Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy.

Nanozymes, which are nanomaterials that replicate the catalytic activities of natural enzymes in biological systems, have recently demonstrated considerable potential in improving cancer immunotherapy by altering the tumor microenvironment. Nanozyme-driven immune responses represent an innovative therapeutic modality with high effectiveness and minimal side effects. These nanozymes activate the immune system to specifically recognize and destroy cancer cells.

Comorbidity-related risk factors for acute respiratory distress syndrome in sepsis patients: A systematic review and meta-analysis.

Background: Acute respiratory distress syndrome (ARDS) presents a significant challenge in the management of sepsis, with various comorbidities potentially influencing its development. Understanding the impact of these comorbidities is crucial for improving patient outcomes.

Objectives: This meta-analysis was conducted to investigate the relationship between various comorbidities and the development of ARDS in patients with sepsis, with the aim of improving understanding and management of this condition.

Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression.

Optogenetics and chemogenetics are emerging neuromodulation techniques that have attracted significant attention in recent years. These techniques enable the precise control of specific neuronal types and neural circuits, allowing researchers to investigate the cellular mechanisms underlying depression. The advancement in these techniques has significantly contributed to the understanding of the neural circuits involved in depression; when combined with other emerging technologies, they provide novel therapeutic targets and diagnostic tools for the clinical treatment of depression.

Research progress on the use of traditional Chinese medicine to treat diseases by regulating ferroptosis.

Ferroptosis is an emerging form of programmed cell death triggered by iron-dependent lipid peroxidation. It is distinguished from other forms of cell death by its unique morphological changes and characteristic fine-tuned regulatory gene network. Since its pivotal involvement in the pathogenesis and therapeutic interventions of various diseases, such as malignant tumors, cardiovascular and cerebrovascular diseases, and traumatic disorders, has been well-established, ferroptosis has garnered significant attention in contemporary physiological and pathological research.

Effect of intensive water-salt diet nursing intervention on blood pressure and volume load in patients with chronic renal failure.

Background: This study aimed to investigate the impact of a comprehensive nursing intervention targeting high water and salt intake on blood pressure and volume burden in patients with chronic renal failure.

Method: From January 2020 to January 2023, 120 patients diagnosed with chronic renal failure were treated at our hospital. Participants were randomly allocated to either a control group ( = 60) receiving standard dietary education or an observation group ( = 60) receiving intensive water-salt diet nursing intervention alongside standard education.

Huoxue Tongluo tablet enhances atherosclerosis efferocytosis by promoting the differentiation of Trem2 macrophages via PPARγ signaling pathway.

Background: Atherosclerosis (AS) serves as the primary pathological basis for various cardiovascular and cerebrovascular diseases. Impaired efferocytosis by macrophages within AS plaques exacerbates lipid metabolism disorders and inflammatory responses. Huoxue Tongluo Tablet (HXTL), a traditional Chinese medicine formula, has shown efficacy in treating AS and modulating macrophage function.

Association of human blood metabolites with rheumatoid arthritis: A Mendelian randomization study.

Rheumatoid arthritis (RA) is a common autoimmune disease, but its specific biological mechanisms, especially the link between metabolites and RA, have not been conclusively hypothesized. This study used a Mendelian randomization (MR) analysis approach to assess the association between 1400 human blood metabolites and risk of RA. Pooled statistics of 1400 blood metabolites were used as exposure factors and genome-wide association studies of RA as endpoints, and MR analysis was used to analyze the relationship between the 2.

Effect of electrical stimulation in the treatment on patients with foot drop after stroke: a Systematic Review and Network Meta-analysis.

Objective: To systematically evaluate the efficacy of electrical stimulation (ES) in the treatment of patients with foot drop (FD) after stroke, and to compare the efficacy of different types of ES.

Data Sources: We searched 5 English database (PubMed, Web of Science, Embase, Cochrane Library and Scopus) and 4 Chinese databases (China National Knowledge Infrastructure (CNKI), SinoMed (CBM), VIP and Wanfang Data) from inception to June, 2024.

