2,354 results match your criteria: "Affiliated Hospital of Guangdong Medical University[Affiliation]"

Background: Ischaemia-reperfusion injury (IRI) is a critical complication post-limb replantation. The oxidative stress and cellular apoptosis due to IRI considerably hinder the healing process. This study aimed to investigate the modulatory effects of pre-perfusion with hydrogen-rich heparin sodium on the nuclear factor erythroid 2-related factor 2 (NRF2)/haeme oxygenase-1 (HO-1) pathway and its potential mechanisms in mitigating skeletal muscle IRI post-limb replantation.

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Key regulators of vascular calcification in chronic kidney disease: Hyperphosphatemia, BMP2, and RUNX2.

PeerJ

September 2024

Affiliated Hospital of Guangdong Medical University, Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Zhanjiang, Guangdong, China.

Vascular calcification is quite common in patients with end-stage chronic kidney disease and is a major trigger for cardiovascular complications in these patients. These complications significantly impact the survival rate and long-term prognosis of individuals with chronic kidney disease. Numerous studies have demonstrated that the development of vascular calcification involves various pathophysiological mechanisms, with the osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) being of utmost importance.

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A novel m-xylylene-diamine/glucose based-supramolecular eutectogels with tissue clearing for three dimensional histological imaging.

Colloids Surf B Biointerfaces

January 2025

The second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China; Marine Biomedical Research Institution, Guangdong Medical University, Zhanjiang 524023,  PR China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, PR China. Electronic address:

Hydrogel-based tissue clearing technologies have shown significant promise for deep-tissue imaging and subcellular-level optical 3D reconstruction of whole organs. This study proposes a novel approach utilizing a deep eutectic solvent (DES) formulated with glucose and m-xylylene-diamine (MXDA) to create a highly efficient tissue-clearing hydrogel system named the passive hydrogel clearing system (PHCS). PHCS achieved efficient tissue clearing through a single-step tissue gelation process.

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Fully Synthetic TF-Based Self-Adjuvanting Vaccine Simultaneously Triggers iNKT Cells and Mincle and Protects Mice against Tumor Development.

J Med Chem

October 2024

Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.

The Thomsen-Friedenreich (TF) antigen has proven to be a promising target for developing novel therapeutic cancer vaccines. Here, a new strategy that TF antigen covalently coupled with KRN7000 and vizantin was developed. The resulting three-component vaccine KRN7000-TF-vizantin simultaneously triggers invariant natural killer T (iNKT) cells and macrophage-inducible C-type lectin (Mincle) signaling pathways, eliciting much stronger TF-specific immune responses than glycoprotein vaccine TF-KLH/alum and the corresponding two-component conjugate vaccines TF-KRN7000 and TF-vizantin.

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Background: Myricetin has various biological activities and health benefits; however, its effects on airway remodeling in asthma have not been reported.

Purpose: We aimed to investigate the possibility that myricetin improves airway remodeling by activating Sirt1 and has potential as a new treatment for asthma.

Methods: RAW 264.

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The Role of Mitochondrial Dysfunction in CKD-Related Vascular Calcification: From Mechanisms to Therapeutics.

Kidney Int Rep

September 2024

Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-communicable Diseases, Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Institute of Nephrology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and is closely associated with cardiovascular events. The transdifferentiation of vascular smooth muscles (VSMCs) into an osteogenic phenotype is hypothesized to be the primary cause underlying VC. However, there is currently no effective clinical treatment for VC.

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SMYD3 (SET and MYND domain-containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for this protein have been developed for cancer treatment. Therefore, the current study describes developing and characterizing a novel small molecule ZYZ384 screened and synthesized based on SMYD3 structure.

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Blood metabolites, neurocognition and psychiatric disorders: a Mendelian randomization analysis to investigate causal pathways.

Transl Psychiatry

September 2024

Key Laboratory of Biomedical Information Engineering of Ministry of Education, Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, P. R. China.

