4 results match your criteria: "Affiliated Hospital of Shandong University of Traditional Chinese Medicine Jinan 250014[Affiliation]"
Objective: This study aims to elucidate the mechanism of action and impact of the "Xuanshen Yishen Mixture" (XYM) on hypertension.
Methods: Active components were identified and potential targets were predicted using the Traditional Chinese Medicine Systems Pharmacology database. Hypertension-related targets were collected from GeneCards, DRUGBANK, OMIM, TTD, and PharmaGKB databases.
Luteolin overcomes acquired resistance to osimertinib in non-small cell lung cancer cells by targeting the HGF-MET-Akt pathway.
Am J Cancer Res
September 2023
Cancer Center, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital) Qingdao 266033, Shandong, PR China.
Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has overcome the acquired resistance of first- and second-generation EGFR-TKIs due to the EGFR T790M mutation in non-small cell lung cancer (NSCLC). However, acquired resistance to osimertinib remains a significant clinical challenge. Luteolin, a natural flavonoid from traditional Chinese medicine, has exerted antitumor effects in various tumors.
View Article and Find Full Text PDFExpressions of serum adiponectin and visfatin in patients with hypertension in cerebrovascular accidents and analysis of risk factors.
Am J Transl Res
November 2022
First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine Jinan 250014, Shandong, China.
Objective: To determine the expressions of serum adiponectin and visfatin in patients with hypertension and cerebrovascular accidents and to analyze the risk factors.
Methods: Data of 161 patients with hypertension treated in The Affiliated Hospital of Shandong University of Traditional Chinese Medicine from March 2019 to July 2021 were retrospectively analyzed. There were 72 patients with cerebrovascular accidents assigned to an occurrence group.
Effect of pollen typhae on inhibiting autophagy in spinal cord injury of rats and its mechanisms.
Int J Clin Exp Pathol
March 2016
Department of Orthopaedic Surgery, General Hospital of Jinan Military Command Jinan 250031, China.
Purpose: To investigate the effects and mechanism of pollen typhae on spinal cord injury (SCI) in rats.
Methods: The SCI model was built and animals were randomly divided into three groups according to different concentrations of pollen typhae. Protein, mRNA, and fluorescence expression levels of light-chain-3 (LC-3) and Beclin-1 were determined by western blotting (WB), real-time PCR and immunofluorescence, along as Akt and mammalian target of rapamycin (mROT) by WB.