357 results match your criteria: "Advanced Diagnostic and Interventional Radiology Research Center[Affiliation]"

Background: Cytokeratins are intracellular proteins known as diagnostic biomarkers or prognostic factors for certain cancers. Cytokeratin 19 (CK-19) expression has been proven to have prognostic value for some cancers, but its relationship with others, such as prostate cancer (PCa), remains unclear. This systematic review article aimed to examine the relationship between CK-19 expression and prostate adenocarcinoma (PAC).

View Article and Find Full Text PDF

Intra-Arterial Stem Cell Injection for Treating Various Diseases: A New Frontier in Interventional Radiology.

Cardiovasc Intervent Radiol

January 2025

Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.

This article provides radiologists with insights into stem cells' functions, sources, and potentially successful clinical treatments via intravascular injection in organs such as the liver, kidney, pancreas, musculoskeletal system, and for ischemic conditions affecting the brain, heart and limbs. Understanding stem cells' significance in interventional radiology and its limitations enables tailored interventions for diverse conditions, ensuring efficient medical care and optimal treatment selection.

View Article and Find Full Text PDF

Breast cancer continues to be a major health concern, and early detection is vital for enhancing survival rates. Magnetic resonance imaging (MRI) is a key tool due to its substantial sensitivity for invasive breast cancers. Computer-aided detection (CADe) systems enhance the effectiveness of MRI by identifying potential lesions, aiding radiologists in focusing on areas of interest, extracting quantitative features, and integrating with computer-aided diagnosis (CADx) pipelines.

View Article and Find Full Text PDF

Background: Phlebotomy has been used as a non-pharmacological treatment for different types of diseases, regarding the philosophy of humors in traditional medicines, such as Persian Medicine. However, according to the narrow-approved indications for phlebotomy in Western Medicine, we aimed to systematically summarize high-level of evidence on safety and efficacy of phlebotomy in treatment of human diseases.

Methods: In this umbrella review, to identify meta-analysis studies of clinical trials on phlebotomy, four electronic databases, including PubMed, web of science, Scopus, and Cochran library were searched until Jun 18, 2022 with relevant keywords for 'phlebotomy' and 'meta-analysis' according to PRISMA guidelines and PICO questions.

View Article and Find Full Text PDF

A Case of Primary Ovarian Primitive Neuroectodermal Tumor.

Med J Islam Repub Iran

July 2024

Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.

Primitive neuroectodermal tumors (PNET) are a family of poorly differentiated malignant neoplasms of neuroectodermal origin. According to the location of origin, PNETs could be further categorized as central or peripheral. Peripheral PNET (pPNET) is an uncommon type that accounts for 1% of all soft tissue sarcomas and occurs outside the central and sympathetic nervous systems.

View Article and Find Full Text PDF
Article Synopsis
  • Surgery is the main treatment for primary hyperparathyroidism (PHPT), but MIBI-avid thyroid nodules can make it hard to find parathyroid adenomas.
  • A 49-year-old woman with hypercalcemia had imaging tests that indicated thyroid nodules, but further scans helped locate an adenoma better.
  • Combining various imaging methods like SPECT/CT and 4D CT is critical for successful surgery and improving results in patients with PHPT.
View Article and Find Full Text PDF

Background: Acute ischemic stroke (AIS) is a major cause of morbidity and mortality, with hemorrhagic transformation (HT) further worsening outcomes. Traditional scoring systems have limited predictive accuracy for HT in AIS. Recent research has explored machine learning (ML) and deep learning (DL) algorithms for stroke management.

View Article and Find Full Text PDF

Early detection of fetal intracranial hemorrhage and infarct during pregnancy is crucial for preventing lethal and debilitating complications in neonatal life. Every radiologist must be aware of the imaging features of these conditions to refer patients to specialists. Sonographic and MRI features of fetal intracranial hemorrhage and infarct have been discussed in many previous articles.

View Article and Find Full Text PDF

Background: Leukemia necessitates continuous research for effective therapeutic techniques. Acute leukemia (AL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) focus on key outcomes such as overall survival (OS), relapse, and graft-versus-host disease (GVHD).

