[The efficacy of vonoprazan fumarate in the treatment of laryngopharyngeal reflux disease evaluated by the Chinese version of the RSS-12 scale].

To explore the efficacy of vonoprazan fumarate in the treatment of laryngopharyngeal reflux disease（LPRD） evaluated by the Chinese version of the RSS-12 scale. A total of 100 LPRD patients treated in the otolaryngology-head and neck surgery outpatient clinic of our hospital were randomly divided into two groups（50 cases each）. The observation group was treated with vonoprazan fumarate（20 mg, once daily）, and the control group was treated with esomeprazole enteric-coated capsules（20 mg, twice daily） for 12 weeks.

Alternative splicing: Therapeutic target for vasculopathy in diabetic complications.

It is becoming increasingly evident that diabetic vascular complications seriously threaten human health. The most prevalent microvascular complications include kidney disease, retinal disease, cardiovascular diseases and amputation. Conventional treatments can only relieve the progression of the diseases, and is no longer appropriate for the long-term management of diabetic patients.

Analyzing the adverse events of NK-1 receptor antagonists: a pharmacovigilance study from the FAERS database.

Background: NK-1 receptor antagonists (NK-1RAs) are proven to be successful in preventing chemotherapy-induced nausea and vomiting (CINV). The safety profile of NK-1RAs has not been systematically analyzed in the real world. This pharmacovigilance study investigated the differences in adverse events (AEs) between NK-1RAs.

Effects of Sodium Bicarbonate Ringer's Solution Combined with Positive End-Expiratory Pressure on the Internal Environment of Patients Undergoing Bariatric Surgery: A Randomized 2 × 2 Factorial Design Pilot.

Background: To evaluate the influence of sodium bicarbonate Ringer's solution (BRS) combined with positive end-expiratory pressure (PEEP) on the internal environment in patients who have undergone laparoscopic bariatric surgery.

Methods: A total of 128 patients undergoing laparoscopic bariatric surgery were randomly divided into the control group (group C), the PEEP group (group P), the BRS group (group B), and the BRS combined with the PEEP group (group BP). The results of arterial blood gas analysis, including pH value, base excess (BE), concentrations of electrolyte, and lactate (Lac) were documented before intravenous infusion (T0) and 5 min after the surgery (T1).

Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease.

Background: The association between co-exposure to multiple air pollutants and the occurrence of chronic kidney disease (CKD) was not well-established, and the mediating role of accelerated aging in this association remained uncertain.

Methods: Using a cohort of 313,908 participants without CKD at baseline from the UK Biobank, we examined the potential association between co-exposure to multiple air pollutants, including PM, PM, PM, NO and NO, and the incidence of CKD by calculating an air pollution score. Mediation analyses were performed to examine the mediating role of accelerated aging (PhenoAgeAccel or KDM-BioAgeAccel) in this association.

Development and Validation of a Nomogram for Predicting Frailty Risk Among Older Patients With Ischaemic Stroke.

Aim: To investigate the risk factors associated with frailty in older patients with ischaemic stroke, develop a nomogram and apply it clinically.

Design: A cross-sectional study.

Methods: Altogether, 567 patients who experienced ischaemic strokes between March and December 2023 were temporally divided into training (n = 452) and validation (n = 115) sets and dichotomised into frail and non-frail groups using the Tilburg Frailty Indicator scale.

The role of cGAS-STING signaling pathway in ferroptosis.

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence and lipid peroxidation, represents a specialized form of cell death. A burgeoning collection of studies has demonstrated that the cGAS-STING signaling pathway participates in the homeostatic regulation of the organism by modulating ferroptosis-associated enzyme activity or gene expression.

Immune checkpoint B7-H3 is a potential therapeutic target in prostate cancer.

High expression of immune checkpoint molecule B7-H3 (CD276) in many cancer types makes it a promising immunotherapeutic target. Both coinhibitory and costimulatory effects of B7-H3 in tumors have been demonstrated, but the mechanism of B7-H3 immune response under dual effects is open to question. B7-H3 is crucially involved in the migration and invasion, angiogenesis, metabolism and chemotherapy resistance of prostate cancer.

Relationships between blood cadmium concentration and risk of nine cancers: evidence from the NHANES 1999-2018 and Mendelian randomization analyses.

