251,318 results match your criteria: "Advanced Scientific Technology & Management Research Institute of Kyoto[Affiliation]"

In the fields of engineering, science, technology, and medicine, artificial intelligence (AI) has made significant advancements. In particular, the application of AI techniques in medicine, such as machine learning (ML) and deep learning (DL), is rapidly growing and offers great potential for aiding physicians in the early diagnosis of illnesses. Depression, one of the most prevalent and debilitating mental illnesses, is projected to become the leading cause of disability worldwide by 2040.

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Exploring the Credibility of Large Language Models for Mental Health Support: Protocol for a Scoping Review.

JMIR Res Protoc

January 2025

Data and Web Science Group, School of Business Informatics and Mathematics, University of Manneim, Mannheim, Germany.

Background: The rapid evolution of large language models (LLMs), such as Bidirectional Encoder Representations from Transformers (BERT; Google) and GPT (OpenAI), has introduced significant advancements in natural language processing. These models are increasingly integrated into various applications, including mental health support. However, the credibility of LLMs in providing reliable and explainable mental health information and support remains underexplored.

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The TOXIN knowledge graph: supporting animal-free risk assessment of cosmetics.

Database (Oxford)

January 2025

Department of In Vitro Toxicology and Dermato-Cosmetology (IVTD), Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels 1090, Belgium.

The European Union's ban on animal testing for cosmetic products and their ingredients, combined with the lack of validated animal-free methods, poses challenges in evaluating their potential repeated-dose organ toxicity. To address this, innovative strategies like Next-Generation Risk Assessment (NGRA) are being explored, integrating historical animal data with new mechanistic insights from non-animal New Approach Methodologies (NAMs). This paper introduces the TOXIN knowledge graph (TOXIN KG), a tool designed to retrieve toxicological information on cosmetic ingredients, with a focus on liver-related data.

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Organic Mixed Conductors for Neural Biomimicry and Biointerfacing.

Annu Rev Chem Biomol Eng

January 2025

Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, Sweden; email:

Organic mixed ionic-electronic conductors (OMIECs) could revolutionize bioelectronics by enabling seamless integration with biological systems. This review explores their role in neural biomimicry and biointerfacing, with a focus on how backbone design, sidechain optimization, and antiambipolarity impact performance. Recent advances highlight OMIECs' biocompatibility and mechanical compliance, making them ideal for bioelectronic applications.

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Vintages for New Fashion: Red-Shifted Photoswitching via the Triplet-Photoreaction Channel with Charge-Transfer Complex Sensitizers.

J Am Chem Soc

January 2025

Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, Frontiers Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai 200237, P. R. China.

Triplet-sensitization has been proven invaluable for creating photoswitches operated over a full visible-light spectrum. While designing efficient triplet-sensitizers is crucial for establishing visible-light photochromism, it remains an appealing yet challenging task. In this work, we propose a versatile strategy to fabricate triplet-sensitizers with intermolecular charge-transfer complexes (CTCs).

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Deep-ultraviolet (DUV) light is essential for applications including fabrication, molecular research, and biomedical imaging. Compact metalenses have the potential to drive further innovation in these fields, provided they utilize a material platform that is cost-effective, durable, and scalable. In this work, we present aluminum nitride (AlN) metalenses as an efficient solution for DUV applications.

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Parasitoid wasp venoms degrade imaginal discs for successful parasitism.

Sci Adv

January 2025

Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba 305-8577, Japan.

Article Synopsis
  • Parasitoid wasps, a highly diverse group of animals, use their venoms to manipulate the physiology of host larvae for their benefit.
  • Researchers discovered that a specific wasp can cause the death and dysfunction of its host's tissue precursors, a process called imaginal disc degradation (IDD).
  • The study identified two venom proteins crucial for IDD, showing how the wasp's venom strategically ensures the host grows but inhibits its transformation into adulthood.
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A hyperelastic torque-reversal mechanism for soft joints with compression-responsive transient bistability.

