Terahertz scanning near-field optical microscopy for biomedical detection: Recent advances, challenges, and future perspectives.

Terahertz (THz) radiation is widely recognized as a non-destructive, label-free, and highly- sensitive tool for biomedical detections. Nevertheless, its application in precision biomedical fields faces challenges due to poor spatial resolution caused by intrinsically long wavelength characteristics. THz scanning near-field optical microscopy (THz-SNOM), which surpasses the Rayleigh criterion, offers micrometer and nanometer-scale spatial resolution, making it possible to perform precise bioinspection with THz imaging.

Computational study of the impact of nasal vestibule anatomy on nasal drug administration with nasal spray.

The nasal airway comprises a complex network of passages and chambers and plays an important role in regulating the respiratory system's functions. The nasal vestibule is the first chamber of the nasal airway. While variations in nasal vestibule geometries are known to exist between humans, details of their implications on how they may affect the efficacy of nasal drug delivery devices are less clear.

Comparative Efficacy and Safety of Different Low-Dose Platelet Inhibitors in Patients With Coronary Heart Disease: A Bayesian Network Meta-Analysis.

Objective: The optimal low-dose antiplatelet agents in patients with coronary heart disease (CHD) had not been determined. The objective of this study was to compare the impact of different low-dose antiplatelet agents on cardiovascular outcomes and bleeding risks in patients with CHD.

Methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, VIP, WanFang Data, and China Biology Medicine.

The Validity of Radiographic Measurements Compared to 3D-surface Model-Based Measurements in Shoulders with Reverse Total Shoulder Arthroplasty.

Background: Postoperative assessment following reverse total shoulder arthroplasty (rTSA) typically involves plain radiographs to evaluate implant positioning parameters, such as humeral distalization and lateralization along with medialization and distalization of the center of rotation (COR). However, the precision of these radiographic measurements remains unclear. This study aimed to validate the accuracy of radiographic two-dimensional (2D) measurements compared to three-dimensional (3D) surface model-based measurements derived from CT data for evaluating postoperative parameters in rTSA.

Spatial modeling algorithms for reactions and transport in biological cells.

Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, particularly in realistic cell geometries. Here we present Spatial Modeling Algorithms for Reactions and Transport (SMART), a software package that takes in high-level user specifications about cell signaling networks and then assembles and solves the associated mathematical systems.

Aerospace medicine in China: advancements and perspectives.

With the rapid growth of China's space industry, long-term manned space missions face challenges from the complex space environment, posing risks to human health. Aerospace medicine, a key field, addresses these risks by researching the impacts of space on biochemical changes, cognitive abilities, and immune systems. This article reviews China's aerospace medicine research, summarizing efforts from various institutions and offering insights for future developments in the field.

Quantifying the Impact of Sustained Acceleration on Critical Care Transport Medical Equipment.

Introduction: Military and commercial stakeholders are investing to explore the use of hypersonic aircraft and orbital spacecraft to transport cargo, medical supplies, passengers, and casualties. These vehicle platforms require periods of sustained acceleration, but to date, these dynamic forces have not been comprehensively considered in the environment of critical care patient movement because injured patients and advanced aeromedical evacuation (AE) equipment are rarely subjected to these conditions. While military AE equipment does undergo crash hazard acceleration testing, equipment functionality during or after sustained acceleration remains to be evaluated.

Development and Evaluation of a Novel Drainage Cannula for Venoarterial Extracorporeal Membrane Oxygenation.

A critical factor in thrombus formation during venoarterial extracorporeal membrane oxygenation (VA ECMO) is prothrombotic flow dynamics generated by the drainage cannula's design. This study aimed to create and evaluate a novel drainage cannula design which optimized blood flow dynamics to reduce thrombus formation. Computational fluid dynamics (CFD) was used to iteratively vary drainage cannula design parameters such as inner wall shape and side hole shape.

Prognostic Value of Systemic Inflammatory Markers in Elderly Patients with Tumor-associated Venous Thromboembolism.

Background: Elderly tumor patients are more prone to venous thrombotic events than nontumor patients. To investigate the relationship between systemic inflammatory markers and overall survival (OS) in elderly patients with tumorassociated venous thromboembolism (TAVTE). And to evaluate the prognostic value of combined lymphocyte platelettolymphocyte ratio (PLR) with neoplasm metastasis in elderly patients.

