The inhibitory effects of nimotuzumab on CD276 expression and immune escape in head and neck squamous cell carcinoma: Insights into anticancer mechanisms.

CD276 has been identified as a novel immune checkpoint, and its overexpression is associated with immune evasion and poor prognosis in various tumors, including head and neck squamous cell carcinoma (HNSCC). Nimotuzumab, a humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody, has been approved for various solid tumors. However, it remains unclear whether its anticancer efficacy involves a reduction in CD276 expression.

[Clinical significance of four quadrant localization in the diagnosis and treatment of metastatic carcinoma of the neck with unknown primary].

The aim of this study is to investigate the clinical significance of four quadrant localization in the diagnosis and treatment of unknown primary cervical metastases. The clinical data with unknown primary cervical metastases, were analyzed retrospectively. All the patients have not been found the original site in the initial treatment.

Excitotoxic effects of glutamate on cochlear organotypic cultures.

Glutamate (Glu) is the major afferent excitatory neurotransmitter in the auditory system, and excessive Glu may play an important role in cochlear dysfunction. It is unclear how excessive Glu plays roles in cochlear dysfunction in cochlear organotypic cultures. In this study neonatal rat cochlear organotypic cultures were prepared, and then the cochlear tissues were incubated with a new medium containing specific concentrations of Glu (0.

Parsimonious model for blood glucose level monitoring in type 2 diabetes patients.

To establish the parsimonious model for blood glucose monitoring in patients with type 2 diabetes receiving oral hypoglycemic agent treatment. One hundred and fifty-nine adult Chinese type 2 diabetes patients were randomized to receive rapid-acting or sustained-release gliclazide therapy for 12 weeks. Their blood glucose levels were measured at 10 time points in a 24 h period before and after treatment, and the 24 h mean blood glucose levels were measured.

Multidisciplinary collaborative therapy for 30 children with orbital rhabdomyosarcoma.

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS).

Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012.

[The application of vibrant sound bridge in microtia whose reconstructive external auditory canal occurred atresia].

Objective: To investigate the effect of vibrant sound bridge implantation in microtia whose reconstructive external auditory canal occurred atresia.

Method: Three cases (2 males and 1 female) of microtia had underwent hearing reconstruction operation (Include the external ear canal reconstructive surgery and tympanoplasty). The age ranged from 15 to 18 years and the average age was 17 years.

[Effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement measured with high-speed digital microscopy].

Objective: To investigate the effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement.

Methods: Ciliary beat frequency (CBF) of cultured human nasal epithelial cells was measured by high-speed digital microscopy in HBSS and oxymetazoline hydrochloride of different concentrations in 20 minutes. RESULTS; CBF of cultured nasal epithelial cells in HBSS and 0.

[Objective evaluation of the patency of nasal airway].

Objective: To obtain the normal values of acoustic rhinometry and rhinomanometry in adult Chinese, analyze the effect of sex and age on the value and investigate the correlation between the two methods.

Method: One hundred and three normal adults were recruited, Eccovision acoustic rhinometry was used to measure the minimum cross-sectional area (MCA) and the nasal volume from 0-5 cm, 2-5 cm, 0-7 cm (V5, V2-5, V7); ATMO 300 Rhinomanometry was used to measure unilateral and bilateral nasal resistance at 75 Pa and 150 Pa point (R75, R150, R75T, R150T) by anterior active rhinomanometry.

Result: MCA was (0.

Effect of oxymetazoline on healthy human nasal ciliary beat frequency measured with high-speed digital microscopy and mucociliary transport time.

Objectives: We investigated the effects of oxymetazoline hydrochloride on the regulation of healthy human nasal ciliary beat frequency (CBF) and its influence on nasal mucociliary transport time (MTT).

Methods: Changes in (cultured) human nasal CBF in response to increasing concentrations of oxymetazoline within 20 minutes were quantified by use of high-speed digital microscopy. Moreover, the MTT before and after application of 0.

[Misdiagnosis of obstructive sleep apnea hypopnea syndrome].

Objective: To enhance the understanding of obstructive sleep apnea hypopnea syndrome (OSAHS) and lower its misdiagnosis.

Methods: 6 misdiagnosed cases were analyzed systemically.

Results: OSAHS can be misdiagnosed as primary hypertension, arrhythmia, asthma, acalcerosis and some other diseases.