Sci Robot

January 2025

Biorobotics Laboratory, Soft Robotics Research Center, Institute of Advanced Machines and Design, Department of Mechanical Engineering, Institute of Engineering, Seoul National University, Seoul, Republic of Korea.

Snap-through, a rapid transition of a system from an equilibrium state to a nonadjacent equilibrium state, is a valuable design element of soft devices for converting a monolithic stimulus into systematic responses with impulsive motions. A common way to benefit from snap-through is to embody it within structures and materials, such as bistable structures. Torque-reversal mechanisms discovered in nature, which harness snap-through instability via muscular forces, may have comparative advantages.

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Calcination-Induced Tight Nano-Heterointerface for Highly Effective Eradication of Rib Fracture-Related Infection by Near-Infrared Irradiation.

ACS Appl Mater Interfaces

January 2025

School of Materials Science & Engineering, The Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China.

Rib fracture-related infection is a challenging complication of thoracic trauma due to the difficulty of treating it with antibiotics alone and the need for a second operation to remove the infected fixator and sterilize the surrounding infected tissue. In this study, inspired by the photocatalytic performance of and ion release from silver-based materials, including AgPO and AgS, a hybrid AgPO-AgS heterojunction was prepared based on anion exchange and a one-step calcination process to design a nonantibiotic coating aimed at preventing and treating rib fracture-related infection with short-term 808 nm near-infrared irradiation. Calcination at 250 °C enhanced the inductive effect of the phosphate radical and led to the formation of a tight nanoheterogeneous interface between AgPO and AgS, thereby promoting interfacial electron transfer and reducing the recombination of photogenerated carriers.

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Article Synopsis
  • The emergence of Next Generation Sequencing (NGS) technology has transformed clinical diagnostics, providing extensive microbiome data for personalized medicine.
  • Despite its potential, microbiome data's complexity and variability pose challenges for traditional statistical and machine learning approaches, including deep learning.
  • The paper presents a novel feature engineering technique that combines two data feature sets, significantly improving the Deep Neural Network's performance in colorectal cancer detection, raising the Area Under the Curve (AUC) from 0.800 to 0.923, thus enhancing microbiome data analysis and disease detection capabilities.
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The proliferation of cyanobacteria has become a significant water management challenge due to the increasing eutrophication of water supply reservoirs. Cyanobacterial blooms thrive on elevated nutrient concentrations and form extensive green mats, disrupting the local ecosystem. Furthermore, many cyanobacterial species can produce toxins that are lethal to vertebrates called cyanotoxins.

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Solar-driven desalination technology is currently an important way to obtain freshwater resources. Significantly, porous materials are used as substrate materials of interface solar evaporator, and their specific impact of water transport property and thermal management during evaporation is worth exploring. In this paper, poly(vinyl alcohol) (PVA) sponges were prepared by a chemical foaming method, adjusted the PVA polymerization degree, and formaldehyde-hydroxyl ratio to regulate the pore size, and polypyrrole (PPy) was grown in situ on the surface skeleton of PVA sponge to construct a new interfacial solar evaporator (PPy/PVA) with different pore structures.

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Cold atmospheric plasma (CAP) has emerged as a promising technology for neutralizing microbes, including multidrug-resistant strains. This study investigates CAP's potential as an alternative to traditional antimicrobial drugs for microbial inactivation. In the era of increasing antimicrobial resistance, there is a persistent need for alternative antimicrobial strategies.

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Impact of Siberian Wildfires on Ice-Nucleating Particle Concentrations over the Northwestern Pacific.

Environ Sci Technol

January 2025

Research Institute for Global Change, Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Yokohama, Kanagawa 236-0001, Japan.

Ice-nucleating particles (INPs) significantly influence aerosol-cloud precipitation interactions at regional and global scales. However, information regarding the concentrations and origins of INPs over the open ocean, particularly at high latitudes, remains insufficient due to access difficulties. In this study, we investigated the concentrations and origins of INPs over the western North Pacific to the Arctic Ocean through ship-borne observations conducted in the early autumn of 2016.

