2,909 results match your criteria: "Affiliated Hospital of Chengdu University of Traditional Chinese Medicine; yfmdoc@163.com.[Affiliation]"
Handwashing sinks as reservoirs of carbapenem-resistant in the intensive care unit: a prospective multicenter study.
Front Public Health
October 2024
Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China.
Introduction: The extent to which sinks are contaminated by carbapenem-resistant (CRAB) in intensive care units (ICUs) and the association between these contaminated sinks and hospital-acquired CRAB infections during the non-cluster period remains largely unknown. Here, we performed a prospective multicenter study in 16 ICUs at 11 tertiary hospitals in Chengdu, China.
Methods: We sampled sinks, collected CRAB clinical isolates, and conducted whole-genome sequencing and analysis.
Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study.
Wound Repair Regen
November 2024
Department of emergency, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Article Synopsis
- The study used a two-sample bidirectional Mendelian randomization (MR) analysis to explore the connection between venous leg ulcers (VLUs) and knee osteoarthritis (KOA).
- Multiple MR methods, including inverse variance weighted and others, showed no significant genetic association between VLUs and KOA, indicating that they do not influence each other.
- The research concluded that there is no causal or reverse causal relationship between VLUs and KOA based on the genetic analysis performed.
A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer.
J Control Release
December 2024
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China; Key Laboratory of Blood-Stasis-Toxin Syndrome of Zhejiang Province, Hangzhou 310053, China. Electronic address:
Dihydroartemisinin (DHA), a compound extracted from the herbal medicine Artemisia annua, has shown promise as a clinical treatment strategy for colorectal cancer. However, its clinical use is hindered by its low water solubility and bioavailability. A pH/glutathione (GSH) dual-responsive nano-herb delivery system (PMDC NPs) has been developed for the targeted delivery of DHA, accompanied by abundant carbon monoxide (CO) release.
View Article and Find Full Text PDFSurgical intervention of a giant bronchogenic cyst in the right middle lobe with recurrent infections: a case report.
J Surg Case Rep
October 2024
Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of the University of Electronic Science and Technology of China, No. 55, Section 4, South Renmin Road, Chengdu 610041, China.
Article Synopsis
- A 53-year-old woman with recurrent respiratory infections had a large bronchogenic cyst found in her right lung, which caused cardiac compression and proved resistant to conservative treatment.
- After complications during surgery led to a thoracotomy, the patient's post-op symptoms were treated effectively with antibiotics, and she was discharged symptom-free, showing the necessity of surgery for large symptomatic cysts.
Chicoric acid exerts therapeutic effects in DSS-induced ulcerative colitis by targeting the USP9X/IGF2BP2 axis.
Br J Pharmacol
October 2024
Department of Nuclear Medicine, The First Hospital of Jilin University, Changchun, China.
Background And Purpose: Chicoric acid, a hydroxycinnamic acid, exhibits anti-inflammation activities. However, the specific mechanisms underlying the effects of chicoric acid on dextran sulfate sodium (DSS)-induced colitis remain unclear. Here, we aimed to elucidate the molecular mechanisms underlying the protective effects of chicoric acid in DSS-induced colitis.
View Article and Find Full Text PDFGLO1 regulates hepatocellular carcinoma proliferation and migration through the cell cycle pathway.
BMC Cancer
October 2024
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, 646000, China.
Background: Hepatocellular carcinoma (HCC) is a malignant tumor characterized by a high mortality rate. The occurrence and progression of HCC are linked to oxidative stress. Glyoxalase-1 (GLO1) plays an important role in regulating oxidative stress, yet the underlying mechanism remains unclear.
View Article and Find Full Text PDF[Study on the protective effect of acupuncture on poor ovarian response in mice].
Zhen Ci Yan Jiu
October 2024
College of Acupuncture-Moxibustion and Massage, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, Shanxi Province.
