Neutrophil Gelatinase-Associated Lipocalin (NGAL) Is Related with the Proteinuria Degree and the Microscopic Kidney Findings in -Infected Dogs.

Early diagnosis of renal damage in infected dogs may allow appropriate treatments and prevent some deaths. This study investigates neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker of kidney disease in dogs experimentally infected with . Serum, urine, and kidney samples were collected from 30 infected beagle dogs and six uninfected control dogs.

Effects of uphill high-intensity interval exercise on muscle damage and exercise performance during recovery.

Background: Active recovery is believed to offer positive benefits related to exercise by improving recovery and potentially managing several symptoms following strenuous exercise. The current study aimed to verify the effects of a session of low-volume and uphill high-intensity interval exercise on muscle soreness and exercise performance within the recovery period after an exercise-induced muscle damage protocol.

Methods: Thirty-one young physically active subjects completed two identical test sessions following an exercise-induced muscle damage protocol, separated by a three-week period, in which they performed uphill high-intensity interval exercise or a passive recovery.

Occurrence and genetic diversity of rotavirus A in faeces of diarrheic calves submitted to a veterinary laboratory in Spain.

A total of 237 faecal specimens from diarrheic calves younger than two months were collected and submitted for diagnosis of enteropathogens over a two-year period (2017-2018) to a veterinary laboratory. Samples originated from 193 dairy and beef farms in 29 provinces distributed throughout Spain, and were tested for the occurrence of three target enteric pathogens by reverse transcription real-time PCR (RT-qPCR): bovine rotavirus A (RVA), Cryptosporidium parvum and bovine coronavirus (BCoV). RT-PCR and nucleotide sequencing analysis were used to determine the G (VP7 gene) and P (VP4 gene) genotypes of 26 specimens positive for RVA.

Replication of Small Ruminant Lentiviruses in Aluminum Hydroxide-Induced Granulomas in Sheep: a Potential New Factor for Viral Dissemination.

Aluminum (Al)-based salts are widely used adjuvants in ruminants and other species to strengthen the immune response elicited against vaccine antigen(s). However, they can lead to the formation of long-lasting granulomas composed of abundant activated macrophages. Small ruminant lentiviruses (SRLV) are widely distributed macrophage-tropic retroviruses that cause persistent infections in sheep and goats.

Identifying Spanish Areas at More Risk of Monthly BTV Transmission with a Basic Reproduction Number Approach.

Bluetongue virus (BTV) causes a disease that is endemic in Spain and its two major biological vector species, and the Obsoletus complex species, differ greatly in their ecology and distribution. Understanding the seasonality of BTV transmission in risk areas is key to improving surveillance and control programs, as well as to better understand the pathogen transmission networks between wildlife and livestock. Here, monthly risk transmission maps were generated using risk categories based on well-known BTV equations and predicted abundances of the two most relevant vectors in Spain.

Snakes and ladders: World development pathways' synergies and trade-offs through the lens of the Sustainable Development Goals.

This paper takes three global visions of world development to 2050 and quantifies their implications for sustainable progress employing the metrics of the Sustainable Development Goals (SDGs). The SDG outcomes are structured through the interconnectivities of the three 'wedding cake' layers of 'economy', 'society' and 'biosphere', as posited by the Stockholm Resilience Centre. The key policy contribution is to quantify the resulting SDG synergies and trade-offs, whilst also decomposing and calculating the part-worth of the market drivers which contribute to these outcomes.

Determinants of the current and future distribution of the West Nile virus mosquito vector Culex pipiens in Spain.

Changes in environmental conditions, whether related or not to human activities, are continuously modifying the geographic distribution of vectors, which in turn affects the dynamics and distribution of vector-borne infectious diseases. Determining the main ecological drivers of vector distribution and how predicted changes in these drivers may alter their future distributions is therefore of major importance. However, the drivers of vector populations are largely specific to each vector species and region.

Coupled DSSAT-SWAT models to reduce off-site N pollution in Mediterranean irrigated watershed.

In any agricultural watershed, best management practices (BMPs) are a conservational way to reduce non-point source pollution and, soil and water resources sustainability. The objectives of this study were to calibrate and validate the modified Soil and Water Assessment Tool (SWAT) in the Violada Watershed (VW), Spain and assess the BMPs scenarios, already tested at field scale, using the Decision Support System for Agro Technology Transfer model (DSSAT), and finally, to access the BMPs impact on water quality off-site. To this end, daily streamflow discharge and NO concentration were measured at VW outlet from October 2015 to September 2017 for model evaluation.

Effects of gamma irradiation on the shelf-life and bioactive compounds of Tuber aestivum truffles packaged in passive modified atmosphere.

The effects of gamma irradiation (0.5, 1.0, 1.

Drug-eluting wound dressings having sustained release of antimicrobial compounds.

