The Sub 2-h Official Marathon is Possible: Developing a Drafting Strategy for a Historic Breakthrough in Sports.

Background: Drafting for drag reduction is a tactic commonly employed by elite athletes of various sports. The strategy has been adopted by Kenyan runner Eliud Kipchoge on numerous marathon events in the past, including the 2018 and 2022 editions of the Berlin marathon (where Kipchoge set two official world records), as well as in two special attempts to break the 2 h mark for the distance, the Nike Breaking2 (2017) and the INEOS 1:59 Challenge (2019), where Kipchoge used an improved drafting formation to finish in 1:59:40, although that is not recognized as an official record.

Results: In this study, the drag of a realistic model of a male runner is calculated by computational fluid dynamics for a range of velocities.

Integrating competency-based, interprofessional teamwork education for students: guiding principles to support current needs and future directions.

Interprofessional teamwork is vital to effective patient care, and targeting healthcare learners earlier in their education can lead to greater improvement in confidence and competence in teamwork skills. Despite this, institutions have continued struggling to integrate competency-based interprofessional teamwork curriculum in undergraduate health care professions' education. The current article provides guidance related to design, implementation, and assessment for institutions seeking to implement competency-based teamwork education and training strategies for healthcare students.

Spillover of active oxygen intermediates of binary RuO/NbO nanowires for highly active and robust acidic oxygen evolution.

Over-oxidation of surface ruthenium active sites of RuO-based electrocatalysts leads to the formation of soluble high-valent Ru species and subsequent structural collapse of electrocatalysts, which results in their low stability for the acidic oxygen evolution reaction (OER). Herein, a binary RuO/NbO electrocatalyst with abundant and intimate interfaces has been rationally designed and synthesized to enhance its OER activity in acidic electrolyte, delivering a low overpotential of 179 mV at 10 mA cm, a small Tafel slope of 73 mV dec, and a stabilized catalytic durability over a period of 750 h. Extensive experiments have demonstrated that the spillover of active oxygen intermediates from RuO to NbO and the subsequent participation of lattice oxygen of NbO instead of RuO for the acidic OER suppressed the over-oxidation of surface ruthenium species and thereby improved the catalytic stability of the binary electrocatalysts.

Mixed Pt-Ni Halide Perovskites for Photovoltaic Application.

CsPtI is a promising photoabsorber with a direct bandgap of 1.4 eV and a high carrier lifetime; however, the cost of Pt inhibits its commercial viability. Here, we performed a cost analysis and experimentally explored the effect of replacing Pt with earth-abundant Ni in solution-processed Cs(PtNi)(I,Cl) thin films on the properties and stability of the perovskite material.

Examining the Emotional and Physical Health Impact in Users of Open-Source Automated Insulin Delivery and Sources of Support: Qualitative Analysis of Patient Narratives.

Background: Although commercially developed automated insulin delivery (AID) systems have recently been approved and become available in a limited number of countries, they are not universally available, accessible, or affordable. Therefore, open-source AID systems, cocreated by an online community of people with diabetes and their families behind the hashtag #WeAreNotWaiting, have become increasingly popular.

Objective: This study focused on examining the lived experiences, physical and emotional health implications of people with diabetes following the initiation of open-source AID systems, their perceived challenges, and their sources of support, which have not been explored in the existing literature.

Detecting Gravitational Wave Memory in the Next Galactic Core-Collapse Supernova.

We present an approach to detecting (linear) gravitational wave memory in a Galactic core-collapse supernova using current interferometers. Gravitational wave memory is an important prediction of general relativity that has yet to be confirmed. Our approach uses a combination of linear prediction filtering and matched filtering.

CHARMER: detecting and harmonizing high-confidence chromatin interactions across tissues and Hi-C protocols.

Motivation: Chromatin conformation capture experiments (CCC), such as Hi-C and Capture Hi-C (CHiC) work to elucidate the three-dimensional organization of the genome and the underlying epigenetic regulatory structures within. CCC experiments produce large amounts of FASTQ sequencing data with a substantial amount of technical noise and require sophisticated computational pipelines in order to extract meaningful results. Large-scale CCC data repositories like 4D Nucleome and ENCODE mostly provide raw contact information but lack annotated, statistically significant interaction data suitable for downstream genetic and genomic analyses.

