The Novel HLA-C*03:681 Allele, Identified by Sanger Dideoxy Nucleotide Sequencing in a Chinese Individual.

The HLA-C*03:681 allele differs from HLA-C*03:02:02:01 by a single non-synonymous nucleotide change in exon 3.

Interlimb and Intralimb Synergy Modeling for Lower Limb Assistive Devices: Modeling Methods and Feature Selection.

The concept of gait synergy provides novel human-machine interfaces and has been applied to the control of lower limb assistive devices, such as powered prostheses and exoskeletons. Specifically, on the basis of gait synergy, the assistive device can generate/predict the appropriate reference trajectories precisely for the affected or missing parts from the motions of sound parts of the patients. Optimal modeling for gait synergy methods that involves optimal combinations of features (inputs) is required to achieve synergic trajectories that improve human-machine interaction.

Reconfiguring Alginate-Based Supra-amphiphiles via Redox-Responsive Pickering Emulsions for Enhancing Pesticide Droplet Retention.

In view of the micro/nanostructure tunability of colloid particles, they acted as agrichemical delivery systems. Herein, supra-amphiphilic colloids were fabricated using a host-guest interfacial recognition-architected emulsion template strategy and controlled their agricultural interfacial interactions with the superhydrophobic target surface. Interestingly, the supramolecular interfacial system possessed redox-stimulated molecular reconfigurability by regulating aggregation/disaggregation behaviors.

Trajectory and predictors of post-stroke depression among patients with newly diagnosed stroke: A prospective longitudinal study.

Background: Post-stroke depression (PSD) is the most prevalent neuropsychological disorder among stroke patients, affecting approximately one-third of stroke survivors at any one time after a stroke. We identified between-person associations between post-stroke depression trajectories across 3 timepoints and predictors affecting trajectory classification among stroke patients.

Methods: This is a prospective longitudinal study using a convenience sample of 119 participants from 2 tertiary hospitals from March 2022 to September 2022.

Heterogeneous subgroups of psychological, physical and social condition and their predictors in Chinese older patients with coronary heart disease after stent implantation.

Objectives: To explore heterogeneous subgroups of the overall health condition in the older coronary heart disease patients with stent implantation and identify their predictors.

Methods: A cross-sectional study was surveyed in Hunan, China. Participants completed the general information questionnaire and PROMIS Profile-57.

Diterpenoids from Isodon serra with promising anti-MRSA activities.

A series of known diterpenoids from Isodon serra (Maxim.) Hara exhibited antibacterial activities against Staphylococcus aureus and even methicillin-resistant S. aureus (MRSA).

Reference values for exhaled nitric oxide in healthy children aged 6-18 years in China: a cross-sectional, multicenter clinical study.

Background: The reference values of eNO have certain differences among people of different countries and races. We aimed to obtain the reference value of eNO in healthy children and adolescents (6-18 years old) in China and to explore the associations between the reference values with ages, gender, heights, BMI, and regions.

Methods: We measured FeNO levels in 5949 healthy Chinese children and adolescents, FeNO and CaNO levels in 658 participants from 16 provinces of 7 administrative areas in China aged 6-18.

In-situ nanozyme catalytic amplification coupled with a universal antibody orientation strategy based electrochemical immunosensor for AD-related biomarker.

An in-situ nanozyme signal tag combined with a DNA-mediated universal antibody-oriented strategy was proposed to establish a high-performance immunosensing platform for Alzheimer's disease (AD)-related biomarker detection. Briefly, a Zr-based metal-organic framework (MOF) with peroxidase (POD)-like activity was synthesized to encapsulating the electroactive molecule methylene blue (MB), and subsequently modified with a layer of gold nanoparticles on its surface. This led to the creation of double POD-like activity nanozymes surrounding the MB molecule to form a nanozyme signal tag.

Recombinant collagen coating 3D printed PEGDA hydrogel tube loading with differentiable BMSCs to repair bile duct injury.

Bile duct injury presents a significant clinical challenge following hepatobiliary surgery, necessitating advancements in the repair of damaged bile ducts is a persistent issue in biliary surgery. 3D printed tubular scaffolds have emerged as a promising approach for the repair of ductal tissues, yet the development of scaffolds that balance exceptional mechanical properties with biocompatibility remains an ongoing challenge. This study introduces a novel, bio-fabricated bilayer bile duct scaffold using a 3D printing technique.

Lack of Nr2e1 expression in hepatocytes impaired cell survival and aggravated palmitate-induced oxidative stress.

