An Act of Auto-Eroticism: Self-Urethral Insertion of Sewing Needle by an Old Man-A Case Report With Literature Review.

Self-insertion of foreign bodies into the urethra is uncommon and is often associated with complex psychological or behavioral factors. Many cases of foreign bodies in the urethra have been reported worldwide with variable complaints of penile pain, penile itching, dysuria, hematuria, and complete obstruction of urine. These foreign objects are managed to remove according to their size, complexity of shape, and location in the urethra.

Response to the Letter on Pakistani Postgraduate Medical Education by Shaikh AJ and Burney I.

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Association Between Seborrhoeic Dermatitis and Hypertension: A Potential Clinical Correlation.

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Paediatric Pain Assessment and Perioperative Pain Management: A Survey of Practice in Teaching Hospitals in the Two Provinces of Pakistan.

Objective: To map the practice of paediatric perioperative pain assessment and management among consultant anaesthetists working in teaching institutions in the two provinces of Pakistan.

Study Design: A cross-sectional survey. Place and Duration of the Study: Department of Anaesthesiology, Teaching institutions of Sindh and Khyber Pakhtunkhwa (KPK), Pakistan, from January to October 2022.

Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study.

Background: Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high levels of natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for extending the breadth and longevity of naturally acquired immunity are warranted. Designing such strategies will require a good understanding of naturally acquired immunity.

Methods: We measured whole-spike immunoglobulin G (IgG) and spike-receptor binding domain (RBD) total immunoglobulins (Igs) on 585 plasma samples collected longitudinally over five successive time points within six months of COVID-19 diagnosis in 309 COVID-19 patients.

Reappraisal of soft tissue myoepithelial tumors by DNA methylation profiling reveals an epigenetically distinct group of mostly fusion-driven neoplasms.

Soft tissue myoepithelial tumors (METs) are diagnostically challenging tumors that require careful histologic and immunohistochemical characterization for accurate classification. Nearly half of METs show recurrent EWSR1 or FUS gene rearrangements with a diverse set of fusion partners. The diversity of fusion partners and lack of known driver abnormalities in many cases raises the question of whether METs represent a uniformly distinct tumor entity.

Blood stream infections in Stevens Johnson Syndrome and Toxic Epidermal Necrolysis: Risk factors and association with poor outcome.

Background & Objective: Blood Stream Infections (BSI) are considered a significant cause of morbidity and mortality in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). We aimed to identify risk factors for BSI upon admission, highlight clinical and microbiological findings and ascertain the frequency of mortality in patients with BSI in SJS/TEN.

Methods: A retrospective cross-sectional study over 12 years (2011-2022) was performed in the department of medicine at a tertiary care hospital in Pakistan.

Exploring the quality of life of pediatric trainees: Mixed-method explanatory design.

Objective: Healthcare workers are at a higher risk of burnout. The aim of the study was to explore the professional quality of life (QOL) i.e.

Outcome analysis of differentiated thyroid cancer: Experience from tertiary care in Karachi.

Objective: Although differentiated thyroid cancers have a good prognosis overall, their incidence is on the rise with extremely limited data available in our region. The objective was to describe the outcomes of differentiated thyroid carcinoma in a tertiary care hospital.

Methods: This was a retrospective study conducted at Aga Khan University Hospital.

Clinical characteristics and outcome of central nervous system tumors harboring NTRK gene fusions.

Purpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.

Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.

NEONATAL HYDROMETROCOLPOS: CLINICAL PRESENTATION AND THERAPEUTIC APPROACH.

Hydrometrocolpos (HMC) is a rare pediatric condition characterized by significant enlargement of the uterus and vagina due to the accumulation of fluid, generally caused by a blockage in the lower vagina. This disorder typically presents in newborns with the retention of normal genital tract secretions. The following case report highlights the clinical features, diagnostic process, and treatment of HMC in a newborn.

Rasmussen aneurysm: A hidden hazard.

Tuberculosis is endemic in Pakistan and other countries in South Asia despite various treatment programs being introduced for its elimination. It leads to a number of serious consequences which involve different organ systems of the body and Rasmussen Aneurysm is one such serious complication. It is the pseudo-aneurysmal dilatation of the pulmonary artery adjacent to a tubercular cavity and manifests as massive hemoptysis, like in the case of our patient.

Factor XIII Deficiency Presenting With Duodenal Hematoma in a 3-Year-Old Female: A Comprehensive Radiological Assessment.

In the pediatric age group, FXIII deficiency can present as abnormal or delayed bleeding from the umbilical stump, soft tissue and subcutaneous bleeding, intracerebral hemorrhages, intraoral bleeding, and poor wound healing. This case report describes an atypical presentation of FXIII deficiency in a 3-year-old female who presented to the emergency department with complaints of abdominal pain and vomiting. She was managed conservatively under the care of the pediatric surgery team.

Investigating Cesarean Section Trends: A Study Using the Modified Robson Classification in a Tertiary Care Setting.

Introduction: The cesarean section (CS) rate is steadily rising in developed and developing nations. While CS is often perceived as a life-saving intervention, it comes with associated dangers for both the present and future pregnancies. The Robson criteria classify CS into 10 groups with further sub-divisions based on the gestational age, various pregnancy categories, prior obstetrical records, and the progress of labor and delivery.

Innovation and application of Large Language Models (LLMs) in dentistry - a scoping review.

Objective: Large Language Models (LLMs) have revolutionized healthcare, yet their integration in dentistry remains underexplored. Therefore, this scoping review aims to systematically evaluate current literature on LLMs in dentistry.

Data Sources: The search covered PubMed, Scopus, IEEE Xplore, and Google Scholar, with studies selected based on predefined criteria.

The Role of Helmet Therapy in Craniosynostosis: A Systematic Review.

The aim of this study was to determine the impact of helmet therapy (HT) as a treatment for craniosynostosis, with a focus on the outcomes of skull morphology, reoperation rate, complications of HT, and quality of life of patients who receive it. A systematic literature review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review utilized the PICO format: Does HT following strip craniectomy (SC) improve outcomes (outcome) compared to SC alone (comparison) in patients undergoing craniosynostosis correction (intervention)? Searches were performed from January 1, 2000 to December 31, 2022, using PubMed, Cochrane Library, and Ovid Medline databases.

Into the Neuroscape: Perceptions of Pakistani Medical Students and Recent Graduates toward Neurosurgery.

 Neurosurgery receives several applicants every year, but the decreasing size of the neurosurgery workforce in Pakistan despite evidence of initial student interest is perplexing. Therefore, it is vital to evaluate the perspective of medical students and recent graduates to get a holistic view of perceptions toward neurosurgery.  A nationwide cross-sectional study was conducted on a sample of medical students and recent graduates from different medical colleges.

Metastatic recurrence in women diagnosed with non-metastatic breast cancer: a systematic review and meta-analysis.

Background: To assess proportions of metastatic recurrence in women initially diagnosed with non-metastatic breast cancer by stage at diagnosis, breast cancer subtype, calendar period and age.

Methods: A systematic search of MEDLINE and Web of Science databases (January 2010-12 May 2022) was conducted. Studies reporting the proportion of distant metastatic recurrence in women with non-metastatic breast cancer were identified and outcomes and characteristics were extracted.