Effects of additional weight-bearing on the in vivo kinematics of the human ankle joint complex during walking.

Studies focusing on the kinematics of the ankle joint complex (AJC) have long been a key area of interest for biomechanists and orthopedic surgeons. However, it is not clear how additional weight-bearing walking affects the motion of the AJC compared to walking with a normal body weight (BW) or what adjustments the AJC would instinctively make to accommodate the additional load. To address this gap in knowledge, advanced dynamic biplane radiography combined with a model-based 2D-3D tracking technique was employed to elucidate the inherent kinematics of the AJC during the stance phase while walking with and without additional weight-bearing.

ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice.

Acute kidney injury (AKI), typically caused by ischemia, is a common clinical complication with a poor prognosis. Although proteinuria is an important prognostic indicator of AKI, the underlying causal mechanism remains unclear. In vitro studies suggest that podocytes have high ATP demands to maintain their structure and function, however, analyzing their ATP dynamics in living kidneys has been technically challenging.

Artificial Intelligence to Diagnose Complications of Diabetes.

Artificial intelligence (AI) is increasingly being used to diagnose complications of diabetes. Artificial intelligence is technology that enables computers and machines to simulate human intelligence and solve complicated problems. In this article, we address current and likely future applications for AI to be applied to diabetes and its complications, including pharmacoadherence to therapy, diagnosis of hypoglycemia, diabetic eye disease, diabetic kidney diseases, diabetic neuropathy, diabetic foot ulcers, and heart failure in diabetes.

Combinatorial treatment with traditional medicinal preparations and VEGFR-tyrosine kinase inhibitors for middle-advanced primary liver cancer: A systematic review and meta-analysis.

Background: This study aimed to investigate the therapeutic efficacy and safety of Traditional medicine preparations (TMPs) given in combination with vascular endothelial growth factor receptor (VEGFR)-associated multi-targeted tyrosine kinase inhibitors (TKIs) for the treatment of middle to advanced-stage primary liver cancer (PLC).

Methods: This systematic literature survey employed 10 electronic databases and 2 clinical trial registration platforms to identify relevant studies on the use of TMPs + VEGFR-TKIs to treat patients with middle-advanced PLC. Furthermore, a meta-analysis was performed following the PRISMA guidelines using the risk ratio (RR) at 95% confidence intervals (CI) or standardized mean difference as effect measures.

A systematic review of energy storing dynamic response foot for prosthetic rehabilitation.

The purpose of this paper is to undertake a systematic review on various mechanical design considerations, simulation and optimization techniques as well as the clinical applications of energy storing and return (ESAR) prosthetic feet used in amputee rehabilitation. Methodological databases including PubMed, EMBASE, and SCOPUS were searched till July 2022, and the retrieved records were evaluated for relevance. The design, mechanism, materials used, mechanical and simulation techniques and clinical applications of ESAR foot used in developed and developing nations were reviewed.

The Application of a Cross-Shaped Advancement Flap in Polysyndactyly of the Fifth Toe.

Polysyndactyly of the foot is a common congenital malformation of the lower extremity. We introduce our surgical technique for reconstruction of polysyndactyly of the fifth toe fused with the fourth toe. The technique includes the removal of the medial hypoplastic ray, web-space reconstruction using a dorsal cross-shaped advancement flap and closure of the lateral incisions of the separated toes with a tongue-shaped flap and zigzag triangular flaps.

Profile of Fruquintinib in the Management of Advanced Refractory Metastatic Colorectal Cancer: Design, Development and Potential Place in Therapy.

Colorectal cancer (CRC) is a prevalent and deadly cancer, with metastatic CRC (mCRC) often leading to poor outcomes despite advancements in screening and chemotherapy. Anti-angiogenic agents targeting vascular endothelial growth factor (VEGF) pathways have become essential in mCRC treatment. Bevacizumab, a VEGF inhibitor, was the first agent used in this context.

Biomechanical conditions of subtalar joint arthrodesis with calcaneal locking nail: A probabilistic numerical study.

Introduction: Subtalar joint arthrodesis is primarily indicated for advanced osteoarthritis, hindfoot deformity, and/or instability. During the first 6-10 weeks after surgery, there is an intermediary structurally weaker state before complete bony fusion of the calcaneus and talus occurs. Loading of the foot can lead to mechanical stresses and relative movements in the former joint gap, which can impede the fusion process.

Musculoskeletal Soreness Location and Intensity in Soccer Athletes Across Multiple Seasons.

Objective: To compare soreness location and intensity between male and female soccer athletes across 2 competitive seasons.

