Cochlear implantation in children without preoperative computed tomography diagnostics. Analysis of procedure and rate of complications.

Introduction: To evaluate the safety in cochlear implantation without preoperative computed tomography diagnostics, which was implemented into the protocol of cochlear implantation in 2013, since in the year before, new evidence concerning the risks of ionizing radiation especially in children arose.

Methods: In this retrospective data analysis 89 children under 36 months, which were cochlear implanted from 2008 until 2018 at a tertiary referral centre with a large cochlear implant program were analysed. Fortyfour of the children were implanted before the date of change in 2013 and 45 in the following years up to now.

Direct Drive Simulation-Preoperative Sound Simulation of "Vibroplasty-Hearing" in Patients With Mixed Hearing Loss.

Objective: Validation of the preoperative sound simulation test for vibroplasty-hearing so-called "Direct Drive Simulation" (DDS) in case of mixed hearing loss.

Study Design: Retrospective data analysis.

Setting: Tertiary referral center with a large hearing implant program.

Bilateral cochlear implantation is regarded as very beneficial: results from a worldwide survey by online questionnaire.

Purpose: Bilateral cochlear implant (CI) provision is now widely regarded as the most beneficial hearing intervention for acceptable candidates. This study sought to determine if a number of well-regarded hearing professionals at highly reputable clinics shared similar practices and beliefs regarding bilateral CI provision, use, and rehabilitation in children and adults.

Methods: An 11-question online questionnaire was created and distributed to all 27 clinics in the HEARRING group.

Cochlear Implantation in Chronic Otitis Media: Investigation of Long-term Speech Comprehension and Rate of Complications.

Objective: To analyze the long-term speech comprehension and rate of complications of cochlear implantation in chronic otitis media.

Study Design: Retrospective data analysis.

Setting: Tertiary referral center with a large cochlear implant program.

Patterned semiconductor structures modulate neuronal outgrowth: Implication for the development of a neurobionic interface.

Auditory implants stimulate the neurons by broad electrical fields, which leads to a low number of spectral channels. A reduction in the distance between the electrode and the neuronal structures might lead to better electrical transduction. The use of microstructured semiconductors offers a large number of contacts, which could attract neurons and stimulate them individually.

Stable Longitudinal Performance of Adult Cochlear Implant Users for More Than 10 Years.

Objective: To analyze the long-term performance of cochlear implant patients.

Study Design: Retrospective longitudinal study.

Setting: Tertiary referral center with a large cochlear implant program.

Cochlear nucleus whole mount explants promote the differentiation of neuronal stem cells from the cochlear nucleus in co-culture experiments.

The cochlear nucleus is the first brainstem nucleus to receive sensory input from the cochlea. Depriving this nucleus of auditory input leads to cellular and molecular disorganization which may potentially be counteracted by the activation or application of stem cells. Neuronal stem cells (NSCs) have recently been identified in the neonatal cochlear nucleus and a persistent neurogenic niche was demonstrated in this brainstem nucleus until adulthood.

Mosaic pattern of Cre recombinase expression in cochlear outer hair cells of the Brn3.1 Cre mouse.

The Brn3.1 gene encodes for the protein Brn3.1, which is a member of the POU-IV class of transcription factors.

Isolation and characterization of neural stem cells from the neonatal rat cochlear nucleus.

Neural stem cells have been identified in multiple parts of the postnatal mammalian brain, as well as in the inner ear. No investigation of potential neural stem cells in the cochlear nucleus has yet been performed. The aim of this study was to investigate potential neural stem cells from the cochlear nucleus by neurosphere assay and in histological sections to prove their capacity for self-renewal and for differentiation into progenitor cells and cells of the neuronal lineage.