Identification of Key Risk Factors for Rupture in Small Intracranial Aneurysms: A Multicenter Study.

Background And Purpose: Predicting rupture risk in small intracranial aneurysms (IAs) < 5 mm is crucial for guiding clinical decisions. This study aims to identify key clinical and morphological risk factors associated with rupture in small IAs, providing better insight for decision-making.

Methods: A retrospective analysis was performed on patients with small IAs from one center, with external validation data from another center.

Prediction of mortality in hemodialysis patients based on autoencoders.

Background: Patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) exhibit a high mortality risk, particularly at the onset of treatment. Conventional risk assessment models, dependent on extensive temporal data accumulation, frequently encounter issues of data incompleteness and lengthy collection periods.

Objective: This study addresses the imbalance in short-term HD data and the issue of missing data features, achieving a robust assessment of mortality risk for HD patients over the subsequent 30 to 450 days.

Erratum: Burden of disease attributable to high body mass index: an analysis of data from the Global Burden of Disease Study 2021.

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[Comparative Evaluation of Encephalon State Index and Bispectral Index in Monitoring the Depth of Anesthesia during the Surgical Anesthesia Stage].

Objective: Evaluate the performance of the encephalon state index (ESI) in depth of anesthesia monitoring during clinical surgery, compared with the bispectral index (BIS).

Methods: ESI and BIS data were collected from 60 patients in a single-center clinical trial to compare their efficacy in measuring the depth of anesthesia.

Results: Consistency analysis revealed mean differences and standard deviations of －0.

Relationship between physical fitness and executive function in preschool children: a cross-sectional study.

Background: Physical fitness (PF) is important for children's physical and cognitive development. There is increasing interest in the relationship between physical fitness, and executive function. Since it is unclear which physical fitness component benefits which domain of executive functioning, it's challenging to develop effective physical intervention programs for children with executive functioning disorders.

SGLT2 inhibitor downregulates ANGPTL4 to mitigate pathological aging of cardiomyocytes induced by type 2 diabetes.

Background: Senescence is recognized as a principal risk factor for cardiovascular diseases, with a significant association between the senescence of cardiomyocytes and inferior cardiac function. Furthermore, type 2 diabetes exacerbates this aging process. Sodium-glucose co-transporter 2 inhibitor (SGLT2i) has well-established cardiovascular benefits and, in recent years, has been posited to possess anti-aging properties.

The impact of gut microbiota in full-term pregnant women on immune regulation during pregnancy: A prospective, exploratory study.

Aim: This study aims to investigate the correlation between gut microbiota and both placental local immune function and the maternal systemic immune system in pregnant women.

Methods: Twenty-six pregnant women were included in this study, utilizing high-throughput sequencing for gut microbiota analysis. Immune cells and cytokine levels were measured in placental tissue and peripheral venous blood.

Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression.

Background: Non-coding RNAs have received increasing attention in human tumors, with RNA interaction networks playing important roles in breast cancer. This study aims to explore novel circular RNAs and their mechanisms of biological function in breast cancer.

Methods: Six HER2-positive breast cancer tissues and paired normal tissues were obtained for the whole transcriptome RNA sequencing.

Fully Bioactive Nanodrugs: Stem Cell-Derived Exosomes Engineered with Biomacromolecules to Treat CCl- and Extreme Hepatectomy-Induced Acute Liver Failure.

Acute liver failure (ALF) is a serious global disease characterized by rapid onset and high mortality. Currently, the clinical treatment of ALF faces considerable hurdles due to limited medication options and the scarcity of liver transplants. Despite biomacromolecules such as hepatocyte growth factor (HGF) and glutathione (GSH) having been applied for ALF symptom relief in the clinic, they still face substantial challenges including poor stability, difficulty in acting on intracellular targets, and inadequate therapeutic outcome.

[Ferroptosis inducer Erastin inhibits proliferation of liver cancer cells by downregulating ACSL4].

Objective: To investigate the expression of Acyl-CoA synthetase long-chain family member 4 (ACSL4) in liver cancer and its role in regulating ferroptosis and proliferation of liver cancer cells.

Methods: Clinical samples of liver cancer and adjacent normal liver tissues were examined for malondialdehyde (MDA) contents and for expressions of mRNA and protein expressions of ACSL4 and proliferating cell nuclear antigen (PCNA) using RT-qPCR and Western blotting. Human liver cancer Huh-7 cells were treated with Erastin (a ferroptosis inducer), Fer-1 (a ferroptosis inhibitor), or both, and the changes in expression levels of MDA, ACSL4 and PCNA were detected, and the cell proliferation was assessed with plate cloning assay.

