8 results match your criteria: "Aghios Savvas Hospital[Affiliation]"
Soft Tissue Undifferentiated Sarcoma Carrying a Novel Onecut1::Nutm1 Fusion.
Pediatr Blood Cancer
January 2025
Division of Pediatric Hematology-Oncology, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Expression of DNA Repair Genes in Ewing Sarcoma.
Cancer Diagn Progn
May 2024
Division of Pediatric Oncology, First Department of Pediatrics, Aghia Sofia Children's Hospital, Athens, Greece.
Article Synopsis
- Ewing sarcoma is a serious cancer that mainly affects children and teens, with the EWSR1/FLI1 fusion gene being a common genetic factor, but it hasn’t been targeted for treatment or used to predict outcomes.
- This study looked at 35 Ewing sarcoma patients to see how DNA repair mechanisms correlate with different clinical features of the disease, focusing on two DNA repair pathways: non-homologous end joining (NHEJ) and homologous recombination (HR).
- Findings indicate that these repair pathways are disrupted in Ewing sarcoma, and low levels of the XRCC4 gene are linked to better survival, suggesting potential new targets for therapy.
Effects of Chemotherapy on Aortic 18-Fluorodeoxyglucose Uptake in Patients With Hodgkin and Non-Hodgkin Lymphoma.
JACC Adv
March 2023
Center for Experimental Surgery, Clinical and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Background: Despite advances in the treatment of oncology patients, therapy-related side effects may lead to premature morbidity. Inflammatory activation that has been linked to cardiovascular disease is crucial for the pathogenesis of both Hodgkin (HL) and non-Hodgkin lymphoma (NHL).
Objectives: The purpose of this study was to assess the vascular effects of chemotherapy in patients with HL and NHL by positron emission tomography/computed tomography with 18-fluorodeoxyglucose (18-FDG PET/CT) and to investigate interactions with systemic inflammation as assessed by circulating inflammatory markers.
Lymphoma Severity and Type Are Associated With Aortic FDG Uptake by F-FDG PET/CT Imaging.
JACC CardioOncol
December 2020
Center for Experimental Surgery, Clinical and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Article Synopsis
- The study investigated the relationship between lymphoma severity and cardiovascular health, specifically looking at arterial inflammation through FDG uptake in patients with active Hodgkin's and non-Hodgkin's lymphoma.
- Sixty-two chemotherapy-naïve patients were compared to previously treated lymphoma patients to assess metabolic tumor volume and glycolysis associated with arterial fluoride uptake.
- Results showed significant correlations between disease severity and arterial inflammation, with higher FDG uptake in active lymphoma patients compared to controls, particularly in advanced stages of the disease.
A Case Series of BCOR Sarcomas With a New Splice Variant of Fusion Gene.
In Vivo
June 2021
Department of Genetics, Aghios Savvas Hospital, Athens, Greece.
Background/aim: Undifferentiated round cell sarcomas are a heterogeneous group of sarcomas. Identification of BCOR alterations, such as BCOR/CCNB3 and BCOR/MAML3 fusion genes and BCOR ITD has recently contributed in the precise diagnosis of these neoplasms, defining a new entity of the current classification of soft tissue and bone sarcomas. BCOR sarcomas share both morphological and genetic characteristics distinct from Ewing sarcomas.
View Article and Find Full Text PDFHypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel antimyeloma therapies.
Eur J Haematol
November 2017
Department of Clinical Therapeutics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Objectives: To evaluate the prognostic impact of hypercalcemia in newly diagnosed patients with symptomatic multiple myeloma (MM), especially after the incorporation of new agents.
Methods: we analyzed the outcomes of newly diagnosed patients with symptomatic myeloma included in the database of the Greek Myeloma Study Group for the prognostic effect of the presence of hypercalcemia (defined as corrected serum calcium ≥11 mg/dL) at diagnosis.
Results: Among 2129 consecutive patients with symptomatic MM, 19.
Recombinant leptin administration improves early angiogenesis in full-thickness skin flaps: an experimental study.
In Vivo
June 2008
Department of Plastic and Reconstructive Surgery, Hellenic Anticancer Institute, Aghios Savvas Hospital, Athens, Greece.
Background: Leptin is a potent direct angiogenic factor that stimulates endothelial cell migration and activation in vitro, and angiogenesis in vivo. In addition, leptin seems to play an important role in angiogenesis as it promotes the formation of new blood vessels.
Objective: To determine the effect of local application of exogenous leptin on the survival of full thickness skin flaps in an experimental animal model.
Evaluation of argyrophilic nucleolar organiser regions (AgNORs) in multiple myeloma.
J Clin Pathol
June 2000
Department of Clinical Haematology, Greek Cancer Institute, Aghios Savvas Hospital, Athens, Greece.
Aim: To investigate the prognostic value of argyrophylic nucleolar organiser regions (AgNORs) in multiple myeloma.
Methods: Bone marrow aspirates from 55 newly diagnosed patients with multiple myeloma were stained with the one step AgNO3 technique. The mean number of AgNORs in each plasma cell nucleus (AgNOR count) was tested for a possible correlation with other clinical and laboratory variables at presentation (clinical stage, substage, heavy and light chain isotype, haemoglobin concentration, platelet count, marrow infiltration rate, degree of skeletal lesions, M protein concentration, plasma cell morphology, and serum concentrations of calcium, albumin, lactate dehydrogenase, C reactive protein, and beta 2 microglobulin) and with outcome (response to first line treatment, first remission duration, and overall survival).