Article Synopsis
- The study aimed to investigate how acupuncture might protect ovarian function in mice with poor ovarian response (POR) by examining its effects on specific molecules in the Hippo signaling pathway, focusing on reducing ovarian cell death.
- Mice were divided into three groups: normal control, POR model (induced by a specific substance), and acupuncture-treated. Acupuncture was administered over ten days, and various physiological and biochemical parameters were measured to assess ovarian health.
- Results indicated that the POR model group showed increased hormonal imbalances and estrous cycle disorders compared to the normal group, suggesting a need for therapeutic interventions like acupuncture to mitigate these effects.
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.
Theranostics
October 2024
Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Key Laboratory of Medical Electrophysiology of Ministry of Education, School of Pharmacy, Southwest Medical University, Luzhou, China, 646000.
Ferroptosis, a recently unveiled iron-dependent form of cellular demise, has emerged as a pivotal process contributing to the pathology of Alzheimer's Disease (AD). Glutathione Peroxidase 4 (GPX4), a vital defense mechanism countering ferroptosis by nullifying lipid peroxides and maintaining cellular redox equilibrium, has garnered significant attention in AD. Thus, identifying ferroptosis inhibitors to target GPX4 activation may help mitigate neuronal damage and impede AD progression.
View Article and Find Full Text PDFUnveiling ferroptosis: a new frontier in skin disease research.
Front Immunol
October 2024
Science Education Department, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
Article Synopsis
- Ferroptosis is a unique type of regulated cell death that differs from apoptosis, necrosis, and autophagy, and is gaining attention for its involvement in skin diseases.
- The review explores how ferroptosis, characterized by iron buildup and lipid damage, affects several skin conditions like psoriasis, dermatitis, and melanoma, while also comparing it to other cell death processes.
- It discusses the role of ferroptosis in five skin diseases and examines potential therapies targeting ferroptosis to improve skin disease management and treatment.
Unilateral polyorchidism with severe male infertility: a case report.
BMC Urol
October 2024
TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, No.37, Twelve Bridges Road, Jinniu District, Chengdu City, Sichuan Province, 610075, China.
Article Synopsis
- Polyorchidism is a rare birth condition where a male has more than two testicles, which can negatively affect fertility.
- A case study of a 34-year-old man with this condition revealed severe issues with sperm quality, even though his hormone levels were normal and no genetic problems were found.
- The findings stress the complex link between polyorchidism and male infertility, indicating the need for tailored treatment approaches and more research into its causes and effects.
Effects of probiotics on the prevention and treatment of children with allergic rhinitis: a meta-analysis of randomized controlled trials.
Front Pediatr
October 2024
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Background And Aim: Recent studies have demonstrated the anti-allergic effects of probiotics in humans. However, their role in preventing and treating pediatric allergic rhinitis has not been thoroughly investigated. This study aimed to systematically review the efficacy and preventive effects of probiotics on pediatric allergic rhinitis.
View Article and Find Full Text PDFTargeting inflammation and gut microbiota with antibacterial therapy: Implications for central nervous system health.
Ageing Res Rev
December 2024
Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Department of Cardiology, the Affiliated Hospital of Southwest Medical University and Key Laboratory of Medical Electrophysiology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. Electronic address:
The complex symbiotic relationship between inflammation, the gut microbiota, and the central nervous system (CNS) has become a pivotal focus of contemporary biomedical research. Inflammation, as a physiological defense mechanism, plays a dual role as both a protective and pathological factor, and is intricately associated with gut microbiota homeostasis, often termed the "second brain." The gutbrain axis (GBA) exemplifies this multifaceted interaction, where gut health exerts significantly regulatory effects on CNS functions.
View Article and Find Full Text PDFFerroptosis and immunosenescence in colorectal cancer.
Semin Cancer Biol
November 2024
School of Basic Medicine, Fourth Military Medical University, Xi'an 710032, China. Electronic address:
Colorectal cancer (CRC), ranked as the globe's third leading malignancy. Despite advancements in therapeutic approaches, the mortality rate remains distressingly high for those afflicted with advanced stages of the disease. Ferroptosis is a programmed form of cell death.
