12,500 results match your criteria: "Adrenal Carcinoma"
Arch Virol
December 2024
Department of Medical Entomology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Most members of the genus Orthonairovirus, represented by Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, are tick-borne, and some have become a public health concern in recent years. Here, we report the isolation and genetic and biological characterization of a new orthonairovirus, designated as "Iwanai Valley virus" (IWVV), from Ixodes ovatus ticks in Hokkaido, Japan. The amino acid sequence of the viral nucleoprotein (NP) was found to be 34-45% identical to those of known orthonairoviruses.
View Article and Find Full Text PDFTransl Cancer Res
November 2024
Department of Clinical Laboratory, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Kinectin 1 () is a membrane protein involved in intracellular organelle motility. However, the role of in human pan-cancer lacks systematic analysis and evaluation. The aim of this study is to evaluate the expression profile and clinical value in human cancers by performing a pan-cancer analysis of .
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Renal cell carcinoma is the most common type of primary renal cancer, and clear cell carcinoma is the most common subtype, accounting for approximately 70% of all adult renal cell carcinoma cases. At the time of diagnosis, many patients already have metastatic manifestations. Cutaneous metastasis of renal clear cell carcinoma is very rare and usually represents a poor prognosis, mostly affecting the head and neck.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
Adrenocortical carcinomas (ACCs) are rare and aggressive malignancies of adrenal cortex, associated with largely unknown mechanisms of biological development and poor prognosis. Currently, mitotane is the sole approved drug for treating advanced adrenocortical carcinomas (ACCs) and is being utilized more frequently as postoperative adjuvant therapy. Although it is understood that mitotane targets the adrenal cortex and disrupts steroid production, its precise mechanism of action requires further exploration.
View Article and Find Full Text PDFCancers (Basel)
November 2024
Department of Public Health and Pediatrics, University of Torino, 10126 Torino, Italy.
Background/objectives: Adrenocortical tumors (ACTs), including adrenocortical adenoma (ACA) and carcinoma (ACC), represent 0.3-0.4% of pediatric tumors.
View Article and Find Full Text PDFJ Thorac Dis
November 2024
Department of Oncology, Zhongshan Hospital, Fudan University, Shanghai, China.
Background: Immune checkpoint inhibitors (ICIs) are emerging as important drugs for patients with locally advanced esophageal cancer (EC). Yet, immune-related adverse events (irAEs) may be a major obstacle for these population. Multidisciplinary team (MDT) is an efficient way to deal with such conditions.
View Article and Find Full Text PDFAm J Transl Res
November 2024
Department of General Practice, Pingjiang New Town Community Health Service Center Sujin Street, Gusu District, Suzhou 215000, Jiangsu, China.
Background: Cancer represents a highly intricate disease, characterized by the uncontrolled proliferation and invasion of aberrant cells, leading to widespread global morbidity and mortality. This study investigates the influence of CD19, a marker specific to B-cells, within the tumor microenvironment (TME) across a spectrum of cancer types.
Methodology: To explore the role of CD19, we employed a wide array of bioinformatics tools and databases, including UALCAN, GEPIA2, univariate Cox regression, KM plotter, HPA, GSCA, cBioPortal, TISIDB, and DAVID.
Am J Transl Res
November 2024
Lower Extremity Division, Orthopedic Trauma Department, Honghui Hospital, Xi'an Jiaotong University Youyi East Road No. 555, Beilin District, Xi'an, Shaanxi, China.
Purpose: The stromal cell protein metalloproteinase 9 (MMP9), associated with extracellular matrix degradation and remodeling, promotes tumor invasion and metastasis and regulates cell adhesion molecule and cytokine activity. This study evaluated MMP9 in pan-cancer and screened for compounds and drug candidates that can inhibit it.
Methods: MMP9 expression in pan-cancer tissues was evaluated in a pan-cancer dataset from the University of California Santa Cruz database, along with the correlation between MMP9 and the tumor microenvironment (TME), RNA modification genes, and tumor mutation burden.
bioRxiv
December 2024
Discipline of Pharmacology & Therapeutics, School of Medicine, University of Galway, Galway, Ireland.
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis, treated primarily through surgery and chemotherapy. Other treatments like radiation or thermal ablation for metastases have limited success, and recurrence is common. More effective management options are needed.
