22,191 results match your criteria: "Affiliated Maternity & Child Health Care Hospital of Nantong University[Affiliation]"

Introduction: The gender disparities and inequities faced by women in academia are widespread, especially in low- and middle-income countries (LMICs). The scholarly output of women scientists remains significantly lower than that of men due to limited opportunities. This widening gap has significant implications for policy-making and prioritizing agendas.

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Background: Unique features and worse outcomes have been reported for breast cancers among adolescents and young adults (AYAs; age 15-39 years). However, there are few up-to-date and comprehensive data to analyze the disease burden of AYA breast cancer.

Patients And Methods: The data of incidence, deaths, and disability-adjusted life years (DALYs) owing to breast cancer was obtained from the Global Burden of Disease (GBD) 2021.

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Human Brain Organoids Model Abnormal Prenatal Neural Development Induced by Thermal Stimulation.

Cell Prolif

December 2024

State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Department of Neurology, Affiliated Zhongda Hospital, Southeast University, Nanjing, China.

The developing human foetal brain is sensitive to thermal stimulation during pregnancy. However, the mechanisms by which heat exposure affects human foetal brain development remain unclear, largely due to the lack of appropriate research models for studying thermal stimulation. To address this, we have developed a periodic heating model based on brain organoids derived from human pluripotent stem cells.

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Maternal gut microbiota influence stem cell function in offspring.

Cell Stem Cell

December 2024

Laboratory for Microbiota-Host Interactions, The Center for Microbes, Development and Health, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100039, China. Electronic address:

The maternal microbiome influences child health. However, its impact on a given offspring's stem cells, which regulate development, remains poorly understood. To investigate the role of the maternal microbiome in conditioning the offspring's stem cells, we manipulated maternal microbiota using Akkermansia muciniphila.

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Background: Postpartum psychiatric disorders (PPDs) have been deemed as a significant public health concern, affecting both maternal health and family dynamics. This study aimed to examine the current status of PPDs, identify the potential risk factors of PPDs, and further develop a clinical nomogram model for predicting PPDs in Chinese women.

Method: In this retrospective cohort study, 1418 postpartum women attending the routine postpartum examination at the 42nd day after delivery in Jiangsu Women and Children Health Hospital were recruited as participants from December 2020 to December 2022.

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Hyaluronic acid regulated facile synthesis of size-tunable multifunctional nanomedicine for effective cancer therapy.

Int J Biol Macromol

December 2024

Obstetrics and Gynecology Department, The Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou, China. Electronic address:

The complex and heterogeneous nature of cancer necessitates the development of innovative multifunctional nanomedicines (MN). Hyaluronic acid (HA) is a functional carbohydrate polysaccharide that is widely used in various biomedical fields. In this study, we employed HA as a stabilizer and regulator for the synthesis of a size-tunable nanomedicine comprising ferric ions, doxorubicin, and epigallocatechin gallate (EGCG), referred to as HDE-MN, for cancer therapy.

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Introduction And Aims: Observational studies suggest an association between metabolic syndrome (MetS) and periodontitis. However, observational studies are susceptible to reverse causation and confounding factors, so the causality of this association is uncertain. Causal association between compounds of MetS and periodontitis has been well studied.

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Risk factors of allergic rhinitis and its prevention strategies.

Front Allergy

November 2024

Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Department of Allergy, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Allergic rhinitis (AR) is a global disease with high prevalence. It reduces the patient's quality of life seriously. The health care and management of AR was also a heavy social burden.

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Autophagy is a catabolic process that has been conserved throughout evolution, serving to degrade and recycle cellular components and damaged organelles. Autophagy is activated under various stress conditions, such as nutrient deprivation, viral infections, and genotoxic stress, and operates in conjunction with other stress response pathways to mitigate oxidative damage and maintain cellular homeostasis. One such pathway is the Nrf2-Keap1-ARE signaling axis, which functions as an intrinsic antioxidant defense mechanism and has been implicated in cancer chemoprevention, tumor progression, and drug resistance.

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Background: Sub-Saharan Africa faces high neonatal and maternal mortality rates due to limited access to skilled healthcare during delivery. This study aims to improve the classification of health facilities and home deliveries using advanced machine learning techniques and to explore factors influencing women's choices of delivery locations in East Africa.

Method: The study focused on 86,009 childbearing women in East Africa.

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Magnetic resonance imaging contrast agents based on albumin nanoparticles.

Biomater Sci

December 2024

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.

Despite the potential safety hazards and side effects, small molecular magnetic resonance imaging (MRI) contrast agents have been generally used in clinical medical imaging. The development of stable, but low-toxicity and high-efficiency magnetic resonance contrast agents has been receiving continuous attention and research interest. With the deepening of studies, the combination of small molecular magnetic resonance contrast agents and albumin-based carriers is an effective strategy to obtain new MRI contrast agents with safety, low toxicity, high relaxation efficiency and targeting capability.

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Background: The literature has been evolving to standardize gestational diabetes mellitus (GDM) diagnosis and terminology. The significance of timing in diagnosing hyperglycemia during pregnancy is underlined by evidence that women diagnosed at 24 weeks of gestation or earlier are at a higher risk of developing postpartum prediabetes, but its association with adverse outcomes for the newborn is controversial. We aimed to investigate the association between early-onset GDM and adverse outcomes in newborns and neonates, comparing it with the late-onset GDM model.

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Upregulation of PD-L1 contributes to improving the apoptosis of granulosa cells via the PI3K/AKT pathway in PCOS.

J Assist Reprod Genet

December 2024

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China.