View Article and Find Full Text PDFTechnical specification for developing a clinical practice guideline for the integration of traditional Chinese medicine and Western medicine.
J Evid Based Med
December 2024
Beijing University of Chinese Medicine, Beijing, P. R. China.
Article Synopsis
- Developing a clinical practice guideline (CPG) for integrating Traditional Chinese Medicine (TCM) and Western Medicine (WM) involves gathering and synthesizing evidence effectively to create meaningful recommendations for specific diseases.
- Current CPGs often struggle with truly integrating TCM and WM, highlighting the need for a detailed, step-by-step guide to improve their preparation.
- This technical specification aims to simplify the process, offering healthcare professionals and researchers reliable methodology to enhance the quality and application of integrated TCM and WM guidelines.
Healthy lifestyle and HPV infection risk: results from a cross-sectional study.
Front Public Health
October 2024
Acupuncture School of Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Human Papillomavirus (HPV) infection constitutes a significant global public health challenge despite the widespread implementation of vaccination programs, with infection rates persistently high. Recent studies suggest that lifestyle factors including diet quality (DQ) and physical activity (PA) could play a pivotal role in the mitigation of HPV infections. This investigation explored the influence of DQ, PA, and a healthy lifestyle on the incidence of HPV infection in adult women.
View Article and Find Full Text PDFPhotothermal FeO nanoparticles induced immunogenic ferroptosis for synergistic colorectal cancer therapy.
J Nanobiotechnology
October 2024
Interventional Cancer Institute of Chinese Integrative Medicine & Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Article Synopsis
- Photothermal therapy (PTT) is a non-invasive treatment that not only kills cancer cells but also helps activate the immune system, although the tumor environment can limit its effectiveness.
- A new dual-targeted nano delivery system (GOx@FeNPs) using specific peptides enhances the delivery of PTT while inducing ferroptosis and bolstering anti-tumor immune responses specifically against colorectal cancer (CRC).
- The combination of GOx@FeNPs with an αPD-L1 immune checkpoint blocker shows a tumor inhibition rate over 90% and also allows for better imaging of tumors, making it a promising strategy for CRC immunotherapy.
Corrigendum: Effectiveness, safety, and treatment pattern of sodium zirconium cyclosilicate in Chinese patients with hyperkalemia: interim analysis from a multicenter, prospective, real-world study (Actualize Study).
Front Pharmacol
October 2024
The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
[This corrects the article DOI: 10.3389/fphar.2024.
View Article and Find Full Text PDFArticle Synopsis
- Chronic obstructive pulmonary disease (COPD) leads to ongoing issues like breathing difficulties, cough, and fatigue, significantly affecting patients’ quality of life and longevity, especially during acute exacerbations.
- Moving cupping therapy, a technique from traditional Chinese medicine, involves applying negative pressure to the skin and is suggested as a complementary treatment for acute exacerbations of COPD.
- The article evaluates the effectiveness of this therapy using health surveys and assessments, indicating that it could be a viable, cost-effective non-drug option for improving symptoms and overall well-being in COPD patients.
Fe-HCOF-PEG as a Hypoxia-Tolerant Photosensitizer to Trigger Ferroptosis and Enhance ROS-Based Cancer Therapy.
Int J Nanomedicine
October 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, People's Republic of China.
Article Synopsis
- Researchers developed a new type of hollow covalent organic framework (HCOF), named Fe-HCOF-PEG, modified to improve photodynamic therapy (PDT) effectiveness in cancer treatment, particularly in hypoxic (low oxygen) environments.
- The nanoparticles incorporate iron and are designed to enhance tumor elimination through both PDT (type I and II) and ferroptosis, a process of programmed cell death, enabling them to work effectively in different oxygen levels.