Background: Neurocognitive dysfunction is observationally associated with the risk of psychiatric disorders. Blood metabolites, which are readily accessible, may become highly promising biomarkers for brain disorders. However, the causal role of blood metabolites in neurocognitive function, and the biological pathways underlying their association with psychiatric disorders remain unclear.

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A general decline in the osteogenic differentiation capacity of human bone marrow mesenchymal stem cells (hBMSCs) in the elderly is a clinical consensus, with diverse opinions on the mechanisms. Many studies have demonstrated that metformin (MF) significantly protects against osteoporosis and reduces fracture risk. However, the exact mechanism of this effect remains unclear.

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Elevated meteorin-like protein from high-intensity interval training improves heart function via AMPK/HDAC4 pathway.

Genes Dis

November 2024

Department of Cardiology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong 518020, China.

High-intensity interval training (HIIT) has been found to be more effective in relieving heart failure (HF) symptoms, than moderate-intensity continuous aerobic training (MICT). Additionally, higher meteorin-like protein (Metrnl) levels are seen after HIIT versus MICT. We investigated whether Metrnl contributed to post-HF cardiac functional improvements, and the signaling pathways involved.

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Background: The extent of skull base invasion (SBI) in nasopharyngeal carcinoma (NPC) directly impacts tumor staging, treatment strategies, and prognosis assessment for NPC patients, emphasizing the critical need for prompt diagnosis and precise assessment of invasion. Thus, we aimed to integrate the advantages of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and conventional magnetic resonance imaging (cMRI), and assess their combined diagnostic efficacy versus that of F-sodium fluoride (F-NaF) positron emission tomography/computed tomography (PET/CT) for detecting SBI in NPC patients.

Methods: The study prospectively and randomly recruited 62 patients newly diagnosed with NPC by pathological biopsy at the Cancer Center of Affiliated Hospital of Guangdong Medical University from January 2021 to September 2022.

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Sepsis is a systemic inflammatory response that can result in cardiac insufficiency or heart failure known as septic myocardial injury. A previous study identified OLFM4 as an important gene in sepsis through bioinformatics analysis. However, there is limited research on the regulatory functions of OLFM4 in sepsis-triggered myocardial injury, and the related molecular mechanisms remain unclear.

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Article Synopsis
  • OCT and OCTA can help assess changes in the optic nerve structure for conditions like chronic primary angle-closure glaucoma (CPACG) and pituitary adenoma (PA).
  • CPACG patients showed reduced retinal blood flow density and thinner retinal layers compared to PA patients, both factors being significant in diagnosis.
  • The study concluded that both OCT and OCTA are effective in differentiating between early CPACG and early PA, even when visual field defects are similar.
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A case of adult medulloblastoma.

Asian J Surg

September 2024

Department of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, China. Electronic address:

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Purpose: With the rapid advancement of time-lapse culture and artificial intelligence (AI) technologies for embryo screening, pregnancy rates in assisted reproductive technology (ART) have significantly improved. However, clinical pregnancy rates in fresh cycles remain dependent on the number and type of embryos transferred. The selection of embryos with the highest implantation potential is critical for embryologists and influences transfer strategies in fertility centers.

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Herein, we report an example of a stereoselective γ-addition reaction of trifluoromethyl ketimines to 1-alkynyl ketones mediated by an isothiourea, BTM, under mild conditions, which afforded tetrasubstituted allenes with central chiralities in high yields (up to 94% yield), good enantioselectivities (up to 91% ee), and excellent diastereoselectivities (all >20 : 1 dr). In addition, the BTM-catalyzed γ-addition reaction was successfully applied to the gram-scale reaction, and an unexpected benzopyrrolothiazine derivative was successfully converted, albeit racemic.