Wound healing is a complex and costly public health problem that should be timely addressed to achieve a rapid and adequate tissue repair avoiding or even eliminating potential pathogenic infection. Chronic infected non-healing wounds represent a serious concern for health care systems. Efficient wound dressings with tailored therapy having the best response and highest safety margin for the management of chronic non-healing wounds are still needed.

Pathological findings in genital organs of bulls naturally infected with Besnoitia besnoiti.

Bulls chronically affected by bovine besnoitiosis can suffer from sterility. There is limited information about the distribution of Besnoitia cysts and their associated lesions within the male genital organs. This work describes the gross and histological abnormalities in the genital organs of 6 bulls chronically infected with Besnoitia besnoiti, including both clinically (n = 4) and subclinically (n = 2) affected cases.

The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level.

Background: Culicoides obsoletus is an abundant and widely distributed Holarctic biting midge species, involved in the transmission of bluetongue virus (BTV) and Schmallenberg virus (SBV) to wild and domestic ruminants. Females of this vector species are often reported jointly with two morphologically very close species, C. scoticus and C.

Neuroprotective Fragment C of Tetanus Toxin Modulates IL-6 in an ALS Mouse Model.

Neuroinflammation plays a significant role in amyotrophic lateral sclerosis (ALS) pathology, leading to the development of therapies targeting inflammation in recent years. Our group has studied the tetanus toxin C-terminal fragment (TTC) as a therapeutic molecule, showing neuroprotective properties in the SOD1G93A mouse model. However, it is unknown whether TTC could have some effect on inflammation.

A model for the assessment of bluetongue virus serotype 1 persistence in Spain.

Bluetongue virus (BTV) is an arbovirus of ruminants that has been circulating in Europe continuously for more than two decades and has become endemic in some countries such as Spain. Spain is ideal for BTV epidemiological studies since BTV outbreaks from different sources and serotypes have occurred continuously there since 2000; BTV-1 has been reported there from 2007 to 2017. Here we develop a model for BTV-1 endemic scenario to estimate the risk of an area becoming endemic, as well as to identify the most influential factors for BTV-1 persistence.

Screening of bioactive compounds in truffles and evaluation of pressurized liquid extractions (PLE) to obtain fractions with biological activities.

Truffles, besides the appreciated aromatic compounds, contain other molecules with interesting bioactive properties. A screening of fungal sterols and β-glucans within different truffle species and locations was carried out. These compounds were extracted with pressurized liquids (PLE) generating enriched fractions.

Multi-platform metabolomic approach to discriminate ripening markers of black truffles (Tuber melanosporum).

Black truffle is characterized by a black ascocarp and white veins. This hypogeous fruit body is known for its aroma. Understanding metabolic variation during ripening can shed light on truffle biology.

Progressive Invasion of in Northern Spain in The Period 2013-2018 and A Possible Association with the Increase in Insect Bites.

1) Background: has rapidly expanded throughout Europe, becoming a public health concern in the Mediterranean Basin. 2) Methods: Following the detection of in the southwestern French region of Aquitaine in 2012, an entomological surveillance programme was implemented in the Basque Country (Northern Spain) in 2013. 3) Results: eggs were first detected in 2014 in a transited parking area in the northeastern sampling point, 22 km away from the nearest French site with recorded presence of tiger mosquito.

Towards a more effective climate policy on international trade.

In the literature on the attribution of responsibilities for greenhouse gas emissions, two accounting methods have been widely discussed: production-based accounting (PBA) and consumption-based accounting (CBA). It has been argued that an accounting framework for attributing responsibilities should credit actions contributing to reduce global emissions and should penalize actions increasing them. Neither PBA nor CBA satisfy this principle.

A Mondrian matrix of seasonal patterns of Culicoides nulliparous and parous females at different latitudes in Spain.

Insects from genus Culicoides (Diptera; Ceratopogonidae) transmit arboviruses such as Bluetongue virus (BTV); affecting wild and domestic ruminants. These insects are age graded for monitoring purposes in surveillance programs. Parous females (PF) are the only fraction of the entire population that could effectively transmit viruses in a subsequent blood meal.

Assessment of targeted selective treatment criteria to control subclinical gastrointestinal nematode infections on sheep farms.

Control of sheep gastrointestinal nematode (GIN) infections mostly relies on the use of anthelmintics. Refugia-based control strategies as targeted selective treatments (TST) can delay anthelmintic resistance development, but the optimal decision criteria for selecting individuals to be treated in subclinical infection scenarios remain unclear. The present study aimed to evaluate the suitability of body condition score (BCS) and faecal egg counts (FEC) as treatment indicators and to determine their optimized threshold values for treatment in TST by determining the relationships of BCS, FEC and anthelmintic treatment with several productive parameters in pre-mating and pre-partum periods at an individual level.

Supercritical Carbon Dioxide Antisolvent Fractionation for the Sustainable Concentration of (Rozeira) Riv.- Mart Antimicrobial and Antioxidant Compounds and Comparison with Its Conventional Extracts.

subsp. is a Spanish subspecies from the family. Its essential oil has been traditionally used for several medical applications though little is known about other extracts.