View Article and Find Full Text PDFSurgery
December 2024
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Suzhou, Jiangsu, China. Electronic address:
Endocrinology
November 2024
Discipline of Pharmacology and Therapeutics, School of Medicine, University of Galway, Galway, H91 V4AY, Ireland.
Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex that is associated with a poor prognosis. Developing effective treatment options for ACC is challenging owing to the current lack of representative preclinical models. This study addressed this limitation by developing and characterizing 3-dimensional (3D) cell cultures incorporating the ACC cell lines, MUC-1, HAC15, and H295R in a type I collagen matrix.
View Article and Find Full Text PDFCureus
November 2024
Department of Internal Medicine, Merit Health Wesley, Hattiesburg, USA.
J Cancer
October 2024
National and Local Joint Engineering Research Cente of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
As a member of the DExD/H-box RNA helicase family, DHX34 has demonstrated a significant correlation with the development of multiple disorders. Nevertheless, a comprehensive investigation between DHX34 and pan-cancer remains unexplored. We analyzed the value of DHX34 in pan-cancer based on some databases, such as The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and The Human Protein Atlas (HPA) by use the R language as well as some online analysis tools, including STRING, TISIDB, TISCH2.
View Article and Find Full Text PDFCan Urol Assoc J
December 2024
Department of Urology, Queen's University, Kingston, ON Canada.
Introduction: Management of adrenal disease requires a multidisciplinary approach often involving varied specialists. Surgical management has often overlapped between general surgeons, usually with an interest in surgical endocrinology, or urologists with minimally invasive surgical skills. The objectives of this study were to define perioperative outcomes of contemporary Canadian adrenal surgery, and determine whether those outcomes are impacted by surgical subspecialty.
View Article and Find Full Text PDFJCEM Case Rep
December 2024
Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa 920-8640, Japan.
Primary malignant lymphomas originating in the adrenal gland, particularly of T-cell origin, are extremely rare. Here we present the primary unilateral adrenal anaplastic large cell lymphoma case. A 64-year-old Japanese male initially presented with fatigue and appetite loss.
View Article and Find Full Text PDFEndocr Relat Cancer
November 2024
T van Ginhoven, Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, Netherlands.
Up to 30% of adrenocortical carcinoma (ACC) patients have metastasised disease upon initial presentation and systemic treatments currently fail to sufficiently improve survival. Palliative primary tumour resection can be considered for symptomatic relief, but its potential survival benefit remains a topic of debate. This systematic review therefore aims to assess the effect of primary tumour resection on overall survival in patients with metastatic ACC.
View Article and Find Full Text PDFEur J Case Rep Intern Med
November 2024
Haematology and Oncology Department, Foundation Valle del Lili, Cali, Colombia.
Introduction: Lung cancer is the second most common cancer worldwide and the leading cause of cancer deaths; non-small cell lung cancer (NSCLC) constitutes about 85% of lung cancer cases, with ALK fusions representing 3-6% of them. The SQSTM1-ALK fusion is a rare finding in NSCLC, accounting for only 1.1% of ALK rearrangements.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Endocrinology, PGIMER, Chandigarh, India.
Cureus
December 2024
Pediatric Pulmonology, King Abdulaziz Medical City Riyadh, Riyadh, SAU.
Renal cell carcinoma (RCC) is the most common primary kidney neoplasm, with clear cell being the predominant histopathological type. Extra-renal RCC, a rare entity, occurs in locations outside the normal kidneys. This report presents a case of metastatic primary extra-renal RCC.
View Article and Find Full Text PDFPathol Res Pract
November 2024
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA; Englander Institute for Precision Medicine, Weill Cornell Medicine, 413 East 69th Street, New York, NY 10021, USA. Electronic address:
Retin Cases Brief Rep
November 2024
Northern California Kaiser Permanente, Roseville, CA, USA.
Purpose: We describe a case of bilateral chronic central serous chorioretinopathy (CSCR) secondary to adrenal cortical carcinoma.
Methods: Case report of a 70-year-old Hispanic man presenting with bilateral multifocal CSCR.
Results: Clinical findings of bilateral chronic CSCR along with 160 µm of subretinal fluid (SRF) and choroidal thickness greater than 400 µm without enhanced depth optical coherence tomography was noted in a patient presenting with distortion in vision in both eyes and weight gain of 15 pounds, weakness, and fatigue starting 8 months prior.
Ann Med
December 2024
Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
J ASEAN Fed Endocr Soc
December 2024
Pathology Department, Sarawak General Hospital, Ministry of Health, Malaysia.