Design: Descriptive Cohort Study.

Setting: Collegiate Sports Medicine Facility.

Management of peroneal tendon subluxation with concominant anterior talofibular ligament tear: A case report and literature review.

Introduction And Importance: Stability of the peroneal tendon and lateral ankle structure is essential. Appropriate treatment is mandatory to improve the outcome.

Case Presentation: A 47-year-old female has had ankle pain for around six months.

Popliteal Artery Injury During Total Knee Replacement: A Single-Center Experience.

The popliteal arteries are rarely injured during total knee replacement. Although uncommon, these complications warrant attention because the consequences can be disastrous, with high mortality rates, amputation risk, and additional comorbidities such as foot drop, infection, and functional impairment. However, it has detrimental consequences for the patient.

Updates on the Utilization of Percutaneous Deep Vein Arterialization in End-Stage Peripheral Arterial Disease.

Progressive peripheral artery disease, especially in the tibial and pedal vessels, can severely limit the interventions that vascular surgeons and interventionalists can provide to patients. End-stage peripheral arterial disease is often described as a disease where there are no distal targets available in the foot. Traditionally, amputation has been the only option for these patients.

Where Minimal Incision Surgery Can Have Maximum Results with Charcot Reconstruction.

Minimally invasive surgery (MIS) continues to develop as a viable alternative to traditional open surgery for various foot and ankle pathologies. The neuropathic foot is one area where MIS can be very beneficial to surgeons and their patients. Improving wound healing and decreasing the surgical footprint and thus reducing complications associated with soft tissue in this population is advantageous.

Controversial Matters of Minimally Invasive Bunion Repair.

New minimally invasive bunion surgery for hallux valgus (HV) has received attention in the last few years. A rapid growth in knowledge and techniques has been seen, with many publications, books, and experienced surgeons worldwide. Several variational advancements have emerged with the most common as a percutaneous subcapital osteotomy first metatarsal with long scaffolding minimally invasive (MI) screw placement.

Minimal Incision Management of Rearfoot & Ankle Trauma.

Minimally invasive surgery is gaining tremendous popularity in reconstructive foot and ankle surgery, as well as with trauma. Minimally invasive approaches have demonstrated equivalent to outcomes to traditional open incisional approaches with the added benefit of less risk for wound healing complications and surgical site infections. Advances in orthopedic hardware and surgical techniques are allowing minimal incision surgery for trauma to become more widespread.

The Unfamiliar Complications of Minimally Invasive Foot Surgery.

Over the last 5 years, minimally invasive surgery (MIS) has seen a significant surge, propelled by advancements in surgical equipment, implants, methodologies, and comprehensive education. The introduction of specialized hardware and advanced bone-cutting burrs has contributed to a reduction in complications. Evidence from peer-reviewed studies suggests that the outcomes of MIS are often on par with, and at times surpass, those of traditional surgical methods.

The History and Instrumentation of Minimally Invasive Pedal Surgery.

The journey through the history of minimally invasive surgery in foot and ankle procedures reveals a remarkable narrative of innovation and progress. Minimally invasive surgery has been adopted in various foot and ankle procedures including elective and trauma surgery. Most notably, the transformative impact of minimally invasive bunion surgery, spanning 3 generations of techniques, showcases a relentless pursuit of precision and efficiency.

Clinical efficacy and mechanism of the combination of autologous platelet-rich gel and recombinant human acidic fibroblast growth factor in the management of refractory diabetic foot.

Objective: This study aims to explore the influence of combining autologous platelet-rich gel (APG) with continuous vacuum-sealed drainage (CVSD) and the exogenous recombinant human acidic fibroblast growth factor (rh-aFGF) on the healing processes of diabetic foot ulcers (DFU). The primary objective is to elucidate the complex molecular mechanisms associated with DFU, providing innovative perspectives for its treatment.

Methods: Ninety patients diagnosed with DFU were randomly allocated into three distinct groups.

A comparison of clinical and radiographic outcomes between isolated total talus replacement and combined total talus replacement with total ankle arthroplasty or hindfoot arthrodesis.

Total talus replacement (TTR) is a viable surgical option in the setting of talar avascular necrosis and collapse, as well as a revision option for failed total ankle arthroplasty with talar implant subsidence. The purpose of the present study was to compare the clinical and radiographic outcomes following isolated TTR and TTR combined with total ankle arthroplasty or hindfoot arthrodesis. Patients who underwent TTR were retrospectively reviewed, as a multicenter consecutive case series.