[Histopathologic study of the ethmoid bone in chronic sinusitis].

Objective: To investigate the histopathologic study of the ethmoid bone in chronic sinusitis (CRS) and the role of bone pathology in the pathogenesis of CRS.

Methods: Specimens of mucosa of ethmoid sinus with bone were collected during operation from 40 patients with CRS, 25 males and 15 females, aged 44.8, and specimens of mucosa of ethmoid sinus were collected from 16 patients with other otorhinolaryngologic diseases, 9 males and 7 females, aged 40.

[Genotype of wild-type measles viruses circulating in Beijing in 2003].

Objective: To investigate genotype of wild-type measles viruses circulated in Beijing in 2003.

Methods: Throat swabs specimens were collected from patients seen during an outbreak of measles and from clinically suspected sporadic measles patients in 2003. Vero/SLAM cell lines recommended by WHO were used to isolate measles virus.

[Prediction and management about perilymph gusher in cochlear implantation].

Objective: To discuss the clinical experience of prediction and management about perilymph gusher in cochlear implantation.

Method: Among 327 cases of cochlear implant, eleven recipients were selected by the high resolution computed tomography (HRCT) findings of cochlear malformations and bony fistula on fundus of the internal auditory canal that caused an abnormal connection between subarachnoid and perilymphatic spaces.

Result: Perilymph gusher was found in all of these 11 recipients during cochlear implantation and was controlled with muscle tissue seal.

[Effects of recombinant eotaxin N terminal mutant (Met/Eotaxin) adenovirus on allergic rhinitis in mice].

Objective: To obtain the recombinant Eotaxin N Terminal Mutant (Met/Eotaxin) adenovirus, and to study its role in allergic diseases.

Methods: A 400 bp DNA fragment of Eotaxin was cloned from human peripheral blood monocyte (PBMC), and the Met/Eotaxin DNA fragment was obtained by NH2-terminal mutant. Then, this DNA fragment was inserted into AdEasy transfer vector -pAdtrack-CMV plasmid.

[Review of study on the mechanism of active ingredients of single Chinese drug in treating intracerebral hemorrhage].

Domestic and overseas literature of clinical and experimental study in recent years concerning treatment of intracerebral hemorrhage (ICH) by active ingredients of single Chinese drug was reviewed, and the therapeutic mechanism, acting pathways and clinical effect of these ingredients were also explored in this paper.

[A new bioassay model of antibiotic susceptibility by corneofungimetry].

Objective: To study the value of a new bioassay model of antibiotic susceptibility by corneofungimetry which is more similar to human internal environment.

Methods: Twenty-one healthy adult volunteers, 12 males and 9 females, aged 32 (22 - 41), were randomly divided into two groups to receive itraconazole 200 mg Bid or 200 mg qd or bid for one week. Stratum corneum strippings were taken from the forearm skin once before administration of itraconazole and 1, 4, 7, 10, 14, 21, 28, and 35 days after administration of itraconazole.

Treatment of severe post-kidney-transplant lung infection by integrative Chinese and Western medicine.

Objective: To explore treatments of severe post-kidney-transplant lung infection by integrative Chinese and Western medicine (ICWM), in order to elevate the curing rate as well as to lower the death rate.

Methods: Based on conventional ways of Western medical treatments of 18 cases of severe post-kidney-transplant lung infection, such as putting the patients in single individual ward, antibiotics to prevent infection, respiratory machines, blood filtration, nutritional support, steroids, and maintaining electrolytes balance, we applied integrated Chinese medicinal treatments, like altering conventional prescription "pneumonia III", and conducted clinical observation of effectiveness, and indexes including white blood cell (WBC), neutrophilic granulocyte, blood urea nitrogen (BUN), blood creatinine (Cr), etc.

Results: Of the 18 cases studied, 7 were already cured, 8 proved the treatment effective, 3 died.

Efficacy of tonsillectomy and adenoidectomy in Asian childhood obstructive sleep apnea/hypopnea syndrome: a case control study.

Objective: To evaluate the efficacy of tonsillectomy and adenoidectomy (T & A) in Asian childhood obstructive sleep apnea/hypopnea syndrome (OSAHS).

Methods: The medical data of the OSAHS patients in the Sleep Center of the Duchess Kent Children's Habilitation Institute from May 1999 to May 2003 were retrospectively reviewed. OSAHS was diagnosed according to the abnormal sleep monitoring results.

[Level of vitamin K-dependent coagulation factors in premature infants and the influence of maternal antenatal administration of vitamin K1 on their activity].

Objective: Infants less than 35 weeks of gestational age are susceptible to peri-/intraventricular hemorrhage (PIVH). This may be due in part to low concentrations of vitamin K-dependent coagulation factors. This study was conducted to determine the umbilical cord blood activities of vitamin K-dependent coagulation factors II, VII, IX and X in premature infants to understand whether preterm infants have absence status of these factors the changes of theses factors' activities in premature infants' umbilical blood after vitamin K(1) was given to mothers antenatally and the preventing effectiveness of PIVH after maternal antenatal supplement of vitamin K(1).

Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment.

Purpose: To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells.

Method: Fifty-seven Chinese psychiatric inpatients who met DSM-IV diagnosis of schizophrenia and 60 healthy controls were enrolled in the study. Patients were assessed with the Positive and Negative Symptoms Scale (PANSS) at admission and at 12 weeks after treatment.

[Prospective 2-year clinical study of patients with positive IgG-antibodies after recovering from severe acute respiratory syndrome].