A multimodal neuroimaging meta-analysis of functional and structural brain abnormalities in attention-deficit/hyperactivity disorder.

Background: Numerous neuroimaging studies utilizing resting-state functional imaging and voxel-based morphometry (VBM) have identified variations in distinct brain regions among individuals with attention-deficit/hyperactivity disorder (ADHD). However, the results have been inconsistent.

Methods: A comprehensive voxel-wise meta-analysis was performed on studies employing resting-state functional imaging and gray matter volume (GMV), examining discrepancies between individuals with ADHD and neurotypical controls (NCs).

Antagonising Yin Yang 1 ameliorates the symptoms of lupus nephritis via modulating T lymphocyte signaling.

Lupus nephritis (LN) is a chronic complication of systemic lupus erythematosus (SLE). At present, no drugs are capable of delaying the progression of LN without a risk of serious side effects. There is thus a pressing need for further studies of LN pathogenesis to identify novel therapeutic targets and aid in the development of new approaches to treating this debilitating disease.

The oncogenic role and prognostic value of PXDN in human stomach adenocarcinoma.

Stomach adenocarcinoma (STAD) is known for its high prevalence and poor prognosis, which underscores the need for novel therapeutic targets. Peroxidasin (PXDN), an enzyme with peroxidase activity, has been linked to cancer development in previous studies. However, its specific role in STAD is not well understood.

Knockout of onecut2 inhibits proliferation and promotes apoptosis of tumor cells through SKP2-mediated p53 acetylation in hepatocellular carcinoma.

Onecut2 (OC2) plays a vital regulatory role in tumor growth, metastasis and angiogenesis. In this study, we report the regulatory role and specific molecular mechanism of OC2 in the apoptosis of hepatocellular carcinoma (HCC) cells. We found that OC2 knockout via the CRISPR/CAS9 system not only significantly inhibited the proliferation and angiogenesis of HCC cells but also significantly promoted apoptosis.

Case Report: Allelic and biallelic variants in cause factor XI deficiency.

Factor XI deficiency is a rare inherited coagulation disorder with an estimated prevalence of affecting 1 in 1 million. It is characterized by mild and variable bleeding phenotypes, including bruises, nosebleeds, hematuria, and postpartum hemorrhage. It can be caused by either allelic or biallelic variants in ().

Association of acetaminophen use with mortality and renal recovery in patients with sepsis-associated acute kidney injury.

Background: Sepsis-associated acute kidney injury (SA-AKI) is common and associated with poor outcomes in critically ill patients. Acetaminophen is often used as an antipyretic and analgesic drug, but the association of acetaminophen use with mortality and recovery of renal function in SA-AKI patients remain unclear. We aimed to investigate the association between acetaminophen use and outcomes in SA-AKI patients.

Effect of remote ischemic preconditioning, nicorandil, and trimetazidine in contrast-induced nephropathy: a network meta-analysis of randomized controlled trials.

Introduction: Contrast-induced nephropathy (CIN) is a potential complication associated with the administration of intravenous contrast agents. The objective of this study was to evaluate the effectiveness of remote ischemic preconditioning (RIPC) and two pharmacological interventions in preventing CIN.

Methods: Randomized controlled trials (RCTs) examining the efficacy of RIPC, nicorandil, and trimetazidine in treating CIN were searched within databases such as PubMed, Cochrane Library, Embase, and Web of Science.

Machine-Learning Mental-Fatigue-Measuring μm-Thick Elastic Epidermal Electronics (MMMEEE).

Electrophysiological (EP) signals are key biomarkers for monitoring mental fatigue (MF) and general health, but state-of-the-art wearable EP-based MF monitoring systems are bulky and require user-specific, labeled data. Ultrathin epidermal electrodes with high performance are ideal for constructing imperceptive EP sensing systems; however, the lack of a simple and scalable fabrication delays their application in MF recognition. Here, we report a facile, scalable printing-welding-transferring strategy (PWT) for printing μm-thickness micropatterned silver nanowires (AgNWs)/sticky polydimethylsiloxane, welding the AgNWs via plasmonic effect, and transferring the electrode to skin as tattoos.