2,850 results match your criteria: "Affiliated Hospital of Chengdu University of Traditional Chinese Medicine; yfmdoc@163.com.[Affiliation]"
Biosensors (Basel)
October 2024
Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Peroxynitrite (ONOO) is a reactive oxygen species (ROS) that takes part in the oxidation-reduction homeostasis while at the same time being responsible for activating numerous pathological pathways. Accordingly, monitoring the dynamic changes in ONOO concentration has attracted a great deal of attention, undoubtedly prompting the development of appropriate fluorescent chemosensors. Herein, we developed a novel N,O-chelated diphenylboron-based fluorescent probe (DPB) for ONOO featuring high selectivity, a quick response time (2.
View Article and Find Full Text PDFFront Genet
November 2024
Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Liver disease is among the top ten causes of death globally. With studies suggesting a link between gut microbiota (GM) and liver disease.
Method: We selected summary statistics data from the largest available whole-genome association study (n = 13,266) of GM by the MiBioGen consortium as the exposure, and obtained liver disease-related data from IEU Open GWAS and The NHGRI-EBI GWAS Catalog.
Sleep Breath
November 2024
Department of Nursing, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Background: Post-stroke depression (PSD) and post-stroke sleep disorders (PSSD) are common concurrent symptoms in post-stroke patients, and their early detection may have an impact on stroke recovery and prognosis. The purpose of this study is to determine the relationship between PSD and PSSD.
Methods: We systematically searched PubMed, Embase, Web of Science, Cochrane Library, APA PsycInfo, Medline, Scopus, Technology Periodical Database (VIP), China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), and WanFang Data databases for studies on the association between PSD and PSSD, with a search timeframe ranging from database construction to May 9, 2024, two researchers independently performed literature search, screening and quality assessment, and RevMan (version 5.
Nat Sci Sleep
November 2024
Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Background: Obesity is a significant risk factor for obstructive sleep apnea (OSA). The weight-adjusted-waist index (WWI) reflects weight-independent centripetal obesity. Our study aims to evaluate the relationship between WWI and OSA.
View Article and Find Full Text PDFGlob Med Genet
December 2024
Department of Respiratory Medicine, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Front Immunol
November 2024
Science and Education Department, Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China.
The skin is the largest organ in the human body and is made up of various cells and structures. Over time, the skin will age, which is not only influenced by internal factors, but also by external environmental factors, especially ultraviolet radiation. Aging causes immune system weakening in the elderly, which makes them more susceptible to dermatosis, such as type 2 inflammatory mediated pruritus.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
November 2024
School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People's Republic of China.
Objective: This study aims to evaluate the efficacy of acupuncture as an adjunct to lifestyle interventions on weight loss in simple obesity.
Methods: Potentially eligible studies that assessed anthropometric outcomes as well as glucose and lipid metabolism following acupuncture combined with lifestyle interventions in simple obesity patients were searched from eight databases from inception to October 2023. All analyses were performed using the Review Manager software v5.
Phytomedicine
November 2024
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, PR China. Electronic address:
Background: YOXINTINE contains >98 % of 20(S)-protopanaxadial (PPD), a metabolic product of ginsenosides with pre-clinical neuroprotective activity. Animal experiments and previous studies have shown that PPD has good antidepressant effect and safety.
Purpose: To evaluate YOXINTINE in treating depression compared with a placebo in Chinese patients.
Mol Cancer
November 2024
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, Sichuan Province, China.
Background: Radiographically, ground-glass nodules (GGN) and part-solid nodules (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity in their clinical manifestations, biological characteristics, and prognosis. This study aimed to explore the heterogeneity of LUAD in different radiological phenotypes and associated factors influencing tumor evolution.
Methods: We performed single-cell RNA sequencing (scRNA-seq) on tumor tissues from eight and seven cases of GGN- and PSN-LUAD, respectively, at different disease stages, including minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IAC), and metastatic lung cancer (MLC).
Chest
November 2024
Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, P. R. China. Electronic address:
Front Immunol
November 2024
Department of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Hepatocellular carcinoma (HCC) ranks among the most prevalent cancers worldwide, highlighting the urgent need for improved diagnostic and therapeutic methodologies. The standard treatment regimen generally involves surgical intervention followed by systemic therapies; however, the median survival rates for patients remain unsatisfactory. Chimeric antigen receptor (CAR) T-cell therapy has emerged as a pivotal advancement in cancer treatment.