Data Synthesis: Traditional meta-analysis and network meta-analysis were performed using RevMan5.

The potential mechanisms by which Xiaoyao Powder may exert therapeutic effects on thyroid cancer were examined at various levels.

Background: Thyroid cancer (TC) is the most prevalent endocrine malignancy, with a rising incidence necessitating safer treatment strategies to reduce overtreatment and its side effects. Xiaoyao Powder (XYP), a widely used herbal formula, shows promise in treating TC. This study aims to investigate the mechanisms by which XYP may affect TC.

Huangqi and Danshen improve the chronic nephrotoxicity of cyclosporin A by regulating lipid metabolism.

Background: The clinical application of cyclosporine A (CsA) is limited due to nephrotoxicity. Lipid metabolism disorders play important roles in renal injury, but their role in CsA nephrotoxicity is not yet clear. Huangqi (Astragalus mongholicus Bunge) and Danshen (Salvia miltiorrhiza Bunge) (HD) play roles in ameliorating the nephrotoxicity of CsA, but their mechanisms still need to be fully clarified.

Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies.

Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to the global public health. It can result in myocardial cell damage and death due to impaired mitochondrial and endoplasmic reticulum (ER) functions. These two organelles are important regulators of cell death.

TSH-stimulated hepatocyte exosomes modulate liver-adipose triglyceride accumulation via the TGF-β1/ATGL axis in mice.

Subclinical hypothyroidism (SCH) contributes to obesity, with the liver acting as a crucial metabolic regulator. Thyroid-stimulating hormone (TSH) affects systemic lipid balance, potentially linking SCH to obesity. While the direct impact of TSH on hepatic lipid metabolism has been extensively documented, its role in modulating lipid dynamics in peripheral organs through liver-mediated pathways remains insufficiently understood.

Aggressive Ablation versus Regular Ablation for Persistent Atrial Fibrillation: A Multicenter Real-World Cohort Study.

Background And Aims: Current guidelines for the optimal ablation strategy for persistent atrial fibrillation(PerAF) remain unclear. While our previous RCT confirmed the favorable prognosis of aggressive ablation, real-world evidence is still lacking.

Methods: Among 4,833 PerAF patients undergoing catheter ablation at 10 centers, two groups were defined: Regular Ablation(PVI-only or PVI plus anatomical ablation) and Aggressive Ablation(anatomical plus electrogram-guided ablation), with 1,560 patients each after propensity score(PS) matching.

Causality of blood metabolites on hepatocellular carcinoma and cholangiocarcinoma: a metabolome-wide mendelian randomization study.

Background: Reportedly, there is an association between body metabolites and the risk of Hepatocellular Carcinoma (HCC) & Cholangiocarcinoma (CCA), possibly due to disrupted metabolic pathways leading to oxidative stress and an imbalance in cell proliferation and apoptosis, thereby increasing the risk of cancer. However, whether metabolites play a role in the onset of HCC or CCA remains inconclusive.

Objective: The aim of our study is to explore the potential causal relationship between metabolites and the risk of HCC&CCA.

Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis.

Cardiovascular diseases (CVDs) encompass a group of diseases that affect the heart and/or blood vessels, making them the leading cause of global mortality. In our study, we performed proteome-wide Mendelian randomization (MR) and colocalization analyses to identify novel therapeutic protein targets for CVDs and evaluate the potential drug-related protein side effects. We conducted a comprehensive proteome-wide MR study to assess the causal relationship between plasma proteins and the risk of CVDs.

Diosgenin alleviates lipid accumulation in NAFLD through the pathways of ferroptosis defensive and executive system.

Background: The most prevalent liver condition globally is non-alcoholic fatty liver disease (NAFLD), for which no approved therapies currently exist. Diosgenin, an important component in plants from the Leguminosae, Dioscoreaceae, and Solanaceae families, has demonstrated considerable anti-inflammatory and antioxidant effects. Nonetheless, the specific mechanism by which it may act in managing NAFLD remains unclear.