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Article Synopsis
  • The study investigates the characteristics of HPV-related primary thyroid squamous cell carcinoma (PSCCT), a rare subtype of anaplastic thyroid carcinoma (ATC), through clinical and pathologic analysis of three cases.
  • The patients were all females aged 60-76, with varying cancer components, including both squamous and papillary types, and specific HPV types were identified in each case.
  • The findings highlight the need for a comprehensive diagnostic approach for PSCCT and suggest the simultaneous presence of HPV DNA in both types of tumors, although more research is needed due to the small sample size.
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Article Synopsis
  • FNIP1 is involved in regulating energy metabolism and is linked to Birt-Hogg-Dubé syndrome, but its specific role in colorectal cancer (CRC) is not well-defined.* -
  • The study found that FNIP1 is significantly downregulated in CRC, which is associated with worse survival rates, suggesting it could be an independent prognostic factor.* -
  • FNIP1 appears to inhibit CRC progression by binding to p-STAT3 and reducing its activity; loss of FNIP1 leads to increased STAT3 phosphorylation and tumor growth, making FNIP1 a potential therapeutic target.*
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Mitochondrial dysfunction is a pivotal event contributing to the development of ageing-related kidney disorders. Lon protease 1 (LONP1) has been reported to be responsible for ageing-related renal fibrosis; however, the underlying mechanism(s) of LONP1-driven kidney ageing with respect to mitochondrial disturbances remains to be further explored. The level of LONP1 was tested in the kidneys of aged humans and mice.

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Background: Recent studies have found that ferroptosis-related genes (FRGs) have broad applications in tumor therapy. However, the predictive potential of these genes in lung adenocarcinoma (LUAD) remains to be fully characterized. We aimed to investigate the FRGs that might be potential targets for LUAD.

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Article Synopsis
  • - The minimal clinically important difference (MCID) is crucial for understanding quality of life (QOL) and patient-reported outcomes (PRO) in clinical settings, acting as a link between statistics and medicine.
  • - This study utilized the ROC curve to determine the MCID for the Quality of Life Instruments for Chronic Diseases of Systemic lupus erythematosus (QLICD-SLE V2.0), involving 279 patients measured on their first day of hospitalization and before discharge.
  • - Results indicated the MCID values across different domains of the QLICD-SLE scale, with a significant overall MCID of 3.2 points, meaning that changes above this threshold can be seen as clinically significant. *
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Objective: The aim of this study is to comprehensively investigate the temporal dynamics of faecal gut microbiota and metabonomics in early postnatal with a focus on very low or extremely low birth weight (VLBW/ELBW) infants.

Methods: We collected faecal samples from 157 VLBW/ELBW infants at three time points: days 1, 14, and 28 in a prospective cohort study. The faecal microbial diversity, abundance, composition, and metabolomic analyses were determined using 16S rRNA sequencing and liquid chromatography tandem mass spectrometry (LC-MS/MS).

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Constructing and validating pan-apoptosis-related features for predicting prognosis and immunotherapy response in hepatocellular carcinoma.

Biochem Biophys Res Commun

November 2024

Laboratory of Hepatobiliary Surgery, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong, China; Hepatobiliary Related Diseases Key Laboratory of Zhanjiang, Zhanjiang, 524001, Guangdong, China. Electronic address:

Article Synopsis
  • The study developed a prognostic model for Hepatocellular Carcinoma (HCC) using six key pan-apoptosis-related genes linked to cancer progression.
  • By analyzing data from the TCGA database, the model effectively predicts overall survival rates in HCC patients and correlates with tumor microenvironment conditions and immune responses.
  • The research also identified potential therapeutic drugs for different risk groups and highlighted the role of the PPP2R5B gene in HCC cell growth, paving the way for targeted treatments.
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Objective: The clinical management of patients with chronic limb-threatening ischemia (CLTI) faces great challenges. Enhancing wound healing and limb preservation rates in this cohort is a critical objective. This study investigates the effectiveness of combining tibial cortex transverse transport (TTT) and endovascular therapy (EVT) for the treatment of patients with severe CLTI.

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