View Article and Find Full Text PDFFront Pharmacol
November 2024
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Bioeng Biotechnol
November 2024
Department of Ultrasound, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Malignant fibroblasts (MFs) are widely present in various diseases and are characterized by connective tissue proliferation; these cells act as a physical barrier that severely limits drug delivery and affects disease outcomes. Based on this, we constructed the smart, integrated, theranostic, targeted lipid nanoprobe HMME-RG3@PFH to overcome the bottleneck in the early diagnosis and treatment of MF-related diseases. The protein glucose transporter protein 1 (GLUT-1) is overexpressed on MFs, and its ideal substrate, ginsenoside RG3 (RG3), significantly enhances the targeted uptake of HMME-RG3@PFH by MFs in a hypoxic environment and endows the nanomaterial with stealthiness to prolong its circulation.
View Article and Find Full Text PDFJ Craniofac Surg
November 2024
Department of Otolaryngology-Head and Neck Surgery, Ganzi Tibetan Autonomous Prefecture People's Hospital, Chengdu, Sichuan, China.
Objective: The authors present a case of a patient with a large branchial cleft cyst on the right side of the neck and face that rapidly increased after eating Angelica-stewed chicken.
Methods: An older adult patient was admitted to West China Hospital on February 28, 2021, with a large branchial cleft cyst. Resection of the right cervical cystic tumor and partial resection of the parotid gland were performed.
Medicine (Baltimore)
November 2024
Department of Laboratory Medicine, Medical Center Hospital of Qionglai City, Chengdu, Sichuan, China.
Front Immunol
November 2024
School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang, China.
Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular homeostasis through different mechanisms. Altered autophagy regulation affects the progression of various skin diseases, including psoriasis (PA), systemic lupus erythematosus (SLE), vitiligo, atopic dermatitis (AD), alopecia areata (AA) and systemic sclerosis (SSc).
View Article and Find Full Text PDFExp Lung Res
November 2024
Affiliated Sichuan Gem Flower Hospital of North Sichuan Medical College, Chengdu, China.
Acute lung injury (ALI) is characterized by severe hypoxemia, reduced lung elasticity, and notable pulmonary edema, often caused by infections and potentially progressing to ARDS. This article explores animal models of ALI and clarifies its main pathogenic mechanisms. we reviewed 20 years of ALI animal model advancements via PubMed, assessing clinical symptoms, histopathology, and reproducibility, and provided guidance on selecting models aligned with ALI pathogenesis.
View Article and Find Full Text PDFSci Rep
November 2024
Department of Intensive Care Unit, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xian, China.
Gastric cancer (GC) is a common digestive system cancer, characterized by a significant mortality rate. Mitochondria is an indispensable organelle in eukaryotic cells. It was previously revealed that a series of nucleus-encoded mitochondrial genes (NMG) mutations and dysfunctions potentially contribute to the initiation and progression of GC.
View Article and Find Full Text PDFNeoplasma
October 2024
Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Cogn Neurodyn
October 2024
Rehabilitation and Physical Therapy Department, Shandong University of Traditional Chinese Medicine Affiliated Hospital, No.42, Wenhuaxi Road Lixia District, Jinan, 250012 Shandong China.
Spinal cord injury (SCI), which is the injury of the spinal cord site resulting in motor dysfunction, has prompted the use of motor imagery (MI)-based brain computer interface (BCI) systems for motor function reconstruction. However, analyzing electroencephalogram signals and brain function mechanisms for SCI patients is challenging. This is due to their low signal-to-noise ratio and high variability.
View Article and Find Full Text PDFFront Pharmacol
October 2024
Department of Anorectal, The Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
PIK3CA gene encodes the p110α catalytic subunit of PI3K, which regulates the PI3K/AKT/mTOR signaling pathway. PIK3CA gene mutation is one of the most common mutations in colorectal cancer (CRC), affecting about 15%-20% of CRC patients. PIK3CA gene mutation leads to the persistent activation of the PI3K/AKT/mTOR signaling pathway, which promotes the proliferation, invasion, metastasis, and drug resistance of CRC.
View Article and Find Full Text PDFBMC Psychiatry
November 2024
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
BMC Geriatr
November 2024
Cancer Prevention and Treatment Institute of Chengdu, Department of Oncology, The Second Clinical Medical College, Chengdu Fifth People's Hospital, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.
Pharmacol Res
December 2024
Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address:
ARID1A deletion mutation contributes to improved treatment of several malignancies with immune checkpoint inhibitors (ICIs). However, its role in modulating of tumor immune microenvironment (TIME) of gastric cancer (GC) remains unclear. Here, we report an increase of CD8 T cells infiltration in GC patients with ARID1A-mutation (MUT), which enhances sensitivity to ICIs.
View Article and Find Full Text PDFJ Gastrointest Surg
November 2024
Department of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. Electronic address:
Background: Acute pancreatitis (AP) and chronic pancreatitis (CP) have high incidences and poor prognoses. The early screening of at-risk populations still awaits further study. The limitation was mainly based on observational studies, with limited sample size and the presence of confounding factors.
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