Association between adherence to behavioral intervention and capability well-being among parents of autistic children: a cross-sectional study from China.

Background: High adherence to behavioral interventions among parents of autistic children contribute to improvement in children's behaviors and parental outcomes. However, most of previous studies focused on the effects of intervention adherence on health-related well-being among parents, which is inadequate to capture the multi-dimensional parental burden of caring for autistic children. The aim of this study is to assess the association between parents' adherence to behavioral intervention and their capability well-being.

Variables Affecting the Histological Quality of Prostate Core Biopsy Samples in Cancer Detection.

The examination of the prostate biopsy procedure is essential in the optimization of the diagnostic pathway of such a prevalent affliction as prostate cancer among men worldwide. With the core needle biopsy being the standard of care for the diagnosis of prostate cancer, the ability to obtain quality core samples is directly related to patient treatment and diagnostic reliability. Needle deflection and dynamic tissue deformation are two chief sources of unrepresentative samples outside of human error.

Comprehensive review on Alzheimer's disease: From the posttranslational modifications of Tau to corresponding treatments.

Alzheimer's disease (AD) is a neurodegenerative disease, which is mainly characterized by the abnormal deposition of β-amyloid peptide (Aβ) and Tau. Since Tau aggregation is more closely associated with synaptic loss, neurodegeneration, and cognitive decline than Aβ, the correlation between Tau and cognitive function in AD has gradually gained attention. The posttranslational modifications (PTMs) of Tau are key factors contributing to its pathological changes, which include phosphorylation, acetylation, ubiquitination, glycosylation, glycation, small ubiquitin-like modifier mediated modification (SUMOylation), methylation, succinylation, etc.

The global effect of aortic coarctation on carotid and renal pulsatile hemodynamics.

Coarctation of the aorta (CoA) is a congenital disease characterized by the narrowing of the aorta, typically the descending portion after the left subclavian artery. If left untreated, by the time individuals reach 50 years of age, the mortality rate can reach 90%. Previous studies have highlighted the adverse effects of CoA on local hemodynamics.

AAV-regulated overexpression promotes hair cell regeneration.

Inner ear hair cell (HC) damage is irreversible in mammals, but it has been shown that supporting cells (SCs) have the potential to differentiate into HCs. , a serine protease inhibitor, encodes protease nexin 1, and this has been suggested to be a factor that promotes HC regeneration. In this study, we overexpressed in inner ear SCs cultured in two- and three-dimensional systems using the adeno-associated virus-inner ear (AAV-ie) vector, which promoted organoid expansion and HC differentiation.

Discovery of a Small Molecule with an Inhibitory Role for RAB11.

RAB11, a pivotal RabGTPase, regulates essential cellular processes such as endocytic recycling, exocytosis, and autophagy. The protein was implicated in various human diseases, including cancer, neurodegenerative disorders, viral infections, and podocytopathies. However, a small-molecular inhibitor is lacking.

DNA Damage and Inflammatory Response of p53 Null H358 Non-Small Cell Lung Cancer Cells to X-Ray Exposure Under Chronic Hypoxia.

Hypoxia-induced radioresistance limits therapeutic success in cancer. In addition, p53 mutations are widespread in tumors including non-small cell lung carcinomas (NSCLCs), and they might modify the radiation response of hypoxic tumor cells. We therefore analyzed the DNA damage and inflammatory response in chronically hypoxic (1% O, 48 h) p53 null H358 NSCLC cells after X-ray exposure.

Effect of Community-Based Integrated Care for Patients With Diabetes and Depression (CIC-PDD) in China: A Pragmatic Cluster-Randomized Trial.

Objective: To develop a care model for patients with both diabetes and depression and assess the model's effectiveness.

Research Design And Methods: In this pragmatic cluster randomized trial, we allocated eight community health centers into two groups: the enhanced usual care group and the intervention group. A comprehensive care plan was developed for the intervention group based on the integrated care model.

Accurate attenuation characterization in optical coherence tomography using multi-reference phantoms and deep learning.

