5 results match your criteria: "Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics[Affiliation]"
Evaluation of the Anti-Viral Activity of Human Recombinant Interferon Lambda-1 against SARS-CoV-2.
Bull Exp Biol Med
November 2021
Research Institute of Clinical and Experimental Lymphology - an Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
The antiviral activity of recombinant human IFN-lambda type 1 (IFNλ-1) against culture strain of SARS-CoV-2 virus was determined by infecting a highly sensitive VeroE6 coronavirus cell culture after preincubation test (the cell monolayer was incubated with 4-fold dilutions of IFNλ-1 in a concentration range of 0.16-42,500 ng/ml in a culture medium for 12 h at 37°C) and without preincubation (simultaneous addition of different concentrations of IFNλ-1 and SARS-CoV-2 infection in a dose of 102 TCID50). The created recombinant human IFNλ-1 demonstrated obvious antiviral activity against SARS-CoV-2 virus in vitro.
View Article and Find Full Text PDFEffect of Melatonin on Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Ovarian Follicular Apparatus after High Temperature Exposure.
Bull Exp Biol Med
March 2021
Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.
Expression of proapoptotic Bad and antiapoptotic Bcl-2 proteins in ovarian follicular apparatus of Wistar rats was evaluated on days 3, 7, and 14 after single experimental hyperthermia (EH) followed by therapeutic correction with subcutaneous melatonin (0.1 mg) dissolved in 0.2 ml physiological saline (PS) injected daily for 3 days.
View Article and Find Full Text PDFEffect of a New Lithium Preparation on the Behavior of CBA/CaLac Mice in an Experimental Conflict Model.
Bull Exp Biol Med
February 2021
Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
The use of lithium drugs in clinical practice requires constant monitoring of lithium plasma concentration, because toxicity is sometimes observed at therapeutic concentrations of lithium. This is often associated with fluctuations of plasma concentration of lithium ions after intake of individual doses. Therefore, the use of a porous carrier providing a stable blood level of the drug is extremely promising and important for clinical practice.
View Article and Find Full Text PDFEffect of Polyethylene Terephthalate on Functional Properties of Endothelial and Mesenchymal Cells.
Bull Exp Biol Med
February 2019
E. N. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Article Synopsis
- The study examined how vascular prostheses made from materials like polytetrafluoroethylene and polyethylene terephthalate affect the behavior of various types of stem cells and endothelial cells.
- Synthetic prostheses were found to hinder the growth and movement of these cells, which could impact healing and integration.
- However, treating the prosthesis surfaces with proteins such as fibronectin or gelatin improved cell colonization, suggesting a way to enhance their performance.
Expression of Bcl-2 Family Proteins in the Ovarian Follicular Apparatus in the Acute Period after Experimental Hyperthermia.
Bull Exp Biol Med
April 2018
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Science, Novosibirsk, Russia.
The expression of apoptosis regulators (proapoptotic protein Bad and anti-apoptotic protein Bcl-2) was analyzed and Bcl-2/Bad ratio in the follicular apparatus of the rat ovary was determined on day 3 after hyperthermia (rectal temperature 43.5°C). Hyperthermia in the catabolic phase leads to different degrees of activation of the molecular "switches" of apoptosis in cells of ovarian follicular epithelium.
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