1,297 results match your criteria: "Advanced Imaging Research Center[Affiliation]"
JCO Clin Cancer Inform
January 2025
SimBioSys Inc, Chicago, IL.
Purpose: Perfusion modeling presents significant opportunities for imaging biomarker development in breast cancer but has historically been held back by the need for data beyond the clinical standard of care (SoC) and uncertainty in the interpretability of results. We aimed to design a perfusion model applicable to breast cancer SoC dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) series with results stable to low temporal resolution imaging, comparable with published results using full-resolution DCE-MRI, and correlative with orthogonal imaging modalities indicative of biophysical markers.
Methods: Subsampled high-temporal-resolution DCE-MRI series were run through our perfusion model and resulting fits were compared for consistency.
Neuroimage
January 2025
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, USA.
Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.
View Article and Find Full Text PDFCells
December 2024
Biotechnology Research and Innovation Council-National Institute of Biomedical Genomics, Kalyani 741251, West Bengal, India.
Breast cancer is a cancer with global prevalence and a surge in the number of cases with each passing year. With the advancement in science and technology, significant progress has been achieved in the prevention and treatment of breast cancer to make ends meet. The scientific intradisciplinary subject of "metabolomics" examines every metabolite found in a cell, tissue, system, or organism from different sources of samples.
View Article and Find Full Text PDFMed Phys
January 2025
Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Background: Diffusion-weighted (DW) turbo-spin-echo (TSE) imaging offers improved geometric fidelity compared to single-shot echo-planar-imaging (EPI). However, it suffers from low signal-to-noise ratio (SNR) and prolonged acquisition times, thereby restricting its applications in diagnosis and MRI-guided radiotherapy (MRgRT).
Purpose: To develop a joint k-b space reconstruction algorithm for concurrent reconstruction of DW-TSE images and the apparent diffusion coefficient (ADC) map with enhanced image quality and more accurate quantitative measurements.
Alzheimers Res Ther
January 2025
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Backgrounds: Digital, online assessments are efficient means to detect early cognitive decline, but few studies have investigated the relationship between remotely collected subjective cognitive change and cognitive decline. We hypothesized that the Everyday Cognition Scale (ECog), a subjective change measure, predicts longitudinal change in cognition in the Brain Health Registry (BHR), an online registry for neuroscience research.
Methods: This study included BHR participants aged 55 + who completed both the baseline ECog and repeated administrations of the CANTAB Paired Associates Learning (PAL) visual learning and memory test.
Cancers (Basel)
December 2024
Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
: Fibroblast activation protein (FAP)-targeted theranostic radiopharmaceuticals have shown desired tumor-to-background organ selectivity due to the ubiquitous presence of FAP within the tumor microenvironment. However, suboptimal tumor retention and fast clearance have hindered their use to deliver effective cancer therapies. With well-documented FAP-targeting moieties and linkers appending them to optimal chelators, the development of copper radiopharmaceuticals has attracted considerable interest, given the fact that an ideal theranostic pair of copper radionuclides (Cu: t = 12.
View Article and Find Full Text PDFJ Magn Reson Imaging
December 2024
Department of Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon, USA.
Front Oncol
November 2024
Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States.
Quantitative dynamic contrast-enhanced (DCE) MRI as a promising method for the prediction of breast cancer response to neoadjuvant chemotherapy (NAC) has been demonstrated mostly in single-center and single-vendor platform studies. This preliminary study reports the initial experience in implementing quantitative breast DCE-MRI in multi-center (MC) and multi-vendor platform (MP) settings to predict NAC response. MRI data, including B mapping, variable flip angle (VFA) measurements of native tissue R (R), and DCE-MRI, were acquired during NAC at three sites using 3T systems with Siemens, Philips, and GE platforms, respectively.
View Article and Find Full Text PDFJ Biol Chem
December 2024
Department of Chemistry, Faculty of Science, Fukuoka University, Fukuoka, Japan. Electronic address:
Prohibitins (PHBs) are ubiquitously expressed proteins in the mitochondrial inner membrane (MIM) that provide membrane scaffolds for both mitochondrial proteins and phospholipids. Eukaryotic PHB complexes contain two highly homologous PHB subunits, PHB1 and PHB2, which are involved in various cellular processes, including metabolic control through the regulation of mitochondrial dynamics and integrity. Their mechanistic actions at the molecular level, however, particularly those of PHB1, remain poorly understood.
View Article and Find Full Text PDFIntern Med
December 2024
Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, Japan.
Magn Reson Med Sci
December 2024
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
RSC Adv
November 2024
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Florida Gainesville Florida USA +1 (352) 273-8646.
Metabolic diseases such as obesity, type 2 diabetes, and cardiovascular diseases have become a global health concern due to their widespread prevalence and profound impact on life expectancy, healthcare expenditures, and the overall economy. Devising effective treatment strategies and management plans for these diseases requires an in-depth understanding of the pathophysiology of the metabolic abnormalities associated with each disease. Mitochondrial dysfunction is intricately linked to a wide range of metabolic abnormalities and is considered an important biomarker for diseases.
View Article and Find Full Text PDFCurr Med Imaging
November 2024
Division of Pediatric Cardiology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA.
Background: Three-dimensional (3D) whole-heart magnetic resonance imaging (MRI) is an excellent tool to check the heart anatomy of patients with congenital and acquired heart disease. However, most 3D whole-heart MRI acquisitions take a long time to perform, and the sequence used is susceptible to banding artifacts.