Objective: To investigate the clinical characteristics of patients recovering from severe acute respiratory syndrome (SARS) during 2 years after the infection.

Methods: The antibody of SARS-IgG, T cell subsets, chest CT, and the pulmonary function were observed in patients 1 month, 3 months, 6 months, and 2 years after convalescence from SARS.

Results: In the 20 SARS cases, the level of antibodies was found to descend gradually and slowly during 2 years after convalescence.

[Blockage of allergic rhinitis in mice with recombinant protein of cytotoxic T lymphocyte associated antigen-4 extracellular domain].

Objective: To explore a new immunotherapy against allergic rhinitis.

Methods: The recombinant protein of CTLA4 extracellular domain was obtained through construction of CTLA4-yeast expression system. The allergic rhinitis in mice was induced by sensitizing and challenging with ovalbumin (OVA).

[Significance of apnea hypopnea time index in obstructive sleep apnea hypopnea syndrome patients and possible correlation between polysomnographic parameters and severity of the disease].

Objective: To find out the polysomnography (PSG) indexes that reflex the degree of pathology of obstructive sleep apnea hypopnea syndrome (OSAHS).

Methods: Six hundred and twenty-one male OSAHS patients, aged over 21, underwent measurement of weight, height, and neck circumference. Polysomnography was conducted to detect the apnea and hypopnea index (AHI), apnea and hypopnea time (AHT), and apnea and hypopnea time index (AHTI).

[Observation on therapeutic effect of acupuncture on no-premonitory migraine at remission stage].

Objective: To observe therapeutic effect of acupuncture on no-premonitory migraine at remission stage.

Methods: The scores of pain extent, attack times, lasting time and accompanied symptoms of headache were investigated before treatment and after treatment of 4 weeks.

Results: After treatment of 4 weeks, the scores of all items had significant changes (P < 0.

[Endoscopic surgery for nasal septal perforation].

Objective: To describe the relevant factors of endoscopic surgery in patients with nasal septal perforation.

Methods: Twenty-three patients with nasal septal perforation were treated under nasal endoscope. Four kinds of reconstruction materials were used to accomplish the closure of perforation: residual osseous septum or temporalis fascia, inverting septal mucoperichondrial flap, autologous connective tissue insert overlaid with mucous flaps and turbinate flap.

[A epidemiological survey and management analysis of asthma among employees of 6 chemical plants in Beijing area].

Objective: To estimate the prevalence and to evaluate the current status for management of asthma among employees in chemical plants in Beijing area.

Methods: A general survey was conducted among 12694 employees in 6 large chemical plants in Beijing area by face to face interview and physical examination.

Results: The prevalence of asthma was 1.

[Susceptibility patterns and mechanisms of macrolide resistance in group B streptococcus isolates].

Objective: To test the antibiotic susceptibility and study mechanisms of macrolide resistance in group B streptococcus isolates (GBS).

Methods: The GBS investigated in this study included 140 and 47 colonizing strains isolated from vaginal or cervical swabs from pregnant women in Beijing (from 1994 to 1999) and Guangzhou obstetrics and gynecology hospitals (from 1999) and 6 invasive strains isolated from infants in Beijing Children's Hospital. Susceptibility to ampicillin, penicillin G, erythromycin, lincomycin, cephazolin, cefuroxime, cefoperazone was assessed by K-B disc diffusion.

[Effects of budesonide on chronic airway inflammation in guinea pigs sensitized with repeated exposure to allergen].

Objective: Inhaled glucocorticosteroids (ICS) remains the first line controller medication for chronic airway inflammation in asthma till now. If the impact of allergen could not be eliminated, how would the improvement of airway inflammation be achieved with inhaled glucocorticosteroids therapy? What was its effect on airway remodeling? In this study, an animal model of asthma was established and the effects of budesonide on airway allergic inflammation and extracellular matrix (ECM) deposition in sensitized guinea pigs with repeated exposure to allergen were investigated.

Methods: Thirty-two male Hartley guinea pigs were randomly divided into four groups with 8 in each group: (A) Group of repeated exposure to ovalbumin (OVA), (B) Group of repeated exposure to OVA plus budesonide (BUD) intervention, (C) Group of stopping repeated exposure to OVA plus stopping BUD intervention, (D) Control group.

Identification of viral agents associated with diarrhea in young children during a winter season in Beijing, China.

Background: Viral diarrhea remains a major cause of childhood morbidity and mortality worldwide. Although rotavirus was extensively studied in China, few comprehensive studies of all viral agents related to diarrhea in children have been conducted.

Objectives: Our study was performed to investigate the role of enteric viruses in acute diarrhea in our country and to evaluate methods that could be used in routine diagnostics.

[Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome].

Objective: To investigate the serum immunological characteristics in patients convalescent from severe acute respiratory syndrome (SARS).

Methods: In the 1 st, 3 rd, 6 th month after their discharge, eg. SARS-IgG, T cell subsets, blood routine, and the blood biochemistry were systemically determined in SARS convalescent patients.

[Evaluation the antimycotic activity of itraconazole in human stratum corneum with vitro fungi cultivation].

Objective: To establish a new model to evaluate the antifungal activity of antimycotics.

Methods: Twenty-one healthy adult volunteers without clinically significant differences in demographic characteristics, hydration status of the skin, and sebum excretion were randomly divided into two groups: group 1 receiving 200 mg itraconazole bid for 1 week, and group 2 receiving itraconazole 200 mg qd for 1 weeks. Stratum corneum stripping was taken from the forearm skin at days 0, 1, 4, 7, 10, 14, 21, 28, and 35.