4 results match your criteria: "Affiliated Hospital of Guangdong Medical University (GDMU)[Affiliation]"
Regulatory Effect of PDGF/PDGFR on Hematopoiesis.
Semin Thromb Hemost
November 2024
Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Platelet-derived growth factor (PDGF) is a critical cytokine with substantial regulatory effects on hematopoiesis. Recent research highlights the essential role of PDGF in the modulation of hematopoietic stem/progenitor cells (HSPCs), megakaryocytes/platelets, and thrombopoietin (TPO) synthesis within the bone marrow microenvironment. PDGF directly stimulates the proliferation and differentiation of HSPCs while also inhibiting apoptosis.
View Article and Find Full Text PDFThrombopoietin improves the functions of bone marrow endothelial progenitor cells via METTL16/Akt signalling of haematological patients with chemotherapy-induced thrombocytopenia.
Br J Haematol
October 2024
The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, P.R. China.
Bone marrow endothelial progenitor cells (BM EPCs) are crucial in supporting haematopoietic regeneration, while the BM EPCs of haematological patients with chemotherapy-induced thrombocytopenia (CIT) are unavoidably damaged. Therefore, the present study aimed to examine the effect of thrombopoietin (TPO) on the recovery of BM EPCs of CIT patients and to identify the underlying mechanisms. The cell functions were determined by 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil)-acetylated low-density lipoprotein (Dil-Ac-LDL) uptake and fluorescein isothiocyanate (FITC)-labeled Ulex europaeus agglutinin-I (FITC-UEA-I) binding assay, as well as proliferation, migration and tube formation experiments.
View Article and Find Full Text PDFComprehensive analysis and prediction model of mitophagy and ferroptosis in primary immune thrombocytopenia.
Br J Haematol
June 2024
Department of Hematology, Affiliated Hospital of Guangdong Medical University (GDMU), Zhanjiang, China.
Article Synopsis
- - The study investigates the role of mitophagy and ferroptosis in primary immune thrombocytopenia (ITP), focusing on identifying new biomarkers and understanding the molecular mechanisms involved.
- - Key genes identified as significant in ITP include GABARAPL1, S100A8, LIN28A, and GDF9, which show potential for diagnostics and are linked to critical cellular processes like T-cell differentiation and signaling pathways.
- - Findings indicate that reduced expression of GABARAPL1 in bone marrow macrophages may hinder processes necessary for cell homeostasis, potentially leading to immune system imbalances in ITP patients.
Platelet dropping, bleeding and new treatment requirements in ITP patients after inactivated COVID-19 vaccination.
Immunol Lett
December 2023
The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China; Department of Hematology, Hematology Research Institute, Affiliated Hospital of Guangdong Medical University (GDMU), Zhanjiang, China. Electronic address:
Significant decreases in platelet counts and ITP relapses have been documented in ITP patients receiving COVID-19 mRNA vaccines; however, the effect of the inactivated COVID-19 vaccine on ITP patients remains unclear. The present study aimed to investigate the impact of inactivated COVID-19 vaccines on ITP patients, with a focus on platelet dropping events, bleeding events/scores, and the requirement of a new round of treatment. A total of 118 ITP patients, with 97 chronic ITP and 21 persistent ITP, who received inactivated COVID-19 immunization were investigated retrospectively.
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