The optical attenuation coefficient (AC), a crucial tissue parameter indicating the rate of light attenuation within a medium, enables quantitative analysis of tissue properties and facilitates tissue differentiation. Despite its growing clinical significance, accurate quantification of AC from optical coherence tomography (OCT) signals remains a pressing concern. This study comprehensively investigates the factors influencing the accuracy of quantitative AC extraction among existing OCT-based AC extraction algorithms.

Teaching Climate and Health in Preventive Medicine Residency Programs: A Survey of Program Directors.

Climate change and related pollution and environmental damage are an urgent focus for public health physicians. Curricular content is increasing in medical schools, but to date, only pediatrics has published guidance for residency education. To survey program directors of Accreditation Council for Graduate Medical Education preventive medicine specialties (public health and preventive medicine [PHPM], occupational and environmental medicine [OEM], and aerospace medicine [AM]) for current teaching on climate and health issues.

Microfluidic impedance flow cytometer leveraging virtual constriction microchannel and its application in leukocyte differential.

Microfluidic impedance flow cytometry has been widely used in leukocyte differential and counting, but it faces a bottleneck due to the trade-off between impedance detection throughput and sensitivity. In this study, a microfluidic impedance flow cytometer based on a virtual constriction microchannel was reported, in which the virtual constriction microchannel was constructed by crossflow of conductive sample and insulated sheath fluids with underneath micro-electrodes for impedance measurements. Compared to conventional mechanical constriction microchannels, this virtual counterpart could effectively avoid direct physical contact between cells and the microchannel walls to maintain high throughputs, and significantly reduce the volume of the impedance detection region for sensitivity improvements.

3D printing of bacterial poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/poly(lactide-co-glycolide) blend loaded with β-tricalcium phosphate for the development of scaffolds to support human mesenchymal stromal cell proliferation.

Polyhydroxyalkanoates (PHAs) are microbially produced aliphatic polyesters investigated for tissue engineering thanks to their biocompatibility, processability, and suitable mechanical properties. Taking advantage of these properties, the present study investigates the development by 3D printing of bacterial poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffolds loaded with β-tricalcium phosphate (β-TCP) for bone tissue regeneration. PHBV blending with poly(lactide-co-glycolide) (PLGA) (30 wt%) was exploited to enhance material processability via an optimized computer-aided wet-spinning approach.

A multi-view contrastive learning and semi-supervised self-distillation framework for early recurrence prediction in ovarian cancer.

Objective: This study presents a novel framework that integrates contrastive learning and knowledge distillation to improve early ovarian cancer (OC) recurrence prediction, addressing the challenges posed by limited labeled data and tumor heterogeneity.

Methods: The research utilized CT imaging data from 585 OC patients, including 142 cases with complete follow-up information and 125 cases with unknown recurrence status. To pre-train the teacher network, 318 unlabeled images were sourced from public datasets (TCGA-OV and PLAGH-202-OC).

Super-resolution left ventricular flow and pressure mapping by Navier-Stokes-informed neural networks.

Intraventricular vector flow mapping (VFM) is an increasingly adopted echocardiographic technique that derives time-resolved two-dimensional flow maps in the left ventricle (LV) from color-Doppler sequences. Current VFM models rely on kinematic constraints arising from planar flow incompressibility. However, these models are not informed by crucial information about flow physics; most notably the forces within the fluid and the resulting accelerations.

Consensus Guideline for Care of Patients in the Prehospital and Aerospace Settings with Exposures to Hydrazine and Hydrazine Derivatives.

Objectives: Hydrazine (HZ) and Hydrazine Derivative (HZ-D) exposures pose health risks to people in industrial and aerospace settings. Several recent systematic reviews and case series have highlighted common clinical presentations and management strategies. Given the low frequency at which HZ and HZ-D exposures occur, a strong evidence base on which to develop an evidence-based guideline does not exist at this time.

Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review).

Ferroptosis is a novel form of regulated cell death that plays a key role in inhibiting tumor malignancy. The ferroptosis signalling cascade provides new opportunities for lung cancer therapy. Non‑coding RNA (ncRNA)‑mediated epigenetic modification can influence the vulnerability of cancer cells to ferroptosis in non‑small‑cell lung cancer (NSCLC).