Wrist joint tuberculosis masquerading as traumatic arthritis sequalae.

Background: Wrist joint tuberculosis(WJ-TB)is a rare manifestation of osteoarticular tuberculosis(OAT).Delayed diagnosis is common and often leads to postponed treatment, resulting in complications such as joint stiffness and persistent pain in the affected limb.

Case Presentation: A 50-year-old man presented with symptoms in the wrist joint suggestive of WJ-TB.

Role of Immune Cells in Mediating the Effect of Lipids on Preeclampsia.

Lipidomes are thought to be associated with preeclampsia (PE). In addition, the immune response has been reported to play an important role in the development of PE. However, the causal relationship between the three remains unclear.

A novel classification method for LUAD that guides personalized immunotherapy on the basis of the cross-talk of coagulation- and macrophage-related genes.

Purpose: The coagulation process and infiltration of macrophages affect the progression and prognosis of lung adenocarcinoma (LUAD) patients. This study was designed to explore novel classification methods that better guide the precise treatment of LUAD patients on the basis of coagulation and macrophages.

Methods: Weighted gene coexpression network analysis (WGCNA) was applied to identify M2 macrophage-related genes, and TAM marker genes were acquired through the analysis of scRNA-seq data.

CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.

Bronchiolitis obliterans (BO) is a destructive fibrotic lung disease, which can be partly induced by 2,3‑butanedione [also known as diacetyl (DA)]; however, the mechanism underlying the effects of DA on BO is not clear. In the present study, a bioinformatics analysis was performed using DA‑treated or untreated lung tissues of rats, and it was observed that cell proliferation regulating inhibitor of protein phosphatase 2A (CIP2A) was significantly increased in samples from the DA group. CIP2A is associated with inflammation and epithelial‑mesenchymal transition (EMT), and facilitates lung injury; however, its effect on DA‑induced BO and the underlying mechanism remain unknown.

The relationship between weight-adjusted waist index and peripheral artery disease.

Background: Obesity is a significant risk factor for peripheral arterial disease (PAD). The weight-adjusted waist index (WWI) is a novel obesity metric that better reflects abdominal obesity than traditional body mass index (BMI). However, research on the relationship between WWI and PAD remains scarce.

Process Optimization of Stir-Fried Inonotus hispidus Based on the Box-Behnken Design-Response Surface Method and the Component Variations During the Stir-Frying Process.

The present study was designed to optimize the processing of Inonotus hispidus (I. hispidus) by single-factor studies and response surface methodology (RSM). Stir-frying temperature, stir-frying time, and rotational speed of the stir-frying machine were considered as the variables under investigation, whereas ergosterol, total polysaccharides, alcohol-soluble leachate, appearance, and shape were the parameters being studied.

Association between lipid ratios and sarcopenia and the mediating roles of inflammatory biomarkers in a cross-sectional study from NHANES 2011-2018.

Sarcopenia, which leads to reduced quality of life and increased medical burden, is challenging to diagnose in a timely manner. Lipid metabolism plays a role in sarcopenia, and this study explored the associations between blood lipid profile parameters and sarcopenia. Using data from the National Health and Nutrition Examination Survey 2011-2018, we conducted weighted multivariate logistic regression to investigate the associations between lipid ratios and sarcopenia, including non-high-density lipoprotein cholesterol (non-HDL-C) to HDL-C, triglyceride (TG) to HDL-C, low-density lipoprotein cholesterol (LDL-C) to HDL-C, and remnant cholesterol (RC) to HDL-C ratios.

Association between air pollution and osteoporosis: A Mendelian randomization study.

Osteoporosis (OP) is a significant disease in the aging society, which poses a threat to the physical well-being of older adults. Some studies suggest that air pollution may contribute to an increased incidence of OP; however, this causal relationship has not been firmly established. To address this gap, we conducted Mendelian randomization (MR) analysis to assess the potential causal association between air pollution (including nitrogen dioxide [N = 456,380], nitrogen oxides [N = 456,380], particulate matter [PM]2.