of Pilea mongolica suppresses LPS-induced inflammatory responses by inhibiting IRAK4/MAPKs/NF-κB/AP-1 pathway in HaCaT cells.

Int Immunopharmacol

October 2024

Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Article Synopsis
  • The skin serves as a protective barrier against external irritants, and Pilea mongolica (P. mongolica) is a traditional Chinese herb that may help reduce inflammation, despite limited research on its effects.
  • This study investigated the anti-inflammatory properties of the methanol extract of P. mongolica (MEPM) on LPS-stimulated human skin cells, showing that it significantly lowered inflammatory markers without being toxic to the cells.
  • The study identified geraniin, an active compound in MEPM, as a key player in these anti-inflammatory effects, suggesting that MEPM and geraniin could be valuable for developing natural cosmetic products.
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  • The study evaluated various colored cherry tomato cultivars ('Jocheong', 'BN Satnolang', 'Gold Chance', 'Black Q', and 'Snacktom') for their firmness, taste, and nutritional metabolites at ripening stage.
  • Findings showed distinct taste variations and metabolite accumulation linked to the tomato colors: 'Black Q' is rich in chlorophylls and anthocyanins, 'Snacktom' in lycopene, 'Gold Chance' in phenolics, and 'Jocheong' in vitamins and amino acids.
  • 'Gold Chance' had the highest antioxidant capacity, highlighting the potential for breeding programs aimed at enhancing nutritional content through diverse cherry tomato selections.
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Background: The Oriental tobacco budworm, Helicoverpa assulta, a specialist herbivorous insect that exclusively feeds on plants of the Solanaceae family, causes considerable damage to crops, such as tobacco and hot pepper. The absence of a genome sequence for this species hinders further research on its pest management and ecological adaptation.

Results: Here, we present a high-quality chromosome-level genome of a Korean strain of H.

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Cheonwangbosimdan mitigates post-traumatic stress disorder-like behaviors through GluN2B-containing NMDA receptor antagonism in mice.

J Ethnopharmacol

August 2024

Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, 02447, Republic of Korea; Department of Oriental Pharmaceutical Science, Kyung Hee University, Seoul, 02447, Republic of Korea. Electronic address:

Article Synopsis
  • Cheonwangbosimdan (CWBSD) is a traditional herbal medicine known for treating anxiety, insomnia, depression, and heart palpitations, and shows potential in reducing PTSD-like behaviors.
  • The study employed a mouse model of PTSD to test CWBSD’s effects on various behavioral tests, signaling improvements in anxiety, depression, and cognitive function.
  • Results indicated that CWBSD improved emotional and cognitive issues in PTSD-like mice and potentially normalized certain protein levels in the amygdala affected by stress.
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() is a medicinal plant with secondary metabolites such as phenolics, flavonoids, glycosides, saponins, and alkaloids. This study was designed to optimize the ultrasonic-assisted extraction (UAE) parameters to enhance the phenolic content and characterize the phenolic compounds using ultra-high-performance liquid chromatography, coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UHPLC-ESI-QTOF-MS/MS), and antioxidant activities in extract. Extraction time, sample-to-solvent ratio, and extraction temperature were considered for UAE optimization.

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Particulate matter (PM) exacerbates on MK-801-induced schizophrenia-like behaviors through the inhibition of ERK-CREB-BDNF signaling pathway.

Ecotoxicol Environ Saf

May 2024

Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea; School of Natural Resources and Environmental Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea; Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Article Synopsis
  • Particulate matter (PM) pollution, linked to various health issues, has not been thoroughly studied in relation to the development of schizophrenia.
  • This study exposed preadolescent mice to PM and examined the impact on schizophrenia-like behaviors, finding that PM exposure worsened symptoms like social deficits and cognitive impairments in adulthood.
  • The research also revealed that PM exposure reduced levels of brain-derived neurotrophic factor (BDNF) and affected related signaling pathways, suggesting a biological mechanism behind the exacerbation of schizophrenia symptoms.
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Genome-Wide Exploration of Long Non-Coding RNAs of in Response to Pyrethroid Insecticide Resistance.

Insects

February 2024

Agriculture and Life Science Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea.

Genome-wide long non-coding RNAs (lncRNAs) in low, moderate, and high pyrethroid insecticide-resistant and -susceptible strains of were identified in this study. Using 45 illumina-based RNA-sequencing datasets, 8394 lncRNAs were identified. In addition, a sublethal dose of deltamethrin was administered to a Korean-resistant strain (Kor-T).

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Artificial saliva induced structural breakdown of surimi gels with starch under continuous compressive motions.

Food Res Int

April 2024

Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon 24341, Republic of Korea; Elder-Friendly Research Center, Agriculture and Life Science Research Institute, Kangwon National University, 1 Kangwondaehak-gil, Chuncheon 24341, Republic of Korea. Electronic address:

Food texture perception is dynamic, influenced by food properties and oral processing. Using the Repeatable Dual Extrusion Cell (RDEC), the oral processing dynamics of surimi gel with different corn starch concentrations (0-15%) in the presence of 1 ml artificial saliva or water were studied. The force-time curve showed increased peak forces with higher corn starch concentrations, peaking significantly at 10%, then decreasing at 15%.