Objective: This study aims to evaluate the capability of machine learning (ML) models in predicting OS, relapse, and GVHD in AL patients post-allo-HSCT.

View Article and Find Full Text PDF

Castleman disease (CD) is a nonclonal lymphoproliferative disorder that causes non-neoplastic lymph node enlargement. With an incidence of approximately 21-25 cases per million, CD presents variably, often mimicking both benign and malignant conditions across various body regions. Clinically, it ranges from asymptomatic lymph node enlargement in Unicentric Castleman's Disease (UCD) to aggressive, multicentric presentations affecting multiple organs.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the effectiveness of splenic artery embolization (SAE) as a treatment for esophageal variceal bleeding caused by portal hypertension (PH), focusing on its efficacy, safety, and overall role in managing this condition.
  • - A systematic review and meta-analysis of 18 studies involving 531 patients found significant reductions in variceal bleeding after SAE, with 26% achieving complete resolution of varices and 78% showing improvement.
  • - The findings indicate that SAE is a safe procedure with low complication rates, effectively increasing platelet counts and reducing bleeding in patients with variceal bleeding due to PH.
View Article and Find Full Text PDF

Cultivating diagnostic clarity: The importance of reporting artificial intelligence confidence levels in radiologic diagnoses.

Clin Imaging

January 2025

Keck School of Medicine of University of Southern California, Los Angeles, CA, United States of America; Department of Radiology, Cedars Sinai Hospital, Los Angeles, CA, United States of America. Electronic address:

Accurate image interpretation is essential in the field of radiology to the healthcare team in order to provide optimal patient care. This article discusses the use of artificial intelligence (AI) confidence levels to enhance the accuracy and dependability of its radiological diagnoses. The current advances in AI technologies have changed how radiologists and clinicians make the diagnoses of pathological conditions such as aneurysms, hemorrhages, pneumothorax, pneumoperitoneum, and particularly fractures.

View Article and Find Full Text PDF

Background And Aim: The present study aimed to evaluate the use of F-2-[F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone.

Methods: We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models.

View Article and Find Full Text PDF

Death Causes Among Iranian Children With Leukodystrophies.

J Child Neurol

November 2024

Myelin Disorders Clinic, Pediatric Neurology Division, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Article Synopsis
  • Leukodystrophies are serious inherited neurological disorders with high mortality rates and limited treatment options, highlighting a gap in data on mortality causes.
  • A study on 165 Iranian pediatric patients found that 38.8% had died, with a mean age at death of 5.2 years and a mortality rate increasing over time.
  • The main causes of death were identified as cardiopulmonary issues (47%), seizures (11%), and sepsis (9%), indicating the need for targeted interventions to address these specific causes in future care.
View Article and Find Full Text PDF
Article Synopsis
  • There's a significant gap in the accuracy of molecular imaging radiotracers for non-seminomatous germ cell tumors (NSGCT).
  • Current imaging methods struggle to distinguish between teratoma and necrotic tissue in these tumors.
  • The article reviews previous attempts and looks at future possibilities for developing better radiotracers for NSGCT imaging.
View Article and Find Full Text PDF

Refining MRI Protocols for Endometriosis: A Comparative Study of Abbreviated and Full MRI Sequences.

Br J Radiol

November 2024

Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Endometriosis is a significant cause of chronic abdominal pain and infertility in females, often overlooked due to its resemblance to other abdominopelvic pathologies. This study aims to compare the diagnostic performance and agreement rate between an abbreviated MRI protocol (aMRI) and a full MRI protocol (fMRI) for detecting pelvic endometriosis.

Methods: We retrospectively analyzed 446 consecutive MRI exams, including both full (fMRI) and abbreviated (aMRI) protocols, performed for suspected pelvic endometriosis.

