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Objective: This study was designed to determine the effects of methotrexate combined with tocilizumab on growth and bone metabolism in children with juvenile idiopathic arthritis (JIA).

Methods: The medical records of 112 children with JIA treated in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine from March 2019 to June 2021 were collected and analyzed retrospectively. There were 51 patients treated with methotrexate alone who were assigned to the control group.

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