KIF21A mutations in two Chinese families with congenital fibrosis of the extraocular muscles (CFEOM).

Purpose: Two Chinese families (XT and YT) with congenital fibrosis of the extraocular muscles (CFEOM) were identified. The purpose of this study was to determine if previously described Homo sapiens kinesin family member 21A (KIF21A) mutations were responsible for CFEOM in these two Chinese pedigrees.

Methods: Clinical characterization and genetic studies were performed.

Management of differentiated thyroid cancer with rising thyroglobulin and negative diagnostic radioiodine whole body scan.

Background: Differentiated thyroid carcinoma (DTC) with rising thyroglobulin (Tg) level and negative radioiodine whole body scan results has been observed in follow-up studies. The management of this condition remains controversial. Most studies support blind (131)I treatment while others oppose this approach.

Expression, purification, and characterization of a functional mutant recombinant human interleukin-2.

In the current study, a mutant recombinant human interleukin-2 (MhIL-2) was generated using site-directed mutagenesis. The bacteria transformed with plasmid pET15b-MhIL-2 were cultured in LB medium containing 0.6mM IPTG for 8 hours at 27°C.

The role of TSH for 18F-FDG-PET in the diagnosis of recurrence and metastases of differentiated thyroid carcinoma with elevated thyroglobulin and negative scan: a meta-analysis.

Purpose: To establish the effects of TSH stimulation on the uptake of fluorine-18-labeled 2-fluoro-2-deoxy-d-glucose for differentiated thyroid carcinoma (DTC) with thyroglobulin-positive and scan negative metastases.

Materials And Methods: We searched the MEDLINE, EMBASE and the Cochrane Library for prospective controlled trials using TSH stimulation as an intervention. The outcomes of positron emission tomography (PET)-positive lesions, tumor-to-background ratio, maximum standard uptake value of the detected lesions were extracted and synthesized, and patients with the altered clinical management were studied.

[Evaluation of the impact of genetic background on islet beta-cell function of normal glucose tolerance and newly diagnosed diabetic patients by L-arginine stimulation test.].

Objective: To explore the impact of genetic background on pancreatic beta-cell first-phase secretion function with L-arginine (L-ARG) stimulation test.

Methods: Plasma insulin level was detected in 201 cases before and after L-ARG stimulation test. Among them, 61 cases were newly diagnosed type 2 diabetic patients with family history of diabetes (FH+DM), 55 newly diagnosed type 2 diabetic patients without family history of diabetes (FH-DM), 31 with normal glucose tolerance and family history of diabetes (FH+) 54 with normal glucose tolerance but without family history of diabetes (FH-).

Amifostine for salivary glands in high-dose radioactive iodine treated differentiated thyroid cancer.

Background: Radioactive iodine treatment for differentiated thyroid cancer possibly results in xerostomia. Amifostine has been used to prevent the effects of irradiation to salivary glands. To date, the effects of amifostine on salivary glands in radioactive iodine treated differentiated thyroid cancer remain uncertain.

Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide.

There has been an increasing appreciation of the role that microglial cells play in neural damage. Marrow stromal cells (MSCs) can dramatically lessen neural damage in animal models, but the mechanisms involved have not been defined. This study aimed to investigate the effects of human MSCs (hMSCs) on the activation of primary microglia and the attendant production of pro-inflammatory factors stimulated by bacterial endotoxin lipopolysaccharide (LPS).

Radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.

Background: Differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases has been observed in follow-up studies. The management of this condition remains controversial. Most studies support blind radioactive iodine treatment while others negate this approach.

Differences in shotgun protein expression profile between superficial bladder transitional cell carcinoma and normal urothelium.

This study was undertaken to identify differences in protein expression profiles between superficial bladder transitional cell carcinoma (BTCC) and normal urothelial cells. We used laser capture microdissection (LCM) to harvest purified cells, and used two-dimensional liquid chromatography (2D-LC) followed by electrospray ionization-tandem mass spectrometry (ESI-MS/MS) to separate and identify the peptide mixture. A total of 440/438 proteins commonly appeared in 4 paired specimens.

Quantitative risk stratification and individual comprehensive therapy for invasive bladder cancers in China.

Background: To evaluate the risk factors for invasive bladder cancer and to develop a predictive model for the improvement of individual comprehensive therapy for invasive bladder cancers.

Materials And Methods: The records of 356 patients with invasive bladder cancer, operated on at three Chinese medical institutes, were reviewed. The Cox proportional hazards regression model was used to assess the clinical and pathological variables affecting disease-free survival (DFS).

Radioiodine treatment for pediatric Graves' disease.

Background: Pediatric Graves' disease (GD) is an autoimmune disease in which excessive amounts of thyroid hormones circulate in the blood. Treatments for pediatric GD include antithyroid drugs (ATD), thyroidectomy and radioiodine. Up to date, the optimal therapy remains controversial.

Outcomes for a large series of radical cystectomies for bladder cancer.

Aims: We present the characteristics and outcomes of a large Chinese series of patients treated with radical cystectomy and pelvic lymphadenectomy for invasive cancer of the bladder. Our aim is to determine the significant independent prognostic factors that determine this outcome.

Methods: The records of 356 patients with invasive bladder cancer, operated at three Chinese medical institutes between 1995 and 2004, were reviewed.

MSM and HIV/AIDS in China.

This article profiles current status of spread and control of HIV/AIDS in China. China has a significant population of MSM (men who have sex with men) and they have been becoming very much alive in many ways since 1990s due to recent social changes. Some surveys indicate that great many of MSM are engaged in high-risk behaviors.

[Obstructive sleep apnea syndrome and hypothyroidism (a report of three cases)].

Objective: To explore the relationship between obstructive sleep apnea syndrome (OSAS) and hypothyroidism, and to discuss the management experience.

Method: Three cases of severity OSAS with hypothyroidism were reported and relevant literatures were reviewed. One patient underwent continuous positive airway pressure (CPAP), one patient was performed uvulopalatopharyngoplasty(UPPP), and one case is in follow-up now.