View Article and Find Full Text PDF
Article Synopsis
  • Stroke is a major global health issue, with about one-third of patients facing a second stroke, prompting this study to explore machine learning (ML) algorithms for predicting recurrent strokes.
  • The study analyzed 12 research papers involving over 24,000 individuals, revealing that ML models have a sensitivity of 71% and a specificity of 88% for predicting recurrent strokes.
  • While the results are promising, indicating that ML could help identify high-risk patients, the study highlights the need for standardized methods and further research to improve the consistency and applicability of these predictive models.
View Article and Find Full Text PDF

Introduction: Paradoxical brain herniation (PBH) represents a rare and potentially life-threatening complication observed in individuals following decompressive craniectomy. Its diagnosis necessitates a high level of suspicion, combined with clinical and imaging evidence, such as midline shift, herniation, and a decreased Glasgow Coma Scale (GCS). Given the rarity and severity of this condition, we conduct a comprehensive literature review to identify all documented predisposing factors, clinical presentations, and appropriate clinical management.

View Article and Find Full Text PDF

Background: Theoretically, endocrine fluctuations occurring during infertility treatments, including ovulation induction (OI) and assisted reproductive techniques (ART), could be associated with an increased risk of benign breast diseases (BBDs). To date, no studies have been conducted on this association. Therefore, the present study investigated the association between different types of infertility treatments and BBDs.

View Article and Find Full Text PDF
Article Synopsis
  • * This systematic review followed PRISMA guidelines to analyze 21 studies out of 249 citations screened, highlighting radiomics' potential to differentiate medulloblastomas from other tumors and identify their subtypes.
  • * The findings suggest that while radiomics shows promise for predicting survival rates in medulloblastoma patients, further research is needed to fully assess its clinical value.
View Article and Find Full Text PDF
Article Synopsis
  • This study investigated the relationship between GAP-43 levels in cerebrospinal fluid (CSF) and changes in brain white matter microstructure in Alzheimer's disease (AD) patients.
  • Over a follow-up period of 2 to 4 years, researchers analyzed data from 133 participants and found significant negative correlations between GAP-43 levels and specific diffusion tensor imaging (DTI) measures in early and late mild cognitive impairment (MCI).
  • The findings suggest that GAP-43 and DTI together can serve as new biomarkers to detect and monitor synaptic degeneration in AD, which could help track disease progression and evaluate treatment effectiveness.
View Article and Find Full Text PDF

Superscan Pattern on Bone Scintigraphy: A Comprehensive Review.

Diagnostics (Basel)

October 2024

Department of Nuclear Medicine, The Hospital for Sick Children, University of Toronto, Toronto, ON M4N 3M5, Canada.

Article Synopsis
  • The superscan pattern is a key finding on bone scans, indicating various metabolic and cancer-related diseases, characterized by widespread radiotracer uptake in the skeleton.
  • This review analyzes existing literature to clarify the pathophysiology, clinical importance, and diagnostic challenges related to the superscan pattern in bone scintigraphy.
  • Accurate diagnosis is essential, as misinterpretation can complicate patient management, highlighting the need for careful differential diagnoses when encountering this pattern.
View Article and Find Full Text PDF
Article Synopsis
  • Developmental dysplasia of the hip (DDH) is a condition with various structural abnormalities in the hip, where early diagnosis and treatment are crucial for optimal outcomes.
  • This study involved 399 infants to assess the prevalence of DDH, particularly focusing on those with and without associated risk factors, as well as the effectiveness of ultrasound screening in diagnosing this condition.
  • Results showed that 25.8% of infants with risk factors had DDH compared to 2.8% without, with factors like being female and having limb anomalies significantly increasing the risk, highlighting ultrasound's effectiveness for early screening.
View Article and Find Full Text PDF
Article Synopsis
  • - Various soft markers identified in fetal ultrasounds may indicate potential chromosomal abnormalities, but some can also be normal variations that resolve over time in pregnancy.
  • - A study was conducted to evaluate the effectiveness of these ultrasonic soft markers in diagnosing chromosomal issues like Trisomy 21 and 18, by reviewing 10 relevant studies published before August 2023, which included over 18,500 cases.
  • - Results showed that Trisomy 21 and 18 were the most frequently linked to these soft markers, along with other chromosomal abnormalities, and indicated a higher chance of pathogenic copy number variations in fetuses with multiple soft markers present.
View Article and Find Full Text PDF