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The side-chain directions in nonfullerene acceptors (NFAs) strongly influence the intermolecular interactions in NFAs; however, the influence of these side chains on the morphologies and charge carrier dynamics of Y6-based acceptors remains underexplored. In this study, we synthesize four distinct Y6-based acceptors, i.e.

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Cooling of Semiconductor Devices via Quantum Tunneling.

Phys Rev Lett

December 2024

Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, Massachusetts 02139, USA.

Classical transport of electrons and holes in nanoscale devices leads to heating that severely limits performance, reliability, and efficiency. In contrast, recent theory suggests that interband quantum tunneling and subsequent thermalization of carriers with the lattice results in local cooling of devices. However, internal cooling in nanoscale devices is largely unexplored.

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Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Phys Rev Lett

December 2024

State Key Laboratory of Particle Detection and Electronics, Beijing 100049, Hefei 230026, People's Republic of China.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

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Z boson events at the Large Hadron Collider can be selected with high purity and are sensitive to a diverse range of QCD phenomena. As a result, these events are often used to probe the nature of the strong force, improve Monte Carlo event generators, and search for deviations from standard model predictions. All previous measurements of Z boson production characterize the event properties using a small number of observables and present the results as differential cross sections in predetermined bins.

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Objective: The primary goal was to investigate whether the presence of preoperative lacunar infarcts (LACI) was associated with postoperative delirium (POD) in elderly patients undergoing elective major abdominal surgery.

Design: A prospective cohort study.

Setting And Participants: Patients aged ≥ 65 years from a tertiary level A hospital in China.

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Phthalates, known as phthalate esters (PAEs), are among the most ubiquitous pervasive env7ironmental endocrine disruptors (EEDs), extensively utilized globally in various facets of modern life due to their irreplaceable role as plasticizers. The exponential production and utilization of plastic goods have substantially escalated plastic waste accumulation. Consequently, PAEs have infiltrated the environment, contaminating food and drinking water reservoirs, posing notable threats to human health.

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Automatic multimodal registration of cone-beam computed tomography and intraoral scans: a systematic review and meta-analysis.

Clin Oral Investig

January 2025

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310006, China.

Objectives: To evaluate recent advances in the automatic multimodal registration of cone-beam computed tomography (CBCT) and intraoral scans (IOS) and their clinical significance in dentistry.

Methods: A comprehensive literature search was conducted in October 2024 across the PubMed, Web of Science, and IEEE Xplore databases, including studies that were published in the past decade. The inclusion criteria were as follows: English-language studies, randomized and nonrandomized controlled trials, cohort studies, case-control studies, cross-sectional studies, and retrospective studies.

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Background: Lung adenocarcinoma is one of the most common malignant tumors worldwide. Its complex molecular mechanisms and high tumor heterogeneity pose significant challenges for clinical treatment. The manganese ion metabolism family plays a crucial role in various biological processes, and the abnormal expression of the NUDT3 gene in multiple cancers has drawn considerable attention.

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is one of the commonly used hosts for heterologous enzyme expression, depending on media rich in carbon, nitrogen, and phosphate sources for optimal growth and enzyme production. Interestingly, our investigation of maltotetraose-forming amylase, a key enzyme for efficient maltotetraose synthesis, revealed that phosphate limitation significantly enhances the growth rate and production of heterologous enzymes in recombinant . Under phosphate-limited conditions in a 15 L fermenter, the enzyme activity reached 679.

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The present study aims to examine the effect of 4 h of continuous sitting on cerebral endothelial function, which is a crucial component of cerebral blood flow regulation. We hypothesized that 4 h of sitting may impair cerebral endothelial function similarly to how it affects lower limb vasculature. Thirteen young, healthy participants were instructed to remain seated for 4 h without moving their lower limbs.

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Unlike homogeneous metal complexes, achieving absolute control over reaction selectivity in heterogeneous catalysts remains a formidable challenge due to the unguided molecular adsorption/desorption on metal-surface sites. Conventional organic surface modifiers or ligands and rigid inorganic and metal-organic porous shells are not fully effective. Here, we introduce the concept of "ligand-porous shell cooperativity" to desirably reaction selectivity in heterogeneous catalysis.

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