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This study investigated the impact of Methyl Jasmonate (MeJA) application on the nutritional content and yield of five different colored radish microgreens. Microgreens were produced without substrate and subjected to 0.5 mM and 1.

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D-Pinitol mitigates post-traumatic stress disorder-like behaviors induced by single prolonged stress in mice through mineralocorticoid receptor antagonism.

Prog Neuropsychopharmacol Biol Psychiatry

June 2024

Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address:

Article Synopsis
  • PTSD is a mental illness that arises from trauma, and current treatments are often ineffective and have significant side effects.
  • This study explored the potential of D-Pinitol, shown to help depression and anxiety, in a mouse model of PTSD, finding it improved symptoms and cognitive functions.
  • D-Pinitol works by antagonizing the mineralocorticoid receptor, which may help explain its effectiveness in reducing PTSD-like behaviors and fear responses in the tested mice.
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Groundwater Charge was introduced in 2005 as one of the sustainable resource management measures in South Korea. The implementation rate, however, stagnated around 37 %, indicating that most local governments chose not to adopt this 'optional' regulation. While previous Stakeholder Analysis studies mainly blamed exclusion - or limited involvement - of stakeholders in the designing and structuring stage of policy-making process for policy failures, this study focused on the interest conflicts and dynamics hindered implementation process.

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Analysis of Mass Transfer and Shrinkage Characteristics of Chinese Cabbage ( L. ssp. ) Leaves during Osmotic Dehydration.

Foods

January 2024

Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, Republic of Korea.

The mass transfer and shrinkage characteristics of Chinese cabbage (CC) during osmotic dehydration (OD) were investigated. The leaves were grouped into four sections and analyzed based on their morphological characteristics (i.e.

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Article Synopsis
  • * A study tested the effects of a novel herbal complex called LK5, which has anti-inflammatory properties, on HaCaT cells and in a mouse model of AD.
  • * Results showed that LK5 reduced expression of inflammatory cytokines, improved clinical symptoms in mice, and inhibited itch, indicating its potential to modulate the immune response and alleviate AD symptoms by targeting the JAK-STAT pathway.
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Introduction: Tannin content and postharvest quality characteristics of persimmon fruit are often determined by the destructive analysis that consumes time, does not allow the acquisition of data from the same fruit continuously, and requires expensive high-performance equipment. This research was done to investigate the potential for non-destructive estimation of astringency and quality parameters in persimmon fruit based on visible/near-infrared (VNIR) spectra.

Methods: VNIR spectra readings, the reference tannin content, and quality parameters were measured from fruits of "Cheongdo-Bansi" and "Daebong" persimmon cultivars at harvest and throughout the ripening/deastringency period.

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This study addresses the propagation challenges faced by 'Shine Muscat', a newly introduced premium grapevine cultivar in South Korea, where multiple viral infections pose considerable economic loss. The primary objective was to establish a robust in vitro propagation method for producing disease-free grapes and to identify effective plant growth regulators to facilitate large-scale mass cultivation. After experimentation, 2.

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Encapsulating potential and functional properties of exopolysaccharide from Limosilactobacillus reuteri KCTC 14626BP isolated from human breast milk.

Int J Biol Macromol

December 2023

Department of Food Science and Biotechnology, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

Exopolysaccharides (EPS) are natural, nontoxic, biocompatible and biodegradable macromolecules produced by microorganisms, including the Lactic acid bacteria, to enhance protection against environmental stress conditions. The current study focused on the encapsulation and functional efficiency of EPS produced by probiotic strains isolated from human milk. Among 27 isolates, the potential high EPS-producing strain Limosilactobacillus reuteri KCTC 14626BP was selected based on biofilm production.

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Growing microgreens on trays without substrate in a vertical multilayered growing unit offers several advantages over traditional agriculture methods. This study investigated the yield performance and nutritional quality of five selections of radish microgreens grown in sprouting trays, without a substrate using only water, in an indoor multilayer cultivation system using artificial light. Various parameters were measured, including fresh weight, dry matter, chlorophyll, minerals, amino acids, phenolics, flavonoids, anthocyanins, vitamin C, glucosinolates, and antioxidant activity with four different assays.

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Article Synopsis
  • Interest in using fermented sprouts from smart farms is growing due to their health benefits, particularly in reducing inflammation.
  • A study found that a fermented extract of CL sprouts (F-CSA) exhibited significant anti-inflammatory effects by reducing harmful cytokines in macrophage cells and mice.
  • The anti-inflammatory action of F-CSA is linked to its high luteolin content and its ability to inhibit the JNK/NF-κB signaling pathway, showing potential for therapeutic applications in inflammatory conditions.
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Torrefaction is a pretreatment method for upgrading biomass into solid fuels. This study aimed to investigate the properties of agro-byproducts pretreated under different oxidative conditions at temperatures of 210-290 °C for 1 h to determine optimal operating conditions for upgrading biomass. The mass yields of lignocellulosic and herbaceous biomass were 90.

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