Purpose: To validate an unsupervised neural network that can reduce acquisition time and improve image quality for 3D whole-heart MRI by superresolving low-resolution images.
Cereb Cortex
November 2024
Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, United States.
Npj Imaging
November 2024
Advanced Imaging Research Center and Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX USA.
Alzheimers Dement
December 2024
Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Introduction: The Health Equity Scholars Program (HESP) addresses the critical need for a diverse, culturally competent workforce to study and treat older adults from underrepresented populations (URPs) with Alzheimer's disease and related dementias (AD/ADRD). The HESP offers tailored mentored training in AD/ADRD research concepts, aiming to develop successful independent researchers. It recruits Scholars from underrepresented backgrounds as well as those passionate about AD/ADRD health equity research.
View Article and Find Full Text PDFPediatr Radiol
December 2024
Division of Pediatric Cardiology, Children's Health-University of Texas Southwestern Medical Center, 1935 Medical District Drive, Dallas, TX, 75235, USA.
Background: The three-dimensional balanced-steady-state-free-precession (3D bSSFP) whole-heart (WH) technique has long been used to depict cardiac morphology in congenital heart disease (CHD) but is prone to banding artifacts. The Relaxation Enhanced Angiography without Contrast and Triggering (REACT) sequence is an alternative method that is resistant to off-resonance effects.
Objective: To evaluate cardiac structures and great vessels in CHD patients using 3D WH REACT sequence and compare it to 3D WH bSSFP sequence.
Alzheimers Dement
December 2024
Department of Veterans Affairs Medical Center, VA Advanced Imaging Research Center, San Francisco, California, USA.
Background: The Everyday Cognition scale (ECog-39) scores are associated with future cognitive decline. We investigated whether the 12-item ECog (ECog-12), which is being collected in Alzheimer's Disease Neuroimaging Initiative (ADNI)4, can predict progression.
Methods: Baseline self (PT)- and study partner (SP)-ECog-12 data were extracted from the 39-item version collected in the ADNI.
Int Immunol
October 2024
Oral Health Science Center, Tokyo Dental College, Tokyo, 101-0061, Japan.
Translocator protein (TSPO) is a mitochondrial outer membrane protein expressed on a variety of immune cells, including macrophages, dendritic cells, and T cells, in addition to neurons and steroid-producing cells. Previous studies of TSPO ligands have suggested that TSPO is involved in multiple cellular functions, including steroidogenesis, immunomodulation, and cell proliferation. Currently, there are limited reports on the effects of TSPO or TSPO ligands on T cell-mediated immune responses.
View Article and Find Full Text PDFJ Clin Med
October 2024
Hypertension Section, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
High-density lipoprotein cholesterol efflux function may prevent brain amyloid beta deposition and neurodegeneration. However, the relevance of this finding has not been established in the diverse middle-aged population. We examined 1826 adults (47% Black adults) who participated in the Dallas Heart Study to determine associations between high-density lipoprotein (HDL) measures and brain structure and function.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
December 2024
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, United States.
Diabetes mellitus (DM) is characterized by chronic hyperglycemia, and despite intensive glycemic control, the risk of heart failure in patients with diabetes remains high. Diabetes-induced heart failure (DHF) presents a unique metabolic challenge, driven by significant alterations in cardiac substrate metabolism, including increased reliance on fatty acid oxidation, reduced glucose utilization, and impaired mitochondrial function. These metabolic alterations lead to oxidative stress, lipotoxicity, and energy deficits, contributing to the progression of heart failure.
View Article and Find Full Text PDFDiagnostics (Basel)
October 2024
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Fat infiltration in skeletal muscle is related to declining muscle strength, whereas excess subcutaneous fat is implicated in the development of metabolic diseases. Using multi-slice axial T2-weighted (T2w) MR images, this retrospective study characterized muscle fat infiltration (MFI) and fat distribution in the lower extremity of 107 subjects (64M/43F, age 11-79 years) with diverse ethnicities (including White, Black, Latino, and Asian subjects). MRI data analysis shows that MFI, evaluated by the relative intensities of the pixel histogram profile in the calf muscle, tends to increase with both age and BMI.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Medicine, Wisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Introduction: The Alzheimer's Disease Neuroimaging Initiative-4 (ADNI-4) Engagement Core was launched to advance Alzheimer's disease (AD) and AD-related dementia (ADRD) health equity research in underrepresented populations (URPs). We describe our evidence-based, scalable culturally informed, community-engaged research (CI-CER) model and demonstrate its preliminary success in increasing URP enrollment.
Methods: URPs include ethnoculturally minoritized, lower education (≤ 12 years), and rural populations.
J Heart Lung Transplant
October 2024
Department of Cardiovascular and Thoracic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
ACS Infect Dis
January 2025
Department of Bioengineering, University of Texas at Arlington, Arlington, Texas 76019, United States.
Orthopedic implant infections (OIIs) present diagnostic and therapeutic challenges, owing to the lack of methods to distinguish between active infection and sterile inflammation. To address this unmet need, d-amino-acid-based radiotracers with unique metabolic profiles in microorganisms have emerged as a novel class of infection-specific imaging agents. Given the pivotal role of d-glutamine in bacterial biofilm formation and virulence, herein, we explored the potential of positron emission tomography (PET) imaging with d-[5-C]-Glutamine (d-[5-C]-Gln) for early detection and treatment monitoring of OIIs.
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