Article Synopsis
  • Polycystic ovary syndrome (PCOS) is a major cause of infertility linked to the apoptosis (cell death) of ovarian granulosa cells, and the role of the PD-1/PD-L1 pathway in this condition is not well understood.
  • Researchers analyzed RNA sequencing data from PCOS patients and established a mouse model to study the effects of PD-L1 intervention on ovarian granulosa cell apoptosis, using various molecular biology techniques.
  • The study found that the PD-L1 pathway can activate the PI3K/AKT signaling, reducing cell death in granulosa cells, suggesting a new potential strategy for treating apoptosis in PCOS.
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Gestational diabetes mellitus (GDM) is linked to a greater risk of various maternal and fetal complications, including the possibility of long-term metabolic issues in offspring. Our initial research suggests that the Traditional Chinese Medicine formula, Shenling Guchang prescription (SLGP), may have an impact on the gut microbiota. However, the specific mechanisms through which it affects intestinal barrier inflammation in GDM are still not fully understood.

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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease. Four major genes associated with ALS-SOD1, TARDBP, FUS, and C9orf72-have been identified, with the fused in sarcoma (FUS) gene demonstrating considerable genetic heterogeneity. Our research group has previously established an induced pluripotent stem (iPS) cell line harboring the c.

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Detection of serum lactate dehydrogenase A and its metabolites on placental function in patients with intrahepatic cholestasis of pregnancy.

Int Immunopharmacol

January 2025

Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Wuxi 214002, China. Electronic address:

Article Synopsis
  • Intrahepatic cholestasis of pregnancy (ICP) is a liver disease diagnosed mainly by serum total bile acid levels, but this method lacks sensitivity and specificity.
  • Recent research identifies lactate dehydrogenase A (LDHA) as a potential new biomarker, which is highly expressed in ICP patients and detected using DIA proteomic technology.
  • A study developed a novel immunochromatographic test strip to quantitatively measure LDHA levels and explored its role in the inflammatory mechanisms of ICP, suggesting LDHA may be a promising target for improved diagnosis and treatment strategies.
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Coping With Anticipatory Grief: A Qualitative Study of Parents of Children With Advanced Cancer.

Cancer Nurs

December 2024

Author Affiliations: Department of Social Work and Social Administration, The University of Hong Kong, Hong Kong SAR (Mr Ng); and Social Work Department, School of Social Development and Public Policy, Fudan University, Shanghai (Dr Fu), China.

Background: Anticipatory grief is a common but understudied phenomenon among parents of children with advanced cancer. Appropriate coping with anticipatory grief may promote better adaptation before and after the death.

Objective: To explore the anticipatory grief experiences and coping approaches of such parents in Shanghai, China.

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Agitation is one of the core symptoms of schizophrenia. The occurrence of agitation may be related to orbitofrontal cortex dysfunction. However, due to methodological heterogeneity, the relationship between agitation and orbitofrontal cortex subregions remains unclear.

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Adipose-derived stromal cells (ADSCs) are commonly used in regenerative medicine, but the genetic features of their development into neuronal cells are unknown. This study used single-cell RNA sequencing (scRNA-seq) to reveal gene expression changes during ADSCs to neuronal differentiation. Sequencing of the ADSCs group, the prei-1d group, and the induction 1 h, 3 h, 5 h, 6 h, and 8 h groups was performed using the BD Rhapsody platform.

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N-Methyladenosine Modification on the Function of Female Reproductive Development and Related Diseases.

Immun Inflamm Dis

December 2024

Department of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Background: N6-methyladenosine (m6A) modification is a widespread and reversible epigenetic alteration in eukaryotic mRNA, playing a pivotal role in various biological functions. Its significance in female reproductive development and associated diseases has recently become a focal point of research.

Objective: This review aims to consolidate current knowledge of the role of m6A modification in female reproductive tissues, emphasizing its regulatory dynamics, functional significance, and implications in reproductive health and disease.

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Triple-negative breast cancer (TNBC) is known for its aggressive nature, and Quercetin (QUE) has shown potential anti-cancer effects. In this study, we determined the IC50 of QUE for inhibiting cell viability in multiple TNBC, non-TNBC, and normal breast cell lines. We compared the expression of ORM2 in TNBC clinical samples and normal tissues.

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Background: Preterm birth is a significant concern in multiple pregnancies, warranting effective strategies to improve outcomes. Delaying delivery of the second fetus is crucial for reducing perinatal mortality rates.

Case Presentation: In a dichorionic diamniotic twin pregnancy, one fetus experienced premature rupture of membranes (PROM) at 16+6 weeks gestation.

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Objective: This study aimed to evaluate the clinical utility of methylation (CISCER) test in triaging high-risk human papillomavirus (hrHPV)-positive women.

Methods: We enrolled women who underwent opportunistic screening at Cervical Disease outpatient clinics of Xuzhou Maternity and Child Health Hospital, and Yueyang Central Hospital from December 2022 to May 2024. The effectiveness of CISCER and cytology tests in triaging hrHPV+ patients was analyzed.

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Background: Wilms tumor (WT) is the most common pediatric kidney cancer, with survival rates exceeding 90% in localized cases. However, advanced or recurrent WT remains difficult to treat due to poor prognosis and limited knowledge of its molecular mechanisms. Gene expression profiling has shown promise in identifying prognostic markers and therapeutic targets.

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Regulation of α-Ketoglutarate levels by affects metabolism and demethylation in porcine early embryos.

Front Cell Dev Biol

November 2024

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, First Hospital, Jilin University, Changchun, China.

The family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of in porcine early embryonic development is not fully understood. This study observed high expression during the four-cell stage of porcine embryos.

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