Impacts of Thunderstorm-Generated Gravity Waves on the Ionosphere-Thermosphere Using TIEGCM-NG/MAGIC Simulations and Comparisons With GNSS TEC, ICON, and COSMIC-2 Observations.

We use the TIEGCM-NG nudged by MAGIC gravity waves to study the impacts of a severe thunderstorm system, with a hundred tornado touchdowns, on the ionospheric and thermospheric disturbances. The generated waves induce a distinct concentric ring pattern on GNSS TIDs with horizontal scales of 150-400 km and phase speeds of 150-300 m/s, which is well simulated by the model. The waves show substantial vertical evolution in period, initially dominated by 0.

Clusters induced electronic delocalization of single atom sites toward efficient electrocatalytic urea synthesis from CO and N.

Electrocatalytic conversion of CO and N into urea product is highly envisaged, whereas symmetrical electronic architecture of inert reactant severely prevents their adsorption and activation and further entail extremely low intrinsic activity. Herein, a novel electrocatalyst consisting of Co clusters and CoN single-atoms dispersed on a carbon matrix is demonstrated to achieve the highest recorded urea yield rate of 20.83 mmol h g and Faradaic efficiency (FE) of 23.

Coming out of isolation: impacts of COVID-19 on physical activity, diet, mental well-being, and sleep over time.

Introduction: The COVID-19 pandemic lockdown significantly disrupted daily routines and impacted physical activity, diet, mental well-being, and sleep. This mixed-methods study investigates these changes over three periods-pre-pandemic, pandemic onset, and one-year post-onset-to understand their causes and inform public health policy for improved resilience during future crises.

Methods: A mixed-methods study was conducted with 34 US participants who completed open-ended qualitative questions and quantitative assessments in May 2020 and May 2021.

Handoff Mnemonics Used in Perioperative Handoff Intervention Studies: A Systematic Review.

Background: Perioperative handoffs are known to present unique challenges to safe and effective patient care. Numerous national accrediting bodies have called for standardized, structured handoff processes. Handoff mnemonics provide a memory aid and standardized structure, as well as promote a shared mental model.

A Novel Checklist Approach to Reduce Time Under Anesthesia in Neurosurgery.

Background: Neurosurgical procedures require meticulous preparation, including extra measures to ensure patient safety and the appropriate setup of the operating room, which must be fully established before the surgeon can initiate the first incision. Neurosurgical delay encompasses the time from anesthesia induction start to when the neurosurgeon makes the first incision.

Methods: 30 neurosurgery procedures were observed randomly.

BAB-GSL: Using Bayesian influence with attention mechanism to optimize graph structure in basic views.

In recent years, Graph Neural Networks (GNNs) have garnered significant attention, with a notable focus on Graph Structure Learning (GSL), a branch dedicated to optimizing graph structures to enhance network training performance. Current GSL methods primarily involve constructing optimized graph representations by analyzing one or more initial graph sources to improve performance in subsequent application tasks. Despite these advancements, achieving high-quality graphs that accurately and robustly reflect node relationships remains challenging.

To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants.

In the era of renewed space exploration, comprehending the effects of the space environment on human health, particularly for deep space missions, is crucial. While extensive research exists on the impacts of spaceflight, there is a gap regarding female reproductive risks. We hypothesize that space stressors could have enduring effects on female health, potentially increasing risks for future pregnancies upon return to Earth, particularly related to small-for-gestational-age (SGA) fetuses.

Optimizing Production, Characterization, and In Vitro Behavior of Silymarin-Eudragit Electrosprayed Fiber for Anti-Inflammatory Effects: A Chemical Study.

Inflammatory Bowel Disease (IBD) is a chronic condition that affects approximately 1.6 million Americans. While current polyphenols for treating IBD can be expensive and cause unwanted side effects, there is an opportunity regarding a new drug/polymer formulation using silymarin and an electrospray procedure.