Background: Previous observational studies examining the relationship between cadmium exposure and various cancers have yielded conflicting results. This study aims to comprehensively clarify the relationship between blood cadmium concentration (BCC) and nine specific cancers.

Methods: A retrospective analysis of National Health and Nutrition Examination Survey (NHANES) 1999-2018 identified 36,991 participants.

Plasma tissue plasminogen activator-inhibitor complex levels in acute myocardial infarction patients: an observational study.

Introduction: The activation of the plasmatic coagulation system is a significant contributor to acute myocardial infarction (AMI). This study aimed to investigate the association between the levels of tissue plasminogen activator-inhibitor complex (t-PAIC), thrombin-antithrombin complex (TAT), plasmin-α2 plasmin-inhibitor complex (PIC), and thrombomodulin (TM) with clinical outcomes in patients with AMI.

Methods: Blood samples were collected from 368 patients presenting with acute myocardial infarction in the emergency department to assess levels of t-PAIC, TAT, PIC, and TM.

The aberrantly activated AURKB supports and complements the function of AURKA in CALR mutated cells through regulating the cell growth and differentiation.

Aurora kinase B (AURKB) was reported to assist Aurora kinase A (AURKA) to regulate cellular mitosis. AURKA has been found activated in myeloproliferative neoplasms (MPNs) patients with CALR gene mutation, however, it's unclear whether AURKB displays a compensatory function of AURKA in regulation of CALR mutant cell growth and differentiation. Here, we found that AURKB, similar with AURKA, was aberrantly activated in CALR mutant patients, and displayed a more tolerance to the aurora kinase inhibitor.

Relaxin Inhibits Angiotensin II-Induced Cardiac Fibrosis by Activating NO/cGMP Signaling Pathway.

Background: Cardiac fibrosis, a key contributor to heart failure, is driven by the activation of cardiac fibroblasts (CFs), often induced by angiotensin II (Ang II). Relaxin, a peptide hormone, has been reported to counteract fibrotic processes. This study aims to investigate the antifibrotic effects of relaxin on Ang II-induced CF activation, with a focus on the involvement of the nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling pathway.

Effect of Baduanjin exercise on health and functional status in patients with chronic obstructive pulmonary disease: a community-based, cluster-randomized controlled trial.

Baduanjin has been shown to be an effective method of exercise for promoting body function in patients with chronic obstructive pulmonary disease (COPD). However, this method is rarely used by rural doctors in rural communities. The aim of this study was to compare the therapeutic effects of Baduanjin exercise with those of conventional pulmonary rehabilitation (CPR) implemented by rural doctors in patients with COPD.

Predictive modeling of ICU-AW inflammatory factors based on machine learning.

Background: ICU-acquired weakness (ICU-AW) is a common complication among ICU patients. We used machine learning techniques to construct an ICU-AW inflammatory factor prediction model to predict the risk of disease development and reduce the incidence of ICU-AW.

Methods: The least absolute shrinkage and selection operator (LASSO) technique was used to screen key variables related to ICU-AW.

Unraveling the Role of SSH1 in Chronic Neuropathic Pain: A Focus on LIMK1 and Cofilin Dephosphorylation in the Prefrontal Cortex.

Background And Objective: Neuropathic pain, a debilitating condition stemming from nervous system injuries, has profound impacts on quality of life. The medial prefrontal cortex (mPFC) plays a crucial role in the modulation of pain perception and emotional response. This study explores the involvement of Slingshot Homolog 1 (SSH1) protein in neuropathic pain and related emotional and cognitive dysfunctions in a mouse model of spared nerve injury (SNI).

Dysfunctional S1P/S1PR1 signaling in the dentate gyrus drives vulnerability of chronic pain-related memory impairment.

Memory impairment in chronic pain patients is substantial and common, and few therapeutic strategies are available. Chronic pain-related memory impairment has susceptible and unsusceptible features. Therefore, exploring the underlying mechanisms of its vulnerability is essential for developing effective treatments.

Combining computed tomography features of left atrial epicardial and pericoronary adipose tissue with the triglyceride-glucose index to predict the recurrence of atrial fibrillation after radiofrequency catheter ablation: a machine learning study.

