Inhibiting stanniocalcin 2 reduces sunitinib resistance of Caki-1 renal cancer cells under hypoxia condition.

Background: Our previous study has suggested that blocking stanniocalcin 2 (STC2) could reduce sunitinib resistance in clear cell renal cell carcinoma (ccRCC) under normoxia. The hypoxia is a particularly important environment for RCC occurrence and development, as well as sunitinib resistance. The authors proposed that STC2 also plays important roles in RCC sunitinib resistance under hypoxia conditions.

The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review.

Circular RNAs (circRNAs) are a class of covalently closed continuous loops of single-stranded RNA molecules, and broadly expressed in the cytoplasm of eukaryotic cells. CircRNAs have attracted considerable research attention in recent years, an attention primarily attributed to their critical roles in the development and progression of diseases, especially in cancers. The circRNA homeodomain-interacting protein kinase 3 (circHIPK3) is a recently identified circRNA, acknowledged to be relevant to human pathology and cancer progression.