Purpose: Nuclear receptor subfamily 2 group E member 1 (Nr2e1) has been regarded as an essential regulator in neural stem cells. However, its function is still not clear in hepatocytes. This study aimed to clarify the effects of Nr2e1-deficiency in hepatocytes in lipotoxic conditions.

Finding key genes (UBE2T, KIF4A, CDCA3, and CDCA5) co-expressed in hepatitis, cirrhosis and hepatocellular carcinoma based on multiple bioinformatics techniques.

Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Hepatitis B virus (HBV) is one of the major causes of liver cirrhosis (LC) and HCC. Therefore, the discovery of common markers for hepatitis B or LC and HCC is crucial for the prevention of HCC.

Aberrant Splicing of Intronic Variant Contribute to the Pathogenesis of X-Linked Alport Syndrome: A Case Series.

Introduction: X-linked Alport syndrome (XLAS) is caused by pathogenic variants in which lead to abnormalities of the glomerular basement membrane (GBM) structural and is characterized by progressive kidney disease, hearing loss, and ocular abnormalities. The aim of this study was to identify gene mutations in a Chinese family with XLAS by whole-exome sequencing (WES) and verified the pathogenicity of the mutation in vitro experiments.

Case Presentation: A five-generation pedigree with a total of 49 family members originating from Hainan province of China was investigated in this study.

Electropositive Citric Acid-Polyethyleneimine Carbon Dots Carrying the PINK1 Gene Regulate ATP-Related Metabolic Dysfunction in APP/PS1-N2a Cells.

(1) Background: Alzheimer's disease (AD) is characterized by β-amyloid (Aβ) peptide accumulation and mitochondrial dysfunction during the early stage of disease. PINK1 regulates the balance between mitochondrial homeostasis and bioenergy supply and demand via the PINK1/Parkin pathway, Na/Ca exchange, and other pathways. (2) Methods: In this study, we synthesized positively charged carbon dots (CA-PEI CDs) using citric acid (CA) and polyethyleneimine (PEI) and used them as vectors to express PINK1 genes in the APP/PS1-N2a cell line to determine mitochondrial function, electron transport chain (ETC) activity, and ATP-related metabolomics.

Increased CD123 HLA-DR Granulocytes in Allergic Rhinitis and Influence of Allergens on Expression of Cell Membrane Markers.

Background: It is reported that CD123 + HLA-DR- cells in PBMC are basophils, and CD203c, CD63, and FcεRI molecules are activation markers of basophils. However, little is known of CD123 + HLA-DR-cells in blood granulocytes.

Objective: To investigate the presence of CD123 + HLA-DR- cells in the blood granulocytes and peripheral PBMC of patients with allergic rhinitis (AR), as well as the impact of allergens on the cell membrane markers of basophils.

Clinical and imaging markers for the prognosis of acute ischemic stroke.

Background And Purpose: Significant differences in the outcomes observed in patients with acute ischemic stroke (AIS) have led to research investigations for identifying the predictors. In this retrospective study, we aimed to investigate the relationship of different clinical and imaging factors with the prognosis of AIS.

Materials And Methods: All clinical and imaging metrics were compared between the good and poor prognosis groups according to the modified Rankin Scale (mRS) score at 90 days after discharge.

Corrigendum: Identification of DYNLT1 associated with proliferation, relapse, and metastasis in breast cancer.

[This corrects the article DOI: 10.3389/fmed.2023.

An effective treatment and suspicious adverse reaction to Ibrutinib in a patient diagnosed with splenic B-cell lymphoma/leukaemia with prominent nucleoli: A first case report.

Rationale: Splenic B-cell lymphoma/leukemia with prominent nucleoli (SBLPN) is a new classification, which is so rare that it lacks clinical data.

Patient Concerns: An increased proportion of prolymphocytes (84%) in the bone marrow smear. Whole exon sequence analysis revealed a TP53 mutation.

Secreted frizzled-related protein 2 ameliorates diabetic cardiomyopathy by activating mitophagy.

Objectives: Secreted frizzled-related protein 2 (SFRP2), a novel adipokine that used to be considered an inhibitor of the canonical Wnt pathway, may play a protective role in metabolic disorders. However, its effect on diabetic cardiomyopathy was still unclear. Accumulating evidence indicates that mitophagy can protect cardiac function in the diabetic heart.

The outcome and the risk factors of mucormycosis among patients with hematological diseases: a systematic and meta-analysis.

Objectives: has come into a significant pathogen over recent decades. Nonetheless, mucormycosis-related mortality rates among patients with hematological disorders remain unascertained. Thus, we conducted a meta-analysis to determine mortality rates of mucormycosis in patients with hematology-related conditions.