Background: Radiofrequency catheter ablation (RFCA) represents an important treatment option for atrial fibrillation (AF); however, the recurrence rate following surgery is relatively high. This study aimed to predict the recurrence of AF after RFCA using interpretable machine learning models that combined the triglyceride-glucose (TyG) index and the quantification of left atrial epicardial and pericoronary adipose tissue.

Methods: This retrospective study included 325 patients with AF who underwent their first successful RFCA, among whom 79 had confirmed recurrence.

[Comparative study of Achillon Achilles tendon suture guide combined with circuit suture via perineural channel and Krachow suture via posterolateral incision of Achilles tendon in treatment of Kuwada type Ⅱ acute closed Achilles tendon rupture].

Objective: To compare the effectiveness of Achillon Achilles tendon suture guide combined with circuit suture under the perineural channel and Krachow suture with posterolateral incision of Achilles tendon in the treatment of Kuwada type Ⅱ acute closed Achilles tendon rupture.

Methods: The clinical data of 38 patients with Kuwada type Ⅱ acute closed Achilles tendon rupture who met the selection criteria between January 2020 and December 2023 were retrospectively analyzed. Krachow suture via posterolateral incision was used in 24 cases (traditional group), and Achillon Achilles tendon suture guide combined with circuit suture via perineural channel was used in 14 cases (minimally invasive group).

FOXF1 promotes ovarian cancer metastasis by facilitating HMGA2-mediated USP30-dependent S100A6 deubiquitination.

Ovarian cancer is the most common type of gynecological malignant tumor, with the highest mortality rate among female genital malignant tumors. In this study, we initially identified forkhead box F1 (FOXF1) as a potential prognostic biomarker of ovarian cancer through bioinformatics analysis. FOXF1 expression was higher in ovarian cancer tissue samples and served as an unfavorable prognostic factor.

Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value.

Objective: Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were explored.

Methods: 138 patients with cervical cancer were included.

Piperlongumine inhibits glioblastoma proliferation by inducing ferroptosis.

Objectives: This study aimed to investigate the effects of Piperlongumine on Glioblastoma multiforme.

Methods: The effects of Piperlongumine on the viability and proliferation of glioma cells LN229 and A172 were measured. Changes in mitochondrial structure were observed.

Altered Hippocampal Subfields Functional Connectivity in Benign Paroxysmal Positional Vertigo Patients With Residual Dizziness: A Resting-State fMRI Study.

Objective: To explore alterations in functional connectivity (FC) focusing on hippocampal subfields in benign paroxysmal positional vertigo (BPPV) patients with residual dizziness (RD) after successful canalith repositioning procedure (CRP).

Methods: We conducted resting-state functional magnetic resonance imaging (fMRI) on 95 BPPV patients, comprising 50 patients with RD and 45 without. Seed-to-voxel and seed-to-seed analyses were employed to examine changes in FC between the two groups.

Proximity hybridization-triggered cascade amplification for label-free SERS detection of Alzheimer's amyloid-β oligomers.

Most of the existing SERS systems failed to achieve satisfactory results in early diagnosis of Alzheimer's disease owing to a lack of effective signal transduction. Herein, we developed a dual signal amplification strategy for SERS detection of amyloid-β oligomers based on proximity hybridization-triggered catalyzed hairpin assembly (CHA) and hybridization chain reaction (HCR). In the presence of the target protein and two DNA-labeled antibodies, a proximate complex formed in a homogeneous solution.

The impact of the subventricular zone invasion types and MGMT methylation status on tumor recurrence and prognosis in glioblastoma.

Purpose: The prognosis of isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) with the subventricular zone (SVZ) invasion is extremely unfavorable but the underlying mechanism remains unclear. We aimed to conduct a retrospective study to mainly investigate the prognostic value of SVZ invasion and MGMT status, and developed a novel clinical prediction model based on our findings.

Methods: 139 patients with IDH wild-type GBM were retrospectively studied.

Prognostic analysis of elective neck dissection in cT3/T4a/T4bN0 maxillary sinus squamous cell carcinoma.

Purpose: This study aimed to examine the effect of elective neck dissection (END) on the prognosis of patients with cT3/T4N0 maxillary sinus squamous cell carcinoma (MSSCC).

Methods: Data were obtained from the SEER database. Patients with cT3/T4a/T4bN0 MSSCC were included in the study and divided into two groups: those who received END treatment and those who did not.