In-situ detection of delamination reinitiation in carbon fiber reinforced polymers post barely visible impact damage.

In this study, advancements are presented in the in-situ detection of delamination reinitiation from Barely Visible Impact Damage (BVID) in composite materials, utilizing enhancements in Digital Image Correlation (DIC) techniques during a Compression After Impact (CAI) test. The study measured strain fields in the longitudinal, transverse, and shear directions, focusing specifically on the point of highest out-of-plane displacement to identify the onset of delamination propagation from BVID sites generated at different impact energy levels. By correlating the measured strains with the peak out-of-plane displacement, a unique determination of onset damage reinitiation associated with BVID during CAI testing was achieved.

Synthesis of a new oil-absorbing PVC oil boom and its application to maritime oil spills.

This paper aims to address the issue of environmental pollution resulting from marine oil spills by evaluating the oil adsorption performance of commonly used fence materials. Conventional oil adsorption materials exhibit limited rates and capacities for oil adsorption. Existing methods have proven insufficient in meeting the requirements for efficient and rapid oil-water separation.

Integrating behavioral assessment in instructional design for competency-based medical education.

As institutions continuously strive to align with the standards set forth within competency-based medical education, there is an increased need to produce evidence of learner achievement in the form of observable behaviors. However, the complexity of healthcare education and clinical environments make it challenging to generate valid and reliable behavioral assessments. In this article, we utilize our interdisciplinary knowledge from the perspectives of experts in medical education, assessment, and academic administration to provide tips to successfully incorporate behavioral assessments into instructional designs.

Daily variation in sleepiness among firefighters while working the 24/48 and 48/96 shift schedules.

Objective: To assess the daily relationship between prior-night total sleep time (TST) and next-day, afternoon sleep propensity among firefighters operating from two popular fire department shift schedules.

Methods: Dataset included 22 firefighters (24/48 shift schedule) and 20 firefighters (48/96 shift schedule). Daily TST was assessed using actigraphy and daily sleep propensity was assessed using the Epworth Sleepiness Scale (ESS), completed every afternoon.

Understanding exercise (in)tolerance in sickle cell disease: impacts of hemolysis and exercise training on skeletal muscle oxygen delivery.

Sickle cell disease (SCD) is characterized by central (cardiac) and peripheral vascular dysfunctions, significantly diminishing exercise capacity and quality of life. Although central cardiopulmonary abnormalities in SCD are known to reduce exercise capacity and quality of life; the impact of hemolysis and subsequent cell-free hemoglobin (Hb)-mediated peripheral vascular abnormalities on those outcomes are not fully understood. Despite the recognized benefits of exercise training for cardiovascular health and clinical management in chronic diseases like heart failure, there remains substantial debate on the advisability of regular physical activity for patients with SCD.

Earth's ambipolar electrostatic field and its role in ion escape to space.

Cold plasma of ionospheric origin has recently been found to be a much larger contributor to the magnetosphere of Earth than expected. Numerous competing mechanisms have been postulated to drive ion escape to space, including heating and acceleration by wave-particle interactions and a global electrostatic field between the ionosphere and space (called the ambipolar or polarization field). Observations of heated O ions in the magnetosphere are consistent with resonant wave-particle interactions.

Tracking Studies on the Effects of Qi Gong Fitness on Stress, Anxiety, and Depression Among Underprivileged Working Youth.

Objective: This study aimed to evaluate the effectiveness of Qi Gong fitness in alleviating stress, anxiety, and depression among underprivileged working youth with a follow-up study.

Methods: Eighty subjects were randomly assigned to normal groups (NG) and treatment groups (TG), with 40 participants in each group. The Perceived Stress Scale (PSS), Generalized Anxiety Disorder 7 (GAD-7), and 24-Item Hamilton Rating Scale for Depression (HAMD-24) were used to evaluate the effect of Qi Gong fitness on alleviating stress, anxiety, and depression symptoms in underprivileged working youth.