1 results match your criteria: "Affiliated Hospital of Yan'an University of Shaanxi Province[Affiliation]"
Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat.
Asian Pac J Trop Med
June 2014
Neonatal Department, Affiliated Hospital of Yan'an University of Shaanxi Province, Yan'an 716000, Shaanxi, China.
Article Synopsis
- - The study aimed to investigate how topiramate (TPM) can protect against brain injury caused by hypoxia and ischemia in neonatal rats, involving 360 subjects divided into four treatment groups.
- - Different dosages of TPM were administered, with treatments lasting over 10 days, and various neurological metrics such as brain water content, neuron-specific enolase (NSE), and GABA levels being measured at set intervals post-treatment.
- - Results indicated that both the conventional and degradation therapy groups experienced lower brain water content and NSE levels, as well as improved GABA levels and cognitive abilities compared to the ischemia and hypoxia group, suggesting that TPM has a protective effect on brain function.