- Fe-HCOF-PEG shows promising antitumor effects and could potentially be translated into clinical applications for cancer therapy.
Efficacy and safety of 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1, 2-benzothiazin-3-carboxamide 1,1-dioxide, a rapid-acting meloxicam formulation, for analgesia after orthopaedic surgery under general anaesthesia: a randomized controlled trial.
Inflammopharmacology
December 2024
Department of Anesthesiology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, 410013, China.
Article Synopsis
- This study investigated the effectiveness and safety of a new pain medication, QP001, for managing postoperative pain in patients after orthopaedic surgery in China.
- In a clinical trial with 198 participants, those taking QP001 consumed significantly less morphine for pain relief compared to those receiving a placebo, both at 24 hours and 48 hours post-surgery.
- QP001 not only reduced the need for opioids but also had fewer adverse drug reactions, indicating it could be a promising alternative for pain management after surgery.
Exploring stem cell technology: Pioneering new pathways for female fertility preservation and restoration.
Reprod Biol
December 2024
Sichuan Provincial Woman's and Children's Hospital / The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu 610045, China. Electronic address:
Article Synopsis
- Female fertility is essential for family well-being, but factors like chemotherapy and lifestyle changes can negatively affect it, highlighting the need for preservation and restoration efforts.
- Stem cells offer potential solutions through advancements in areas like ovarian tissue freezing, in vitro culture of ovarian tissue, and creating ovarian-like organs.
- The review discusses the importance of stem cell technology in fertility preservation, the need for interdisciplinary collaboration, and personalized treatment strategies for effective fertility solutions.
LINC00941 is a diagnostic biomarker for lung adenocarcinoma and promotes tumorigenesis through cell autophagy.
J Cell Mol Med
October 2024
School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Non-small cell lung cancer (NSCLC) is a lethal malignancy. There is mounting evidence indicating that lncRNAs are crucial players with dual roles as both biomarkers and regulators across various cancers. It was reported that LINC00941 plays a cancer-promoting role in NSCLC.
View Article and Find Full Text PDFArticle Synopsis
- The increasing aging population has led to erectile dysfunction (ED) becoming a significant health issue among older men, prompting ongoing research into its relationship with aging.
- This analysis aims to create a detailed framework for developing preventive and therapeutic strategies for ED in elderly men, improving their overall quality of life.
- Findings indicate that various factors, including physical damage, vascular and neuronal issues, hormonal changes, psychological barriers, and over 20 aging-related diseases, contribute to the development of ED in older individuals.
Visual Endoscopic Retrograde Appendicitis Therapy Vs Antibiotic Therapy for Treatment of Uncomplicated Acute Appendicitis.
Am J Gastroenterol
October 2024
Department of Gastroenterology and Hepatology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China .
Introduction: Visual endoscopic retrograde appendicitis therapy (V-ERAT) involves a single-use video scope, allowing for real-time visualization of the appendiceal lumen during the procedure to treat uncomplicated acute appendicitis (AA). This study aims to compare V-ERAT to antibiotic therapy in treating uncomplicated AA.
Methods: This multicenter, retrospective cohort study was conducted at 9 hospitals in China from August 2021 to July 2023.
Crosstalk between macrophages and immunometabolism and their potential roles in tissue repair and regeneration.
Heliyon
September 2024
Department of Cardiovascular Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, 518110, China.
Article Synopsis
- Immune metabolism involves various metabolic pathways like glycolysis, TCA cycle, and fatty acid oxidation, which are crucial for cell growth and regulating cellular functions.
- Macrophage metabolism is key in tissue repair, with proinflammatory M1 macrophages relying on glycolysis and TCA, while anti-inflammatory M2 macrophages use the TCA cycle alongside fatty acid oxidation and oxidative phosphorylation.
- The article reviews the roles of glucose, lipid, and amino acid metabolism in macrophages, highlighting the need for further research in their mechanisms during tissue repair and regeneration.